JP2000511527A5 - - Google Patents

Download PDF

Info

Publication number
JP2000511527A5
JP2000511527A5 JP1997542369A JP54236997A JP2000511527A5 JP 2000511527 A5 JP2000511527 A5 JP 2000511527A5 JP 1997542369 A JP1997542369 A JP 1997542369A JP 54236997 A JP54236997 A JP 54236997A JP 2000511527 A5 JP2000511527 A5 JP 2000511527A5
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
JP1997542369A
Other languages
English (en)
Japanese (ja)
Other versions
JP2000511527A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US1997/006591 external-priority patent/WO1997044350A1/en
Publication of JP2000511527A publication Critical patent/JP2000511527A/ja
Publication of JP2000511527A5 publication Critical patent/JP2000511527A5/ja
Abandoned legal-status Critical Current

Links

JP09542369A 1996-05-22 1997-04-29 タンパク質ファルネシルトランスフェラーゼの阻止 Abandoned JP2000511527A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US1611096P 1996-05-22 1996-05-22
US3366296P 1996-12-17 1996-12-17
US60/016,110 1996-12-17
US60/033,662 1996-12-17
PCT/US1997/006591 WO1997044350A1 (en) 1996-05-22 1997-04-29 Inhibitors of protein farnesyl transferase

Publications (2)

Publication Number Publication Date
JP2000511527A JP2000511527A (ja) 2000-09-05
JP2000511527A5 true JP2000511527A5 (enrdf_load_stackoverflow) 2005-01-13

Family

ID=26688183

Family Applications (1)

Application Number Title Priority Date Filing Date
JP09542369A Abandoned JP2000511527A (ja) 1996-05-22 1997-04-29 タンパク質ファルネシルトランスフェラーゼの阻止

Country Status (18)

Country Link
EP (1) EP0938494A1 (enrdf_load_stackoverflow)
JP (1) JP2000511527A (enrdf_load_stackoverflow)
CN (1) CN1219174A (enrdf_load_stackoverflow)
AU (1) AU728477B2 (enrdf_load_stackoverflow)
BG (1) BG102936A (enrdf_load_stackoverflow)
BR (1) BR9709354A (enrdf_load_stackoverflow)
CA (1) CA2253934A1 (enrdf_load_stackoverflow)
CO (1) CO4960642A1 (enrdf_load_stackoverflow)
CZ (1) CZ376498A3 (enrdf_load_stackoverflow)
EA (1) EA199801031A1 (enrdf_load_stackoverflow)
EE (1) EE9800408A (enrdf_load_stackoverflow)
GE (1) GEP20012500B (enrdf_load_stackoverflow)
IL (1) IL126833A0 (enrdf_load_stackoverflow)
NO (1) NO985405L (enrdf_load_stackoverflow)
NZ (1) NZ332712A (enrdf_load_stackoverflow)
PL (1) PL330120A1 (enrdf_load_stackoverflow)
SK (1) SK161098A3 (enrdf_load_stackoverflow)
WO (1) WO1997044350A1 (enrdf_load_stackoverflow)

Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5968965A (en) * 1996-01-30 1999-10-19 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US6028201A (en) * 1996-01-30 2000-02-22 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
AU703203B2 (en) * 1996-01-30 1999-03-18 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
EP1011669A4 (en) * 1996-01-30 2001-09-12 Merck & Co Inc FARNESYL PROTEIN TRANSFERASE INHIBITORS
US5981562A (en) * 1996-01-30 1999-11-09 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US6300501B1 (en) 1996-05-22 2001-10-09 Warner-Lambert Company Histidine-(N-benzyl glycinamide) inhibitors of protein farnesyl transferase
US6265382B1 (en) * 1997-04-11 2001-07-24 Warner-Lambert Company Dipeptide inhibitors of protein farnesyltransferase
US6737410B1 (en) 1997-04-11 2004-05-18 Warner-Lambert Company Inhibitors of protein farnesyl transferase
US20030069231A1 (en) 1999-10-12 2003-04-10 Klaus Rudolf Modified aminoacids, pharmaceuticals containing these compounds and method for their production
NZ507165A (en) * 1998-04-27 2003-06-30 Warner Lambert Co Functionalized alkyl and alkenyl side chain derivatives of glycinamides as farnesyl transferase inhibitors
AU2477400A (en) 1998-12-08 2000-06-26 Merck & Co., Inc. Inhibitors of prenyl-protein transferase
WO2000034239A2 (en) 1998-12-08 2000-06-15 Merck & Co., Inc. Inhibitors of prenyl-protein transferase
US6632818B2 (en) 2000-01-12 2003-10-14 Merck & Co., Inc. Inhibitors of prenyl-protein transferase
JP2002188646A (ja) * 2000-12-20 2002-07-05 Nsk Ltd 転がり軸受及び軸受装置
US7595312B2 (en) 2002-10-25 2009-09-29 Boehringer Ingelheim Pharma Gmbh & Co. Kg Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions
WO2005049589A2 (en) * 2003-10-14 2005-06-02 Cadila Healthcare Limited Heterocyclic compounds for the treatment of hyperlipidemia, diabetes, obesity and similar diseases
DE102004015723A1 (de) 2004-03-29 2005-10-20 Boehringer Ingelheim Pharma Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel
ES2382814T3 (es) 2005-05-17 2012-06-13 Merck Sharp & Dohme Ltd. Ácido cis-4-[(4-clorofenil)sulfonil]-4-(2,5-difluorofenil)ciclohexanopropanoico para el tratamiento del cáncer
TW200804345A (en) 2005-08-30 2008-01-16 Novartis Ag Substituted benzimidazoles and methods of preparation
GB0603041D0 (en) 2006-02-15 2006-03-29 Angeletti P Ist Richerche Bio Therapeutic compounds
EA018917B1 (ru) 2006-04-19 2013-11-29 Новартис Аг 6-о-замещенные бензоксазолы и бензотиазолы и способы подавления передачи сигналов от csf-1r
WO2008039327A2 (en) 2006-09-22 2008-04-03 Merck & Co., Inc. Method of treatment using fatty acid synthesis inhibitors
US20110218176A1 (en) 2006-11-01 2011-09-08 Barbara Brooke Jennings-Spring Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
AR064777A1 (es) 2007-01-10 2009-04-22 Inst Di Reserche D Biolog Mole Indazoles sustituidos con amida como inhibidores de poli (adp- ribosa) polimerasa (parp)
KR101514853B1 (ko) 2007-03-01 2015-04-24 노파르티스 아게 Pim 키나제 억제제 및 이들의 사용 방법
ES2452349T3 (es) 2007-05-21 2014-04-01 Novartis Ag Inhibidores de CSF-1R, composiciones, y métodos de uso
EP2170076B1 (en) 2007-06-27 2016-05-18 Merck Sharp & Dohme Corp. 4-carboxybenzylamino derivatives as histone deacetylase inhibitors
EP2413932A4 (en) 2009-04-01 2012-09-19 Merck Sharp & Dohme INHIBITORS OF AKT ACTIVITY
EP2440058A4 (en) 2009-06-12 2012-11-21 Dana Farber Cancer Inst Inc MELTED HETEROCYCLIC COMPOUNDS AND APPLICATIONS THEREOF
CA2777043C (en) 2009-10-14 2015-12-15 Schering Corporation Substituted piperidines that increase p53 activity and the uses thereof
WO2011090738A2 (en) 2009-12-29 2011-07-28 Dana-Farber Cancer Institute, Inc. Type ii raf kinase inhibitors
EP2547661A2 (en) 2010-03-16 2013-01-23 Dana-Farber Cancer Institute, Inc. Indazole compounds and their uses
WO2011163330A1 (en) 2010-06-24 2011-12-29 Merck Sharp & Dohme Corp. Novel heterocyclic compounds as erk inhibitors
AU2011285909B2 (en) 2010-08-02 2016-11-10 Sirna Therapeutics, Inc. RNA interference mediated inhibition of catenin (cadherin-associated protein), beta 1 (CTNNB1) gene expression using short interfering nucleic acid (siNA)
US9029341B2 (en) 2010-08-17 2015-05-12 Sirna Therapeutics, Inc. RNA interference mediated inhibition of hepatitis B virus (HBV) gene expression using short interfering nucleic acid (siNA)
US8883801B2 (en) 2010-08-23 2014-11-11 Merck Sharp & Dohme Corp. Substituted pyrazolo[1,5-a]pyrimidines as mTOR inhibitors
WO2012030685A2 (en) 2010-09-01 2012-03-08 Schering Corporation Indazole derivatives useful as erk inhibitors
US9242981B2 (en) 2010-09-16 2016-01-26 Merck Sharp & Dohme Corp. Fused pyrazole derivatives as novel ERK inhibitors
EP3766975A1 (en) 2010-10-29 2021-01-20 Sirna Therapeutics, Inc. Rna interference mediated inhibition of gene expression using short interfering nucleic acid (sina)
US9351965B2 (en) 2010-12-21 2016-05-31 Merck Sharp & Dohme Corp. Indazole derivatives useful as ERK inhibitors
WO2012145471A1 (en) 2011-04-21 2012-10-26 Merck Sharp & Dohme Corp. Insulin-like growth factor-1 receptor inhibitors
US9023865B2 (en) 2011-10-27 2015-05-05 Merck Sharp & Dohme Corp. Compounds that are ERK inhibitors
US9382239B2 (en) 2011-11-17 2016-07-05 Dana-Farber Cancer Institute, Inc. Inhibitors of c-Jun-N-terminal kinase (JNK)
WO2013165816A2 (en) 2012-05-02 2013-11-07 Merck Sharp & Dohme Corp. SHORT INTERFERING NUCLEIC ACID (siNA) COMPOSITIONS
BR112015006990A2 (pt) 2012-09-28 2017-07-04 Merck Sharp & Dohme composto, composição farmacêutica, e, uso de pelo menos um composto
EP2909194A1 (en) 2012-10-18 2015-08-26 Dana-Farber Cancer Institute, Inc. Inhibitors of cyclin-dependent kinase 7 (cdk7)
WO2014063054A1 (en) 2012-10-19 2014-04-24 Dana-Farber Cancer Institute, Inc. Bone marrow on x chromosome kinase (bmx) inhibitors and uses thereof
WO2014063061A1 (en) 2012-10-19 2014-04-24 Dana-Farber Cancer Institute, Inc. Hydrophobically tagged small molecules as inducers of protein degradation
JP6290237B2 (ja) 2012-11-28 2018-03-07 メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. 癌を処置するための組成物および方法
MX373639B (es) 2012-12-20 2020-05-04 Merck Sharp & Dohme Imidazopiridinas sustituidas como inhibidores de doble minuto 2 humana.
EP2951180B1 (en) 2013-01-30 2018-05-02 Merck Sharp & Dohme Corp. 2,6,7,8 substituted purines as hdm2 inhibitors
WO2015034925A1 (en) 2013-09-03 2015-03-12 Moderna Therapeutics, Inc. Circular polynucleotides
JP6491202B2 (ja) 2013-10-18 2019-03-27 デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド サイクリン依存性キナーゼ7(cdk7)の多環阻害剤
CA2927917C (en) 2013-10-18 2022-08-09 Syros Pharmaceuticals, Inc. Heteroaromatic compounds useful for the treatment of proliferative diseases
WO2015164614A1 (en) 2014-04-23 2015-10-29 Dana-Farber Cancer Institute, Inc. Janus kinase inhibitors and uses thereof
US9862688B2 (en) 2014-04-23 2018-01-09 Dana-Farber Cancer Institute, Inc. Hydrophobically tagged janus kinase inhibitors and uses thereof
JO3589B1 (ar) 2014-08-06 2020-07-05 Novartis Ag مثبطات كيناز البروتين c وطرق استخداماتها
WO2016105528A2 (en) 2014-12-23 2016-06-30 Dana-Farber Cancer Institute, Inc. Inhibitors of cyclin-dependent kinase 7 (cdk7)
WO2016160617A2 (en) 2015-03-27 2016-10-06 Dana-Farber Cancer Institute, Inc. Inhibitors of cyclin-dependent kinases
AU2016276963C1 (en) 2015-06-12 2021-08-05 Dana-Farber Cancer Institute, Inc. Combination therapy of transcription inhibitors and kinase inhibitors
JP7028766B2 (ja) 2015-09-09 2022-03-02 ダナ-ファーバー キャンサー インスティテュート, インコーポレイテッド サイクリン依存性キナーゼの阻害剤
JOP20190055A1 (ar) 2016-09-26 2019-03-24 Merck Sharp & Dohme أجسام مضادة ضد cd27
EP3525785B1 (en) 2016-10-12 2025-08-27 Merck Sharp & Dohme LLC Kdm5 inhibitors
TWI841526B (zh) 2017-04-13 2024-05-11 荷蘭商賽羅帕公司 抗-SIRPα 抗體
US10947234B2 (en) 2017-11-08 2021-03-16 Merck Sharp & Dohme Corp. PRMT5 inhibitors
US11098059B2 (en) 2017-11-08 2021-08-24 Merck Sharp & Dohme Corp. PRMT5 inhibitors
WO2019148412A1 (en) 2018-02-01 2019-08-08 Merck Sharp & Dohme Corp. Anti-pd-1/lag3 bispecific antibodies
CA3099763A1 (en) 2018-06-25 2020-01-02 Dana-Farber Cancer Institute, Inc. Taire family kinase inhibitors and uses thereof
US11993602B2 (en) 2018-08-07 2024-05-28 Merck Sharp & Dohme Llc PRMT5 inhibitors
EP3833667B1 (en) 2018-08-07 2024-03-13 Merck Sharp & Dohme LLC Prmt5 inhibitors
BR112021002267A8 (pt) 2018-08-07 2023-02-07 Merck Sharp & Dohme Inibidores de prmt5
US12281126B2 (en) 2018-12-28 2025-04-22 Dana-Farber Cancer Institute, Inc. Inhibitors of cyclin-dependent kinase 7 and uses thereof
AU2024228641A1 (en) 2023-03-02 2025-07-24 Carcimun Biotech Gmbh Means and methods for diagnosing cancer and/or an acute inflammatory disease

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5352705A (en) * 1992-06-26 1994-10-04 Merck & Co., Inc. Inhibitors of farnesyl protein transferase
CA2172125A1 (en) * 1993-09-30 1995-04-06 S. Jane Desolms Inhibitors of farnesyl-protein transferase
WO1995012612A1 (en) * 1993-11-05 1995-05-11 Warner-Lambert Company Substituted di- and tripeptide inhibitors of protein:farnesyl transferase
US5571792A (en) * 1994-06-30 1996-11-05 Warner-Lambert Company Histidine and homohistidine derivatives as inhibitors of protein farnesyltransferase

Similar Documents

Publication Publication Date Title
JP2001507604A5 (enrdf_load_stackoverflow)
JP2000502280A5 (enrdf_load_stackoverflow)
JP2000501771A5 (enrdf_load_stackoverflow)
JP2000501599A5 (enrdf_load_stackoverflow)
JP2000501018A5 (enrdf_load_stackoverflow)
JP2000509273A5 (enrdf_load_stackoverflow)
JP2000501324A5 (enrdf_load_stackoverflow)
JP2001508475A5 (enrdf_load_stackoverflow)
JP2000511527A5 (enrdf_load_stackoverflow)
JP2001507177A5 (enrdf_load_stackoverflow)
JP2000502472A5 (enrdf_load_stackoverflow)
JP2000501338A5 (enrdf_load_stackoverflow)
JP2000501825A5 (enrdf_load_stackoverflow)
JP2001504696A5 (enrdf_load_stackoverflow)
JP2000514789A5 (enrdf_load_stackoverflow)
JP2000502485A5 (enrdf_load_stackoverflow)
JP2000502425A5 (enrdf_load_stackoverflow)
JP2001526706A5 (enrdf_load_stackoverflow)
JP2000502568A5 (enrdf_load_stackoverflow)
JP2000501774A5 (enrdf_load_stackoverflow)
JP2000500912A5 (enrdf_load_stackoverflow)
JP2000501876A5 (enrdf_load_stackoverflow)
JP2001502735A5 (enrdf_load_stackoverflow)
JP2001501236A5 (enrdf_load_stackoverflow)
JP2000501744A5 (enrdf_load_stackoverflow)