|
US20050112121A1
(en)
*
|
1992-04-30 |
2005-05-26 |
Yale University |
Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids
|
|
US5786158A
(en)
*
|
1992-04-30 |
1998-07-28 |
Yale University |
Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids
|
|
US20030225019A1
(en)
*
|
2002-05-30 |
2003-12-04 |
Freier Susan M. |
Notch1 inhibitors for inducing apoptosis
|
|
ATE442373T1
(de)
*
|
1995-06-28 |
2009-09-15 |
Imp Cancer Res Tech |
Nukleotid- und proteinsequenzen von delta-genen von vertebraten und darauf basierende methoden
|
|
US20050158859A1
(en)
*
|
1995-09-29 |
2005-07-21 |
Yale University |
Manipulation of non-terminally differentiated cells using the Notch pathway
|
|
US5780300A
(en)
*
|
1995-09-29 |
1998-07-14 |
Yale University |
Manipulation of non-terminally differentiated cells using the notch pathway
|
|
BR9711805A
(pt)
|
1996-06-20 |
2002-01-15 |
Regents The Univesity Of Texas |
Compostos e métodos para providenciar preparações farmacologicamente ativas e uso dos mesmos
|
|
US6887475B1
(en)
|
1996-11-07 |
2005-05-03 |
Lorantis Limited |
Notch
|
|
AU736361B2
(en)
*
|
1996-11-07 |
2001-07-26 |
Lorantis Limited |
Notch
|
|
US20060122373A1
(en)
*
|
1997-04-04 |
2006-06-08 |
Millennium Pharmaceuticals, Inc. |
Delta3, FTHMA-070, Tango85, Tango77, SPOIL,NEOKINE, Tango129 and integrin alpha subunit protein and nucleic acid molecules and uses thereof
|
|
US6121045A
(en)
*
|
1997-04-04 |
2000-09-19 |
Millennium Biotherapeutics, Inc. |
Human Delta3 nucleic acid molecules
|
|
US6136952A
(en)
|
1997-06-25 |
2000-10-24 |
University Of Washington |
Human jagged polypeptide, encoding nucleic acids and methods of use
|
|
US6692919B1
(en)
*
|
1997-07-23 |
2004-02-17 |
Yale University |
Activated forms of notch and methods based thereon
|
|
US6436650B1
(en)
|
1997-07-23 |
2002-08-20 |
Yale University |
Activated forms of notch and methods based thereon
|
|
SE9802264D0
(sv)
*
|
1998-06-25 |
1998-06-25 |
Neuronova Ab |
A method of isolating cells
|
|
US6541247B1
(en)
|
1998-06-25 |
2003-04-01 |
Neuronova Ab |
Method of isolating ependymal neural stem cells
|
|
EP1117778A2
(en)
*
|
1998-10-02 |
2001-07-25 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES |
Methods and compositions for inducing differentiation and apoptosis in cells that overexpress the notch protein
|
|
GB9824045D0
(en)
*
|
1998-11-03 |
1998-12-30 |
European Molecular Biology Lab Embl |
Regulator protein
|
|
EP1200133A4
(en)
*
|
1999-07-12 |
2003-05-28 |
Walter Gehring |
HANDLING OF FABRIC OR ORGAN TYPE USING THE NOTCH WAY
|
|
US8084258B2
(en)
|
1999-07-12 |
2011-12-27 |
University Of Basel |
Manipulation of tissue of organ type using the notch pathway
|
|
US6720173B1
(en)
|
1999-11-08 |
2004-04-13 |
Lexicon Genetics Incorporated |
Human kinase protein and polynucleotides encoding the same
|
|
US7575921B2
(en)
*
|
1999-12-30 |
2009-08-18 |
Vbi Technologies, L.L.C. |
Spore-like cells and uses thereof
|
|
US7560275B2
(en)
*
|
1999-12-30 |
2009-07-14 |
Vbi Technologies, L.L.C. |
Compositions and methods for generating skin
|
|
US7785882B2
(en)
*
|
2000-01-18 |
2010-08-31 |
Cornell Research Foundation, Inc. |
Neuronal progenitor cells from hippocampal tissue and a method for isolating and purifying them
|
|
US7037493B2
(en)
|
2000-05-01 |
2006-05-02 |
Cornell Research Foundation, Inc. |
Method of inducing neuronal production in the brain and spinal cord
|
|
US7442390B2
(en)
*
|
2000-06-05 |
2008-10-28 |
University Of South Florida |
Method for enhancing engraftment of cells using mesenchymal progenitor cells
|
|
US6936281B2
(en)
*
|
2001-03-21 |
2005-08-30 |
University Of South Florida |
Human mesenchymal progenitor cell
|
|
WO2001094541A2
(en)
*
|
2000-06-05 |
2001-12-13 |
University Of South Florida |
Human mesenchymal progenitor cell
|
|
US7303769B2
(en)
*
|
2000-06-05 |
2007-12-04 |
University Of South Florida |
Method for purifying pluri-differentiated mesenchymal progenitor cells
|
|
US6984522B2
(en)
*
|
2000-08-03 |
2006-01-10 |
Regents Of The University Of Michigan |
Isolation and use of solid tumor stem cells
|
|
US8044259B2
(en)
|
2000-08-03 |
2011-10-25 |
The Regents Of The University Of Michigan |
Determining the capability of a test compound to affect solid tumor stem cells
|
|
GB0019242D0
(en)
*
|
2000-08-04 |
2000-09-27 |
Lorantis Ltd |
Assay
|
|
AU2001284160A1
(en)
*
|
2000-08-19 |
2002-03-04 |
Axordia Limited |
Modulation of stem cell differentiation
|
|
US20020151487A1
(en)
*
|
2000-08-31 |
2002-10-17 |
Loyola University Chicago |
Method and reagents for epithelial barrier formation and treatment of malignant and benign skin disorders by modulating the notch pathway
|
|
WO2002059285A1
(en)
*
|
2000-10-27 |
2002-08-01 |
Fred Hutchinson Cancer Research Center |
Methods for immortalizing cells
|
|
US20020151050A1
(en)
*
|
2000-10-30 |
2002-10-17 |
Vacanti Charles A. |
Isolation of spore-like cells from tissues exposed to extreme conditions
|
|
US6458588B1
(en)
|
2001-01-31 |
2002-10-01 |
The General Hospital Corporation |
Renal stem cells and uses thereof
|
|
WO2002077204A2
(en)
*
|
2001-03-23 |
2002-10-03 |
Axordia Limited |
Stem cell differentiation
|
|
WO2002078449A2
(en)
*
|
2001-04-02 |
2002-10-10 |
Advanced Cell Technology, Inc. |
Method for facilitating the production of differentiated cell types and tissues from embryonic and adult pluripotent and multipotent cells
|
|
CN1513148A
(zh)
*
|
2001-05-29 |
2004-07-14 |
���µ�����ҵ��ʽ���� |
烹调实绩管理方法、内容管理方法、服务器和烹调设备
|
|
WO2002102989A2
(en)
*
|
2001-06-18 |
2002-12-27 |
Psychiatric Genomics, Inc. |
Method for neural stem cell differentiation using valproate
|
|
AU2002344768A1
(en)
*
|
2001-06-18 |
2003-01-02 |
The General Hospital Corporation |
Methods and compositions based on protein interactions with mastermind
|
|
AU2002315336A1
(en)
*
|
2001-06-18 |
2003-01-02 |
Psychiatric Genomics, Inc. |
Method for neural stem cell differentiation using 5ht-1a agonists
|
|
WO2003011317A1
(en)
*
|
2001-07-25 |
2003-02-13 |
Lorantis Limited |
Modulators of notch signalling for use in immunotherapy
|
|
US7452532B2
(en)
*
|
2001-09-30 |
2008-11-18 |
Scicotec Gmbh |
Transluminal application of adult stem cells for body organ tissue repair
|
|
US20030119080A1
(en)
*
|
2001-10-15 |
2003-06-26 |
Mangano Joseph A. |
Strategies for the identification and isolation of cancer stem cells and non-cancerous stem cells
|
|
JP2005511754A
(ja)
*
|
2001-12-07 |
2005-04-28 |
リージェンツ オブ ザ ユニバーシティ オブ ミシガン |
乳癌幹細胞の予測的同定および特徴づけ
|
|
US7682825B2
(en)
*
|
2002-02-06 |
2010-03-23 |
Sanbio, Inc. |
Differentiation of bone marrow stromal cells to neural cells or skeletal muscle cells by introduction of notch gene
|
|
WO2003070189A2
(en)
*
|
2002-02-15 |
2003-08-28 |
Cornell Research Foundation, Inc. |
Enhancing neurotrophin-induced neurogenesis by endogenous neural progenitor cells by concurrent overexpression of brain derived neurotrophic factor and an inhibitor of a pro-gliogenic bone morphogenetic protein
|
|
US20040102390A1
(en)
*
|
2002-11-21 |
2004-05-27 |
Isis Pharmaceuticals Inc. |
Modulation of Notch3 expression
|
|
US20040101847A1
(en)
*
|
2002-11-22 |
2004-05-27 |
Isis Pharmaceuticals Inc. |
Modulation of Notch2 expression
|
|
US20050124572A1
(en)
*
|
2002-06-17 |
2005-06-09 |
Freier Susan M. |
Compositions and their uses directed to signal tranducers
|
|
US20040028661A1
(en)
*
|
2002-08-07 |
2004-02-12 |
Bartelmez Stephen H. |
Expansion of cells using thrombopoietin and anti-transforming growth factor-beta
|
|
JP2007516693A
(ja)
*
|
2003-06-09 |
2007-06-28 |
ザ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・ミシガン |
癌の治療および診断のための組成物および方法
|
|
US8029984B2
(en)
*
|
2003-08-08 |
2011-10-04 |
Licentia, Ltd. |
Materials and methods for colorectal cancer screening, diagnosis and therapy
|
|
US7927599B2
(en)
|
2003-09-08 |
2011-04-19 |
Ethicon, Inc. |
Chondrocyte therapeutic delivery system
|
|
US8257963B2
(en)
*
|
2007-06-01 |
2012-09-04 |
Depuy Mitek, Inc. |
Chondrocyte container and method of use
|
|
US7897384B2
(en)
*
|
2003-09-08 |
2011-03-01 |
Ethicon, Inc. |
Chondrocyte therapeutic delivery system
|
|
AU2005209909B8
(en)
*
|
2004-02-03 |
2009-01-15 |
The Regents Of The University Of Michigan |
Compositions and methods for characterizing, regulating, diagnosing, and treating cancer
|
|
US7837993B2
(en)
*
|
2004-03-19 |
2010-11-23 |
The Board Of Trustees Of The Leland Stanford Junior University |
Methods and compositions for regeneration of aged skeletal muscle tissues
|
|
PT1855700E
(pt)
*
|
2005-03-07 |
2013-12-10 |
Sanbio Inc |
Utilização de materiais para tratamento de lesões do sistema nervoso central
|
|
US20060252073A1
(en)
*
|
2005-04-18 |
2006-11-09 |
Regents Of The University Of Michigan |
Compositions and methods for the treatment of cancer
|
|
JP2008546387A
(ja)
*
|
2005-06-13 |
2008-12-25 |
ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン |
癌を処置および診断するための組成物および方法
|
|
US20070099209A1
(en)
*
|
2005-06-13 |
2007-05-03 |
The Regents Of The University Of Michigan |
Compositions and methods for treating and diagnosing cancer
|
|
WO2007030693A2
(en)
*
|
2005-09-08 |
2007-03-15 |
The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Methods for promoting stem cell proliferation and survival
|
|
JP5368798B2
(ja)
|
2005-10-31 |
2013-12-18 |
オンコメッド ファーマシューティカルズ インコーポレイテッド |
癌を診断し処置するための組成物および方法
|
|
US7723477B2
(en)
|
2005-10-31 |
2010-05-25 |
Oncomed Pharmaceuticals, Inc. |
Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth
|
|
US7723112B2
(en)
|
2005-10-31 |
2010-05-25 |
The Regents Of The University Of Michigan |
Compositions and methods for treating and diagnosing cancer
|
|
WO2008121102A2
(en)
*
|
2006-02-21 |
2008-10-09 |
The Regents Of The University Of Michigan |
Hedgehog signaling pathway antagonist cancer treatment
|
|
US7994285B2
(en)
|
2006-10-19 |
2011-08-09 |
Genentech, Inc. |
Anti-Notch3 antibodies
|
|
WO2008136848A2
(en)
|
2006-10-19 |
2008-11-13 |
Genentech Inc. |
Novel anti-notch3 antibodies and their use in the detection and diagnosis of disease
|
|
CL2007003661A1
(es)
*
|
2006-12-18 |
2008-07-18 |
Genentech Inc |
Regiones de cadena pesada variable y liviana variable; acidos nucleicos que las codifican; metodo de produccion; anticuerpos anti-notch3 que las comprenden; y uso de los anticuerpos para tratar enfermedades relacionadas con el receptor notch3.
|
|
US8148147B2
(en)
*
|
2007-01-24 |
2012-04-03 |
The Regents Of The University Of Michigan |
Compositions and methods for treating and diagnosing pancreatic cancer
|
|
PE20090321A1
(es)
|
2007-06-04 |
2009-04-20 |
Genentech Inc |
Anticuerpos anti-notch1 nrr, metodo de preparacion y composicion farmaceutica
|
|
AU2008289209A1
(en)
*
|
2007-08-16 |
2009-02-26 |
The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services |
Methods for promoting stem cell proliferation and survival
|
|
SG190568A1
(en)
|
2008-09-26 |
2013-06-28 |
Oncomed Pharm Inc |
Frizzled-binding agents and uses thereof
|
|
US8551789B2
(en)
|
2010-04-01 |
2013-10-08 |
OncoMed Pharmaceuticals |
Frizzled-binding agents and their use in screening for WNT inhibitors
|
|
CA2736429A1
(en)
*
|
2008-10-01 |
2010-04-08 |
Genentech, Inc. |
Anti-notch2 antibodies and methods of use
|
|
US20100125265A1
(en)
*
|
2008-11-20 |
2010-05-20 |
Medtronic Vascular, Inc. |
Cell Delivery System to Induce Cell Growth and Angiogenesis
|
|
US8551775B2
(en)
|
2009-11-12 |
2013-10-08 |
Vbi Technologies, L.L.C. |
Subpopulations of spore-like cells and uses thereof
|
|
WO2011063237A2
(en)
|
2009-11-19 |
2011-05-26 |
Oncomed Pharmaceuticals, Inc. |
Jagged-binding agents and uses thereof
|
|
TWI535445B
(zh)
|
2010-01-12 |
2016-06-01 |
安可美德藥物股份有限公司 |
Ｗｎｔ拮抗劑及治療和篩選方法
|
|
US20130095080A1
(en)
|
2010-04-09 |
2013-04-18 |
Fred Hutchinson Cancer Reserach Center |
Compositions and methods for providing hematopoietic function
|
|
CA2795627C
(en)
|
2010-04-09 |
2023-03-14 |
Fred Hutchinson Cancer Research Center |
Compositions and methods for providing hematopoietic function without hla matching
|
|
JP2011019520A
(ja)
*
|
2010-08-13 |
2011-02-03 |
Walter Gehring |
Ｎｏｔｃｈ経路を用いた組織型または器官型の操作
|
|
WO2012048275A2
(en)
|
2010-10-08 |
2012-04-12 |
Caridianbct, Inc. |
Configurable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system
|
|
WO2013086436A1
(en)
|
2011-12-08 |
2013-06-13 |
Fred Hutchinson Cancer Research Center |
Compositions and methods for enhanced generation of hematopoietic stem/progenitor cells
|
|
EP2864476A4
(en)
*
|
2012-06-14 |
2016-04-06 |
Hutchinson Fred Cancer Res |
EX VIVO EXPANSION OF MYOGENIC STEM CELLS BY NOTCH ACTIVATION
|
|
EP2911691B1
(en)
|
2012-10-23 |
2018-10-10 |
OncoMed Pharmaceuticals, Inc. |
Methods of treating neuroendocrine tumors using wnt pathway-binding agents
|
|
WO2014110020A1
(en)
|
2013-01-08 |
2014-07-17 |
Fred Hutchinson Cancer Research Center |
Compositions and methods for expansion of embryonic hematopoietic stem cells
|
|
JP2016510411A
(ja)
|
2013-02-04 |
2016-04-07 |
オンコメッド ファーマシューティカルズ インコーポレイテッド |
Ｗｎｔ経路インヒビターによる処置の方法およびモニタリング
|
|
US9168300B2
(en)
|
2013-03-14 |
2015-10-27 |
Oncomed Pharmaceuticals, Inc. |
MET-binding agents and uses thereof
|
|
WO2015004762A1
(ja)
*
|
2013-07-10 |
2015-01-15 |
株式会社日立製作所 |
細胞培養方法、装置、及び細胞シート
|
|
RU2733652C2
(ru)
|
2013-10-31 |
2020-10-06 |
Фред Хатчинсон Кэнсер Рисерч Сентер |
МОДИФИЦИРОВАННЫЕ ГЕМОПОЭТИЧЕСКИЕ СТВОЛОВЫЕ КЛЕТКИ/КЛЕТКИ-ПРЕДШЕСТВЕННИКИ И Не-Т ЭФФЕКТОРНЫЕ КЛЕТКИ, И ИХ ПРИМЕНЕНИЕ
|
|
JP6633522B2
(ja)
|
2013-11-16 |
2020-01-22 |
テルモ ビーシーティー、インコーポレーテッド |
バイオリアクターにおける細胞増殖
|
|
WO2015148704A1
(en)
|
2014-03-25 |
2015-10-01 |
Terumo Bct, Inc. |
Passive replacement of media
|
|
BR112016028537A2
(pt)
*
|
2014-06-04 |
2017-08-22 |
Hutchinson Fred Cancer Res |
expansão e enxerto de células-tronco utilizando agonistas de notch 1 e/ou de notch 2
|
|
JP6830059B2
(ja)
|
2014-09-26 |
2021-02-17 |
テルモ ビーシーティー、インコーポレーテッド |
スケジュール化された細胞フィーディング
|
|
US10626372B1
(en)
|
2015-01-26 |
2020-04-21 |
Fate Therapeutics, Inc. |
Methods and compositions for inducing hematopoietic cell differentiation
|
|
JP6784687B2
(ja)
*
|
2015-02-24 |
2020-11-11 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
結合誘発型転写スイッチ及びその使用方法
|
|
US11827904B2
(en)
|
2015-04-29 |
2023-11-28 |
Fred Hutchinson Cancer Center |
Modified stem cells and uses thereof
|
|
EP3288569A4
(en)
|
2015-04-29 |
2018-12-19 |
Fred Hutchinson Cancer Research Center |
Modified hematopoietic stem/progenitor and non-t effector cells, and uses thereof
|
|
WO2017004592A1
(en)
|
2015-07-02 |
2017-01-05 |
Terumo Bct, Inc. |
Cell growth with mechanical stimuli
|
|
CN108368520B
(zh)
|
2015-11-04 |
2023-01-17 |
菲特治疗公司 |
多能细胞的基因组工程改造
|
|
CA3003152A1
(en)
|
2015-11-04 |
2017-05-11 |
Fate Therapeutics, Inc. |
Methods and compositions for inducing hematopoietic cell differentiation
|
|
CN108473949A
(zh)
|
2015-12-04 |
2018-08-31 |
弗莱德哈钦森癌症研究中心 |
扩增的造血干细胞/祖细胞群体的用途
|
|
US11400116B2
(en)
|
2016-05-06 |
2022-08-02 |
The Regents Of The University Of California |
Systems and methods for targeting cancer cells
|
|
WO2017205667A1
(en)
|
2016-05-25 |
2017-11-30 |
Terumo Bct, Inc. |
Cell expansion
|
|
US11104874B2
(en)
|
2016-06-07 |
2021-08-31 |
Terumo Bct, Inc. |
Coating a bioreactor
|
|
US11685883B2
(en)
|
2016-06-07 |
2023-06-27 |
Terumo Bct, Inc. |
Methods and systems for coating a cell growth surface
|
|
AU2017316649A1
(en)
|
2016-08-23 |
2019-03-07 |
The Regents Of The University Of California |
Proteolytically cleavable chimeric polypeptides and methods of use thereof
|
|
US10767164B2
(en)
|
2017-03-30 |
2020-09-08 |
The Research Foundation For The State University Of New York |
Microenvironments for self-assembly of islet organoids from stem cells differentiation
|
|
US11624046B2
(en)
|
2017-03-31 |
2023-04-11 |
Terumo Bct, Inc. |
Cell expansion
|
|
US11629332B2
(en)
|
2017-03-31 |
2023-04-18 |
Terumo Bct, Inc. |
Cell expansion
|
|
WO2019141270A1
(zh)
*
|
2018-01-19 |
2019-07-25 |
科济生物医药（上海）有限公司 |
SynNotch受体调控表达IL12
|
|
WO2020047099A1
(en)
|
2018-08-28 |
2020-03-05 |
Fred Hutchinson Cancer Research Center |
Methods and compositions for adoptive t cell therapy incorporating induced notch signaling
|
|
US20220098613A1
(en)
|
2018-09-12 |
2022-03-31 |
Fred Hutchinson Cancer Research Center |
Reducing cd33 expression to selectively protect therapeutic cells
|
|
WO2023150393A2
(en)
|
2022-02-07 |
2023-08-10 |
Ensoma, Inc. |
Inhibitor-resistant mgmt modifications and modification of mgmt-encoding nucleic acids
|
|
CN115925925B
(zh)
*
|
2022-08-23 |
2024-02-06 |
江苏芯超生物科技(集团)有限公司 |
一种诱导脐带间充质干细胞分化并生产细胞因子的方法
|
