JP2000510688A - ストレプトコッカス・ニューモニアエのアスパルチルｔＲＮＡシンセターゼ - Google Patents
ストレプトコッカス・ニューモニアエのアスパルチルｔＲＮＡシンセターゼInfo
- Publication number
- JP2000510688A JP2000510688A JP09537430A JP53743097A JP2000510688A JP 2000510688 A JP2000510688 A JP 2000510688A JP 09537430 A JP09537430 A JP 09537430A JP 53743097 A JP53743097 A JP 53743097A JP 2000510688 A JP2000510688 A JP 2000510688A
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- polynucleotide
- asps
- seq
- sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
- C07K14/3156—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci from Streptococcus pneumoniae (Pneumococcus)
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- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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Landscapes
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9607993.4A GB9607993D0 (en) | 1996-04-18 | 1996-04-18 | Novel compounds |
| GB9607993.4 | 1996-04-18 | ||
| PCT/US1997/006638 WO1997039014A1 (en) | 1996-04-18 | 1997-04-18 | STREPTOCOCCUS PNEUMONIAE ASPARTYL tRNA SYNTHETASE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP2000510688A true JP2000510688A (ja) | 2000-08-22 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP09537430A Pending JP2000510688A (ja) | 1996-04-18 | 1997-04-18 | ストレプトコッカス・ニューモニアエのアスパルチルｔＲＮＡシンセターゼ |
| JP9537449A Pending JP2000509263A (ja) | 1996-04-18 | 1997-04-18 | 新規化合物 |
| JP09537452A Pending JP2000515366A (ja) | 1996-04-18 | 1997-04-18 | 新規化合物 |
| JP09537428A Pending JP2000515724A (ja) | 1996-04-18 | 1997-04-18 | 新規化合物 |
| JP09537450A Pending JP2000509975A (ja) | 1996-04-18 | 1997-04-18 | 新規化合物 |
| JP9537451A Pending JP2000509264A (ja) | 1996-04-18 | 1997-04-18 | ストレプトコッカス・ニューモニアエのヒスチジルｔＲＮＡシンセターゼ |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP9537449A Pending JP2000509263A (ja) | 1996-04-18 | 1997-04-18 | 新規化合物 |
| JP09537452A Pending JP2000515366A (ja) | 1996-04-18 | 1997-04-18 | 新規化合物 |
| JP09537428A Pending JP2000515724A (ja) | 1996-04-18 | 1997-04-18 | 新規化合物 |
| JP09537450A Pending JP2000509975A (ja) | 1996-04-18 | 1997-04-18 | 新規化合物 |
| JP9537451A Pending JP2000509264A (ja) | 1996-04-18 | 1997-04-18 | ストレプトコッカス・ニューモニアエのヒスチジルｔＲＮＡシンセターゼ |
Country Status (5)
| Country | Link |
|---|---|
| US (9) | US5747313A (Direct) |
| EP (6) | EP0951469A1 (Direct) |
| JP (6) | JP2000510688A (Direct) |
| GB (1) | GB9607993D0 (Direct) |
| WO (6) | WO1997038722A1 (Direct) |
Families Citing this family (47)
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| US5795758A (en) * | 1997-04-18 | 1998-08-18 | Smithkline Beecham Corporation | DNA encoding histidyl tRNA synthetase variant from Streptococcus pneumoniae |
| US5834276A (en) * | 1996-04-18 | 1998-11-10 | Smithkline Beecham Corporation | Asparaginyl TRNA synthetase polynucleotides of streptococcus |
| US5858720A (en) * | 1997-07-23 | 1999-01-12 | Smithkline Beecham Corporation | Hiss |
| US5882892A (en) | 1997-07-23 | 1999-03-16 | Smithkline Beecham Corporation | Asps |
| EP0916728A1 (en) * | 1997-10-17 | 1999-05-19 | Smithkline Beecham Corporation | Phenyl alanyl tRNA synthetase [EC 6.1.1.20] alpha subunit family, pheS (alpha), from Streptococcus pneumoniae |
| WO1999027129A1 (en) | 1997-11-25 | 1999-06-03 | The General Hospital Corporation | Virulence-associated nucleic acid sequences and uses thereof |
| EP1087984A4 (en) * | 1998-05-28 | 2005-02-09 | Smithkline Beecham Corp | ACPs |
| US6245539B1 (en) | 1998-10-06 | 2001-06-12 | Board Of Trustees Operating Michigan State University | Human asparaginyl-tRNA synthetase DNA |
| WO2001040332A1 (en) | 1999-11-29 | 2001-06-07 | Daikin Industries, Ltd. | Fluororesin material lowly permeable to liquid chemical |
| US7112716B2 (en) | 2000-04-06 | 2006-09-26 | The General Hospital Corporation | Methods for screening and identifying host pathogen defense genes |
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| EP2509625B1 (en) | 2009-12-11 | 2015-01-28 | Atyr Pharma, Inc. | Histidyl trna synthetases for reducing inflammation |
| US8828395B2 (en) | 2009-12-11 | 2014-09-09 | Atyr Pharma, Inc. | Antibodies that bind tyrosyl-tRNA synthetases |
| US8980253B2 (en) | 2010-04-26 | 2015-03-17 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of cysteinyl-tRNA synthetase |
| WO2011139801A2 (en) | 2010-04-27 | 2011-11-10 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of threonyl trna synthetases |
| AU2011248614B2 (en) | 2010-04-27 | 2017-02-16 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of isoleucyl tRNA synthetases |
| CN103097524B (zh) | 2010-04-28 | 2016-08-03 | Atyr医药公司 | 与丙氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 |
| CN103097523B (zh) | 2010-04-29 | 2016-09-28 | Atyr医药公司 | 与天冬酰胺酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 |
| JP5991963B2 (ja) | 2010-04-29 | 2016-09-14 | エータイアー ファーマ， インコーポレイテッド | バリルｔＲＮＡ合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見 |
| US9068177B2 (en) | 2010-04-29 | 2015-06-30 | Atyr Pharma, Inc | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glutaminyl-tRNA synthetases |
| US9034321B2 (en) | 2010-05-03 | 2015-05-19 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-alpha-tRNA synthetases |
| ES2668207T3 (es) | 2010-05-03 | 2018-05-17 | Atyr Pharma, Inc. | Descubrimiento innovador de composiciones terapéuticas, de diagnóstico y de anticuerpos relacionadas con fragmentos de proteínas de metionil-ARNt sintetasas |
| CN103108655B (zh) | 2010-05-03 | 2017-04-05 | Atyr 医药公司 | 与丝氨酰‑tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 |
| JP5976638B2 (ja) | 2010-05-03 | 2016-08-23 | エータイアー ファーマ， インコーポレイテッド | アルギニルｔＲＮＡ合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見 |
| WO2011140266A2 (en) | 2010-05-04 | 2011-11-10 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glutamyl-prolyl-trna synthetases |
| US9062302B2 (en) | 2010-05-04 | 2015-06-23 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of p38 multi-tRNA synthetase complex |
| EP2568996B1 (en) | 2010-05-14 | 2017-10-04 | aTyr Pharma, Inc. | Therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-beta-trna synthetases |
| WO2011146410A2 (en) * | 2010-05-17 | 2011-11-24 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of leucyl-trna synthetases |
| EP2575857B1 (en) | 2010-06-01 | 2018-01-24 | aTyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of lysyl-trna synthetases |
| US8999321B2 (en) | 2010-07-12 | 2015-04-07 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glycyl-tRNA synthetases |
| JP6116479B2 (ja) | 2010-07-12 | 2017-04-19 | エータイアー ファーマ， インコーポレイテッド | グリシルｔＲＮＡ合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見 |
| JP5991973B2 (ja) | 2010-07-12 | 2016-09-14 | エータイアー ファーマ， インコーポレイテッド | アスパルチルｔＲＮＡ合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見 |
| KR20180059953A (ko) | 2010-07-12 | 2018-06-05 | 에이티와이알 파마, 인코포레이티드 | 히스티딜trna 합성효소의 단백질 단편에 관련된 치료적, 진단적, 및 항체 조성물의 혁신적 발견 |
| EP2608801B1 (en) | 2010-08-25 | 2019-08-21 | aTyr Pharma, Inc. | INNOVATIVE DISCOVERY OF THERAPEUTIC, DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN FRAGMENTS OF TYROSYL-tRNA SYNTHETASES |
| WO2012048125A2 (en) | 2010-10-06 | 2012-04-12 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related protein fragments of tryptophanyl trna synthetases |
| WO2013022982A2 (en) | 2011-08-09 | 2013-02-14 | Atyr Pharma, Inc. | Pegylated tyrosyl-trna synthetase polypeptides |
| US9822353B2 (en) | 2011-12-06 | 2017-11-21 | Atyr Pharma, Inc. | PEGylated aspartyl-tRNA synthetase polypeptides |
| US9816084B2 (en) | 2011-12-06 | 2017-11-14 | Atyr Pharma, Inc. | Aspartyl-tRNA synthetases |
| WO2013115926A2 (en) * | 2011-12-29 | 2013-08-08 | Atyr Pharma, Inc. | Aspartyl-trna synthetase-fc conjugates |
| US8835387B2 (en) | 2012-02-16 | 2014-09-16 | Atyr Pharma, Inc. | Histidyl-tRNA synthetases for treating autoimmune and inflammatory diseases |
| ES2847383T3 (es) | 2013-03-15 | 2021-08-03 | Atyr Pharma Inc | Conjugados de Fc-histidil-ARNt sintetasa |
| ES2994451T3 (en) | 2017-04-20 | 2025-01-24 | Atyr Pharma Inc | Compositions for treating lung inflammation |
| US11530413B2 (en) | 2017-07-21 | 2022-12-20 | Novartis Ag | Compositions and methods to treat cancer |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU6958194A (en) * | 1993-05-28 | 1994-12-20 | Massachusetts Institute Of Technology | Trna binding-dependent inhibition of microbial pathogen growth |
| WO1996033276A1 (en) * | 1995-04-21 | 1996-10-24 | Human Genome Sciences, Inc. | NUCLEOTIDE SEQUENCE OF THE HAEMOPHILUS INFLUENZAE Rd GENOME, FRAGMENTS THEREOF, AND USES THEREOF |
| US6737248B2 (en) * | 1996-01-05 | 2004-05-18 | Human Genome Sciences, Inc. | Staphylococcus aureus polynucleotides and sequences |
| JPH11502425A (ja) * | 1996-01-19 | 1999-03-02 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | スタフィロコッカス・アウレウスのアスパラギニルｔＲＮＡシンセターゼ |
| EP1300468A3 (en) * | 1996-01-19 | 2004-02-04 | Smithkline Beecham Plc | TRNA synthetase |
| JP2001501833A (ja) * | 1996-10-31 | 2001-02-13 | ヒューマン ジノーム サイエンシーズ，インコーポレイテッド | Ｓｔｒｅｐｔｏｃｏｃｃｕｓ ｐｎｅｕｍｏｎｉａｅのポリヌクレオチドおよび配列 |
-
1996
- 1996-04-18 GB GBGB9607993.4A patent/GB9607993D0/en active Pending
-
1997
- 1997-04-18 EP EP97923452A patent/EP0951469A1/en not_active Withdrawn
- 1997-04-18 JP JP09537430A patent/JP2000510688A/ja active Pending
- 1997-04-18 JP JP9537449A patent/JP2000509263A/ja active Pending
- 1997-04-18 EP EP97922434A patent/EP0909181A4/en not_active Withdrawn
- 1997-04-18 JP JP09537452A patent/JP2000515366A/ja active Pending
- 1997-04-18 US US08/844,055 patent/US5747313A/en not_active Expired - Fee Related
- 1997-04-18 US US08/844,086 patent/US5866390A/en not_active Expired - Lifetime
- 1997-04-18 WO PCT/US1997/006876 patent/WO1997038722A1/en not_active Ceased
- 1997-04-18 EP EP97921361A patent/EP0904281A4/en not_active Withdrawn
- 1997-04-18 JP JP09537428A patent/JP2000515724A/ja active Pending
- 1997-04-18 US US08/844,154 patent/US5827708A/en not_active Expired - Fee Related
- 1997-04-18 JP JP09537450A patent/JP2000509975A/ja active Pending
- 1997-04-18 EP EP97921302A patent/EP0904280A4/en not_active Withdrawn
- 1997-04-18 WO PCT/US1997/006875 patent/WO1997039022A1/en not_active Ceased
- 1997-04-18 US US08/843,521 patent/US5753479A/en not_active Expired - Lifetime
- 1997-04-18 US US08/844,280 patent/US5747315A/en not_active Expired - Fee Related
- 1997-04-18 EP EP97918764A patent/EP0894006A4/en not_active Withdrawn
- 1997-04-18 WO PCT/US1997/006634 patent/WO1997038717A1/en not_active Ceased
- 1997-04-18 WO PCT/US1997/006638 patent/WO1997039014A1/en not_active Ceased
- 1997-04-18 WO PCT/US1997/006879 patent/WO1997038719A1/en not_active Ceased
- 1997-04-18 JP JP9537451A patent/JP2000509264A/ja active Pending
- 1997-04-18 WO PCT/US1997/006877 patent/WO1997039017A1/en not_active Ceased
- 1997-04-18 EP EP97918806A patent/EP0904104A4/en not_active Withdrawn
-
1998
- 1998-01-14 US US09/006,849 patent/US6071731A/en not_active Expired - Fee Related
- 1998-01-23 US US09/012,871 patent/US6200787B1/en not_active Expired - Fee Related
- 1998-02-03 US US09/018,211 patent/US6048716A/en not_active Expired - Lifetime
- 1998-07-30 US US09/126,192 patent/US6040163A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0894006A4 (en) | 1999-11-24 |
| EP0904281A4 (en) | 2000-01-12 |
| WO1997039014A1 (en) | 1997-10-23 |
| EP0951469A4 (Direct) | 1999-11-03 |
| EP0909181A4 (en) | 1999-11-03 |
| US6200787B1 (en) | 2001-03-13 |
| EP0951469A1 (en) | 1999-10-27 |
| EP0909181A1 (en) | 1999-04-21 |
| WO1997039022A1 (en) | 1997-10-23 |
| WO1997038722A1 (en) | 1997-10-23 |
| EP0904281A1 (en) | 1999-03-31 |
| JP2000515724A (ja) | 2000-11-28 |
| US6071731A (en) | 2000-06-06 |
| JP2000515366A (ja) | 2000-11-21 |
| WO1997038717A1 (en) | 1997-10-23 |
| GB9607993D0 (en) | 1996-06-19 |
| US5747315A (en) | 1998-05-05 |
| JP2000509263A (ja) | 2000-07-25 |
| EP0904104A4 (en) | 1999-11-03 |
| US5747313A (en) | 1998-05-05 |
| JP2000509264A (ja) | 2000-07-25 |
| EP0904280A1 (en) | 1999-03-31 |
| EP0904280A4 (en) | 1999-10-20 |
| EP0904104A1 (en) | 1999-03-31 |
| JP2000509975A (ja) | 2000-08-08 |
| US6040163A (en) | 2000-03-21 |
| WO1997038719A1 (en) | 1997-10-23 |
| WO1997039017A1 (en) | 1997-10-23 |
| US5827708A (en) | 1998-10-27 |
| US6048716A (en) | 2000-04-11 |
| EP0894006A1 (en) | 1999-02-03 |
| US5753479A (en) | 1998-05-19 |
| US5866390A (en) | 1999-02-02 |
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