JP2000510129A - ジスタマイシン誘導体、その調製方法並びに抗腫瘍薬及び抗ウイルス薬としてのその使用 - Google Patents

ジスタマイシン誘導体、その調製方法並びに抗腫瘍薬及び抗ウイルス薬としてのその使用

Info

Publication number
JP2000510129A
JP2000510129A JP09540439A JP54043997A JP2000510129A JP 2000510129 A JP2000510129 A JP 2000510129A JP 09540439 A JP09540439 A JP 09540439A JP 54043997 A JP54043997 A JP 54043997A JP 2000510129 A JP2000510129 A JP 2000510129A
Authority
JP
Japan
Prior art keywords
methyl
pyrrole
carboxamide
chloroethyl
aminocinnamoylamide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP09540439A
Other languages
English (en)
Japanese (ja)
Inventor
コツツイ，パオロ
ベリア，イタロ
カルダレツリ，マリナ
ジエローニ，マリア・クリスチーナ
ペゼンテイ，エンリコ
Original Assignee
フアルマシア・エ・アツプジヨン・エツセ・ピー・アー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by フアルマシア・エ・アツプジヨン・エツセ・ピー・アー filed Critical フアルマシア・エ・アツプジヨン・エツセ・ピー・アー
Publication of JP2000510129A publication Critical patent/JP2000510129A/ja
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP09540439A 1996-05-14 1997-04-24 ジスタマイシン誘導体、その調製方法並びに抗腫瘍薬及び抗ウイルス薬としてのその使用 Withdrawn JP2000510129A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9610079.7 1996-05-14
GBGB9610079.7A GB9610079D0 (en) 1996-05-14 1996-05-14 Distamycin deriratives process for preparing them and their use as antitumor and antiviral agents
PCT/EP1997/002158 WO1997043258A1 (en) 1996-05-14 1997-04-24 Distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents

Publications (1)

Publication Number Publication Date
JP2000510129A true JP2000510129A (ja) 2000-08-08

Family

ID=10793694

Family Applications (1)

Application Number Title Priority Date Filing Date
JP09540439A Withdrawn JP2000510129A (ja) 1996-05-14 1997-04-24 ジスタマイシン誘導体、その調製方法並びに抗腫瘍薬及び抗ウイルス薬としてのその使用

Country Status (27)

Country Link
US (1) US6177408B1 (xx)
EP (1) EP0912509B1 (xx)
JP (1) JP2000510129A (xx)
CN (1) CN1089755C (xx)
AR (1) AR007108A1 (xx)
AT (1) ATE203011T1 (xx)
AU (1) AU721140B2 (xx)
BR (1) BR9709451A (xx)
CA (1) CA2253652A1 (xx)
DE (1) DE69705622T2 (xx)
DK (1) DK0912509T3 (xx)
EA (1) EA002273B1 (xx)
ES (1) ES2160951T3 (xx)
GB (1) GB9610079D0 (xx)
GR (1) GR3036824T3 (xx)
HK (1) HK1020734A1 (xx)
HU (1) HUP9901387A3 (xx)
IL (1) IL126840A (xx)
MY (1) MY118004A (xx)
NO (1) NO311886B1 (xx)
NZ (1) NZ332923A (xx)
PL (1) PL329878A1 (xx)
PT (1) PT912509E (xx)
TW (1) TW498066B (xx)
UA (1) UA45457C2 (xx)
WO (1) WO1997043258A1 (xx)
ZA (1) ZA973883B (xx)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9806689D0 (en) 1998-03-27 1998-05-27 Pharmacia & Upjohn Spa Acryloyl derivatives analogous to distamycin,process for preparing them,and their use as antitumour and antiviral agents
GB9806692D0 (en) * 1998-03-27 1998-05-27 Pharmacia & Upjohn Spa Benzoheterocyclic distamycin derivatives, process for preparing them and their use as antitumour agents
GB9812211D0 (en) 1998-06-05 1998-08-05 Pharmacia & Upjohn Spa Cinnamoyl distamycin analogous derivatives,process for their preparation,and their use as antitumor agents
GB9816652D0 (en) * 1998-07-30 1998-09-30 Pharmacia & Upjohn Spa Sulfurated distamycin derivatives process for preparing them and their use as antitumor agents
GB9816653D0 (en) * 1998-07-30 1998-09-30 Pharmacia & Upjohn Spa Oxidised sulfurated distamycin derivatives process for preparing them and their use as antitumor agents
GB9928703D0 (en) * 1999-12-03 2000-02-02 Pharmacia & Upjohn Spa Acryloyl peptidic derivatives,process for their preparation and their use as antitumour agents
US6559125B1 (en) 2000-01-28 2003-05-06 California Institute Of Technology Polyamide-alkylator conjugates and related products and method
GB0011059D0 (en) 2000-05-08 2000-06-28 Pharmacia & Upjohn Spa Use of substituted acryloyl distamycin derivatives in the treatment of tumours associated with high levels of glutathione
GB0015446D0 (en) 2000-06-23 2000-08-16 Pharmacia & Upjohn Spa Combined therapy against tumors comprising substituted acryloyl distamycin derivates,taxanes and/or antimetabolites
GB0015447D0 (en) 2000-06-23 2000-08-16 Pharmacia & Upjohn Spa Combined therapy against tumors comprising substituted acryloyl derivates and alkylating agents
GB0016447D0 (en) 2000-07-04 2000-08-23 Pharmacia & Upjohn Spa Process for preparing distamycin derivatives
GB0017852D0 (en) * 2000-07-20 2000-09-06 Pharmacia & Upjohn Spa Process for preparing distamycin derivatives
GB0029004D0 (en) 2000-11-28 2001-01-10 Pharmacia & Upjohn Spa Process for preparing distamycin derivatives
WO2002101007A2 (en) * 2001-06-13 2002-12-19 Genesoft Pharmaceuticals, Inc Antipathogenic benzamide compounds
CA2450628A1 (en) * 2001-06-13 2002-12-19 Genesoft Pharmaceuticals, Inc. Benzothiophene compounds having antiinfective activity
US6969592B2 (en) 2001-09-26 2005-11-29 Pharmacia Italia S.P.A. Method for predicting the sensitivity to chemotherapy
KR102573190B1 (ko) 2015-10-16 2023-09-01 삼성전자주식회사 전자장치 및 전자장치 제조방법

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8612218D0 (en) * 1986-05-20 1986-06-25 Erba Farmitalia Site specific alkylating agents
GB9416005D0 (en) * 1994-08-08 1994-09-28 Erba Carlo Spa Peptidic compounds analogous to distamycin a and process for their preparation

Also Published As

Publication number Publication date
US6177408B1 (en) 2001-01-23
ZA973883B (en) 1997-12-08
DE69705622T2 (de) 2002-05-08
DE69705622D1 (de) 2001-08-16
AR007108A1 (es) 1999-10-13
PT912509E (pt) 2001-12-28
CA2253652A1 (en) 1997-11-20
MY118004A (en) 2004-08-30
GB9610079D0 (en) 1996-07-17
IL126840A (en) 2002-03-10
PL329878A1 (en) 1999-04-12
AU2701697A (en) 1997-12-05
ES2160951T3 (es) 2001-11-16
AU721140B2 (en) 2000-06-22
CN1222144A (zh) 1999-07-07
NO311886B1 (no) 2002-02-11
NO985307D0 (no) 1998-11-13
HK1020734A1 (en) 2000-05-19
NO985307L (no) 1999-01-12
TW498066B (en) 2002-08-11
EP0912509A1 (en) 1999-05-06
GR3036824T3 (en) 2002-01-31
EA002273B1 (ru) 2002-02-28
ATE203011T1 (de) 2001-07-15
DK0912509T3 (da) 2001-10-22
EA199801013A1 (ru) 1999-06-24
CN1089755C (zh) 2002-08-28
WO1997043258A1 (en) 1997-11-20
EP0912509B1 (en) 2001-07-11
BR9709451A (pt) 1999-08-10
UA45457C2 (uk) 2002-04-15
HUP9901387A2 (hu) 2000-04-28
HUP9901387A3 (en) 2002-10-28
NZ332923A (en) 2000-03-27
IL126840A0 (en) 1999-09-22

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Legal Events

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A621 Written request for application examination

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Effective date: 20040401

A761 Written withdrawal of application

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Effective date: 20060301