JP2000509994A5 - - Google Patents
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- Publication number
- JP2000509994A5 JP2000509994A5 JP1997540800A JP54080097A JP2000509994A5 JP 2000509994 A5 JP2000509994 A5 JP 2000509994A5 JP 1997540800 A JP1997540800 A JP 1997540800A JP 54080097 A JP54080097 A JP 54080097A JP 2000509994 A5 JP2000509994 A5 JP 2000509994A5
- Authority
- JP
- Japan
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9601855A SE9601855D0 (sv) | 1996-05-14 | 1996-05-14 | Process for producing a protein |
| US1887496P | 1996-05-29 | 1996-05-29 | |
| US60/018,874 | 1996-05-29 | ||
| US9601855-1 | 1996-05-29 | ||
| PCT/SE1997/000783 WO1997043436A1 (en) | 1996-05-14 | 1997-05-13 | A process for producing a recombinant polypeptide involving the addition of an inhibitor of metal-dependent proteases or chymotrypsins to the cell culture medium |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009001597A Division JP4896999B2 (ja) | 1996-05-14 | 2009-01-07 | 細胞培養培地への金属依存性プロテアーゼ又はキモトリプシンの阻害物質の添加を含む組換えポリペプチドの製造法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2000509994A JP2000509994A (ja) | 2000-08-08 |
| JP2000509994A5 true JP2000509994A5 (cg-RX-API-DMAC7.html) | 2004-12-09 |
Family
ID=26662616
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP09540800A Pending JP2000509994A (ja) | 1996-05-14 | 1997-05-13 | 細胞培養培地への金属依存性プロテアーゼ又はキモトリプシンの阻害物質の添加を含む組換えポリペプチドの製造法 |
| JP2009001597A Expired - Fee Related JP4896999B2 (ja) | 1996-05-14 | 2009-01-07 | 細胞培養培地への金属依存性プロテアーゼ又はキモトリプシンの阻害物質の添加を含む組換えポリペプチドの製造法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009001597A Expired - Fee Related JP4896999B2 (ja) | 1996-05-14 | 2009-01-07 | 細胞培養培地への金属依存性プロテアーゼ又はキモトリプシンの阻害物質の添加を含む組換えポリペプチドの製造法 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US5851800A (cg-RX-API-DMAC7.html) |
| EP (1) | EP0934424B1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP2000509994A (cg-RX-API-DMAC7.html) |
| AT (2) | ATE321141T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU716245B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2253287C (cg-RX-API-DMAC7.html) |
| DE (2) | DE69735510T2 (cg-RX-API-DMAC7.html) |
| DK (1) | DK0934424T3 (cg-RX-API-DMAC7.html) |
| ES (2) | ES2260524T3 (cg-RX-API-DMAC7.html) |
| NO (2) | NO325358B1 (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ332751A (cg-RX-API-DMAC7.html) |
| PT (2) | PT1318198E (cg-RX-API-DMAC7.html) |
| WO (1) | WO1997043436A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6475725B1 (en) * | 1997-06-20 | 2002-11-05 | Baxter Aktiengesellschaft | Recombinant cell clones having increased stability and methods of making and using the same |
| CN100553678C (zh) | 1999-02-22 | 2009-10-28 | 巴克斯特国际有限公司 | 新的无白蛋白的因子ⅷ制剂 |
| AT409379B (de) | 1999-06-02 | 2002-07-25 | Baxter Ag | Medium zur protein- und serumfreien kultivierung von zellen |
| ATE330003T1 (de) * | 1999-08-05 | 2006-07-15 | Baxter Ag | Rekombinanter stabiler zellklon, seine herstellung und verwendung |
| WO2001052891A1 (fr) * | 2000-01-20 | 2001-07-26 | Nippon Organon K. K. | Inhibiteurs d'invasion plasmodiale dans des erythrocytes |
| CN100591759C (zh) * | 2002-07-09 | 2010-02-24 | 巴克斯特国际有限公司 | 用于细胞培养的无动物蛋白质培养基 |
| PL377731A1 (pl) * | 2002-12-23 | 2006-02-06 | Bristol-Myers Squibb Company | Sposoby hodowli komórek ssaczych do wytwarzania białka |
| PL377603A1 (pl) * | 2002-12-23 | 2006-02-06 | Bristol-Myers Squibb Company | Poprawa jakości produktu w hodowlach komórek ssaczych do wytwarzania białka |
| MXPA05011486A (es) * | 2003-04-25 | 2006-04-18 | Immunex Corp | Inductores de expresion de proteina recombinante. |
| US7255288B2 (en) * | 2004-03-08 | 2007-08-14 | Wan Shan Chan | Aroma therapy for fountain |
| US20060094104A1 (en) | 2004-10-29 | 2006-05-04 | Leopold Grillberger | Animal protein-free media for cultivation of cells |
| EP1707634A1 (en) * | 2005-03-29 | 2006-10-04 | Octapharma AG | Method for isolation of recombinantly produced proteins |
| DK2522717T3 (da) * | 2006-01-04 | 2014-04-22 | Baxter Int | Oligopeptid-frie cellekulturmedier |
| PT2126106T (pt) | 2007-02-23 | 2017-12-12 | Sk Chemicals Co Ltd | Proceso para produzir e purificar o fator viii e seus derivados |
| WO2008135498A2 (en) * | 2007-05-04 | 2008-11-13 | Novo Nordisk A/S | Prevention of protein degradation in mammalian cell cultures |
| EP1988101A1 (en) | 2007-05-04 | 2008-11-05 | Novo Nordisk A/S | Improvement of factor VIII polypeptide titers in cell cultures |
| CA2742328C (en) | 2008-11-07 | 2019-02-26 | Baxter International Inc. | Factor viii formulations |
| US9540426B2 (en) | 2009-10-06 | 2017-01-10 | Bristol-Myers Squibb Company | Mammalian cell culture processes for protein production |
| US10138290B2 (en) | 2010-10-05 | 2018-11-27 | Novo Nordisk Healthcare Ag | Process for protein production |
| CN104822826B (zh) | 2012-10-15 | 2019-04-30 | 百时美施贵宝公司 | 用于蛋白产生的哺乳动物细胞培养过程 |
| KR102668200B1 (ko) | 2015-10-28 | 2024-05-23 | 주식회사유한양행 | 지속형 fgf21 융합 단백질 및 이를 포함하는 약학적 조성물 |
| KR102670157B1 (ko) | 2015-10-28 | 2024-05-29 | 주식회사유한양행 | 이중 작용 단백질 및 이를 포함하는 약학적 조성물 |
| BR112019009581A2 (pt) | 2016-11-10 | 2019-10-08 | Yuhan Corp | composição farmacêutica para evitar ou tratar hepatite, fibrose hepática, e cirrose hepática que compreende proteínas de fusão |
| MX2019012331A (es) | 2017-04-21 | 2020-01-23 | Yuhan Corp | Metodo para producir proteinas de doble funcion y sus derivados. |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5149787A (en) * | 1984-05-22 | 1992-09-22 | The Blood Center Research Foundation | Method for maintaining intact, non-degraded factor VIII/von-Willebrand factor during blood processing |
| SE8501050D0 (sv) * | 1985-03-05 | 1985-03-05 | Kabivitrum Ab | Biologically active fragments of human antihemophilic factor and method for preparation thereof |
| US5279939A (en) * | 1986-08-18 | 1994-01-18 | Smithkline Beecham Corporation | Protein protease inhibitors from streptomyces |
| US4891356A (en) * | 1987-07-15 | 1990-01-02 | Brigham & Women's Hospital | Proteinase inhibitors for treatment of gastrointestinal ulcer disease |
| JPH0387173A (ja) * | 1987-09-10 | 1991-04-11 | Teijin Ltd | ヒト活性化天然型ファクター８ｃの製造方法及びそれに用いる形質転換体 |
| JP2769170B2 (ja) * | 1987-12-08 | 1998-06-25 | ザイモジェネティクス，インコーポレイティド | 真核細肪中での同時発現 |
| CA1340740C (en) * | 1987-12-08 | 1999-09-14 | Eileen R. Mulvihill | Co-expression in eukaryotic cells |
| DK457788D0 (da) * | 1988-08-16 | 1988-08-16 | Nordisk Gentofte | Fremgangsmaade til fremstilling af et oensket polypeptid |
| WO1990002175A1 (en) * | 1988-08-16 | 1990-03-08 | Novo Nordisk A/S | A method of producing polypeptides by culturing eukaryotic cells in the presence of protease inhibitors |
| GB8827305D0 (en) * | 1988-11-23 | 1988-12-29 | British Bio Technology | Compounds |
| DK105489D0 (da) * | 1989-03-03 | 1989-03-03 | Novo Nordisk As | Polypeptid |
| SE465222C5 (sv) * | 1989-12-15 | 1998-02-10 | Pharmacia & Upjohn Ab | Ett rekombinant, humant faktor VIII-derivat och förfarande för dess framställning |
| CA2076386C (en) * | 1990-02-26 | 2003-04-22 | David S. Hogness | Identification and expression of insect steroid receptor dna sequence |
| US5189178A (en) * | 1990-11-21 | 1993-02-23 | Galardy Richard E | Matrix metalloprotease inhibitors |
| US5304603A (en) * | 1991-06-18 | 1994-04-19 | The Population Council | Leydig cell stimulator |
| US5661034A (en) * | 1991-07-18 | 1997-08-26 | Fuji Yakuhin Kogyo Kabushiki Kaisha | Serum-free medium for tissue culture containing tissue inhibitor of metalloproteinases and method for growing cells using the medium |
| CA2116774C (en) * | 1991-09-19 | 2003-11-11 | Paul J. Carter | Expression in e. coli antibody fragments having at least a cysteine present as a free thiol. use for the production of bifunctional f(ab') 2 antibodies |
| CA2078721A1 (en) * | 1991-09-24 | 1993-03-25 | Hiroshi Yonemura | Process for preparing human coagulation factor viii protein complex |
| US5278289A (en) * | 1991-11-12 | 1994-01-11 | Johnson Alan J | Antihemophilic factor stabilization |
| US5296471A (en) * | 1992-12-22 | 1994-03-22 | Glycomed Incorporated | Method for controlling o-desulfation of heparin and compositions produced thereby |
| WO1995005477A1 (en) * | 1993-08-12 | 1995-02-23 | University Of Maryland | Thermostable alkaline metalloprotease produced by a hyphomonas, and preparation thereof |
| US5631159A (en) * | 1993-09-22 | 1997-05-20 | Creative Biomolecules, Inc. | Lipid-modified serum free media |
| US5543396A (en) * | 1994-04-28 | 1996-08-06 | Georgia Tech Research Corp. | Proline phosphonate derivatives |
-
1997
- 1997-05-07 US US08/852,783 patent/US5851800A/en not_active Expired - Lifetime
- 1997-05-13 DE DE69735510T patent/DE69735510T2/de not_active Expired - Lifetime
- 1997-05-13 PT PT03000391T patent/PT1318198E/pt unknown
- 1997-05-13 JP JP09540800A patent/JP2000509994A/ja active Pending
- 1997-05-13 NZ NZ332751A patent/NZ332751A/en not_active IP Right Cessation
- 1997-05-13 DE DE69736391T patent/DE69736391T2/de not_active Expired - Lifetime
- 1997-05-13 EP EP97923382A patent/EP0934424B1/en not_active Expired - Lifetime
- 1997-05-13 WO PCT/SE1997/000783 patent/WO1997043436A1/en not_active Ceased
- 1997-05-13 ES ES03000391T patent/ES2260524T3/es not_active Expired - Lifetime
- 1997-05-13 CA CA002253287A patent/CA2253287C/en not_active Expired - Fee Related
- 1997-05-13 PT PT97923382T patent/PT934424E/pt unknown
- 1997-05-13 ES ES97923382T patent/ES2270460T3/es not_active Expired - Lifetime
- 1997-05-13 AU AU29197/97A patent/AU716245B2/en not_active Ceased
- 1997-05-13 AT AT03000391T patent/ATE321141T1/de active
- 1997-05-13 AT AT97923382T patent/ATE334223T1/de active
- 1997-05-13 DK DK97923382T patent/DK0934424T3/da active
-
1998
- 1998-11-13 NO NO19985297A patent/NO325358B1/no not_active IP Right Cessation
-
2006
- 2006-11-02 NO NO20065027A patent/NO325633B1/no not_active IP Right Cessation
-
2009
- 2009-01-07 JP JP2009001597A patent/JP4896999B2/ja not_active Expired - Fee Related