JP2000508900A - 腸三葉型蛋白質 - Google Patents
腸三葉型蛋白質Info
- Publication number
- JP2000508900A JP2000508900A JP9537224A JP53722497A JP2000508900A JP 2000508900 A JP2000508900 A JP 2000508900A JP 9537224 A JP9537224 A JP 9537224A JP 53722497 A JP53722497 A JP 53722497A JP 2000508900 A JP2000508900 A JP 2000508900A
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- itf
- tissue
- trefoil
- patient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pulmonology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Otolaryngology (AREA)
- Neurology (AREA)
- Reproductive Health (AREA)
- Rheumatology (AREA)
- Ophthalmology & Optometry (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Communicable Diseases (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Peptides Or Proteins (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.病変の形成の治療または阻害のための、三葉型ポリペプチドまたは生物学 的に活性なその断片を含むポリペプチド。 2.三葉型ポリペプチドがヒト三葉型ポリペプチドである、請求項1記載のポ リペプチド。 3.三葉型ポリペプチドが腸三葉型ポリペプチド(ITF)である、請求項1記 載のポリペプチド。 4.三葉型ポリペプチドが鎮痙性ポリペプチド(SP)である、請求項1記載の ポリペプチド。 5.三葉型ポリペプチドがPS2である、請求項1記載のポリペプチド。 6.病変が消化管内にある、請求項1記載のポリペプチド。 7.病変が患者の口内にある、請求項6記載のポリペプチド。 8.病変が患者の食道内にある、請求項6記載のポリペプチド。 9.病変が患者の胃の内部にある、請求項6記載のポリペプチド。 10.病変が患者の腸内にある、請求項6記載のポリペプチド。 11.患者が、癌の治療のため放射線治療を受けている、請求項6記載のポリ ペプチド。 12.患者が、癌の治療のため化学療法を受けている、請求項6記載のポリペ プチド。 13.患者が、消化管に損傷を与える薬物を受けている、請求項6記載のポリ ペプチド。 14.患者が消化性疾患に罹患している、請求項6記載のポリペプチド。 15.消化性疾患が、非潰瘍性消化不良である、請求項14記載のポリペプチ ド。 16.消化性疾患が胃炎である、請求項14記載のポリペプチド。 17.消化性疾患が胃食道逆流性障害である、請求項14記載のポリペプチド 。 18.消化性疾患が、消化性潰瘍または十二指腸漬瘍である、請求項14記載 のポリペプチド。 19.投与が経口投与である、請求項6記載のポリペプチド。 20.経口投与が、約10ミリグラム〜約100ミリグラムのポリペプチドの投与 を含む、請求項6記載のポリペプチド。 21.病変が、消化管の組織以外の組織の内部にある、請求項1記載のポリペ プチド。 22.組織が皮膚である、請求項21記載のポリペプチド。 23.投与が局所的投与である、請求項22記載のポリペプチド。 24.局所的投与が、約1mg/ml〜約10mg/mlのポリペプチドを含む軟膏の投与 を含むものである、請求項23記載のポリペプチド。 25.組織に、眼の角膜表面が含まれる、請求項21記載のポリペプチド。 26.組織に、気道の組織が含まれる、請求項21記載のポリペプチド。 27.組織に、尿生殖管の組織が含まれる、請求項21記載のポリペプチド。 28.患者の組織における病変の形成を治療または阻害するための三葉型ポリ ペプチドを含む組成物。 29.患者の組織における病変の治療を目的とする医薬品の製造における、請 求項28記載の組成物の使用。 30.ポリペプチドが、マーカーをさらに含む、請求項1記載の三葉型ポリペ プチド。 31.マーカーが造影剤を含む、請求項30記載の三葉型ポリペプチド。 32.ある組織においてITFレセプターを検出するための方法であって、検出 可能な標識を施された三葉型ポリペプチドに該組織を接触させる段階と、該組織 に結合した検出可能な標識を施された三葉型ポリペプチドのレベルを測定する段 階とを含む方法。 33.ある組織において三葉型ポリペプチドを検出するための方法であって、 該三葉型ポリペプチドに特異的に結合する抗体に該組織を接触させる段階を含む 方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/631,469 US6221840B1 (en) | 1991-02-14 | 1996-04-12 | Intestinal trefoil proteins |
US08/631,469 | 1996-04-12 | ||
PCT/US1997/006004 WO1997038712A1 (en) | 1996-04-12 | 1997-04-11 | Intestinal trefoil proteins |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2007193980A Division JP2008037866A (ja) | 1996-04-12 | 2007-07-26 | 腸三葉型蛋白質 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2000508900A true JP2000508900A (ja) | 2000-07-18 |
JP2000508900A5 JP2000508900A5 (ja) | 2004-12-09 |
Family
ID=24531337
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP9537224A Withdrawn JP2000508900A (ja) | 1996-04-12 | 1997-04-11 | 腸三葉型蛋白質 |
JP2007193980A Withdrawn JP2008037866A (ja) | 1996-04-12 | 2007-07-26 | 腸三葉型蛋白質 |
JP2009069639A Pending JP2009149687A (ja) | 1996-04-12 | 2009-03-23 | 腸三葉型蛋白質 |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2007193980A Withdrawn JP2008037866A (ja) | 1996-04-12 | 2007-07-26 | 腸三葉型蛋白質 |
JP2009069639A Pending JP2009149687A (ja) | 1996-04-12 | 2009-03-23 | 腸三葉型蛋白質 |
Country Status (12)
Country | Link |
---|---|
US (4) | US6221840B1 (ja) |
EP (2) | EP0954330B1 (ja) |
JP (3) | JP2000508900A (ja) |
AT (1) | ATE364394T1 (ja) |
AU (1) | AU729564B2 (ja) |
BR (1) | BR9710654A (ja) |
CA (1) | CA2251631A1 (ja) |
DE (1) | DE69737816T2 (ja) |
DK (1) | DK0954330T3 (ja) |
ES (1) | ES2287952T3 (ja) |
PT (1) | PT954330E (ja) |
WO (1) | WO1997038712A1 (ja) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2004534075A (ja) * | 2001-06-14 | 2004-11-11 | ノボ ノルディスク アクティーゼルスカブ | Tffダイマーペプチドによる粘膜修復 |
JP2005524641A (ja) * | 2002-02-11 | 2005-08-18 | ノボ ノルディスク アクティーゼルスカブ | Tffモノマーペプチドによる粘膜の粘性の管理 |
JP2005532988A (ja) * | 2001-11-28 | 2005-11-04 | ザ ジェネラル ホスピタル コーポレーション | 呼吸上皮の病変を治療するための方法および組成物 |
JP2006516964A (ja) * | 2002-10-31 | 2006-07-13 | ザ ジーアイ カンパニー インコーポレーティッド | 三つ葉型ドメイン含有ポリペプチドおよびその使用 |
JP2006232754A (ja) * | 2005-02-25 | 2006-09-07 | Gi Biopolis:Kk | 消化管粘膜切除後の消化管潰瘍治癒促進用スプレー剤 |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6221840B1 (en) * | 1991-02-14 | 2001-04-24 | The General Hospital Corporation | Intestinal trefoil proteins |
DK6893D0 (da) * | 1993-01-21 | 1993-01-21 | Novo Nordisk As | Peptid |
US6525018B1 (en) * | 1999-05-17 | 2003-02-25 | The General Hospital Corp. | Treating eye disorders using intestinal trefoil proteins |
US20030185838A1 (en) * | 2001-11-28 | 2003-10-02 | Podolsky Daniel K. | Methods and compositions for treating lesions of the respiratory epithelium |
US20030186882A1 (en) * | 2001-07-31 | 2003-10-02 | Podolsky Daniel K. | Methods and compositions for treating and preventing distal bowel lesions |
CA2377107C (en) * | 1999-07-05 | 2013-04-23 | Wolfgang Christian Hans | Delivery of trefoil peptides |
EP1842858A3 (en) * | 2001-04-24 | 2008-04-02 | The General Hospital Corporation | Methods and compositions for treating oral and esophageal lesions |
US20030105016A1 (en) * | 2001-09-06 | 2003-06-05 | Podolsky Daniel K. | Methods and compositions for treating vaginal, cervical, and uterine epithelial lesions |
US20030166535A1 (en) * | 2001-04-24 | 2003-09-04 | Podolsky Daniel K. | Methods and compositions for treating oral and esophageal lesions |
US7538082B2 (en) * | 2001-04-24 | 2009-05-26 | The General Hospital Corporation | Methods and compositions for treating oral and esophageal lesions |
US20060189526A1 (en) * | 2002-04-24 | 2006-08-24 | Podolsky Daniel K | Compositions containing an intestinal trefoil peptide and a mucoadhesive |
US20040171544A1 (en) * | 2001-04-24 | 2004-09-02 | Barker Nicholas P. | Trefoil domain-containing polypeptides and uses thereof |
US20030153496A1 (en) * | 2001-06-14 | 2003-08-14 | Lars Thim | Mucosal repair by TFF dimer peptides |
EP1418930A2 (en) * | 2001-06-14 | 2004-05-19 | Novo Nordisk A/S | Mucosal repair by tff2 peptides |
WO2003011117A2 (en) * | 2001-07-31 | 2003-02-13 | The General Hospital Corporation | Methods and compositions for treating and preventing distal bowel lesions |
EP1925316A3 (en) * | 2001-09-06 | 2008-06-04 | The General Hospital Corporation | Compositions for treating vaginal, cervical and uterine epithelial lesions |
US20030181384A1 (en) * | 2001-09-06 | 2003-09-25 | Podolsky Daniel K. | Methods and compositions for treating vaginal, cervical, and uterine epithelial lesions |
US20030185839A1 (en) * | 2001-10-05 | 2003-10-02 | Podolsky Daniel K. | Methods and compositions for treating dermal lesions |
MXPA04003267A (es) * | 2001-10-05 | 2004-07-08 | Gen Hospital Corp | Metodos y composiciones para tratar lesiones dermicas. |
US20030215431A1 (en) * | 2002-02-11 | 2003-11-20 | Lars Thim | Management of mucosal viscosity by TFF monomer peptides |
CN1655675A (zh) * | 2002-03-26 | 2005-08-17 | 综合医院公司 | 利用三叶肽的联合治疗 |
DE10215320A1 (de) * | 2002-04-02 | 2003-10-23 | Metagen Pharmaceuticals Gmbh | Verwendungen von TFF3 bindenden Substanzen zur Diagnose und Behandlung von Krebserkrankungen |
US20060188471A1 (en) * | 2002-10-31 | 2006-08-24 | Podolsky Daniel K | Methods of treating epithelial lesions |
US6984628B2 (en) * | 2003-07-15 | 2006-01-10 | Allergan, Inc. | Ophthalmic compositions comprising trefoil factor family peptides |
US20070042951A1 (en) * | 2003-10-08 | 2007-02-22 | Allergan, Inc. | Pharmaceutical compositions comprising alpha-2-adrenergics and trefoil factor family peptides |
CA2566292A1 (en) * | 2004-05-13 | 2005-11-24 | Regents Of The University Of Minnesota | Mucin3 egf-like domains |
EP2115146B1 (en) | 2007-01-12 | 2016-07-06 | Intrexon Actobiotics NV | Lactococcus promoters and uses thereof |
US20120183503A1 (en) | 2009-09-29 | 2012-07-19 | Actogenix N.V. | Lactobacillus and streptococcus promoters and uses thereof |
US9119869B2 (en) | 2010-04-29 | 2015-09-01 | Ronald J. Shebuski | Mucin derived polypeptides |
RS55372B1 (sr) | 2011-04-29 | 2017-03-31 | Moberg Pharma Ab | Farmaceutske kompozicije koje sadrže lokalni anestetik kao što je bupivakain, za lokalnu administraciju u ustima ili grlu |
RU2644346C2 (ru) | 2011-06-01 | 2018-02-08 | Интрексон Актобиотикс Н.В. | Система полицистронной экспрессии для бактерий |
CA3011331A1 (en) | 2016-01-14 | 2017-07-20 | Intrexon Actobiotics N.V. | Compositions and methods for the treatment of type 1 diabetes |
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US5192676A (en) * | 1991-02-05 | 1993-03-09 | New England Biolabs, Inc. | Type ii restriction endonuclease, asci, obtainable from arthrobacter species and a process for producing the same |
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WO1992014837A1 (en) | 1991-02-14 | 1992-09-03 | The General Hospital Corporation | Intestinal trefoil proteins |
US6063755A (en) * | 1991-02-14 | 2000-05-16 | The General Hospital Corporation | Intestinal trefoil proteins |
DE4132005A1 (de) * | 1991-09-26 | 1993-04-01 | Merck Patent Gmbh | Kombination enthaltend wachstumsfaktoren und polyelektrolyte |
DK6893D0 (da) * | 1993-01-21 | 1993-01-21 | Novo Nordisk As | Peptid |
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PT777687E (pt) | 1994-08-26 | 2006-10-31 | Novo Nordisk As | Dimeros do peptideo com uma estrutura em forma de folha de trevo |
US6525018B1 (en) * | 1999-05-17 | 2003-02-25 | The General Hospital Corp. | Treating eye disorders using intestinal trefoil proteins |
US6426404B1 (en) * | 1997-08-25 | 2002-07-30 | The General Hospital Corporation | Receptor for intestinal trefoil factor |
US6372439B2 (en) * | 1998-10-01 | 2002-04-16 | James R. Goldenring | Screen for gastric adenocarcinoma |
JP2004515235A (ja) * | 2000-12-08 | 2004-05-27 | ノボ ノルディスク アクティーゼルスカブ | Tffペプチド |
EP1418930A2 (en) * | 2001-06-14 | 2004-05-19 | Novo Nordisk A/S | Mucosal repair by tff2 peptides |
US20030153496A1 (en) * | 2001-06-14 | 2003-08-14 | Lars Thim | Mucosal repair by TFF dimer peptides |
US20030215431A1 (en) * | 2002-02-11 | 2003-11-20 | Lars Thim | Management of mucosal viscosity by TFF monomer peptides |
US6984628B2 (en) * | 2003-07-15 | 2006-01-10 | Allergan, Inc. | Ophthalmic compositions comprising trefoil factor family peptides |
US20060241037A1 (en) * | 2003-10-03 | 2006-10-26 | Allergan Inc. | Compositions comprising trefoil factor family peptides and/or mucoadhesives and proton pump ihhibitor prodrugs |
EP1667705A1 (en) * | 2003-10-03 | 2006-06-14 | Allergan, Inc. | Compositions and methods comprising prostaglandin-related compounds and trefoil factor family peptides for the treatment of glaucoma with reduced hyperemia |
-
1996
- 1996-04-12 US US08/631,469 patent/US6221840B1/en not_active Expired - Fee Related
-
1997
- 1997-04-11 PT PT97921148T patent/PT954330E/pt unknown
- 1997-04-11 ES ES97921148T patent/ES2287952T3/es not_active Expired - Lifetime
- 1997-04-11 DK DK97921148T patent/DK0954330T3/da active
- 1997-04-11 BR BR9710654A patent/BR9710654A/pt not_active Application Discontinuation
- 1997-04-11 EP EP97921148A patent/EP0954330B1/en not_active Expired - Lifetime
- 1997-04-11 AU AU27268/97A patent/AU729564B2/en not_active Ceased
- 1997-04-11 AT AT97921148T patent/ATE364394T1/de not_active IP Right Cessation
- 1997-04-11 CA CA002251631A patent/CA2251631A1/en not_active Abandoned
- 1997-04-11 JP JP9537224A patent/JP2000508900A/ja not_active Withdrawn
- 1997-04-11 WO PCT/US1997/006004 patent/WO1997038712A1/en active IP Right Grant
- 1997-04-11 DE DE69737816T patent/DE69737816T2/de not_active Expired - Fee Related
- 1997-04-11 EP EP07011520A patent/EP1875922A3/en not_active Withdrawn
-
2001
- 2001-03-16 US US09/811,259 patent/US20020052483A1/en not_active Abandoned
-
2003
- 2003-07-11 US US10/353,334 patent/US20030225250A1/en not_active Abandoned
-
2007
- 2007-07-26 JP JP2007193980A patent/JP2008037866A/ja not_active Withdrawn
-
2009
- 2009-03-23 JP JP2009069639A patent/JP2009149687A/ja active Pending
- 2009-06-15 US US12/484,368 patent/US20100184657A1/en not_active Abandoned
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2004534075A (ja) * | 2001-06-14 | 2004-11-11 | ノボ ノルディスク アクティーゼルスカブ | Tffダイマーペプチドによる粘膜修復 |
JP2005532988A (ja) * | 2001-11-28 | 2005-11-04 | ザ ジェネラル ホスピタル コーポレーション | 呼吸上皮の病変を治療するための方法および組成物 |
JP2005524641A (ja) * | 2002-02-11 | 2005-08-18 | ノボ ノルディスク アクティーゼルスカブ | Tffモノマーペプチドによる粘膜の粘性の管理 |
JP2006516964A (ja) * | 2002-10-31 | 2006-07-13 | ザ ジーアイ カンパニー インコーポレーティッド | 三つ葉型ドメイン含有ポリペプチドおよびその使用 |
JP2006232754A (ja) * | 2005-02-25 | 2006-09-07 | Gi Biopolis:Kk | 消化管粘膜切除後の消化管潰瘍治癒促進用スプレー剤 |
Also Published As
Publication number | Publication date |
---|---|
EP0954330A4 (en) | 2004-08-18 |
US20030225250A1 (en) | 2003-12-04 |
DE69737816T2 (de) | 2008-02-21 |
CA2251631A1 (en) | 1997-10-23 |
ES2287952T3 (es) | 2007-12-16 |
US6221840B1 (en) | 2001-04-24 |
EP1875922A3 (en) | 2008-01-16 |
DE69737816D1 (de) | 2007-07-26 |
PT954330E (pt) | 2007-08-24 |
AU2726897A (en) | 1997-11-07 |
EP1875922A2 (en) | 2008-01-09 |
JP2008037866A (ja) | 2008-02-21 |
DK0954330T3 (da) | 2007-09-24 |
BR9710654A (pt) | 1999-08-17 |
JP2009149687A (ja) | 2009-07-09 |
EP0954330A1 (en) | 1999-11-10 |
AU729564B2 (en) | 2001-02-01 |
ATE364394T1 (de) | 2007-07-15 |
EP0954330B1 (en) | 2007-06-13 |
US20100184657A1 (en) | 2010-07-22 |
WO1997038712A1 (en) | 1997-10-23 |
US20020052483A1 (en) | 2002-05-02 |
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