JP2000507232A - 慢性関節リウマチの病理発生に必要な関節炎誘発性ペプチドに対して免疫防御を誘発するために有用なワクチン組成物と方法 - Google Patents
慢性関節リウマチの病理発生に必要な関節炎誘発性ペプチドに対して免疫防御を誘発するために有用なワクチン組成物と方法Info
- Publication number
- JP2000507232A JP2000507232A JP9532622A JP53262297A JP2000507232A JP 2000507232 A JP2000507232 A JP 2000507232A JP 9532622 A JP9532622 A JP 9532622A JP 53262297 A JP53262297 A JP 53262297A JP 2000507232 A JP2000507232 A JP 2000507232A
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- peptide
- dnajp1
- vaccine
- dnaj
- host
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Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.ホスト内において関節炎誘発性ペプチドに対して免疫防御を誘発する場合に 有用な、実質的に純粋なdnaJp1ペプチドを、医薬的に許容できる担体中に 含むワクチン。 2.当該dnaJp1ペプチドが単離された細菌性ペプチドである請求項1に記 載のワクチン。 3.当該dnaJp1ペプチドが合成または組換えペプチドである請求項1に記 載のワクチン。 4.さらにdnaJp1ペプチド以外のdnaJタンパク質またはそのペプチド フラグメントを含む請求項1に記載のワクチン。 5.当該dnaJタンパク質またはペプチドフラグメントが、細菌性dnaJタ ンパク質で見出される配列で構成されたアミノ酸を含む、請求項4に記載のワク チン。 6.当該dnaJタンパク質またはペプチドフラグメントが、ヒトdnaJタン パク質で見出される配列で構成されたアミノ酸を含む、請求項4に記載のワクチ ン。 7.当該dnaJp1ペプチドが、エシエリキア属(Escherichia)、ラクトコッ カス属(Lactococcus)、クレブシーラ属(Klebsiella)、プロテウス属(Proteus) 、およびサルモネラ属(Salmonella)から成る属の少なくとも1つから選ばれる 細菌によって産生される請求項2に記載のワクチン。 8.さらに免疫刺激化合物を含む請求項1に記載のワクチン。 9.当該免疫刺激化合物がTGF−αである請求項8に記載のワクチン。 10.ホスト内において関節炎誘発性ペプチドに対して免疫防御を誘発する場合 に有用な、dnaJp1ペプチドをコードする組換え遺伝子発現ベクターを含む ワクチン。 11.ホストに免疫学的に有効な量のdnaJp1ペプチドを投与することを含 む、ホスト内において関節炎誘発性ペプチドに対して免疫 防御を誘発する場合に有用な方法。 12.免疫学的に有効な量のdnaJp1ペプチドをホスト内において発現させ るために、dnaJp1ペプチドをコードする組換え遺伝子発現ベクターをホス トに投与することを含む、ホスト内において関節炎誘発性ペプチドに対して免疫 防御を誘発する場合に有用な方法。 13.ホストから得られた生物学的サンプル中の抗関節炎誘発性ペプチド抗体の 有無を当該サンプルの免疫アッセイによって決定することを含む該ホスト固体が 慢性関節リウマチの素因を有するか否かを決定する方法であって、そのような抗 体の存在が慢性関節リウマチの素因を示唆するものである当該決定方法。 14.当該免疫アッセイの標的とされる抗関節炎誘発性ペプチド抗体が抗dna Jp1抗体である請求項13に記載の方法。 15.その一時構造がRA感受性配列を含むHLADR抗原を当該個体が有する か否かを決定することをさらに含む請求項13に記載の方法。 16.個体から得られた生物学的サンプル中に抗関節炎誘発性ペプチド抗体が存 在するか否かを決定する、標識抗dnaJp1ペプチド抗体を含むキット。 17.既知のHLADR抗原と特異的にハイブリダイズするオリゴヌクレオチド をさらに含む請求項16に記載のキット。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/618,464 US5773570A (en) | 1994-05-20 | 1996-03-15 | Vaccine compositions and methods useful in inducing immune protection against arthritogenic peptides involved in the pathogenesis of rheumatoid arthritis |
US08/618,464 | 1996-03-15 | ||
PCT/US1997/002957 WO1997034002A1 (en) | 1996-03-15 | 1997-02-20 | Vaccine compositions and methods useful in inducing immune protection against arthritogenic peptides involved in the pathogenesis of rheumatoid arthritis |
Publications (1)
Publication Number | Publication Date |
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JP2000507232A true JP2000507232A (ja) | 2000-06-13 |
Family
ID=24477812
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP9532622A Pending JP2000507232A (ja) | 1996-03-15 | 1997-02-20 | 慢性関節リウマチの病理発生に必要な関節炎誘発性ペプチドに対して免疫防御を誘発するために有用なワクチン組成物と方法 |
Country Status (9)
Country | Link |
---|---|
US (2) | US5773570A (ja) |
EP (2) | EP1939295A1 (ja) |
JP (1) | JP2000507232A (ja) |
KR (1) | KR100328112B1 (ja) |
AU (1) | AU727087B2 (ja) |
CA (1) | CA2247804A1 (ja) |
NO (1) | NO984244L (ja) |
NZ (1) | NZ331989A (ja) |
WO (1) | WO1997034002A1 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2004518430A (ja) * | 2000-08-09 | 2004-06-24 | ザ レジェンツ オブ ザ ユニバーシティー オブ カリフォルニア サン ディエゴ | ストレスタンパク質およびペプチドならびにその使用方法 |
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US5773570A (en) * | 1994-05-20 | 1998-06-30 | The Regents Of The University Of California | Vaccine compositions and methods useful in inducing immune protection against arthritogenic peptides involved in the pathogenesis of rheumatoid arthritis |
US7094597B1 (en) * | 1994-05-20 | 2006-08-22 | The Regents Of The University Of California | Vaccine compositions and methods useful in inducing immune protection against arthritogenic peptides involved in the pathogenesis of rheumatoid arthritis |
US6787154B2 (en) * | 1998-10-20 | 2004-09-07 | Salvatore Albani | Artificial antigen presenting cells |
JP2002527467A (ja) | 1998-10-20 | 2002-08-27 | サルバトーレ・アルバーニ | 抗原特異的t細胞の単離、定量、特徴づけおよび調節方法 |
US7807377B2 (en) | 1998-10-20 | 2010-10-05 | Salvatore Albani | Method of isolating antigen-specific T cells employing artificial antigen presenting cells |
DE10007771A1 (de) * | 2000-02-14 | 2001-08-23 | Kleine & Steube Entoxin Gmbh | Immunmodulatorisch wirksame Zusammensetzungen, Verfahren zu ihrer Herstellung und ihre Verwendung |
EP1652856A1 (en) * | 2000-08-09 | 2006-05-03 | The Regents of The University of California San Diego | Stress proteins-derived peptides and method of use thereof |
US7608683B2 (en) * | 2000-08-09 | 2009-10-27 | The Regents Of The University Of California | Stress proteins and peptides and methods of use thereof |
IL155610A0 (en) * | 2000-11-01 | 2003-11-23 | Univ California | Immunomodulatory peptides derived from heat shock proteins and uses thereof |
US20030096748A1 (en) * | 2001-06-04 | 2003-05-22 | The Regents Of The University Of Michigan | Methods and compositions for the treatment of diseases associated with signal transduction aberrations |
US7074893B2 (en) | 2002-06-03 | 2006-07-11 | Regents Of The University Of Michigan | Methods and compositions for the treatment of diseases associated with signal transduction aberrations |
AU2002950934A0 (en) * | 2002-08-21 | 2002-09-12 | U. S. Filter Wastewater Group, Inc. | Aeration method |
EP1625148B1 (en) * | 2003-05-21 | 2012-09-26 | Biotech Tools S.A. | Peptide complex |
US8436136B2 (en) | 2003-05-21 | 2013-05-07 | Biotech Tools S.A. | Peptide complex |
US7414168B2 (en) | 2003-07-24 | 2008-08-19 | Clozex Medical Llc | Device for laceration or incision closure |
CU23504A1 (es) | 2004-09-24 | 2010-04-13 | Ct Ingenieria Genetica Biotech | Péptidos y derivados tipo apl de la hsp60 y composiciones farmacéuticas |
CN104313028A (zh) * | 2014-09-30 | 2015-01-28 | 北京生科东方科技有限公司 | 抗类风湿关节炎的小肽基因及其生产方法 |
CN113388012B (zh) * | 2021-06-15 | 2022-09-20 | 南华大学 | Uu-DnaJ蛋白的应用以及抗Uu感染的疫苗 |
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US4732757A (en) * | 1978-02-06 | 1988-03-22 | Stolle Research And Development Corporation | Prevention and treatment of rheumatoid arthritis |
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US5310732A (en) * | 1986-02-03 | 1994-05-10 | The Scripps Research Institute | 2-halo-2'-deoxyadenosines in the treatment of rheumatoid arthritis |
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US5891435A (en) * | 1993-04-16 | 1999-04-06 | Research Corporation Technologies, Inc. | Methods and compositions for delaying or preventing the onset of autoimmune disease |
US5728385A (en) * | 1993-08-12 | 1998-03-17 | Classen Immunotherapies, Inc. | Method and composition for an early vaccine to protect against both common infectious diseases and chronic immune mediated disorders or their sequelae |
US5773570A (en) * | 1994-05-20 | 1998-06-30 | The Regents Of The University Of California | Vaccine compositions and methods useful in inducing immune protection against arthritogenic peptides involved in the pathogenesis of rheumatoid arthritis |
AU696646B2 (en) * | 1994-05-20 | 1998-09-17 | Regents Of The University Of California, The | Method and reagents for the treatment of rheumatoid arthritis |
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-
1996
- 1996-03-15 US US08/618,464 patent/US5773570A/en not_active Expired - Lifetime
-
1997
- 1997-02-20 EP EP07023676A patent/EP1939295A1/en not_active Ceased
- 1997-02-20 NZ NZ331989A patent/NZ331989A/xx not_active IP Right Cessation
- 1997-02-20 WO PCT/US1997/002957 patent/WO1997034002A1/en active IP Right Grant
- 1997-02-20 JP JP9532622A patent/JP2000507232A/ja active Pending
- 1997-02-20 AU AU19755/97A patent/AU727087B2/en not_active Ceased
- 1997-02-20 CA CA002247804A patent/CA2247804A1/en not_active Abandoned
- 1997-02-20 KR KR1019980707257A patent/KR100328112B1/ko not_active IP Right Cessation
- 1997-02-20 EP EP97907862A patent/EP0923646A1/en not_active Withdrawn
-
1998
- 1998-06-30 US US09/107,615 patent/US6153200A/en not_active Expired - Lifetime
- 1998-09-14 NO NO984244A patent/NO984244L/no unknown
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2004518430A (ja) * | 2000-08-09 | 2004-06-24 | ザ レジェンツ オブ ザ ユニバーシティー オブ カリフォルニア サン ディエゴ | ストレスタンパク質およびペプチドならびにその使用方法 |
Also Published As
Publication number | Publication date |
---|---|
CA2247804A1 (en) | 1997-09-18 |
NO984244D0 (no) | 1998-09-14 |
WO1997034002A1 (en) | 1997-09-18 |
EP1939295A1 (en) | 2008-07-02 |
KR100328112B1 (ko) | 2002-07-02 |
EP0923646A1 (en) | 1999-06-23 |
US6153200A (en) | 2000-11-28 |
NZ331989A (en) | 2000-01-28 |
AU727087B2 (en) | 2000-11-30 |
NO984244L (no) | 1998-11-16 |
AU1975597A (en) | 1997-10-01 |
US5773570A (en) | 1998-06-30 |
KR19990087777A (ko) | 1999-12-27 |
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