JP2000504314A - 真珠層からの活性物質の製造法、特に医薬品用途としての生成物 - Google Patents
真珠層からの活性物質の製造法、特に医薬品用途としての生成物Info
- Publication number
- JP2000504314A JP2000504314A JP09524082A JP52408297A JP2000504314A JP 2000504314 A JP2000504314 A JP 2000504314A JP 09524082 A JP09524082 A JP 09524082A JP 52408297 A JP52408297 A JP 52408297A JP 2000504314 A JP2000504314 A JP 2000504314A
- Authority
- JP
- Japan
- Prior art keywords
- nacre
- fraction
- water
- biologically active
- solvent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Physical Education & Sports Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Marine Sciences & Fisheries (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Materials For Medical Uses (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1. 下記a)〜d)により行われることを特徴とする、生物活性物質の製造 法。 a) 真珠層を、粒度が約200μm未満の粉末状にして、 b) これを、水性溶媒と緊密に接触させ、 c) 接触時間の終了時に、不溶性画分を分離して、水性画分を回収し、 d) 水性画分の溶媒を濃縮して、真珠層の可溶性または水中で輸送可能な画分で あって、無機成分を本質的に含まない生物活性物質からなるものを回収する。 2. 段階a)において、真珠層を50〜100μmの粒度に粉砕する、請求項 1に記載の方法。 3. 段階a)において、真珠層を15〜50μmの粒度に粉砕する、請求項1 に記載の方法。 4. 段階b)において、溶媒が、純水、2回蒸留水または発熱性物質不含水、 または特にNaClまたはグアニジン塩酸塩から選択される塩を補足した水から 選択される、請求項1〜3のいずれか一項に記載の方法。 5. 段階d)を、濃縮の後に透析および/または凍結乾燥によって行なう、請 求項1〜4のいずれか一項に記載の方法。 6. 段階d)の後に、エタノールを用いる沈澱を行ない、生物活性を有するサ ブ画分を構成する残渣を回収する、請求項1〜5のいずれか一項に記載の方法。 7. 段階b)を、真珠層粉末を水性溶媒に機械攪拌下にて懸濁することによっ て行なう、請求項1〜6のいずれか一項に記載の方法。 8. 段階b)を、固定した真珠層粉末中を溶媒を加圧下で通過させることによ って行なう、請求項1〜6のいずれか一項に記載の方法。 9. 請求項1〜8のいずれか一項に記載の方法によって得ることができる生 成物。 10. 真珠層から得ることができ、および下記の特徴を有するBMPsなど の非繊維状骨誘導タンパク質。 水溶性であり、 細胞毒性がなく、 アルカリホスファターゼ活性および骨芽細胞によるI型コラーゲン合成を増 加する。 11. 請求項9に記載の少なくとも1種類の生成物または請求項10に記載 の1種類のタンパク質を含むことを特徴とする、医薬組成物。 12. 生体適合性の固形支持体をさらに含有することを特徴とする、請求項 11に記載の医薬組成物。 13. 経皮投与に適切な賦形剤を含有する、請求項11に記載の医薬組成物 。 14. 医薬品としての、請求項1〜8のいずれか一項に記載の方法によって 得ることができる生成物、または請求項11に記載のタンパク質。 15. 組織、特に骨、軟骨または皮膚組織の再生を増加することを目的とす る医薬品の製造のための請求項1〜8のいずれか一項に記載の方法によって得る ことができる生成物、または請求項9に記載のタンパク質の使用。 16. 医薬品が、関節症、多発性関節炎、骨粗鬆症、退行性老化、腫瘍病変 、および外傷後病変、例えば偽関節および疼痛ジストロフィーから選択される疾 患の治療に有用である、請求項15に記載の使用。 17. 請求項9に記載の少なくとも1種類の生成物を含有する、化粧用組成 物。 18. 請求項9に記載の少なくとも1種類の生成物または請求項10に記載 のタンパク質を含有する、細胞培地。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR95/15650 | 1995-12-28 | ||
FR9515650A FR2743075B1 (fr) | 1995-12-28 | 1995-12-28 | Procede de preparation de substances actives a partir de la nacre, produits obtenus, utiles notamment comme medicaments |
PCT/FR1996/002098 WO1997024133A1 (fr) | 1995-12-28 | 1996-12-27 | Procede de preparation de substances actives a partir de la nacre, produits obtenus, utiles notamment comme medicaments |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2000504314A true JP2000504314A (ja) | 2000-04-11 |
JP4063877B2 JP4063877B2 (ja) | 2008-03-19 |
Family
ID=9486075
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP52408297A Expired - Lifetime JP4063877B2 (ja) | 1995-12-28 | 1996-12-27 | 真珠層からの活性物質の製造法、特に医薬品用途としての生成物 |
Country Status (9)
Country | Link |
---|---|
US (1) | US6251438B1 (ja) |
EP (1) | EP0869805B1 (ja) |
JP (1) | JP4063877B2 (ja) |
AT (1) | ATE214284T1 (ja) |
AU (1) | AU1381697A (ja) |
CA (1) | CA2254791A1 (ja) |
DE (1) | DE69619860T2 (ja) |
FR (1) | FR2743075B1 (ja) |
WO (1) | WO1997024133A1 (ja) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2010095464A (ja) * | 2008-10-15 | 2010-04-30 | Mikimoto Pharmaceut Co Ltd | 皮膚外用剤およびその製造方法 |
JP2011162469A (ja) * | 2010-02-08 | 2011-08-25 | Mikimoto Pharmaceut Co Ltd | 皮膚角化促進剤 |
JP2017513923A (ja) * | 2014-03-14 | 2017-06-01 | 欧詩漫生物股▲ふん▼有限公司Osmun Biological Co., Ltd | 一種の真珠からの真珠抽出物分離・製造方法 |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2777190B1 (fr) * | 1998-04-14 | 2001-07-27 | Georges Camprasse | Procede d'extraction, identification des principes actifs contenus dans la coquille interne et externe des mollusques marins, leur utilisation dans des preparations a visee thera peutique,diagnostic et cosmetique |
GB9823307D0 (en) * | 1998-10-23 | 1998-12-23 | Regent Genus Organisms Interna | Composition for traetment of periodontopathy and related diseases |
FR2799125B1 (fr) * | 1999-10-05 | 2002-01-18 | Centre Nat Rech Scient | Procede de preparation d'une composition par extraction de nacre, comprenant l'integralite des composants de la nacre, composition obtenue par ce procede et son utilisation en pharmacie et cosmetique. |
FR2808657B1 (fr) * | 2000-05-11 | 2003-06-13 | Pharma Futura | Composition commestible comprenant de la poudre de nacre micronisee |
FR2827478B1 (fr) * | 2001-07-18 | 2003-10-24 | Jean Louis Montero | Procede de preparation d'une poudre a base de nacre, proteine isolee de ladite poudre et leurs utilisations en chirurgie osseuse et dans diverses pathologies osteoarticulaires |
FR2856303B1 (fr) * | 2003-06-20 | 2007-09-07 | Innovation Et De Rech Applique | Utilisation therapeutique de lipides extraits de nacre |
FR2863163B1 (fr) * | 2003-12-04 | 2006-02-24 | Oreal | Composition, notamment cosmetique, comprenant des extraits de fougere et de nacre |
FR2866238B1 (fr) * | 2004-02-13 | 2006-12-15 | Innovation Et De Rech Applique | Liquides extrapalleaux de mollusques, obtention, formulation et utilisation |
FR2899478A1 (fr) * | 2006-04-05 | 2007-10-12 | Innovation Et De Rech Applique | Procede d'extraction de molecules de nacre, compositions et utilisation |
CN100362912C (zh) * | 2006-04-12 | 2008-01-23 | 中国科学院南海海洋研究所 | 一种红壳色品系马氏珠母贝的制种方法 |
FR2900343B1 (fr) * | 2006-04-26 | 2008-07-04 | Robert Wan Luxury Ltd | Composition inhibitrice de proteases, notamment la papainee, la cathepsine k et la cathepsine b, et procede de purification de molecules inhibitrices de proteases |
CA2566562A1 (en) * | 2006-10-31 | 2008-01-24 | Scallop Shell Pollution Solution Ltd. | System and process for producing a cleaner containing shell extract and low-suspended solids |
FR2944214B1 (fr) * | 2009-04-10 | 2012-04-27 | Centre Nat Rech Scient | Obtention et utilisation de principe actifs des calcaires |
FR2946883B1 (fr) * | 2009-06-22 | 2012-04-13 | Newco Brevets | Produit et procede pour ameliorer la fertilite des mammiferes |
FR2949323B1 (fr) * | 2009-08-28 | 2011-10-21 | Newco Brevets | Produit d'obturation et de traitement pour les canaux des racines dentaires |
US8205623B2 (en) * | 2010-04-05 | 2012-06-26 | Rovcal, Inc. | Coatings for personal grooming apparatus containing calcium carbonate derived from mollusk shells or pearls |
FR3037801B1 (fr) * | 2015-06-23 | 2017-08-11 | Jd Invest | Materiau semi-synthetique pulverulent, obtenu par modification de la composition d'un biomateriau naturel marin, son procede de fabrication, ses applications |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2715568B1 (fr) * | 1994-01-28 | 1996-04-12 | Joseph Virassamy | Utilisation de poudre de nacre pour prothèse et implants de prothèse conçus pour cela. |
-
1995
- 1995-12-28 FR FR9515650A patent/FR2743075B1/fr not_active Expired - Fee Related
-
1996
- 1996-12-27 DE DE69619860T patent/DE69619860T2/de not_active Expired - Lifetime
- 1996-12-27 US US09/091,989 patent/US6251438B1/en not_active Expired - Lifetime
- 1996-12-27 AT AT96944098T patent/ATE214284T1/de not_active IP Right Cessation
- 1996-12-27 EP EP96944098A patent/EP0869805B1/fr not_active Expired - Lifetime
- 1996-12-27 AU AU13816/97A patent/AU1381697A/en not_active Abandoned
- 1996-12-27 CA CA002254791A patent/CA2254791A1/fr not_active Abandoned
- 1996-12-27 JP JP52408297A patent/JP4063877B2/ja not_active Expired - Lifetime
- 1996-12-27 WO PCT/FR1996/002098 patent/WO1997024133A1/fr active IP Right Grant
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2010095464A (ja) * | 2008-10-15 | 2010-04-30 | Mikimoto Pharmaceut Co Ltd | 皮膚外用剤およびその製造方法 |
JP2011162469A (ja) * | 2010-02-08 | 2011-08-25 | Mikimoto Pharmaceut Co Ltd | 皮膚角化促進剤 |
JP2017513923A (ja) * | 2014-03-14 | 2017-06-01 | 欧詩漫生物股▲ふん▼有限公司Osmun Biological Co., Ltd | 一種の真珠からの真珠抽出物分離・製造方法 |
Also Published As
Publication number | Publication date |
---|---|
US6251438B1 (en) | 2001-06-26 |
DE69619860D1 (de) | 2002-04-18 |
ATE214284T1 (de) | 2002-03-15 |
WO1997024133A1 (fr) | 1997-07-10 |
EP0869805B1 (fr) | 2002-03-13 |
EP0869805A1 (fr) | 1998-10-14 |
FR2743075A1 (fr) | 1997-07-04 |
FR2743075B1 (fr) | 1998-03-27 |
DE69619860T2 (de) | 2002-11-07 |
AU1381697A (en) | 1997-07-28 |
CA2254791A1 (fr) | 1997-07-10 |
JP4063877B2 (ja) | 2008-03-19 |
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