JP2000502951A - スルフィド、スルフォキシド、スルフォンまたはスルフォネート基からなる結合基を介して結合しているリガンドを有する樹脂の調製法 - Google Patents
スルフィド、スルフォキシド、スルフォンまたはスルフォネート基からなる結合基を介して結合しているリガンドを有する樹脂の調製法Info
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- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
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- Inorganic Chemistry (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Processing And Handling Of Plastics And Other Materials For Molding In General (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
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- Graft Or Block Polymers (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.標的化合物と結合することができ、スルフィド、スルフォキシドまたはスル フォン反応性基からなる結合基を介してマトリックスに共有結合しているリガ ンドを有する支持マトリックスを含むクロマトグラフィー樹脂の調製方法であ って、 (a)エチレン系不飽和反応性基が結合している支持マトリックスを生成し、 (b)該マトリックスに共有−SR結合を形成するのに十分なフリーラジカル 条件下において、上記のマトリックス(a)を構造式R−SHで表される反 応性チオール化合物と反応させ(ここで、Rは標的化合物と結合することが できるリガンド)、さらに、 (c)必要に応じて、該スルフィド結合を酸化してスルフォキシドまたはスル フォンとする ことからなる方法。 2.該マトリックスが無機固体支持体であることを特徴とする請求の範囲第1項 記載の方法。 3.該無機固体支持体が、シリカ、アルミナおよびゼオライト類からなる群から 選択されることを特徴とする請求の範囲第2項記載の方法。 4.該マトリックスが有機固体支持体であることを特徴とする請求の範囲第1項 記載の方法。 5.該有機固体マトリックスが、セルロース、アガロース、デキストラン、ポリ アクリレート類、ポリスチレンおよびポリアクリルアミドからなる群から選択 されることを特徴とする請求の範囲第4項記載の方法。 6.該エチレン系不飽和反応性基が構造式>C=CH2で表される末端オレフィ ンを含むことを特徴とする請求の範囲第4項記載の方法。 7.該末端オレフィンがアリル基であることを特徴とする請求の範囲第6記載の 方法。 8.該アリル基が、アリルハライドおよびアリルグリシジルエーテルからなる群 から選択される反応性アリル基に由来するものであることを特徴とする請求の 範囲第7項記載の方法。 9.該リガンドが、スルフィド結合を介して該マトリックスに共有結合している ことを特徴とする請求の範囲第1項記載の方法。 10.該リガンドが、スルフォキシド結合を介して該マトリックスに共有結合して いることを特徴とする請求の範囲第1項記載の方法。 11.該リガンドが、スルフォン結合を介して該マトリックスに共有結合している ことを特徴とする請求の範囲第1項記載の方法。 12.該リガンドが、アミノ、ヒドロカルビルアミノ、ジヒドロカルビルアミノ、 ヒドロキシル、カルボキシル、スルフェート、ホスフェート、ヘテロアリール およびカルボアミジン反応性基からなる群から選択される1個またはそれ以上 の反応性基を有することを特徴とする請求の範囲第1項記載の方法。 13.標的化合物と結合することができ、結合基を介してマトリックスに共有結合 しているリガンド(ここで、該リガンドは末端スルフォネート反応性基を有す る)を有する支持マトリックスを含むクロマトグラフィー樹脂の調製方法であ って、 (a)エチレン系不飽和反応性基が結合している支持マトリックスを生成し、 (b)該マトリックスにスルフォネート基の共有結合を形成するのに十分なフ リーラジカル条件下において、上記のマトリックス(a)をビスルファイト 塩と反応させる、 ことからなる方法。 14.該マトリックスが有機固体支持体であることを特徴とする請求の範囲第13項 記載の方法。 15.該マトリックスが無機固体支持体であることを特徴とする請求の範囲第14項 記載の方法。 16.該無機固体支持体が、シリカ、アルミナおよびゼオライト類からなる群から 選択されることを特徴とする請求の範囲第15項記載の方法。 17.該エチレン系不飽和反応性基が構造式>C=CH2で表される末端オレフィ ンを含むことを特徴とする請求の範囲第14項記載の方法。 18.該末端オレフィンが非共役オレフィンであることを特徴とする請求の範囲第 16項記載の方法。 19.該非共役末端オレフィンがアリル基であることを特徴とする請求の範囲第18 項記載の方法。 20.該アリル基が、アリルハライドおよびアリルグリシジルエーテルからなる群 から選択される反応性アリル基に由来するものであることを特徴とする請求の 範囲第19項記載の方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US08/584,423 | 1996-01-11 | ||
US08/584,423 US5789578A (en) | 1996-01-11 | 1996-01-11 | Methods for the preparation of resins with ligands attached thereto through a linking group comprising sulfide, sulfoxide or sulfone functionality |
PCT/NZ1997/000002 WO1997025139A1 (en) | 1996-01-11 | 1997-01-10 | Methods for the preparation of resins with ligands attached thereto through a linking group comprising sulfide, sulfoxide, sulfone or sulfonate functionality |
Publications (2)
Publication Number | Publication Date |
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JP2000502951A true JP2000502951A (ja) | 2000-03-14 |
JP3970928B2 JP3970928B2 (ja) | 2007-09-05 |
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Application Number | Title | Priority Date | Filing Date |
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JP52511097A Expired - Lifetime JP3970928B2 (ja) | 1996-01-11 | 1997-01-10 | スルフィド、スルフォキシド、スルフォンまたはスルフォネート基からなる結合基を介して結合しているリガンドを有する樹脂の調製法 |
Country Status (12)
Country | Link |
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US (1) | US5789578A (ja) |
EP (2) | EP1464391A3 (ja) |
JP (1) | JP3970928B2 (ja) |
AT (1) | ATE279977T1 (ja) |
AU (1) | AU722740B2 (ja) |
CA (1) | CA2240064C (ja) |
DE (1) | DE69731287T2 (ja) |
DK (1) | DK0891223T3 (ja) |
ES (1) | ES2227666T3 (ja) |
NZ (1) | NZ326487A (ja) |
PT (1) | PT891223E (ja) |
WO (1) | WO1997025139A1 (ja) |
Cited By (5)
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JP2007522444A (ja) * | 2004-01-20 | 2007-08-09 | ポール・コーポレーション | 生理的イオン強度でタンパク質を吸着させるためのクロマトグラフィー材料 |
JP2007332380A (ja) * | 1999-05-14 | 2007-12-27 | Regents Of The Univ Of California | 薬剤および診断薬の送達のための高分子担体 |
JP2013033040A (ja) * | 2011-07-27 | 2013-02-14 | Pall Corp | 混合モード配位子 |
JP2015094757A (ja) * | 2013-11-14 | 2015-05-18 | 学校法人兵庫医科大学 | 新規固相担体 |
JP2016050897A (ja) * | 2014-09-02 | 2016-04-11 | Jsr株式会社 | 担体の製造方法、担体、クロマトグラフィーカラム、及び目的物質の精製方法 |
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US5998606A (en) * | 1997-11-10 | 1999-12-07 | Grandics; Peter | Mn(IV)-mediated crosslinking and functionalization of chromatography media |
US7001745B1 (en) * | 1998-09-30 | 2006-02-21 | New England Biolabs, Inc. | Intein mediated peptide ligation |
US6623655B1 (en) † | 2000-04-24 | 2003-09-23 | Sigma-Aldrich Co. | Metal chelating compositions |
SE0003358D0 (sv) * | 2000-09-19 | 2000-09-19 | Amersham Pharm Biotech Ab | Charged carrier material and its use |
SE0004808D0 (sv) * | 2000-12-20 | 2000-12-20 | Apbiotech Ab | Method for the purification of an enzyme |
GB2377447B (en) * | 2001-04-18 | 2003-06-25 | Amersham Biosciences Ab | Isolation of dna molecules |
SE0103084D0 (sv) * | 2001-09-14 | 2001-09-14 | Amersham Pharm Biotech Ab | Generation of ion exchange media |
JP2005539223A (ja) * | 2002-09-13 | 2005-12-22 | ポール コーポレイション | クロマトグラフィーの吸着剤およびバイオチップアレイのための混合モード固体基材の調製および使用 |
SE529259C2 (sv) * | 2005-08-31 | 2007-06-12 | Ge Healthcare Bio Sciences Ab | Tillverkning av kromarografimatriser, en kromarografimatris, en vätskekromatografikolonn, prcess för att isolera målföreningar och användning av en kromarografimatris för vätskekromatografi |
WO2007058599A1 (en) * | 2005-11-21 | 2007-05-24 | Ge Healthcare Bio-Sciences Ab | Manufacture of a chromatography matrix |
CA2635948C (en) * | 2006-01-16 | 2015-02-10 | Bwe I Malmo Ab | Low protonation constant hydroxy acids |
US9375499B2 (en) | 2006-07-14 | 2016-06-28 | Wisconsin Alumni Research Foundation | Adsorptive membranes for trapping viruses |
WO2009126603A1 (en) * | 2008-04-08 | 2009-10-15 | Bio-Rad Laboratories, Inc. | Chromatography purification of antibodies |
US20100196272A1 (en) | 2009-01-30 | 2010-08-05 | Neoprobe Corporation | Compositions for radiolabeling diethylenetriaminepentaacetic acid (dtpa)-dextran |
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- 1996-01-11 US US08/584,423 patent/US5789578A/en not_active Expired - Lifetime
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- 1997-01-10 JP JP52511097A patent/JP3970928B2/ja not_active Expired - Lifetime
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- 1997-01-10 DE DE69731287T patent/DE69731287T2/de not_active Expired - Lifetime
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- 1997-01-10 EP EP97901278A patent/EP0891223B1/en not_active Expired - Lifetime
- 1997-01-10 PT PT97901278T patent/PT891223E/pt unknown
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- 1997-01-10 AU AU14577/97A patent/AU722740B2/en not_active Expired
- 1997-01-10 DK DK97901278T patent/DK0891223T3/da active
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Cited By (7)
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JP2007332380A (ja) * | 1999-05-14 | 2007-12-27 | Regents Of The Univ Of California | 薬剤および診断薬の送達のための高分子担体 |
JP2007522444A (ja) * | 2004-01-20 | 2007-08-09 | ポール・コーポレーション | 生理的イオン強度でタンパク質を吸着させるためのクロマトグラフィー材料 |
US8021889B2 (en) | 2004-01-20 | 2011-09-20 | Pall Corporation | Chromatographic material for the absorption of proteins at physiological ionic strength |
JP4801598B2 (ja) * | 2004-01-20 | 2011-10-26 | ポール・コーポレーション | 生理的イオン強度でタンパク質を吸着させるためのクロマトグラフィー材料 |
JP2013033040A (ja) * | 2011-07-27 | 2013-02-14 | Pall Corp | 混合モード配位子 |
JP2015094757A (ja) * | 2013-11-14 | 2015-05-18 | 学校法人兵庫医科大学 | 新規固相担体 |
JP2016050897A (ja) * | 2014-09-02 | 2016-04-11 | Jsr株式会社 | 担体の製造方法、担体、クロマトグラフィーカラム、及び目的物質の精製方法 |
Also Published As
Publication number | Publication date |
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DK0891223T3 (da) | 2005-02-14 |
CA2240064A1 (en) | 1997-07-17 |
US5789578A (en) | 1998-08-04 |
CA2240064C (en) | 2005-08-02 |
ES2227666T3 (es) | 2005-04-01 |
EP1464391A3 (en) | 2004-12-29 |
AU1457797A (en) | 1997-08-01 |
DE69731287T2 (de) | 2005-10-13 |
DE69731287D1 (de) | 2004-11-25 |
AU722740B2 (en) | 2000-08-10 |
PT891223E (pt) | 2005-02-28 |
EP0891223B1 (en) | 2004-10-20 |
WO1997025139A1 (en) | 1997-07-17 |
NZ326487A (en) | 1999-11-29 |
EP0891223A4 (en) | 1999-07-28 |
EP1464391A2 (en) | 2004-10-06 |
JP3970928B2 (ja) | 2007-09-05 |
ATE279977T1 (de) | 2004-11-15 |
EP0891223A1 (en) | 1999-01-20 |
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