JP2000500751A - 血液調節化合物 - Google Patents
血液調節化合物Info
- Publication number
- JP2000500751A JP2000500751A JP9519005A JP51900597A JP2000500751A JP 2000500751 A JP2000500751 A JP 2000500751A JP 9519005 A JP9519005 A JP 9519005A JP 51900597 A JP51900597 A JP 51900597A JP 2000500751 A JP2000500751 A JP 2000500751A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- alkyl
- compound
- bis
- independently
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- 229960002897 heparin Drugs 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- 125000002632 imidazolidinyl group Chemical group 0.000 description 1
- 125000002636 imidazolinyl group Chemical group 0.000 description 1
- 125000002883 imidazolyl group Chemical group 0.000 description 1
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- 125000003387 indolinyl group Chemical group N1(CCC2=CC=CC=C12)* 0.000 description 1
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- 239000004615 ingredient Substances 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
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- 208000014674 injury Diseases 0.000 description 1
- 229940047122 interleukins Drugs 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 125000005438 isoindazolyl group Chemical group 0.000 description 1
- 125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 description 1
- 125000001786 isothiazolyl group Chemical group 0.000 description 1
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- 231100001022 leukopenia Toxicity 0.000 description 1
- 239000012669 liquid formulation Substances 0.000 description 1
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- 125000002757 morpholinyl group Chemical group 0.000 description 1
- 239000004570 mortar (masonry) Substances 0.000 description 1
- PSHKMPUSSFXUIA-UHFFFAOYSA-N n,n-dimethylpyridin-2-amine Chemical compound CN(C)C1=CC=CC=N1 PSHKMPUSSFXUIA-UHFFFAOYSA-N 0.000 description 1
- 125000004593 naphthyridinyl group Chemical group N1=C(C=CC2=CC=CN=C12)* 0.000 description 1
- 239000007922 nasal spray Substances 0.000 description 1
- 239000006199 nebulizer Substances 0.000 description 1
- 210000000440 neutrophil Anatomy 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 210000002997 osteoclast Anatomy 0.000 description 1
- 125000001715 oxadiazolyl group Chemical group 0.000 description 1
- BGLDQQONMUSAQA-UHFFFAOYSA-N oxane-4,4-diamine Chemical compound NC1(N)CCOCC1 BGLDQQONMUSAQA-UHFFFAOYSA-N 0.000 description 1
- 239000000312 peanut oil Substances 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 125000004193 piperazinyl group Chemical group 0.000 description 1
- 125000005936 piperidyl group Chemical group 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
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- 230000002035 prolonged effect Effects 0.000 description 1
- 239000003380 propellant Substances 0.000 description 1
- 125000000561 purinyl group Chemical group N1=C(N=C2N=CNC2=C1)* 0.000 description 1
- 125000003226 pyrazolyl group Chemical group 0.000 description 1
- 125000000168 pyrrolyl group Chemical group 0.000 description 1
- 125000002294 quinazolinyl group Chemical group N1=C(N=CC2=CC=CC=C12)* 0.000 description 1
- 125000001567 quinoxalinyl group Chemical group N1=C(C=NC2=CC=CC=C12)* 0.000 description 1
- 125000004621 quinuclidinyl group Chemical group N12C(CC(CC1)CC2)* 0.000 description 1
- 238000001959 radiotherapy Methods 0.000 description 1
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- 239000012266 salt solution Substances 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 235000002639 sodium chloride Nutrition 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- BEOOHQFXGBMRKU-UHFFFAOYSA-N sodium cyanoborohydride Chemical compound [Na+].[B-]C#N BEOOHQFXGBMRKU-UHFFFAOYSA-N 0.000 description 1
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 239000012258 stirred mixture Substances 0.000 description 1
- 210000002536 stromal cell Anatomy 0.000 description 1
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- 239000000829 suppository Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 125000003039 tetrahydroisoquinolinyl group Chemical group C1(NCCC2=CC=CC=C12)* 0.000 description 1
- 125000003831 tetrazolyl group Chemical group 0.000 description 1
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- 231100000419 toxicity Toxicity 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
- Junction Field-Effect Transistors (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Microwave Amplifiers (AREA)
- Amplifiers (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US657395P | 1995-11-13 | 1995-11-13 | |
| US657195P | 1995-11-13 | 1995-11-13 | |
| US60/006,573 | 1995-11-13 | ||
| US60/006,571 | 1995-11-13 | ||
| PCT/US1996/018126 WO1997017964A1 (en) | 1995-11-13 | 1996-11-12 | Hemoregulatory compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP2000500751A true JP2000500751A (ja) | 2000-01-25 |
Family
ID=26675804
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP9519005A Pending JP2000500751A (ja) | 1995-11-13 | 1996-11-12 | 血液調節化合物 |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP0861077B1 (cs) |
| JP (1) | JP2000500751A (cs) |
| KR (1) | KR19990067506A (cs) |
| CN (1) | CN1209061A (cs) |
| AT (1) | ATE212839T1 (cs) |
| AU (1) | AU711239B2 (cs) |
| BR (1) | BR9611520A (cs) |
| CZ (1) | CZ147098A3 (cs) |
| DE (1) | DE69619123D1 (cs) |
| IL (1) | IL124354A0 (cs) |
| NO (1) | NO310656B1 (cs) |
| NZ (1) | NZ323207A (cs) |
| PL (1) | PL326631A1 (cs) |
| TR (1) | TR199800850T2 (cs) |
| WO (1) | WO1997017964A1 (cs) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000500466A (ja) * | 1995-11-13 | 2000-01-18 | スミスクライン・ビーチャム・コーポレイション | 血液調節化合物 |
| ATE261336T1 (de) * | 1998-12-07 | 2004-03-15 | Hoffmann La Roche | Verfahren und vorrichtung zum mischen oder dispergieren von flüssigkeiten |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3917626A (en) * | 1971-03-29 | 1975-11-04 | Ici Ltd | 3,6-Dioxa-1,8-octandiamido bis (pyridinium) compounds |
| FI77875C (fi) * | 1982-11-26 | 1989-05-10 | Nyegaard & Co As | Foerfarande foer framstaellning av nya terapeutiskt anvaendbara peptider. |
| US4544661A (en) * | 1983-09-23 | 1985-10-01 | Chevron Research Company | Fungicidal N-pyridyloxy alkyl amines |
| JPH0381222A (ja) * | 1989-08-22 | 1991-04-05 | Yoshitomi Pharmaceut Ind Ltd | 制癌剤 |
| JP2994182B2 (ja) * | 1992-07-23 | 1999-12-27 | 石原産業株式会社 | アミド系化合物又はその塩、それらの製造方法及びそれらを含有する有害動物防除剤 |
| AU7044994A (en) * | 1993-05-24 | 1994-12-20 | Nycomed Pharma | Hemoregulatory peptides |
-
1996
- 1996-11-12 JP JP9519005A patent/JP2000500751A/ja active Pending
- 1996-11-12 AT AT96940390T patent/ATE212839T1/de not_active IP Right Cessation
- 1996-11-12 NZ NZ323207A patent/NZ323207A/xx unknown
- 1996-11-12 CN CN96199489A patent/CN1209061A/zh active Pending
- 1996-11-12 BR BR9611520-3A patent/BR9611520A/pt active Search and Examination
- 1996-11-12 EP EP96940390A patent/EP0861077B1/en not_active Expired - Lifetime
- 1996-11-12 AU AU77282/96A patent/AU711239B2/en not_active Ceased
- 1996-11-12 CZ CZ981470A patent/CZ147098A3/cs unknown
- 1996-11-12 KR KR1019980703528A patent/KR19990067506A/ko not_active Withdrawn
- 1996-11-12 PL PL96326631A patent/PL326631A1/xx unknown
- 1996-11-12 IL IL12435496A patent/IL124354A0/xx unknown
- 1996-11-12 DE DE69619123T patent/DE69619123D1/de not_active Expired - Lifetime
- 1996-11-12 WO PCT/US1996/018126 patent/WO1997017964A1/en not_active Application Discontinuation
- 1996-11-12 TR TR1998/00850T patent/TR199800850T2/xx unknown
-
1998
- 1998-05-12 NO NO19982151A patent/NO310656B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| PL326631A1 (en) | 1998-10-12 |
| EP0861077A1 (en) | 1998-09-02 |
| AU711239B2 (en) | 1999-10-07 |
| NO310656B1 (no) | 2001-08-06 |
| AU7728296A (en) | 1997-06-05 |
| ATE212839T1 (de) | 2002-02-15 |
| EP0861077B1 (en) | 2002-02-06 |
| CZ147098A3 (cs) | 1999-02-17 |
| TR199800850T2 (xx) | 1998-09-21 |
| NO982151D0 (no) | 1998-05-12 |
| CN1209061A (zh) | 1999-02-24 |
| KR19990067506A (ko) | 1999-08-25 |
| WO1997017964A1 (en) | 1997-05-22 |
| NO982151L (no) | 1998-07-03 |
| EP0861077A4 (en) | 1999-03-03 |
| IL124354A0 (en) | 1998-12-06 |
| DE69619123D1 (de) | 2002-03-21 |
| BR9611520A (pt) | 1999-12-28 |
| NZ323207A (en) | 1999-11-29 |
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