JP2000053538A - Hair growth inhibitor - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a novel hair growth-inhibitor or a novel cosmetic composition from a safe plant. SOLUTION: This hair growth-inhibitor or the objective cosmetic composition contains at least one plant extract selected from hydrangea (Hydrargea macrophylla) and tea-ofheaven (Hydrargea serrata var. angustata). The extract has hair growth and trichogenous action-inhibiting actions and can improve the skin roughening after hair removal, allevlate the pain of the skin, thus the application frequency of a depilation agent cab be reduced. They are safe to human as well as animals.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to a hair growth inhibitor containing at least one plant extract selected from hydrangea and amateur, and a cosmetic composition containing the same.

[0002] The field of application is various cosmetic compositions, for example, various external preparations (including preparations for animals) in general, and specifically, ampoules,
Capsule, pill, tablet, powder, granule, solid,
Liquid, gel or foam 1) pharmaceuticals, 2) quasi-drugs, 3) topical or systemic skin cosmetics (eg, lotions, emulsions, creams, ointments, lotions, oils, packs, etc.) Basic cosmetics, facial cleansers and skin cleansers, hair removers,
Hair removal agent, shaving treatment fee, after shave lotion,
Pre-show lotion, shaving cream, etc.), 4) medicinal or / and cosmetic preparations applied to the scalp / hair (eg, shampoos, rinses, treatments, permanent solutions, hair dyes, hair dressings, hair tonics) 5) In addition, liquid odor and deodorant inhibitors, sanitary articles, sanitary cotton, wet tissues, etc.

[0003]

2. Description of the Related Art Hair and body hair are biologically important protection means for the body, and protect the head, chest, armpits, limbs, etc.
It can be said to be one of the leading armor to protect. However, with the recent changes in lifestyle, artificial protective means such as clothes and protective equipment have appeared, and the body hair except for the head hair no longer needs a function or role as a protective means.

[0004] Recently, abundant hair has been desired from the viewpoints of aesthetic sense and fashionability. However, with regard to body hair, on the contrary, it is more preferable to have less than less hair. Under the current situation, various cosmetics having functions such as depilatory cream and depilatory cream have been developed recently as physical hair removing means from physical means such as shaver and depilatory equipment, for example, thioglycol. Acids or salts thereof, strontium sulfate, sodium sulfide, barium sulfide, calcium sulfide and the like are blended and used in depilatory and depilatory creams.

[0005]

However, all of these hair removal / hair removal treatment methods involve physical or chemical irritation (rough skin, irritating pain, etc.), generate an unpleasant odor, and cause headache. And vomiting and other symptoms.

[0006]

In view of such circumstances, the present inventors have developed a useful plant having an action of suppressing hair growth as a theme of development, and as a result, extracted one or more types of plants selected from hydrangea and amateur. A highly safe hair growth inhibitor and a cosmetic composition containing the same, which are confirmed to significantly inhibit hair growth, improve skin roughness after hair removal, and reduce skin pain. The present invention has been completed by providing a product.

[0007]

BEST MODE FOR CARRYING OUT THE INVENTION

[0008] "Hydrangea: hydrangea" is a plant of the genus Hydrangea (Saxifragaceae).
Hydrangea "Hydrangea macrophylla (Thunb.) Ser. (= Hydr
angeamacrophylla (Thunb.) Ser.var otakusa (Sieb.et Z
ucc.) Makino), (= Hydrangeahortensis Sm.) ", leaves, foliage, branches and branches are used. In addition, congener species of Hydrangea involcurata Sieb.
ydrangea petiolaris Sieb.et Zucc.), (Hydrangea s
trigosa Rehd.), gaku hydrangea (Forma normalis (Wils)
on) Hara), hydrangea (Subsp.serratum (Thunb.) Mak
Ino), hydrangea leaves, foliage, branches, branch tips can also be used.

"Amacha: sweet tea" is a plant of the family Saxifragaceae or Hydrangea.
Amateur (Hydrangea serrata Seringe var. Thunbergi
i Sugimoto) leaves, foliage, branches, and tips are used.

The various plant extracts of hydrangea and amateur used in the present invention are those obtained by pulverizing various parts of each plant (leaves, foliage, branches, foliage, branches, etc.) as they are or after crushing. Alternatively, it is extracted with a solvent as it is or after pulverization.

Examples of the extraction solvent include water, alcohols (eg, lower alcohols such as methanol, anhydrous ethanol and ethanol, or polyhydric alcohols such as propylene glycol and 1,3-butylene glycol), ketones such as acetone, and diethyl. Esters such as ether, dioxane, acetonitrile and ethyl acetate, and organic solvents such as xylene, benzene and chloroform can be used alone or in any combination of two or more. It can be used even when the objects are combined.

The plant extracts of hydrangea and amacha may be optionally dried, concentrated, or diluted depending on the type and form of the hair growth inhibitor and the cosmetic composition to be applied.

[0013] The production method is not particularly limited, but usually may be in the range of the boiling point of the solvent at normal temperature to normal pressure.
A solution, paste, gel, or powder may be obtained by decoloring and purifying. In many cases, it can be used as it is, but if necessary, purification treatment such as deodorization and decolorization may be added as far as the effect is not affected. An activated carbon column or the like may be used, and ordinary means generally applied to the extracted substance may be arbitrarily selected.

Each of the plant extracts of hydrangea and amacha of the present invention can be incorporated into a hair growth inhibitor and a cosmetic composition, and the amount thereof is not particularly limited.
It varies slightly depending on the type, quality and expected degree of action of the cosmetic composition, and is usually 0.001% by weight or more (hereinafter, referred to as
(Expressed in% by weight), preferably 3 to 20%. If the amount is less than 0.001%, the effect cannot be expected sufficiently.

The hair growth inhibitor and the cosmetic composition of the present invention may further contain, if necessary, pharmaceuticals, quasi-drugs, and cosmetics in addition to the above-mentioned essential components as long as the effects of the present invention are not impaired. Arbitrarily select the components and additives used in pharmaceuticals such as
It can be manufactured in combination.

(1) Various fats and oils Avocado oil, almond oil, fennel oil, perilla oil,
Olive oil, orange oil, orange luffer oil, sesame oil,
Cocoa butter, chamomile oil, carrot oil, cucumber oil, tallow fatty acid, kukuinut oil, safflower oil, shea butter oil, soybean oil, camellia oil, corn oil, rapeseed oil, persic oil, castor oil, cottonseed oil, peanut oil, turtle oil , Mink oil, egg yolk oil, cocoa butter, palm oil, palm kernel oil, mocro, coconut oil, tallow, lard, hydrogenated products of these oils (hardened oil, etc.).

(2) Waxes Beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax,
Montan wax, shellac wax, etc.

(3) Mineral oil Liquid paraffin, vaseline, paraffin, ozokeride, ceresin, microcrystalline wax, squalene, squalane, pristane and the like.

(4) Fatty acids Natural fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, 12-hydroxystearic acid, undecylenic acid, tall oil, lanolin fatty acid, isononanoic acid, caproic acid , 2-ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, 2
-Synthetic fatty acids such as ethylhexanoic acid and isopentanoic acid.

(5) Alcohols Ethanol, isopiranol, lauryl alcohol,
Natural alcohols such as cetanol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, and phytosterol; and synthetic alcohols such as 2-hexyldecanol, isostearyl alcohol, and 2-octyldodecanol.

(6) Polyhydric alcohols Ethylene oxide, ethylene glycol, diethylene glycol, triethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, polyethylene glycol, propylene oxide, propylene glycol , Polypropylene glycol, 1,3-butylene glycol, glycerin, pentaerythritol, sorbitol, mannitol and the like.

(7) Esters Isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, decyl oleate, octyl dodecyl myristate, hexyl decyl dimethyloctanoate, cetyl lactate, Myristyl lactate, diethyl phthalate, dibutyl phthalate, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, propylene glycol dioleate, and the like.

(8) Metal soaps Aluminum stearate, magnesium stearate, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate, zinc laurate, zinc undecylenate and the like.

(9) Gum, saccharides and water-soluble polymer compounds Arabic gum, benzoin gum, dammar gum, guaiac oil, Irish moss, karaya gum, tragacanth gum,
Carob gum, quinseed, agar, casein, lactose,
Fructose, sucrose and its esters, trehalose and its derivatives, dextrin, gelatin, pectin, starch, carrageenan, carboxymethyl chitin or hydroxyalkyl (C2-C4) to which alkylene (C2-C4) oxide such as ethylene oxide is added. ) Chitin or chitosan, low molecular weight chitin or chitosan, chitosan salt, sulfated chitin or chitosan, phosphorylated chitin or chitosan, alginic acid and its salts, hyaluronic acid and its salts, chondroitin sulfate and its salts, heparin, ethyl cellulose, methyl cellulose, carboxy Methylcellulose, carboxyethylcellulose, sodium carboxyethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, nitrocellulose, crystalline cellulose, Vinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, polyvinyl methacrylate, polyacrylic acid salts, polyalkylene oxide or crosslinked polymer thereof such as polyethylene oxide or polypropylene oxide, carboxyvinyl polymers, such as polyethyleneimine.

(10) Surfactant Anionic surfactant (alkyl carboxylate, alkyl sulfonate, alkyl sulfate, alkyl phosphate), cationic surfactant (alkyl amine salt, alkyl quaternary ammonium salt) ), Amphoteric surfactant:
Carboxylic acid type amphoteric surfactant (amino type, betaine type), sulfate ester type amphoteric surfactant, sulfonic acid type amphoteric surfactant, phosphate type amphoteric surfactant, nonionic surfactant (ether type nonionic) Surfactants, ether ester type nonionic surfactants, ester type nonionic surfactants, block polymer type nonionic surfactants, nitrogen-containing nonionic surfactants), other surfactants (natural surfactants) , Derivatives of protein hydrolysates,
Polymer surfactant, surfactant containing titanium and silicon,
Fluorocarbon surfactants).

(11) Various vitamins Vitamin A group: retinol, retinal (vitamin A
1), dehydroretinal (vitamin A2), carotene, lycopene (provitamin A), vitamin B group: thiamine hydrochloride, thiamine sulfate (vitamin B1), riboflavin (vitamin B2), pyridoxine (vitamin B)
6), cyanocobalamin (vitamin B12), folic acids,
Nicotinic acids, pantothenic acids, biotins, choline,
Inositols, vitamin C group: ascorbic acid and its derivatives, vitamin D group: ergocalciferol (vitamin D2), cholecalciferol (vitamin D)
3), dihydrotaxerol, vitamin E group: tocopherol and its derivatives, ubiquinones, vitamin K
Group: phytonadione (vitamin K1), menaquinone (vitamin K2), menadione (vitamin K3), menadiol (vitamin K4), other essential fatty acids (vitamin F), carnitine, ferulic acid, γ-oryzanol, orotic acid, vitamin Ps (Rutin, eriocitrin, hesperidin), vitamin U, etc.

(12) Various amino acids valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid , Hydroxylysine, arginine, ornithine, histidine, and the like, and their sulfates, phosphates, nitrates, citrates, and amino acid derivatives such as pyrrolidone carboxylic acid.

(13) Various additives derived from plant or animal raw materials These can be processed in a conventional manner according to the type and form of the product to be added (for example, pulverization, milling, washing, hydrolysis, Fermentation, purification, squeezing, extraction, fractionation, filtration, drying, pulverization, granulation, dissolution, sterilization, pH adjustment, deodorization, decolorization, etc. You can choose to serve.

The solvent used for the extraction may be selected in consideration of the purpose and type of the product to be provided, and the processing to be performed later. However, usually, water and a water-soluble organic solvent (for example, ethanol) are used. , Propylene glycol, 1,3-butylene glycol, etc.).
However, when the content of the organic solvent is not preferable depending on the application, only water may be used, or ethanol which is easily removed after extraction may be used, and may be used alone or in an arbitrary mixed solution with water, Exploited extract may be used.

In addition, additives derived from plant or animal raw materials are
When applied to systemic or topical external preparations and cosmetics, including protection of skin and hair, moisturizing, improvement of feel and texture,
Gives flexibility, relieves irritation, relieves stress due to aroma, activates cells (prevents cell aging), suppresses inflammation, improves skin and hair quality, prevents and improves rough skin, hair growth, hair growth, hair loss prevention, gloss Application, cleaning effect, alleviation of fatigue, promotion of blood flow,
In addition to cosmetic effects such as a warm bath effect, effects such as flavoring, deodorizing, thickening, preserving, and buffering can be expected.

Specific plants (crude drugs) as raw materials include:
For example, almond (Hen peach), eye (Aiba), blue oak
(Seifu Wisteria), Aotsu-Luffaji (Kibo), Ao-Agyu-Agetsuran, Fukurin-Agyu-etsuran, Acacia, Akasugi Fruit, Akagrape, Akaminoki (Logwood), Akamegawiwa (Akabu Kashiwa), Akane (Akane Grassroot), Akajioji-jiou (Jihuang), Agi (Awei), Akinire (Royu bark), Akebi (Kidori), Asa (Ajihito), Malva Asagao or Asagao (Toshibushi), Ashitaba (Amyoha), Amana (Kojimitsu), Azuki (red azuki bean), Acerola, Asenyaku (Asenyaku), Anise, Abemaki fruit, Avocado, Ama, Amacha (Amacha), Amachaworu, Amadokoro (Tamatake), Amigasa lily (Shellfish), Altea, Arnica, Aloe (lux), Aloe vera, Angelica, Apricot・ Hong apricot (Anjin), Ansokkou (Benzou), Ikakouzolina (Biliary head), Igusa (Kokoro grass), Knotweed (Tiger root), Strawberry, Fig (No flower) (Fruit) or its leaves, Ichihatsu (primary), Ichibai (Aoiko), Ichiyakusou (one medicinal herb), Ginkgo (Ginkgo leaves, Ginkgo), Itohimemegi
(Enshi), locust bean, rice seed or seed coat, Inondo seed, Ibuki-kusou-so, nettle, ylang-ylang, fennel (Fenka), ukiyagara (Mitsuryo), fragrant fruit, Himeuikyo, turmeric (Utsukushi),
Keirin saishin (spicy), Usbania oyster, Usbenitachioi, Utsubogusa (summer hay), Udo or Shishido (Qang activity, independent activity, Tang activity), Ume (Umebume) or its flesh, Vladogashi, Oolong tea, Uwaurushi (Kusakokomomo), Unshumikan (Chest skin), Estragon, Eleuthero (Ezo Goka), Echinashi (Hymenoptera), Enishida, Enokitake (Enoki mushroom), Ebisugusa (Keiko), Elderberry fruit, Elemi, Eringyi (pre-lotus erinji), Endju , Solanaceae rice), ogi, olive (orange), ouren (yellow), giant crow squirrel (caronin), oots alga (prevention of self), psyllium (vegetative child, vegetative herb), tou-habami (haruko), obanana okera okera (White ajutsu), fruit of the beetle shabashi, hawthorn hawthorn, hawthorn (Yamatoko), Ousei (narco lily) Key Small pink flowers Le Koyuri), Ouhisasanoyuki, Sasanoyuki, barley
(Barley), giant croaker (cereal grass), oguruma (turnover), okra fruit, panax ginseng and carrot (carrot),
St. John's wort, St. John's wort (Losing sauce), Dutch mustard (watercress),
Dutch jelly, Dutch honeybee, olive, oregano,
Orange fruit or pericarp, lycaenium (ripe ground yellow), cacao seeds, oysters or their leaves (persimmon), kagi kazura (choto)
Cassia, Kasinaki fruit (Kouzo), Gajutsu (Shadoju), Kashiwa
(Kazuki, Kazaha), Cascarilla, Kanixa (Kinosato), Kanokosou (Kisakune), Birch or Weeping birch (White birch), Pumpkin, Kapokinoki seeds, Kahoku Sansho (shopper), Gama (Kaba yellow), Chamomile roma Chamomile, kamiyatsude (herb weed), camucum / duck, duckweed (roasted melon), crowbishaku (midsummer), oak mulberry, guarana seeds, karahoo (thick), karaya, karin (course), garcinia, kawayanagi, kawataketake, kawaranadeshiko (stone bamboo) ) ・ Ezokawaranadeshiko (Quargo, Quirco), Mulberry (Inchinko), Kansui (Kansai), Licorice (Licorca), Kantaraasa, Candelilla, Kantou, Canna, Raspberry (Ezostrawberry, Holland strawberry, Shrimp strawberry, Raspberry European strawberry), Kiwi fruit, Kikarasuuri (Ururone), Kikyo (Kikyo) , Bellflower root),
Chrysanthemums (chrysanthemums, oaks, oaks), catalpa (Azumitsu), daisies (yotei), pheasants (kikomi), kizuta,
Kidachi aloe, Kidney mint, Kinna, Chinese linden (Shincona, Red linden), Yellowfin (Huangkashii), Gymnema sylvesta, Cabbage, Cabbage immature fruit, Cucumber, Kiraja saponaria, Kiraya, Kiransu (Kinkan small grass), Kumquat fruit, Kinma, Kinkihiki Sengaku grass), guava fruit, guayule, Quercus infectria (gallicia), cucumber nuts, wolfberry (Gugi, gugiko, gugi leaf, skeletal bark), Kusagi Kazura (Tenmen winter), Kudzu (Kuzuki), camphor tree, gooseberry fruit , Gardenia, garden oak, black clover, kumazasa, black croaker, horseradish, clara, bittersweet, cranberry fruit, chestnut or its astringent skin, curculigo latifolia fruit, grapefruit, buckthorn, black crocodile (rescue), Kurobana Hikikoshi, Clove (clove, clove), Kaigai Horned ears, celosia (rooster corolla, rooster), bay laurel (laurel), kenashisarutoribara (tochibukuryo, mountain return), gentiana, gennoshoko (old tomato), koji / tachibana / obeninican / ponkan / santara (tachibana), Koshinbara (monthly flower),
Kosui mint, Kozo fruit, Kocha (tea), Kouhone (river bone), Kouhon (straw and kara straw), Kouriang, koendro fruit, koganebana (yellow gon), lingonberry (koshibachi), coconut fruit, goshyu (goshuyu) , Goshoi strawberry (covered bonito), pepper (pepper), copaiba balsam, coffee beans, kobushi magnolia (hot spring), burdock (burdock, burdock),
Kobotdur, sesame (sesame), sesame clover (ginseng), beetle (gomiko), sanekazura binankazura matsubusa,
Wheat (wheat), rice, rice bran (red bran, white bran), rice oil, cola acuminata seeds, cola vera seeds, fenugreek fruit, colombo, conzulango, kelp, konjac, comfrey (finnari grass), sisal, sisalasa , Sakisima button doll (weird sen), Sakura (Oshimazakura, Yamazakura,
Leaves, flowers, fruits, bark (cherry bark), cherries, pomegranate, sasa, oyamazakura, edhigashi, mamezakura, miyamazakura, yoshino cherry, takanezakura, kasumizakura, choujizakura, kohigan, satsakura, kanzakura)
Sazanka, Sajiomodaka (Sawahka), Sweet potato, Sugarcane, Sugar beet, Sanebu jujube (Acid jujube), Saffron (Bamboo safflower, West safflower), Pomelo fruit, Sabonsou, Salmonberry fruit, Sarashinashoma (Masame), Salvia (Sage), Sawagikyo (Yamakona), Sawagurumi (Yamatomo), Sanshin ginseng (Sanjin ginseng), Sanshuyu (sanshuyu), Sansho (Sansho), Sandscon (Yamazone), Shea (Karite), Cyanoki fruit, Shiitake (Shiitake mushroom) ), Shion (Shi-en), Dikitaris, Shikunshi (Kimiko), Shiso, Aodiso, Chirimenzo, Catamendiso (Shiyoha, Shiso), Rosewood, Shinanoki, Shinanohonoki, Sinarengiyou (renryasu),
Shimeji (Hinshimeji, Shakashimeji, Hatakeshimeji, Oshiroishishimeji, Bunashimeji, Shirotamogitake), Shimotsukesou, Potato, Peony (Shakuyaku), Shajin (Sasan), Janohige (Bakumonyu), Juzudama, Palm fruit,
Ginger (ginger), shobu (iris, iris root), shizuku fruit, shirakashi seed, white squirrel seed, white squirrel (small iris), white syllabus flower, white scented minami (southern Tami), cinconas sacyl bra, ginseng (mizu, mizuka) Flower, shencho flower), cinnamon, watermelon (watermelon), honeysuckle (gold and silver flowers, shintofu), sorrel (acidic model), swimberry fruit, stevia, strawberry fruit, suzu psycho (Xucho Lord), succulent (intercrop), suberhide (horse dent) , Horse tooth dents), plum fruits, pine cones, larch, European larch, European hawthorn, European hawthorn, European dandelion, European horse chestnut (Maroniye), European pear fruit, European snow pear, European elder Northern shrews (juniper and pine pine) Perilla (milfoil), rose, rose, mistletoe, mistletoe, rose, rose, horseradish, horseradish, sekisho (stone iris), zenioi, hirohasenega, senega, seri, celery, senkyu (kawasen, sen) This medicine), senna fruit or leaf, senninso (large tate), souka (grass), buckwheat seed, soybean,
Rhubarb (daioh), radish, soybean, rhubarb (orange, kikomi),
Takatodai (Daigei), Takawarabi (Inu), Dark Sweet Cherry Fruit, Tachiaoi, Tachikusou (Thyme, Momika), Tachiyanagi, Tamarind Seeds, Onion, Tamashiba (Spicy), Taranoki or its root bark, Tanjin
(Dan ginseng), Dandelion (Gankohide) or White dandelion / Moko dandelion, Danmar, Cherry fruit, Chigaya or its root (Chinese), Chicset ginseng (Bamboo ginseng), Chicory, Korean ginseng (Gomiko), Korean daisies (Ohuang), Ginseng (Wuyi), Ginseng (Ginseng), Artemisia (Aiba), Choreimaitake (Irei), Tsukimisou, Tsukuritake (Mushroom), Camellia, Camellia, Tsumekusa (lacquer lacustrine), Camellia (Duckweed) ) 、 Tsuruazuki
(Red azuki bean), tsuldokudami (what a crow), tsuruna (ban-an), tsujin carrot (four-leaf ginseng), tsuwabuki, deiko, teuchigurumi,
Duberry fruit, Tengusa, Tencha (Tencha), Tendai Yaku (Wakayaku), Pepper (Winter melon), Pepper (Pan pepper),
Touki (Toki), Calendula (marigold), Corn or corn hair (Nanban hair)
(Sadako), Toudondo (Ryubile), Tokusa (Pirates), Dokudami (Juyaku), Tokon (Stone), Toshishi, Mamedaoshi, Nenokazura, Tochu (Tonaka, Tonakaha), Ash (Hinata), Tomato, Tragant , Triacanthus seeds, Tormentilla, Dronoki, Trolo-aoi, Niseria berry fruit, Yam yam (Yamayaku), Nagikadada (Butcher Bloom), Naginata Kouju, Nazuna, Rape, Natsumikan, Jujube (Daijutsu), Naniwaibara (Kanezakura) Nameko, Narco lily (yellow), peanut (peanut), Nanten (minamiminami), Nigaki (bitter tree), sagebrush (bitter berry), nutmegium, Kei Nikkei (cinnamon bark) Keishi (Keishi), Chinese chive (Nirako) , Elderberry (bone-attached tree) fruit / flower or foliage, garlic (garlic), nulde (fivefold), leek, thistle
(Ohi), Noibara (real fruit), Yarrow, Japanese radish (Maehu), Nobara, Nomomo, Palm, Pineapple fruit, Hibiscus (Bussouge, Furinbussouge, Roselle), Hakamauraboshi (Bone crushing), Hakusen (White ring skin), Huckleberry fruit, chickweed (red), hazel (haruko), hasidoro (roth root), basil, lotus (lotus, lotus, lotus),
Parsley (Netherlands jelly), naked mussels, batata, and hachik
Madake (bamboo-boiled), patchouli, mint (lightly loaded, lightly-leaved leaves), barley (yokuinin), hanasuge (chimbo), banana, hanahacka, hanabishi (situri, shisitsuri), vanilla bins, papaya, lycopodium (rat), hub Grass, paprika, hamago / mitsubahamago (vines), hamasuge (kosuke), hamabishi (ritsuko), hamanas (maikai flower),
Hamabofu (beach storm), hamamelis, rose (rose), agarita (aratake, white-bellied agaric, usukimolinokasa), parietaria, harunire (yellow, yu white skin, yu leaf),
Breadfruit, Hiougi (sun-dried), Lycopodium carrot (party party), pecan nut, giganbana (stone garlic, mulberry flower),
Hikiokoshi (prolonged life grass), Hishi (Hishimi), pistachio, beet, hitsuba (stone reed), hitsuneenida, hinotainokozuchi (cow knee), hinoki, hiba, castor, sunflower, bell pepper, hemigama (Kabamaritake) ,
(Hiromatsutake), Pimenta fruit, Juniper, Biancuum, Hydrangea fruit, Biloba mallow, Hiroha okinagusa (Hakuto oka), Loquat (Loquat, Loquat leaf), Betel wax (Large garment skin, Aretaroko), Scallop (Southern rattan), Fuki, Bukidan poppo (Winter flower, winter leaf), fujibakama (orchid grass), wisteria bean (tomato), grape fruit or pericarp, seeds and leaves, beech, sycamore mushroom (corbicula), Brazilian fern, Brazilian carrot, black currant fruit, blackberry , Plum fruit, furcellaria, blueberry (Prunus aegypti), prunes, blond psyllium, bundou (green beans), loofah, safflower (safflower), henneken, belladonna, berry fruits, peruvianberg, boysenberry fruits, boufu (windproof), spinach , Physalis (Torone), honoki (Japanese thick, magnolia), bokeh (gourd), hosoba Naokera (Aojutsu), Hosobabarengiku, Bodaiju (Bodai tree), Button (peony, Peony bark), Hop, Jojoba, White berry fruit, Honshimeji, Meisurutennanshaw (Tennan star), Maitake (Maitake mushroom), Maou (Maoh) , Macadamia nuts, macri (sea grass), maguwa (mulberry white skin, mulberry leaf), magnolia splengeri, matabi (mokuten tate), matsukasa, matsuha, matsuhodo (bukuryo), mayolam (hanahanakka), malvanojazine (bitan) , Mulberry fruit, quince, mango, mangosteen, manshou walnut, mandarin fruit, mantake mushroom (reishiba), citrus fruit (kokomi), mishima maiko (saiko), mizokashii (half-end lotus), misohagi (sentsuna), Honeywrinkle, honeysuckle, green peppermint, mimosa,
Ginger, miracle fruit fruit, myrrh, myrobaran, mukuge (Mokuge), mukunoki, mukuroji, murasaki (purple root), murasakisekibu, oomurasakishikibu (purple),
(Murasaki maize, swordfish (meadow grass), mebogi, melaleuca, melissa, melilot, melon fruit,
Sagebrush, moso bamboo, mokkou (wood incense), maple leaves, peach leaves (peach leaves), fruits and seeds (peach kernels), bean sprouts, morello cherry fruit, moroheiya (burlap), yakawamurasakiimo, yakuchi (masuchi), Cornflower (cornflower), cornflower mint, yashabushi (arrow wheel), yachiyanagi, yatsude (octagonal gold plate), mistletoe (yanagi parasitism), willow leaf, yabugarashi, yabukouji (purple gold cow), yamagobo
(Land), alder (Yamaharu), bayberry (Yumebai), mugwort, eucalyptus, snowy citrus (tiger ear grass), yucca flebifolia, yuzu fruit, lily, yorigusa, mugwort
(Aiba leaf), lime fruit, rye, lacanca fruit, raspberry leaf and fruit, lavender, longan (green eye), ryocha (green tea), apple fruit, gentian, lubas suavisimus (lethal), lettuce, red currant fruit, lemon Fruits, lemongrass, forsythia, astragalus,
Examples include wax palm, lokon (reed: Root), loganberry fruit, rosemary (mannenrow), rosehip (nobara), wasabi, and valerium (chiyu).

Examples of the seaweeds include seaweeds [green algae: Chlorella vulgaris, Chlorella pyrenoidsa, Chlorella ellipsoidia, Aonori (Usubaaonori, Susiaonori, Hiraaonori, Bowaonori, Hosoedaoonori), and seaweed [brown algae: Kombu algae: brown algae: brown algae: Kombu algae: , Resiliconibu, hosomekombu, mitsuishikomubu), wakame, hirome, aookame, giant kelp (macrocystis pilifera, macrocystis integrifolia, neocitys luetokeana), hijiki, hibamata), seaweed [red algae: hijirimen, maxa ( Tengsa),
Hirakusa, Onyxa, Obakusa, Kataobaxa, Yatabegusa, Yuikiri, Shimatengusa, Tosakanori, Togekirinsai, Akumasakirinsai, Kirinsai, Byaksinkirinsai, Tsunomata, Obatsunomata, Tochaka, Tohkanota, Tojika , Ibotsunomata, Yaleus Banori, Kagius Banori,
Suzius Banori, Hyus Banori, Akamomininori] and the like.

In addition, other algae such as green algae (Chlamydomonas: Chlamydomonas, Akayukimo, Dunaliella: Dunaliella, Chlorococcus: Chlorococcus, Kwanomimo: Kwanomimo, Volvox: Ohikawawari, Volvox, Palmera, Yotsume js
Genus Genus, Spirogyra: Hizaori, Spirogyra, Tulsimidro, Hibimidro: Himidoro, Aosa: Anaoasa, Amiosaa, Nagaoasa, Kawanori: Kawanori, Frichella, Shiogusa: Oshiogusa, Asamiridoshiogusa, Genitalia :
Tamago Baronia, Tamabalonia, Magnificium: Magnificent Eel, Iwata: Fusaiwata, Sricogita, Helaiwata, Croquidita, Hanemona, Mill: Mill, Chromil, Sakibuchimil, Nagamil, Hiramil, Casanoli, Zuzumo, Zuzumo, Juzumo, Juzumo, Juzumo, Zuzumozu Genus, genus Genus, genus Colecaete, genus Tsutsumimo, genus F. spp., Genus A. spp., Genus H., s. Elegans, genus U., ssp., Ssp., Sp.

Blue-green algae (Genus Papilio xylophila: L. spp., Phyllophyllum, Genus Noctuida: Kawatake, Ishikurage,
(Hassai, Yuremo, Racenmo (Spirulina) genus: Spirulina, Trichodesmium (Aiacacio), etc.).

Brown algae (Piraella spp .: Piraella spp., Shiomidoro spp.
Genus Isogawara, genus Isogasula, genus genus: Gunsenkurogashira, genus Kashirazaki, genus Kashirazaki, genus Muchimo: genus Muchimo, Hiramutimo, Kebelligsa, genus Amis. Artemisia spp.
Genus Matsumo: genus Matsumo, genus matsumo: genus sylvestris, genus okinawa, genus okinawa-mozuku, genus niseftomozuku: niseftomozuku, futomozuku: genus futomozuku, ishimozuku: ishimozuku, kuromo: kuromo, nisemozuku: genus, spruce, spruce Ishige, Irolo, Icmegasa: Ichimegasa, Keyari: Keyari, Umibos: Umibos, Urushigusa: Urushigusa,
Species of the genus Coleoptera, Tobacco planta, Laminaria genus: Laminaria genus: Habanomodo genus: Habanomodo genus, Habanori genus: Havanori, genus Habanori: genus Habanori, genus bukuro: common bukuro, Ezobukuro genus: Ezobukuro, Fukuronori genus: Fukuronori, Watanabe Genus Kagomenori: Kagomenori, Muraridori: Murachidori, Shakusugusa: Sharks,
Genus Genus: Genus Genus, Genus Genus: Genus Genus: Genus Genus, Genus Kayamonori, Genus Kayamono, Genus Genus: Genus Ligustrum, Genus Tsurumo: Genus Turrum, Genus Anana: Genus Anastasia, Genus Ligustrum: Sujime, Genus Missiscoma: Genus Genus Ligustrum, G. , Onikombu, Goheikombu, Nagakombu, Pea kelp, Ochimikombu, Torokombu genus: Torokombu, Antokume genus: Antokume, Kajime: Kajime, Tsuruarame, Kurome, Kikuishikomu: Genus Kikuishi, Nejirekomu: Neshilecomb, Kuroshiomeko : Nekoshikambu,
Alame: Alame, Ainuwakame: Ainuwakame, Chigaiso, Oniwakameezoishige: Ezoishige, Yabanemoku: Yabanemoku, Rapamoku: Rapamoku, Jiromoku: Uganomok, Jiromoku, Hiemomoku, Honamomaku, Tamamomaku, Tamamomoku Akamoku, Shidamoku, Hondawara, Nejimoku, Narasamo, Mametawara, Tatsukuri, Yasumatamoku, Umitranoo, Oobamoku, Fushizushimoku, Hahakimokum, Togemoku, Jolemoku, Saw-mokum, Obanoki-moku, Genus genus: Genus
Bulukimo, genus cynomolgus: cynomolgus etc.).

Red algae (Genus genus: Ushikenori, Funorinoushike, Genus Amanori: Asakusanori, Susabinori,
Genus Upirinori, Onimanori, Tasa, Filitasa, Benitasa, Rhodocorton: Milnoveni, Akebonomozuku: Akebonomozuku, Konahada: Haikonahada, Yogorekonahada, Aokonahada, Sea Species: Acer genus : Larch, Fusanori: Fusanori, Nisefusanori: Nisefusanori,
Sodegarami: sodegarami, rattles: rattle, hiraragara, hirohatamataki: hirohatamatamadaki, tamamaidaki: tamaitadaki, kakenokenori: kaginori, kakenenori, tengusa, kurobana, kurobana, swordfish, swordfish, squirrel Genus: hibiroudo, himehibiroudo,
Genus genus: genus isensis, genus genus:
Genus spruce, Ryumonsou: Ryumonsou, Hera Ryumon, Nisekarequigusa: Nisekarequigusa, Okitsubara genus: Obaokitsubara, Akaba: Akaba, Malvaacaba, Naminohana: Genus Hosobanamino, Naminohanagosa, Coralthus Genus Ikawanokawa, Genus Kanokawa: Kinokawa, Genus Kaninote: Kaninote, Coralum: Coralum, Genus Mucadenori: Mucadenori, Sujimukade, Catanori, Hiramukade, Kyonohimo, Sakuranori, Nikunukade, Tambanori, Tsurutsuru,
Genus Isonohana: Nuracusa, Chronulaxa, Stinging genus, Hirakintoki Genus: Hirakintoki, Matabou: Matabou, Kintoki: Chabokintoki, Kintoki, Matsunori, Komenori, Tosakamatsu, Aedes pine, Kakureto: Genus Otokinari, Genus genus Genus Nagaobane, Genus Funori: Hanafunori, Fukuronori, Makhunori, Karenikusa Genus: Kalexigusa, Tosakamaki Genus: Hosobanotokamaki, Hirohanotosakamodoroki, Yatsudegatotoka, Kurotosakamodoki, Nezashinokidoka, Nezashinokinusakada Genus: Ezotosaka, Tsukasanori: Enashikarimenia, Otsukasanori, Hanagatakarimenia, Honoo: Honoo, Hikagenoito: Hikagenoito, Usuginu, Nikuhono: Nikuhono Oh, the genus Venice: genus Venice, genus Suskabeni: genus Suskebeni, genus Okamuragusa:
Yamadagusa, Mirin genus: Mirin, Hosobamilin, Tosakanori genus: Kikutosaka, Ezonameshi: Ezonameshi, Isomokka: Isomocca, Yukari: Yukari, Hosoyukari, Ibaranori: Ibaranori, Saidaibara, Tachiibara, Kagiinobaliso, Phyllophorus Isanthus, Atsubanori: Atsubanori,
Ogonori: Ogonori, Tsurushiramo, Shiramo, Ogogonori, Mizokonori, Kabanori, Tengusamodoki: Hachijotengusamodoki, Fushikrenori: Fushikenori, Namiiwatake: Namiiwatake, Spiraea:
Sponge, genus: ssp.
Genus: crocodile, saimi, crocodile, crocus genus: genus genus: moss genus, genus cynosum: squid moss, hosoibonori, nobonori, kurohaginnansou genus: kurohaginnansou, akabaginnansou genus: akabaginnansou, genus genus: genus serrata The genus Thaliosa: The genus Thalassium, Hanasakura, The genus Scrophulari: The genus Scrophulari, Schikonori, The genus Hananoeda: Hanaeda, The genus Hirata: The genus Hirata goat, The genus Darus: The darth, Masagoshibari, Anadarus, The genus Webagusa, Benifukunori
Genus Fusinagi: Fussushinagi, Himefusushinagi, Hirohafushinagisagi, Satsumagiso Genus: Hirawaginagiso, Usubawaginagiso, Igis Genus: Igis, Keigisu, Harigigissu, Haneigisu, Amigusa, Egonomida, Chrysanthemum Genus, Genus genus Family: Habutaenori, Konohanori, Suzuronori, Usveni genus: Usbeni, Hasujiginu: Hasujiginu, Nagakonohanori: Nagakonohanori, Suzuginu: Sujiginu, Atubastinu, Hyasubanori: Kagiusubanori, Jaureusubanoli, Jareusubanoli
Genus Ayanishiki: Genus Ayanishiki, Genus Ayaginu: Genus Ayaginu, Genus Dadia: Enashidazia, Genus Shimadagia: Isohagi, Simadadia, Dazimodoki: Genus Dazimomodoki, Genus Itogusa: Moleutogusa, Genus Genus: Makuri, Yanaginori, Hanayana, Rana Salix var. Genus Isomegusa: Isomegusa, Suzinasugusa: Suzinasugusa, Isobashou Genus: Isobashou, Fujimatsumo Genus: Fujimatsumo, Sawtooth Lilium: Scutellaria Rihiba, genus: genus kawamozuku, okamomozuku, himekamozuku, genus idiomyme: ideyugomegome, genus okitamozuku: genus okitimozuku,
Genus genus, genus chinorimo: chinorimo, genus genus: chisinori).

The axle algae (genera spp.
Hossiturimo: Hossiturimo, Lichnotumnus, Flasksmo: Himefuramocha, Chaboflasmo, Tripera, etc., and yellow algae (Hikarimo: Hikarimo etc.).

[0038] Materials derived from animal raw materials include a cockscomb extract, a cow / human placenta extract, a pig / cattle stomach, a duodenum or intestinal extract or a decomposition product thereof, and a pig / cattle spleen extract. Products or their degradation products, extracts of swine or bovine brain tissue, water-soluble collagen, collagen derivatives such as acylated collagen, collagen hydrolysates, elastin, elastin hydrolysates, water-soluble elastin derivatives, keratin and its decomposed products Or a derivative thereof, a silk protein and its degradation product or a derivative thereof, a pig / bovine blood cell protein degradation product (globin peptide), a pig / bovine hemoglobin degradation product (hemin,
Hematin, heme, protohem, heme iron, etc.), milk, casein and its decomposition products or their derivatives, skim milk powder and its decomposition products or their derivatives, lactoferrin or its decomposition products, chicken egg components, fish meat decomposition products and the like.

(14) Microbial culture metabolites Yeast metabolites, yeast extract, rice ferment extract, rice bran extract, euglena extract, trehalose or derivatives thereof.

(15) α-hydroxy acid Glycolic acid, citric acid, malic acid, tartaric acid, lactic acid and the like.

(16) Inorganic pigments Silicic anhydride, magnesium silicate, talc, kaolin,
Bentonite, mica, titanium mica, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide,
Titanium oxide, calcium carbonate, magnesium carbonate, yellow iron oxide, red iron oxide, black iron oxide, gunjou, chromium oxide,
Chromium hydroxide, carbon black, calamine, etc.

(17) Ultraviolet absorbing / blocking agent p-aminobenzoic acid derivative, salicylic acid derivative, anthranilic acid derivative, coumarin derivative, amino acid compound,
Benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives,
Nucleic acid derivatives, allantoin derivatives, nicotinic acid derivatives,
Vitamin B6 derivatives, benzophenones, oxybenzone, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, neoheliopan, urocanic acid derivatives, escalol, zinc oxide, talc, kaolin and the like.

(18) Whitening agent p-aminobenzoic acid derivative, salicylic acid derivative, anthranilic acid derivative, coumarin derivative, amino acid compound,
Benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives,
Nucleic acid derivatives, allantoin derivatives, nicotinic acid derivatives,
Vitamin B6 derivatives, oxybenzone, benzophenone, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine and the like.

(19) Tyrosinase activity inhibitor Ascorbic acid and its derivatives, hydroquinone and its glycosides, kojic acid and its derivatives, placental extract, silk peptide, plant extract (mulberry, corn, waremoko,
Artemisia, honeysuckle, yellowfin, dokudami, matsuhodo, adlay barley, odorisus, hawthorn, eucalyptus, american millefolium, althea, keihi, mankeishi, hamamelis, yamaguwa, life-extended grass, bellflower, toshishi, maikoboshi, kyoto, makko, senkyu, dokka Psycho, Bohu,
Hamabofu, Ogon, Peonies, Gennoshoko, Licorice, Fivefold, Aloe, Ginger, Safflower, Asenyaku).

(20) Reduction / decomposition of melanin pigment Hydroquinone monobenzyl ether, phenylmercury hexachlorophene, mercuric oxide, mercurous chloride, aqueous hydrogen peroxide, zinc peroxide, etc.

(21) Promoting action of turnover / cell activation Hydroquinone, lactic acid bacteria extract, placenta extract, reishi extract, vitamin A, vitamin E, allantoin, spleen extract, thymus extract, yeast extract, fermented milk extract, plant extract ( Aloe, ogon, horsetail, gentian, burdock,
Sicon, carrot, hamamelis, hop, yokunin,
Odikoso, Assemble, Touki, Toukensenka, Amacha, Hypericum, Cucumber, Periwinkle,
Rosemary, parsley, etc.).

(22) Astringent Succinic acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc p-phenolsulfonate, potassium aluminum sulfate, resorcinol, ferric chloride, tannic acid (including catechin compound) Such.

(23) Active oxygen scavenger SOD, catalase, glutathione peroxidase and the like.

(24) Antioxidants ascorbic acid and its salts, stearic acid ester, tocopherol and its ester derivatives, nordihydroguaseletenic acid, butylhydroxytoluene (BHT),
Butylhydroxyanisole (BHA), hydroxytyrosol, parahydroxyanisole, propyl gallate, sesamol, sesamolin, gossypol and the like.

(25) Lipid peroxide production inhibitor β-carotene, plant extract (cultured sesame cells, amateur,
Hypericum, Hamamelis, Clove, Melissa, Emmeiso, Birch, Sage, Rosemary, Minami Minami,
Kina, age, ginkgo).

(26) Anti-inflammatory agent Ictamole, indomethacin, kaolin, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, diphenhydramine hydrochloride, d or dl-
Camphor, hydrocortisone, guaiazulene, camazulene, chlorpheniramine maleate, glycyrrhizic acid and its salts, glycyrrhetinic acid and its salts, licorice extract components, sicon extract, age extract extract and the like.

(27) Disinfectant / Disinfectant Acrinol, sulfur, benzalkonium chloride, benzethonium chloride, methylrosaniline chloride, cresol, calcium gluconate, chlorhexidine gluconate, sulfamine, mercurochrome, lactoferrin or a hydrolyzate thereof, alkyldiaminoethyl chloride Glycine solution, isopropylmethylphenol, triclosan, quinidine, etc.

(28) Humidifier Glycerin, propylene glycol, 1,3-butylene glycol, hyaluronic acid and its salt, polyethylene glycol, chondroitin sulfate and its salt, water-soluble chitin or chitosan derivative, pyrrolidone carboxylic acid and its salt, lactic acid Sodium, Mini Sasanishiki extract, etc.

(29) Hair preparations Selenium disulfide, alkylisoquinolinium bromide solution, zinc pyrithione, biphenamine, thianthol, castal tincture, ginger tincture, capsicum tincture, quinine hydrochloride, strong aqueous ammonia, potassium bromate, bromate Sodium, thioglycolic acid, etc.

(30) Antiandrogens Estrogen (eg, estrone, estradiol, ethinylestradiol), isoflavones, oxendrone, etc.

(31) Peripheral vascular blood flow promoter Vitamin E and its derivatives, assembly extract, garlic extract, carrot extract, aloe extract, gentian extract, touki extract, cepharanthin, carpronium chloride, minoxidil and the like.

(32) Topical stimulant Pepper tincture, nonylate vanillamide, cantaris tincture, ginger tincture, peppermint oil, l-menthol, camphor, benzyl nicotinate and the like.

(33) Metabolic activator Photosensitizer No. 301, hinokitiol, pantothenic acid and its derivatives, allantoin, placental extract, biotin, pentadecanoic acid glyceride and the like.

(34) Antiseborrheic agents pyridoxine and its derivatives, sulfur, vitamin B6 and the like.

(35) Keratolytic agent Resorcin, salicylic acid, lactic acid and the like.

(36) Oxidizing agent Hydrogen peroxide solution, sodium persulfate, ammonium persulfate, sodium perborate, urea peroxide, sodium percarbonate, sodium tripolyphosphate, sodium bromate, potassium bromate, pyrroline peroxide Sodium acid, sodium orthophosphate, sodium silicate hydrogen peroxide adduct, sodium sulfate sodium chloride hydrogen peroxide adduct, β-tyrosinase enzyme solution, mushroom extract and the like.

(37) Hair remover strontium sulfate, sodium sulfide, barium sulfide,
Inorganic reducing agents such as calcium sulfide; thioglycolic acid or salts thereof (calcium thioglycolate, sodium thioglycolate, lithium thioglycolate, magnesium thioglycolate, strontium thioglycolate, etc.).

(38) Hair swelling agent Ethanolamine, urea, guanidine and the like.

(39) Dye agent 5-aminoorthocresol, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, 1-
Amino-4-methylaminoanthraquinone, 3,3'-
Iminodiphenol, 2,4-diaminophenoxyethanol hydrochloride, 2,4-diaminophenol hydrochloride, toluene-2,5-diamine hydrochloride, nitroparaphenylenediamine hydrochloride, paraphenylenediamine hydrochloride, N-phenylparaphenylenediamine hydrochloride, meta-hydrochloride Phenylenediamine, orthoaminophenol, N-phenylparaphenylenediamine acetate, 1,4-diaminoanthraquinone, 2,6-diaminopyridine, 1,5-dihydroxynaphthalene, toluene-2,5-diamine, toluene
3,4-diamine, nitroparaphenylenediamine, paraaminophenol, paranitroorthophenylenediamine, paraphenylenediamine, paramethylaminophenol, piclamic acid, sodium piclamate,
N, 'N-bis (4-aminophenyl) -2,5-diamino-1, -4-quinonediimine, 5- (2-hydroxyethylamino) -2-methylphenol, N-phenylparaphenylenediamine, metaamino Phenol, metaphenylenediamine, 5-aminoorthocresol sulfate, 2-amino-5-nitrophenol sulfate, orthoaminophenol sulfate, orthochloroparaphenylenediamine sulfate, 4,4'-diaminodiphenylamine sulfate,
2,4-diaminophenol sulfate, toluene-2 sulfate,
5-diamine, nitroparaphenylenediamine sulfate, paraaminophenol sulfate, paranitroorthophenylenediamine sulfate, paranitrometaphenylenediamine sulfate, paraphenylenediamine sulfate, paramethylaminophenol sulfate, metaaminophenol sulfate, metaphenylenediamine sulfate, catechol , Diphenylamine, α
-Naphthol, hydroquinone, pyrogallol, phloroglucin, gallic acid, resorcin, tannic acid, sodium 2-hydroxy-5-nitro-2 ', 4'-diaminoazobenzozen-5'-sulfonate, hematein and the like.

(40) Flavors Natural animal flavors such as musk, civet, castorium, ambergris, anise essential oil, angelica essential oil, ylang ylang essential oil, iris essential oil, fennel essential oil, orange essential oil, cananga essential oil, caraway essential oil, cardamom essential oil, Guaiac wood essential oil, cumin essential oil, black letter essential oil, cinnamon essential oil, cinnamon essential oil, geranium essential oil, copaiba balsam essential oil, coriandel essential oil, cedarwood essential oil,
Citronella essential oil, jasmine essential oil, gingergrass essential oil, cedar essential oil, spearmint essential oil, western mint essential oil, great fragrance essential oil, tuberose essential oil, clove essential oil, orange flower essential oil, winter green essential oil, true balsam essential oil, batchure essential oil, rose essential oil, palmarosa essential oil , Hinoki essential oil, Hiba essential oil, Sandalwood essential oil,
Petit glen essential oil, bay essential oil, vetiver essential oil, bergamot essential oil, peruvian balsam essential oil, boad rose essential oil, camphor essential oil, mandarin essential oil, eucalyptus essential oil, lime essential oil, linaloe essential oil, lemongrass essential oil, lemon essential oil, rosemary essential oil, Japanese mint essential oil And other vegetable flavors, and other synthetic flavors.

(41) Dyes / colorants Red cabbage dye, red rice dye, madder dye, anato dye, squid dye, turmeric dye, ende dye, krill dye, persimmon dye, caramel, gold, silver, gardenia dye, corn dye , Onion pigment, tamarind pigment, spirulina pigment, buckwheat whole plant pigment, cherry pigment, laver pigment, hibiscus pigment, grape juice pigment, marigold pigment, purple potato pigment, purple yam pigment, lac pigment, rutin, etc.

In addition, humectants, hormones, sequestering agents, pH adjusters, chelating agents, preservatives / anti-binders, fresheners, stabilizers, emulsifiers, animal and plant proteins and their decomposed products, animal and plant Vegetable polysaccharides and their degradation products, animal and vegetable glycoproteins and their degradation products, blood flow enhancers, anti-inflammatory and anti-allergic agents, cell activators, keratolytic agents, wound healing agents, foam enhancers, thickeners Agents, oral agents, deodorants / deodorants, bitters, enzymes, and the like are listed, and when used in combination therewith, various additive and synergistic effects can be expected.

Further, the dosage form of the hair growth inhibitor and the cosmetic composition of the present invention is arbitrary, and may be capsule, powder, granule, solid, liquid, gel, foam, emulsion, cream. And ointments, sheets and the like, pharmaceuticals, quasi-drugs, and skin / hair cosmetics.

Specifically, for example, topical preparations such as topical medicinal preparations, lotions, emulsions, creams, ointments, lotions, oils, and packs, facial cleansers and skin cleansers, depilatory agents, depilatory agents, after-shave lotions , Pre-show lotion, shaving cream, shampoo, rinse,
Hair treatments, hair styling agents, perm agents, hair tonics, hair dyes, hair growth and hair growth products, etc., makeup cosmetics such as foundation, lipstick, blusher, eyeshadow, eyeliner, mascara, perfumes, bath agents In addition, it can be applied to various products such as toothpaste, mouth freshener / gargle, deodorant / deodorant, sanitary cotton, wet tissue, and can be used for general food / drinks.

Further, the hair growth inhibitor and the cosmetic composition of the present invention can be used alone at a site where hair growth inhibition of body hair is desired, and a conventionally known hair remover, depilatory or shaver, It may be used with a hair remover.

The hair growth inhibitor and the cosmetic composition of the present invention may be added in advance or may be added during the production.
What is necessary is just to select suitably in consideration of workability.

[0072]

EXAMPLES The present invention will now be described with reference to production examples, test examples, and prescription examples, but the present invention is not limited to these examples.

(Preparation Example 1) 100 g of each plant of hydrangea and amacha was immersed in a 50% ethanol solution, extracted at room temperature for 5 days and nights, and then filtered to obtain an extract (dry solid content: approx.
0.05-2.5% by weight).

(Production Example 2) 100 g of each plant of hydrangea and amacha was extracted with warming in purified water (about 80 ° C.) for about 5 hours, filtered and extracted (dry solid content: about 0.05 to 2.5 wt. %) Of about 1.0 kg.

(Production Example 3) 100 g of each plant of hydrangea and amateur is immersed in 70% ethanol solution, 30% 1,3-butylene glycol solution, 60% propylene glycol solution, or purified water (about 30 ° C.) After extraction at room temperature for 5 days and nights, the extract was filtered and dried (dry solid content: about 0.05 to 3.0).
% By weight).

[0076]

The hair growth inhibitor of the present invention or the cosmetic composition containing the hair growth inhibitor has an action of suppressing hair growth of body hair,
It can suppress hair growth at sites and places where body hair is not preferable, reduce the frequency of use of depilatory and depilatory agents, and furthermore, the safety of depilatory and depilatory agents (rough skin, Pain, etc.) can be reduced.

(Test 1) Test for Inhibition of Hair Growth in C3H Mice Approximately 8 cm ² of the back of an animal was shaved with an electric clipper and an electric shaver. Next, apply the sample once a day to the depilated back 5 times a week.
For 20 days. The determination was made on the 13,14,15,18 days after application by using an image analyzer to measure the area ratio (%) at which hair regeneration was observed with respect to the depilated area, and compared with the control group. The results are shown in FIGS. "Ogawa et al.'S test method (Refer to Flexural Journal, Vol. 17, No. 5, P. 20-29 (1989)")

(Test Method) a. Samples The various plant extracts obtained in Production Example 1 of the present invention were used as undiluted solutions, and as a control, only a 50% aqueous ethanol solution as a base was used. b. Experimental animals 8-week-old male C3H mice were used. These animals were bred in an environment of room temperature 22 ± 2 ° C., humidity 50 ± 15%, all-fresh ventilation 15 times / hour, and lighting 9 hours / day. Animals had free access to solid feed MF (Oriental Yeast Industry) and tap water.

(Test Results) As shown in FIGS. 1 and 2, the plant extracts of hydrangea and amacha of the present invention contained hair regeneration (hair growth).
Was significantly suppressed.

(Test 2) Safety test (1) Primary skin irritation test Various plant extracts obtained in Production Examples 1 to 3 were added to purified water so that the dry solid concentration was about 0.5 W / V%. White rabbits (Female, 3 per group, weight 2.3k)
g) of the skin. The judgment was made 24, 48, and 72 hours after application by the primary irritation scoring method using erythema and edema as indices. The result was negative in all animals without any erythema and edema.

(Test 3) Safety Test (2) Skin Cumulative Irritation Test Similarly, the various plant extracts obtained in Production Examples 1 to 3 were purified so that the dry solid content was about 0.5 W / V%. Hartley guinea pigs prepared with water and shaved on the flank (female,
Once a day, 5 times a week on the skin of 3 animals per group, weight around 320g)
0.5 ml / animal was applied. Application was performed over two weeks and shaving was performed on the last application day of each week. Judgment was made on the day of each application and on the day after the last application using the primary irritancy scoring method using erythema and edema as indices. As a result, all animals were judged as negative without any erythema and edema over 2 weeks.

(Test 4) Safety test (3) Acute toxicity test Similarly, powders obtained by concentrating and drying the various plant extracts obtained in Production Examples 1 to 3 (dry solid content: about 1.0 W / V
%) Was orally administered to ddy mice (male and female, 5 mice / group, 5 weeks old) in a 2,000 mg / kg dose fasted for 4 hours before the test, and the appearance and extent of toxic symptoms were observed over time. did. As a result, no abnormalities were observed in all the mice for 14 days, and no abnormalities were observed in the dissection results. Therefore, LD50
Was determined to be 2,000 mg / kg or more.

(Prescription Examples) Production of Cosmetic Composition for Hair Removal / Hair Removal The following formulation examples are shown below in accordance with the above evaluation results. Each of the formulation examples may be those produced by a conventional method in the production of each product. , Only the blending amount is shown. Further, the present invention is not limited to these.

(Formulation Example 1) Hair removal cream weight% 1. Calcium thioglycolate 5.0 2. Cetyl alcohol 6.0 3. Vaseline 15.0 4. Liquid paraffin 10.0 5. Polyoxyethylene oleyl alcohol ether 4.0 6. Polyoxyethylene stearyl alcohol Ether 2.0 7. Appropriate amount of fragrances and preservatives 8. Residual water with purified water of 100

(Formulation Example 2) Hair tonic weight% 1. Ethanol 50.0 2. Ethyl oleate 1.0 3. Polyoxyethylene (40) hydrogenated castor oil 2.0 4. Hydrangea 50% 1,3-butylene glycol extract 3.0 5. Amacha 50% phenolic alcohol extract 3.0 6. Suitable amount of preservative 7. Purified water 100 residue

(Formulation Example 3) Shampoo wt% 1. Triethanolamine lauryl sulfate 5.0 2. Sodium polyoxyethylene lauryl ether sulfate 12.0 3.1,3-butylene glycol 4.0 4. Diethanolamide laurate 2.0 5. Disodium edetate 0.1 6.50% hydrangea 1,3-butylene glycol extract 5.0 7.50% amazon phenylene glycol extract 5.0 8.Perfume, preservatives qs 9. Purified water 100

(Formulation Example 4) Rinse weight% 1. Stearyltrimethylammonium chloride 2.0 2. Cetostearyl alcohol 2.0 3. Polyoxyethylene lanolin ether 3.0 4. Propylene glycol 5.0 6. Hydrangea extract 5.0 (Ethanol: 1,3- (Phenylene glycol = 1: 1 extract) 7. Amacia 70% phenolic alcohol extract 5.0 8. Appropriate amount of pH adjuster 9. Appropriate preservative 10. Purified water 100

(Formulation Example 5) Hair liquid weight% 1. Ethanol 29.0 2. Polyoxypropylene butyl ether phosphoric acid 10.0 3. Polyoxypropylene monobutyl ether 5.0 4. Triethanolamine 1.0 5. 50% phenolic alcohol extract of odor iris 7.0 6 Hydrangea extract 5.0 (Ethanol: 1,3-butylene glycol = 1: 1 extract) 7. Amacia 50% 1,3-butylene glycol extract 5.0 8. Preservatives qs 9. Purified water 100

(Formulation Example 6) Lotion weight% 1. Sorbit 2.0 2.1.3-butylene glycol 2.0 3. Polyethylene glycol 1000 1.0 4. Polyoxyethylene oleyl ether (25E.O.) 2.0 5. Ethanol 10.0 6. Armature 50 % 1,3-butylene glycol extract 5.0 7. Appropriate amount of pH adjuster 8. Appropriate amount of preservative 9. Purified water 100

(Formulation Example 7) Coating protective agent Gauze or liniment cloth was coated with 50% ethanol extract
Hydrangea 50% ethanol extract, impregnated with a prescribed solution mixed with appropriate amounts of antibiotics and anti-inflammatory, and attached to the wound site. or,
An armature 50% ethanol extract and a hydrangea 50% ethanol extract may be directly sprayed locally and covered with gauze or the like.

(Test 5) Use effect test The effect of the hair growth inhibitor of the present invention actually used was examined. The use test was for 10 healthy men and women (15
２５25 years old) as a paneler, after applying an appropriate amount of the depilatory cream of Formulation Example 1 to both arms and both shins and removing the hair, simply washing it with purified water as it is, and after washing, extracting various plants of Production Example 1 A usage test was conducted by applying an appropriate amount of the liquid (dry solid content: about 1.0% by weight) and applying an appropriate amount of the various plant extracts of Production Example 1 once a day for two months. The control was compared with a case where the hair was removed with a hair removal cream and then washed with purified water. The evaluation was performed according to the following criteria. The results are as shown in Tables 1 and 2, and the numerical values in the table represent the number of persons. During the period of use, no one complained of abnormalities of both arms and both shins.

"Hair Growth Inhibiting Effect" Effective: After removing hairs, some hairs were formed. Slightly effective: Hair removal was slightly increased after hair removal. Ineffective: After removal of hair, very much downy hair or growing hair was generated.

"Improvement effect of skin disease" Efficacy: Skin roughness was improved. Or, the pain in the skin disappeared. Slightly effective: Skin roughness or pain was slightly improved. Ineffective: The skin became rough and irritation remained on the skin.

[0094]

[Table 1]

[0095]

[Table 2]

(Test Results) As shown in Table 1, the plant extracts of hydrangea and amacha of the present invention showed a hair growth inhibitory effect capable of delaying hair growth.

(Test Results) As shown in Table 2, it was confirmed that the plant extracts of hydrangea and amacha of the present invention significantly improved skin roughness after hair removal and reduced skin pain.

[0098]

Either hydrangea or amateur of the present invention
Hair growth inhibitors containing more than one plant extract have a hair growth inhibitory effect (hair removal performance) that significantly suppresses hair growth.
In addition, skin roughness after hair removal can be improved and skin pain can be reduced, so that the frequency of use of a hair remover and a hair remover can be reduced. It is safe for humans and animals.

[Brief description of the drawings]

BRIEF DESCRIPTION OF DRAWINGS FIG. 1 is a view showing a regenerated hair area ratio of various plant extracts of hydrangea and a control (50% ethanol).

FIG. 2 is a view showing the area ratio of regenerated hair of various plant extracts of amacha and a control (50% ethanol).

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Claims (3)

[Claims] 1. A hair growth inhibitor comprising at least one plant extract selected from hydrangea and amateur. 2. A cosmetic composition comprising the hair growth inhibitor according to claim 1. 3. The cosmetic composition is any one of a hair remover, a hair remover, a pre-shaving treatment, a post-shaving treatment, a shaving, a skin cosmetic, and a hair cosmetic. Item 3. The cosmetic composition according to Item 2.