JO3007B1 - مركبات و تركيبات كمثبطات كيناز بروتين - Google Patents

مركبات و تركيبات كمثبطات كيناز بروتين

Info

Publication number
JO3007B1
JO3007B1 JOP/2010/0298A JOP20100298A JO3007B1 JO 3007 B1 JO3007 B1 JO 3007B1 JO P20100298 A JOP20100298 A JO P20100298A JO 3007 B1 JO3007 B1 JO 3007B1
Authority
JO
Jordan
Prior art keywords
compounds
compositions
protein kinase
kinase inhibitors
formula
Prior art date
Application number
JOP/2010/0298A
Other languages
Arabic (ar)
English (en)
Inventor
Q Costales 1-Abran
Haung 2-Shenlin
Tellew John
Jeff, (Xianming) Jin
Poon Daniel
Liu Zuosheng
Pecchi Sabina
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Application granted granted Critical
Publication of JO3007B1 publication Critical patent/JO3007B1/ar

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JOP/2010/0298A 2009-08-28 2010-08-26 مركبات و تركيبات كمثبطات كيناز بروتين JO3007B1 (ar)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23808309P 2009-08-28 2009-08-28
US31306110P 2010-03-11 2010-03-11

Publications (1)

Publication Number Publication Date
JO3007B1 true JO3007B1 (ar) 2016-09-05

Family

ID=42829939

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2010/0298A JO3007B1 (ar) 2009-08-28 2010-08-26 مركبات و تركيبات كمثبطات كيناز بروتين

Country Status (19)

Country Link
US (3) US8242260B2 (cg-RX-API-DMAC7.html)
EP (1) EP2470528B1 (cg-RX-API-DMAC7.html)
JP (1) JP5726190B2 (cg-RX-API-DMAC7.html)
KR (1) KR101714107B1 (cg-RX-API-DMAC7.html)
CN (1) CN102596937B (cg-RX-API-DMAC7.html)
AR (1) AR077977A1 (cg-RX-API-DMAC7.html)
AU (1) AU2010288455B2 (cg-RX-API-DMAC7.html)
BR (1) BR112012004448A2 (cg-RX-API-DMAC7.html)
CA (1) CA2771673C (cg-RX-API-DMAC7.html)
EA (1) EA020479B1 (cg-RX-API-DMAC7.html)
ES (1) ES2527176T3 (cg-RX-API-DMAC7.html)
IN (1) IN2012DN00869A (cg-RX-API-DMAC7.html)
JO (1) JO3007B1 (cg-RX-API-DMAC7.html)
MX (1) MX2012002542A (cg-RX-API-DMAC7.html)
PL (1) PL2470528T3 (cg-RX-API-DMAC7.html)
PT (1) PT2470528E (cg-RX-API-DMAC7.html)
TW (1) TWI487701B (cg-RX-API-DMAC7.html)
UY (1) UY32859A (cg-RX-API-DMAC7.html)
WO (1) WO2011023773A1 (cg-RX-API-DMAC7.html)

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TR201809185T4 (tr) * 2013-08-28 2018-07-23 Medivation Tech Llc Heterosiklik bileşikler ve kullanım yöntemleri.
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UY36294A (es) 2014-09-12 2016-04-29 Novartis Ag Compuestos y composiciones como inhibidores de quinasa
JP6930913B2 (ja) 2014-10-14 2021-09-01 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニアＴｈｅ Ｒｅｇｅｎｔｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃａｌｉｆｏｒｎｉａ 炎症を阻害するためのｃｄｋ９及びｂｒｄ４阻害剤の使用法
CN104402920B (zh) * 2014-11-27 2018-04-03 河南科技学院 一种合成2‑卤代‑3‑频那醇硼酸酯‑5‑氯苯胺的方法
EP3515446B1 (en) 2016-09-19 2023-12-20 Novartis AG Therapeutic combinations comprising a raf inhibitor and a erk inhibitor
US11471538B2 (en) 2017-02-10 2022-10-18 INSERM (Institut National de la Santéet de la Recherche Medicale) Methods and pharmaceutical compositions for the treatment of cancers associated with activation of the MAPK pathway
DK3618875T3 (da) 2017-05-02 2023-07-10 Novartis Ag Kombinationsterapi omfattende en raf-inhibitor og trametinib
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WO2020124397A1 (en) * 2018-12-19 2020-06-25 Inventisbio Shanghai Ltd. C-terminal src kinase inhibitors
KR102881316B1 (ko) 2019-05-13 2025-11-05 노파르티스 아게 암 치료를 위한 raf 억제제로서의 n-(3-(2-(2-하이드록시에톡시)-6-모르폴리노피리딘-4-일)-4-메틸페닐)-2 (트리플루오로메틸)이소니코틴아미드의 새로운 결정질 형태
WO2022036176A1 (en) * 2020-08-13 2022-02-17 Albert Einstein College Of Medicine N-cyclyl-sulfonamides useful for inhibiting raf
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Also Published As

Publication number Publication date
JP5726190B2 (ja) 2015-05-27
KR20120092577A (ko) 2012-08-21
JP2013503139A (ja) 2013-01-31
CN102596937B (zh) 2014-02-12
US20140011825A1 (en) 2014-01-09
TWI487701B (zh) 2015-06-11
US8563553B2 (en) 2013-10-22
US20120225899A1 (en) 2012-09-06
MX2012002542A (es) 2012-04-02
AR077977A1 (es) 2011-10-05
TW201111365A (en) 2011-04-01
CA2771673A1 (en) 2011-03-03
UY32859A (es) 2011-03-31
PL2470528T3 (pl) 2015-03-31
US8242260B2 (en) 2012-08-14
AU2010288455B2 (en) 2013-01-31
AU2010288455A1 (en) 2012-02-23
US8859548B2 (en) 2014-10-14
KR101714107B1 (ko) 2017-03-08
CN102596937A (zh) 2012-07-18
PT2470528E (pt) 2014-12-29
WO2011023773A1 (en) 2011-03-03
EP2470528A1 (en) 2012-07-04
IN2012DN00869A (cg-RX-API-DMAC7.html) 2015-07-10
EA201200323A1 (ru) 2012-09-28
EP2470528B1 (en) 2014-10-01
ES2527176T3 (es) 2015-01-21
US20110052578A1 (en) 2011-03-03
CA2771673C (en) 2016-07-12
EA020479B1 (ru) 2014-11-28
BR112012004448A2 (pt) 2017-05-30

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