JP5726190B2 - タンパク質キナーゼ阻害剤としての化合物および組成物 - Google Patents

タンパク質キナーゼ阻害剤としての化合物および組成物 Download PDF

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Publication number
JP5726190B2
JP5726190B2 JP2012526067A JP2012526067A JP5726190B2 JP 5726190 B2 JP5726190 B2 JP 5726190B2 JP 2012526067 A JP2012526067 A JP 2012526067A JP 2012526067 A JP2012526067 A JP 2012526067A JP 5726190 B2 JP5726190 B2 JP 5726190B2
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Prior art keywords
methyl
imidazol
alkyl
cyclopropyl
pyrimidin
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Japanese (ja)
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JP2013503139A (ja
JP2013503139A5 (cg-RX-API-DMAC7.html
Inventor
アブラン・キュー・コスタレス
フアン・シェンリン
ジェフ（シャンミン）・ジン
リウ・ズオシェン
サビーナ・ペッキ
ダニエル・プーン
ジョン・テリュー
チャン・キオン
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ノバルティス アーゲー
ノバルティス アーゲー
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2012526067A 2009-08-28 2010-08-26 タンパク質キナーゼ阻害剤としての化合物および組成物 Active JP5726190B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US23808309P 2009-08-28 2009-08-28
US61/238,083 2009-08-28
US31306110P 2010-03-11 2010-03-11
US61/313,061 2010-03-11
PCT/EP2010/062495 WO2011023773A1 (en) 2009-08-28 2010-08-26 Compounds and compositions as protein kinase inhibitors

Publications (3)

Publication Number Publication Date
JP2013503139A JP2013503139A (ja) 2013-01-31
JP2013503139A5 JP2013503139A5 (cg-RX-API-DMAC7.html) 2013-07-04
JP5726190B2 true JP5726190B2 (ja) 2015-05-27

Family

ID=42829939

Family Applications (1)

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JP2012526067A Active JP5726190B2 (ja) 2009-08-28 2010-08-26 タンパク質キナーゼ阻害剤としての化合物および組成物

Country Status (19)

Country Link
US (3) US8242260B2 (cg-RX-API-DMAC7.html)
EP (1) EP2470528B1 (cg-RX-API-DMAC7.html)
JP (1) JP5726190B2 (cg-RX-API-DMAC7.html)
KR (1) KR101714107B1 (cg-RX-API-DMAC7.html)
CN (1) CN102596937B (cg-RX-API-DMAC7.html)
AR (1) AR077977A1 (cg-RX-API-DMAC7.html)
AU (1) AU2010288455B2 (cg-RX-API-DMAC7.html)
BR (1) BR112012004448A2 (cg-RX-API-DMAC7.html)
CA (1) CA2771673C (cg-RX-API-DMAC7.html)
EA (1) EA020479B1 (cg-RX-API-DMAC7.html)
ES (1) ES2527176T3 (cg-RX-API-DMAC7.html)
IN (1) IN2012DN00869A (cg-RX-API-DMAC7.html)
JO (1) JO3007B1 (cg-RX-API-DMAC7.html)
MX (1) MX2012002542A (cg-RX-API-DMAC7.html)
PL (1) PL2470528T3 (cg-RX-API-DMAC7.html)
PT (1) PT2470528E (cg-RX-API-DMAC7.html)
TW (1) TWI487701B (cg-RX-API-DMAC7.html)
UY (1) UY32859A (cg-RX-API-DMAC7.html)
WO (1) WO2011023773A1 (cg-RX-API-DMAC7.html)

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TR201809185T4 (tr) * 2013-08-28 2018-07-23 Medivation Tech Llc Heterosiklik bileşikler ve kullanım yöntemleri.
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UY36294A (es) 2014-09-12 2016-04-29 Novartis Ag Compuestos y composiciones como inhibidores de quinasa
JP6930913B2 (ja) 2014-10-14 2021-09-01 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニアＴｈｅ Ｒｅｇｅｎｔｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃａｌｉｆｏｒｎｉａ 炎症を阻害するためのｃｄｋ９及びｂｒｄ４阻害剤の使用法
CN104402920B (zh) * 2014-11-27 2018-04-03 河南科技学院 一种合成2‑卤代‑3‑频那醇硼酸酯‑5‑氯苯胺的方法
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KR102881316B1 (ko) 2019-05-13 2025-11-05 노파르티스 아게 암 치료를 위한 raf 억제제로서의 n-(3-(2-(2-하이드록시에톡시)-6-모르폴리노피리딘-4-일)-4-메틸페닐)-2 (트리플루오로메틸)이소니코틴아미드의 새로운 결정질 형태
WO2022036176A1 (en) * 2020-08-13 2022-02-17 Albert Einstein College Of Medicine N-cyclyl-sulfonamides useful for inhibiting raf
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Also Published As

Publication number Publication date
KR20120092577A (ko) 2012-08-21
JP2013503139A (ja) 2013-01-31
CN102596937B (zh) 2014-02-12
US20140011825A1 (en) 2014-01-09
TWI487701B (zh) 2015-06-11
US8563553B2 (en) 2013-10-22
US20120225899A1 (en) 2012-09-06
MX2012002542A (es) 2012-04-02
AR077977A1 (es) 2011-10-05
TW201111365A (en) 2011-04-01
CA2771673A1 (en) 2011-03-03
UY32859A (es) 2011-03-31
PL2470528T3 (pl) 2015-03-31
US8242260B2 (en) 2012-08-14
AU2010288455B2 (en) 2013-01-31
AU2010288455A1 (en) 2012-02-23
US8859548B2 (en) 2014-10-14
KR101714107B1 (ko) 2017-03-08
CN102596937A (zh) 2012-07-18
JO3007B1 (ar) 2016-09-05
PT2470528E (pt) 2014-12-29
WO2011023773A1 (en) 2011-03-03
EP2470528A1 (en) 2012-07-04
IN2012DN00869A (cg-RX-API-DMAC7.html) 2015-07-10
EA201200323A1 (ru) 2012-09-28
EP2470528B1 (en) 2014-10-01
ES2527176T3 (es) 2015-01-21
US20110052578A1 (en) 2011-03-03
CA2771673C (en) 2016-07-12
EA020479B1 (ru) 2014-11-28
BR112012004448A2 (pt) 2017-05-30

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