ITMI920720A1 - Forma cristallina dell'endo-3-etil-2, 3-diidro-n-(8-metil-8-azabiciclo (3. 2. 1) ott-3-il)- 2-oxo-1h-benzimidazolo-1-carbossamide cloridrato - Google Patents

Forma cristallina dell'endo-3-etil-2, 3-diidro-n-(8-metil-8-azabiciclo (3. 2. 1) ott-3-il)- 2-oxo-1h-benzimidazolo-1-carbossamide cloridrato

Info

Publication number
ITMI920720A1
ITMI920720A1 IT000720A ITMI920720A ITMI920720A1 IT MI920720 A1 ITMI920720 A1 IT MI920720A1 IT 000720 A IT000720 A IT 000720A IT MI920720 A ITMI920720 A IT MI920720A IT MI920720 A1 ITMI920720 A1 IT MI920720A1
Authority
IT
Italy
Prior art keywords
carbossamide
azabicycle
endo
benzimidazole
dihydro
Prior art date
Application number
IT000720A
Other languages
English (en)
Inventor
Enzo Cereda
Enrica Dubini
Antoine Ezhaya
Grazia Maffione
Marco Turconi
Original Assignee
Boehringer Ingelheim Italia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Italia filed Critical Boehringer Ingelheim Italia
Publication of ITMI920720A0 publication Critical patent/ITMI920720A0/it
Priority to ITMI920720A priority Critical patent/IT1254562B/it
Priority to PH45858A priority patent/PH30413A/en
Priority to EP93104564A priority patent/EP0567767B1/en
Priority to CZ1993443A priority patent/CZ286590B6/cs
Priority to DE69319955T priority patent/DE69319955T2/de
Priority to ES93104564T priority patent/ES2118846T3/es
Priority to AT93104564T priority patent/ATE169016T1/de
Priority to SG1996005867A priority patent/SG43225A1/en
Priority to DK93104564T priority patent/DK0567767T3/da
Priority to SK226-93A priority patent/SK280555B6/sk
Priority to HRMI92A000723A priority patent/HRP930479B1/xx
Priority to IL10514393A priority patent/IL105143A/en
Priority to NZ247234A priority patent/NZ247234A/en
Priority to AU35413/93A priority patent/AU654082B2/en
Priority to TW082102205A priority patent/TW385310B/zh
Priority to NO931112A priority patent/NO300975B1/no
Priority to MX9301668A priority patent/MX9301668A/es
Priority to KR1019930004676A priority patent/KR100256148B1/ko
Priority to FI931329A priority patent/FI113472B/fi
Priority to JP06649293A priority patent/JP3279707B2/ja
Priority to HU9300868A priority patent/HU211075B/hu
Priority to RU93004710A priority patent/RU2125054C1/ru
Priority to CA002092510A priority patent/CA2092510C/en
Priority to PL93298263A priority patent/PL172890B1/pl
Priority to SI9300150A priority patent/SI9300150B/sl
Priority to UA93002686A priority patent/UA37179C2/uk
Publication of ITMI920720A1 publication Critical patent/ITMI920720A1/it
Priority to US08/264,104 priority patent/US5468758A/en
Priority to HU95P/P00677P priority patent/HU211131A9/hu
Application granted granted Critical
Publication of IT1254562B publication Critical patent/IT1254562B/it
Priority to BR1100564-5A priority patent/BR1100564A/pt
Priority to HK98111436A priority patent/HK1010719A1/xx
Priority to UY25938A priority patent/UY25938A1/es
Priority to UY25939A priority patent/UY25939A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Emergency Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ITMI920720A 1992-03-26 1992-03-26 Forma cristallina dell'endo-3-etil-2,3-diidro-n-(8-metil-8-azabiciclo (3.2.1) ott-3-il)- 2-oxo-1h-benzimidazolo-1-carbossamide cloridrato IT1254562B (it)

Priority Applications (32)

Application Number Priority Date Filing Date Title
ITMI920720A IT1254562B (it) 1992-03-26 1992-03-26 Forma cristallina dell'endo-3-etil-2,3-diidro-n-(8-metil-8-azabiciclo (3.2.1) ott-3-il)- 2-oxo-1h-benzimidazolo-1-carbossamide cloridrato
PH45858A PH30413A (en) 1992-03-26 1993-03-11 Crystalline forms of endo-2,3-dihydro-n-(8-methyl)-8-azabicyclo-(3,2,1)oct-3-yl)-2-oxo-1h-benzimidazole-1-carboxamides
EP93104564A EP0567767B1 (en) 1992-03-26 1993-03-19 Crystalline forms of endo-2,3-dihydro-N-(8-methyl-8-azabicyclo (3.2.1)oct-3-yl)-2-oxo-1H-benzimidazole-1-carboxamide hydrochloride monohydrate and of endo-3-ethyl-2,3-dihydro-N-(8-methyl-8-azabicyclo (3.2.1) oct-3-yl)-2-oxo-1H-benzimidazole-1-carboxamide hydrochloride monohydrate as 5-HT antagonists
CZ1993443A CZ286590B6 (cs) 1992-03-26 1993-03-19 Krystalické formy monohydrátu hydrochloridu endo 2,3-dihydro-N-(8-methyl-8-azabicyklo/3,2,1/okt-3 yl)-2-oxo-1H-benzimidazol-1-karboxamidu a monohydrátu hydrochloridu endo-3-ethyl-2,3-dihydro-...
DE69319955T DE69319955T2 (de) 1992-03-26 1993-03-19 Kristalline Formen von Endo-2,3-Dihydro-N-(8-Methyl-8-Azabicyclo(3.2.1)Oct-3-yl)-2-Oxo-1H-Benzimidazol-1-Carboxamid Hydrochlorid Monohydrat und von Endo-3-Ethyl-2,3-Dihydro-N-(8-Methyl-8-Azabicyclo(3.2.1)Oct-3-yl)-2-Oxo-1H-Benzimidazol-1-Carboxamid Hydrochlorid Monohydrat als 5-HT Antagonisten
ES93104564T ES2118846T3 (es) 1992-03-26 1993-03-19 Formas cristalinas de monohidrato de hidrocloruro de endo-2,3-dihidro-n-(8-metil-8-azabiciclo(3.2.1)oct-3-il)-2-oxo-1h-bencimidazol-1-carboxamida y de monohidrato de hidrocloruro de endo-3-etil-2,3-dihidro-n-(8-metil-8-azabiciclo(3.2.1)oct-3-il)-2-oxo-1h-bencimidazol-1-carboxamid
AT93104564T ATE169016T1 (de) 1992-03-26 1993-03-19 Kristalline formen von endo-2,3-dihydro-n-(8- methyl-8-azabicyclo(3.2.1)oct-3-yl)-2-oxo-1h- benzimidazol-1-carboxamid hydrochlorid monohydrat und von endo-3-ethyl-2,3-dihydro-n-(8-methyl-8- azabicyclo(3.2.1)oct-3-yl)-2-oxo-1h-benzimidazo - 1-carboxamid hydrochlorid monohydrat als 5-ht antagonisten
SG1996005867A SG43225A1 (en) 1992-03-26 1993-03-19 Crystalline forms of endo-2, 3-dihydro-n-(8-methyl -8-azabicyclo [3.2.1]oct-3-yl)-2-oxo-1h-benzimidazole-1-carboxamide hydrochloride monohydrate (see file for full title)
DK93104564T DK0567767T3 (da) 1992-03-26 1993-03-19 Krystallinske former af endo-2,3-dihydro-N-(8-methyl-8-azabicyclo[3.2.1]oct-3-yl)-2-oxo-1H-benzimidazol-1-carboxamid-hydroc
SK226-93A SK280555B6 (sk) 1992-03-26 1993-03-22 Kryštalické monohydráty hydrochloridu endo-2,3-dih
HRMI92A000723A HRP930479B1 (en) 1992-03-26 1993-03-23 Crystalline forms of endo-2,3-dihydro-n-(8-methyl-8-azabicyclo (3.2.1)oct-3-yl)-2-oxo-1h-benzimidazole-1-carboxamide hydrochloride monohydrate and of endo-3-ethyl-2,3-dihydro-n-(8-methyl-8-azabicyclo (3.2.1)oct-3-yl)-2-oxo-1h-benzimidazole-1-carboxamide hydrochloride monohydrate
IL10514393A IL105143A (en) 1992-03-26 1993-03-24 Resistant crystalline monohydrates of endo-2,3-dihydro-N) -8-methyl-8-azabicyclo [3.2.1] oct-3-yl (-2-oxo-H1-benzimidase
NZ247234A NZ247234A (en) 1992-03-26 1993-03-24 Crystalline monohydrates of 8-azabicyclo[3.2.1]octyl-1h-benzimidazole-1-carboxamide derivatives and pharmaceutical compositions
AU35413/93A AU654082B2 (en) 1992-03-26 1993-03-24 Crystalline monohydrates of azabicyclo-1H-benzimidozole-1- carboxamides, the preparation and use thereof
TW082102205A TW385310B (en) 1992-03-26 1993-03-24 Crystalline forms of endo-2,3-dihydro-N-(8-methyl-8-azabicyclo[3.2.1]oct-3-yl)-2-oxo-1H-benzimidazole-1-carboxamide hydrochloride monohydrate and of endo-3-ethyl-2,3-dihydro-N-(8-methyl-8-azabicyclo[3.2.1]oct-3-yl)-2-oxo-1H-benzimidazole-1-carboxamide
MX9301668A MX9301668A (es) 1992-03-26 1993-03-25 Monohidratos cristalinos de– clorhidrato de endo-2,3-dihidro-n-(8-metil-8-azabiciclo(3.2.1)oct-3-il)-2-oxo-1h-benc imidazol-1-carboxamida y del clorhidrato de endo-3-etil-2,3-dihidro-n-(8-metil-8-azabiciclo(3.2.1)oct-3-il)-2-oxo- 1h-bencimidazol-1-car.
NO931112A NO300975B1 (no) 1992-03-26 1993-03-25 Krystallinske former av endo-2,3-dihydro-N-(8-metyl/hydrogen-8-azabicyklo-£3.2.1|okt-3-yl)-2-okso-1H-benzimidazol-1-karboksamid-hydroklorid-monohydrat
KR1019930004676A KR100256148B1 (ko) 1992-03-26 1993-03-25 결정 형태의 엔도-2,3-디하이드로-n-(8-메틸-8-아자비사이클로(3.2.1)옥트-3-일)-2-옥트-1h-벤즈이미다졸-1-카복스아미드 하이드로클로라이드 1수화물 및 엔도-3-에틸-2,3-디하이드로-n-(8-메틸-8-아자비시클로(3.2.1)옥트-3-일)-2옥소-1h-벤즈이미다졸-1-카복스아미드 하이드로클로라이드 1수화물
FI931329A FI113472B (fi) 1992-03-26 1993-03-25 Menetelmä valmistaa farmakologisesti aktiivisia endo-2,3-dihydro-N-(8-metyyli-8-atsabisyklo[3.2.1]okt-3-yyli)-2-okso-1H-bentsimidatsoli-1-karboksamidihydrokloridimonohydraatin ja endo-3-etyyli-2,3-dihydro-N-(8-metyyli-8-atsabisyklo[3.2.1]okt-3-yyli)-2-okso-1H-bentsimidatsoli-1-karboksamidi-hydrokloridimonohydraatin kiteisiä muotoja
JP06649293A JP3279707B2 (ja) 1992-03-26 1993-03-25 エンド−２，３−ジヒドロ−ｎ−（８−メチル−８−アザビシクロ〔３．２．１〕オクタ−３−イル）−２−オキソ−１ｈ−ベンズイミダゾール−１−カルボン酸アミド及びエンド−３−エチル−２，３−ジヒドロ−ｎ−（８−メチル−８−アザビシクロ〔３．２．１〕オクタ−３−イル）−２−オキソ−１ｈ−ベンズイミダゾール−１−カルボン酸アミド・塩酸塩の結晶１水和物
HU9300868A HU211075B (en) 1992-03-26 1993-03-25 Process for producing crystalline endo-2,3-dihydro-n-(8-methyl-8-aza-bicyclo-[3.2.1]okt-3-yl)-2-oxo-1h-benzimidazol-1-carboxamide-hydrochloride-monohydrate and endo-3-ethyl-2,3-dihydro-n-(8-methyl-8-azabicyclo[3.2.1]okt-3-yl)-2-oxo-1h-benzimidazol -1-carb
RU93004710A RU2125054C1 (ru) 1992-03-26 1993-03-25 Кристаллические моногидраты гидрохлоридов эндо-2,3-дигидро-n-[8-метил-8- азабицикло(3,2,1)-окт-3-ил]-2-оксо-1h-бензимидазол-1-карбоксамида и эндо-3-этил-2,3- дигидро-n-[8-метил-8-азабицикло (3,2,1)-окт-3-ил]-2-оксо-1h-бензимидазол-1- карбоксамида, способ их получения и фармацевтическая композиция
CA002092510A CA2092510C (en) 1992-03-26 1993-03-25 Crystalline forms of endo-2,3-dihydro-n-(8-methyl-8-azabicyclo-[3.2.1.]oct-3-yl)-2-oxo-1h-benzimidazole-1-carboxamide hydrochloride monohydrate and of endo-3 ethyl-2,3-dihydro-n-(8-methyl-8-azabicyclo[3.2.1.]oct-3-yl)-2-oxo-1h-benzimidazole-1-carboxamide hydrochloride monohydrate
PL93298263A PL172890B1 (pl) 1992-03-26 1993-03-25 K rystaliczne postacie monowodzianów chlorowodorków endo-2,3-dihydro-N-(8-metylo-8- azabicyklo [3.2.1] okt-3-ylo)-2--okso-1H-benzimidazolo-1-karboksamidu i endo-3-etylo-2,3- dihydro-N-(8-metylo-8-azabicyklo [3.2.1] okt-3-ylo)-2-okso-1H-benzimidazolo-1-karboksamidu i sposób wytwarzania krystalicz-nych postaci monowodzianów chlorowodorków endo-2,3-dihydro-N-(8-metylo-8-azabicy- klo [3.2.1] okt-3-ylo)-2-okso-1H-benzimidazolo-1-karboksamidu lub endo-3-etylo-2,3-dihydro-N-(8-metylo-8-azabicyklo [3.2.1] okt-3-ylo)-2-okso-1 H-benzimida- zolo-1 -karboksamidu PL PL PL PL PL PL PL PL
SI9300150A SI9300150B (sl) 1992-03-26 1993-03-26 Kristalne oblike endo-2,3-dihidro-N-(8-metil-8-azabicilo/3.2.1./okt-3-il)-2-okso-1H- benzimidazol-1-karboksamid hidroklorid monohidrata in endo-3-etil-2,3-dihidro-N-(8-metil-8-azabiciklo/3.2.1/okt-3-il)-2-okso- 1H-benzimidazol-1-karboksamid hidroklorid monohidrata
UA93002686A UA37179C2 (uk) 1992-03-26 1993-06-08 Кристалічні моногідрати гідрохлориду ендо-2,3-дигідро-n-(8-метил-8-азабіцикло [ 3.2.1 ] окт-3-іл) -2-оксо-1н-бензимідазол-1-карбоксаміду та ендо-3-етил-2,3-дигідро-n-(8-метил-8-азабіцикло[3.2.1]окт-3-іл)-2-оксо-1н-бензимідазол-1-карбоксаміду, спосіб їх одержання та фармацевтична композиція
US08/264,104 US5468758A (en) 1992-03-26 1994-06-22 Crystalline forms of endo-2,3-dihydro-N-(8-methyl)-8-azabicyclo[3.2.1]oct-3-yl)-2-oxo-1H-benzimidazole-1-carboxamides
HU95P/P00677P HU211131A9 (en) 1992-03-26 1995-06-30 Crystalline forms of benzimidazole carboxamide compounds
BR1100564-5A BR1100564A (pt) 1992-03-26 1997-05-13 Formas cristalinas de mono-hidrato do cloridrato de endo-2,3-dihidro-n-(8-metil-8-azabiciclo[3.2.1]oct-3-il)-2 - -oxo-1h-benzimidazol-1-carboxamida e de mono-hidrato do cloridrato de endo-3-etil-2,3-di-hidro-n-(8-metil-8-azabiciclo[3.2.1]oc t-3-il)-2-oxo-1h-benzimidazol-1-carboxamida como antagonistas do 5-ht
HK98111436A HK1010719A1 (en) 1992-03-26 1998-10-21 Crystalline forms of endo-2,3-dihydro-n-(8-methyl-8- azabicyclo(3.2.1)oct-3-yl)-2-oxo-1h-benzimidazole-1- carboxamide hydrochloride monohydrate and of endo-3-ethyl-2,3-dihydro-n-(8-methyl-8- azabicyclo (3.2.1.)-2-oxo- 1 h-benzimidazole-1- carboxamide hydrochloride monohydrate as 5-ht antagonists
UY25938A UY25938A1 (es) 1992-03-26 2000-01-17 Procedimiento para preparar formas cristalinas de monohidrato de hidrocloruro de endo-2,3-dihidro-n-(8-metil-8-azabiciclo(3.2.1)oct-3-il)-2-oxo-1h-benzimidazol-1- carboxamida y de monohidrato de hidrocloruro de endo-3-etil -2,3-dihidro-n-(8-metil-8-a
UY25939A UY25939A1 (es) 1992-03-26 2000-01-17 Formas cristalinas de monohidrato de hidrocloruro de endo-2,3 -dihidro-n-(8-metil-8-azabiciclo(3.2.1)oct-3-il)-2-oxo-1h-bencimidazol-1-carboxamida y de monohidrato de hidrocloruro de endo-3-etil-2,3-dihidro-n-(8-metil-8-azabiciclo(3.2.1)oct-3- il)-2-

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI920720A IT1254562B (it) 1992-03-26 1992-03-26 Forma cristallina dell'endo-3-etil-2,3-diidro-n-(8-metil-8-azabiciclo (3.2.1) ott-3-il)- 2-oxo-1h-benzimidazolo-1-carbossamide cloridrato

Publications (3)

Publication Number Publication Date
ITMI920720A0 ITMI920720A0 (it) 1992-03-26
ITMI920720A1 true ITMI920720A1 (it) 1993-09-26
IT1254562B IT1254562B (it) 1995-09-25

Family

ID=11362627

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI920720A IT1254562B (it) 1992-03-26 1992-03-26 Forma cristallina dell'endo-3-etil-2,3-diidro-n-(8-metil-8-azabiciclo (3.2.1) ott-3-il)- 2-oxo-1h-benzimidazolo-1-carbossamide cloridrato

Country Status (2)

Country Link
KR (1) KR100256148B1 (it)
IT (1) IT1254562B (it)

Also Published As

Publication number Publication date
ITMI920720A0 (it) 1992-03-26
IT1254562B (it) 1995-09-25
KR100256148B1 (ko) 2000-05-15
KR930019670A (ko) 1993-10-18

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