ITMI20010206A1 - Uso della metansolfonammide di (r)-ibuprofene e dei suoi sali non tossici per la preparazione di medicamenti per il trattamento e la prevenz - Google Patents
Uso della metansolfonammide di (r)-ibuprofene e dei suoi sali non tossici per la preparazione di medicamenti per il trattamento e la prevenz Download PDFInfo
- Publication number
- ITMI20010206A1 ITMI20010206A1 IT2001MI000206A ITMI20010206A ITMI20010206A1 IT MI20010206 A1 ITMI20010206 A1 IT MI20010206A1 IT 2001MI000206 A IT2001MI000206 A IT 2001MI000206A IT MI20010206 A ITMI20010206 A IT MI20010206A IT MI20010206 A1 ITMI20010206 A1 IT MI20010206A1
- Authority
- IT
- Italy
- Prior art keywords
- prevention
- treatment
- hours
- kidney
- ischemia
- Prior art date
Links
- 238000011282 treatment Methods 0.000 title claims description 12
- 230000002265 prevention Effects 0.000 title claims description 9
- 231100000252 nontoxic Toxicity 0.000 title claims description 8
- 230000003000 nontoxic effect Effects 0.000 title claims description 8
- 239000003814 drug Substances 0.000 title claims description 6
- 238000002360 preparation method Methods 0.000 title claims description 6
- HNQIVZYLYMDVSB-UHFFFAOYSA-N methanesulfonimidic acid Chemical compound CS(N)(=O)=O HNQIVZYLYMDVSB-UHFFFAOYSA-N 0.000 title claims description 4
- 229940079593 drug Drugs 0.000 title description 3
- 210000003734 kidney Anatomy 0.000 claims description 35
- 208000028867 ischemia Diseases 0.000 claims description 21
- 230000000302 ischemic effect Effects 0.000 claims description 14
- 230000006378 damage Effects 0.000 claims description 12
- 210000000056 organ Anatomy 0.000 claims description 11
- 206010063837 Reperfusion injury Diseases 0.000 claims description 10
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims description 9
- URZONQSEPBBTSB-HNCPQSOCSA-N methanesulfonamide;(2r)-2-[4-(2-methylpropyl)phenyl]propanoic acid Chemical compound CS(N)(=O)=O.CC(C)CC1=CC=C([C@@H](C)C(O)=O)C=C1 URZONQSEPBBTSB-HNCPQSOCSA-N 0.000 claims description 9
- 150000003839 salts Chemical class 0.000 claims description 7
- 238000006243 chemical reaction Methods 0.000 claims description 6
- KDXKERNSBIXSRK-UHFFFAOYSA-N lysine Chemical class NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 5
- 230000010410 reperfusion Effects 0.000 claims description 5
- HEFNNWSXXWATRW-SNVBAGLBSA-N levibuprofen Chemical compound CC(C)CC1=CC=C([C@@H](C)C(O)=O)C=C1 HEFNNWSXXWATRW-SNVBAGLBSA-N 0.000 claims description 3
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- 102100021943 C-C motif chemokine 2 Human genes 0.000 description 1
- 101710155857 C-C motif chemokine 2 Proteins 0.000 description 1
- 208000021709 Delayed Graft Function Diseases 0.000 description 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
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- 241000699670 Mus sp. Species 0.000 description 1
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- 229940124639 Selective inhibitor Drugs 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 101150057615 Syn gene Proteins 0.000 description 1
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- RMEDXOLNCUSCGS-UHFFFAOYSA-N droperidol Chemical compound C1=CC(F)=CC=C1C(=O)CCCN1CC=C(N2C(NC3=CC=CC=C32)=O)CC1 RMEDXOLNCUSCGS-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Emergency Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Transplantation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
Priority Applications (27)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2001MI000206A ITMI20010206A1 (it) | 2001-02-02 | 2001-02-02 | Uso della metansolfonammide di (r)-ibuprofene e dei suoi sali non tossici per la preparazione di medicamenti per il trattamento e la prevenz |
| MXPA03006686A MXPA03006686A (es) | 2001-02-02 | 2002-01-30 | Uso de metanosulfonamida de ( r ) ibuprofen y sales de la misma en el tratamiento y prevencion de las reacciones de rechazo de organos transplantados. |
| KR1020037009714A KR100857898B1 (ko) | 2001-02-02 | 2002-01-30 | 이식된 장기의 거부반응의 치료와 예방에 사용되는(ｒ)-이부프로펜 메탄설폰아마이드 및 이의 염 |
| CNA028042263A CN1561205A (zh) | 2001-02-02 | 2002-01-30 | (r)－异丁苯丙酸甲基磺酰胺及其盐在治疗和预防移植器官排斥反应中的应用 |
| PL363576A PL215109B1 (pl) | 2001-02-02 | 2002-01-30 | Zastosowanie (R)-ibuprofeno-metanosulfonamidu i jego nietoksycznych soli do wytwarzania leków |
| SK973-2003A SK287632B6 (sk) | 2001-02-02 | 2002-01-30 | Použitie (R)-ibuprofénmetánsulfonamidu alebo jeho solí |
| BRPI0206804A BRPI0206804B1 (pt) | 2001-02-02 | 2002-01-30 | utilização de (r)-ibuprofeno metanossulfonamida e sais do mesmo no tratamento e prevenção de lesão funcional resultante de reações de rejeição de orgãos transplantados |
| AT02719742T ATE304846T1 (de) | 2001-02-02 | 2002-01-30 | Verwendung von r-ibuprofen methanesulfonamied und dessen salzen zur behandlung und verhinderung von abstossungreaktionen in transplartierten organen |
| HU0303024A HU229070B1 (hu) | 2001-02-02 | 2002-01-30 | (R)-ibuprofen-metánszulfonamid és sói alkalmazása kilökõdési reakciók kezelésére és megelõzésére alkalmas gyógyászati készítmény elõállítására |
| DK02719742T DK1355641T3 (da) | 2001-02-02 | 2002-01-30 | Anvendelse af (R)-ibuprofen-methansulfonamid og salte deraf ved behandling og forebyggelse af afstödningsreaktioner i transplanterede organer |
| AU2002250869A AU2002250869B2 (en) | 2001-02-02 | 2002-01-30 | Use of (R)-ibuprofen methanesulfonamide and salts thereof in the treatment and prevention of rejection reactions of transplanted organs |
| ES02719742T ES2248541T3 (es) | 2001-02-02 | 2002-01-30 | Uso de (r)-iboprufen metanosulfonamida y sales del mismo en el tratamiento y prevencion de las reacciones de rechazo de organos transplantad0s. |
| PCT/EP2002/000946 WO2002062330A2 (en) | 2001-02-02 | 2002-01-30 | Use of (r)-ibuprofen methanesulfonamide and salts thereof in the treatment and prevention of rejection reactions of transplanted organs |
| EP02719742A EP1355641B1 (en) | 2001-02-02 | 2002-01-30 | Use of (r)-ibuprofen methanesulfonamide and salts thereof in the treatment and prevention of rejection reactions of transplanted organs |
| BR0206804-4A BR0206804A (pt) | 2001-02-02 | 2002-01-30 | Utilização de (r)-ibuprofeno metanossulfonamida e sais do mesmo no tratamento e prevenção de reações de rejeição a órgãos transplantados |
| RU2003126600/15A RU2257895C2 (ru) | 2001-02-02 | 2002-01-30 | Применение (r)-ибупрофенметансульфонамида и его солей для лечения и предотвращения реакций отторжения трансплантируемых органов |
| NZ526655A NZ526655A (en) | 2001-02-02 | 2002-01-30 | Use of (R)-ibuprofen methanesulfonamide and salts thereof in the treatment and prevention of rejection reactions of transplanted organs |
| CZ20032095A CZ303665B6 (cs) | 2001-02-02 | 2002-01-30 | Farmaceutický prostredek |
| CA002432432A CA2432432C (en) | 2001-02-02 | 2002-01-30 | Use of (r)-ibuprofen methanesulfonamide and salts thereof in the treatment and prevention of rejection reactions of transplanted organs |
| EEP200300340A EE05233B1 (et) | 2001-02-02 | 2002-01-30 | (R)-ibuprofeenmetaansulfoonamiidi v?i selle soola kasutamine ravimite valmistamiseks, mis on ette nhtud siiratud elundite isheemia/reperfusiooni kahjustuse rahoidmiseks v?i raviks |
| JP2002562337A JP2004517948A (ja) | 2001-02-02 | 2002-01-30 | 移植器官の拒絶反応の治療および予防における（ｒ）−イブプロフェンメタンスルホンアミドおよびその塩の使用 |
| PT02719742T PT1355641E (pt) | 2001-02-02 | 2002-01-30 | Utilizacao de (r)-ibuprofen-metanossulfonamida e os seus sais no tratamento e prevencao das reaccoes de rejeicao de orgaos transplantados |
| DE60206245T DE60206245T2 (de) | 2001-02-02 | 2002-01-30 | Verwendung von r-ibuprofen methanesulfonamid und dessen salzen zur behandlung und verhinderung von abstossungsreaktionen in transplantierten organen |
| US10/250,465 US7560487B2 (en) | 2001-02-02 | 2003-01-30 | Use of (R)—ibuprofen methanesulfonamide and salts thereof in the treatment and prevention of rejection reactions of transplanted organs |
| ZA200304861A ZA200304861B (en) | 2001-02-02 | 2003-06-23 | The use of (R)-ibuprofen methanesulfonamide and salts thereof in the treatment and prevention of rejection reactions of transplanted organs. |
| NO20033273A NO334285B1 (no) | 2001-02-02 | 2003-07-18 | Anvendelse av (R)-ibuprofen-metansulfonamid og salter derav til behandling og forhindring av avstøtning av transplanterte organer |
| IL157180A IL157180A (en) | 2001-02-02 | 2003-07-31 | Use of (R) - ibupropane methanesulfonamide and its salts for the preparation of drugs for the treatment and prevention of rejection reactions of transplanted organs |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2001MI000206A ITMI20010206A1 (it) | 2001-02-02 | 2001-02-02 | Uso della metansolfonammide di (r)-ibuprofene e dei suoi sali non tossici per la preparazione di medicamenti per il trattamento e la prevenz |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ITMI20010206A1 true ITMI20010206A1 (it) | 2002-08-02 |
Family
ID=11446717
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT2001MI000206A ITMI20010206A1 (it) | 2001-02-02 | 2001-02-02 | Uso della metansolfonammide di (r)-ibuprofene e dei suoi sali non tossici per la preparazione di medicamenti per il trattamento e la prevenz |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US7560487B2 (enExample) |
| EP (1) | EP1355641B1 (enExample) |
| JP (1) | JP2004517948A (enExample) |
| KR (1) | KR100857898B1 (enExample) |
| CN (1) | CN1561205A (enExample) |
| AT (1) | ATE304846T1 (enExample) |
| AU (1) | AU2002250869B2 (enExample) |
| BR (2) | BRPI0206804B1 (enExample) |
| CA (1) | CA2432432C (enExample) |
| CZ (1) | CZ303665B6 (enExample) |
| DE (1) | DE60206245T2 (enExample) |
| DK (1) | DK1355641T3 (enExample) |
| EE (1) | EE05233B1 (enExample) |
| ES (1) | ES2248541T3 (enExample) |
| HU (1) | HU229070B1 (enExample) |
| IL (1) | IL157180A (enExample) |
| IT (1) | ITMI20010206A1 (enExample) |
| MX (1) | MXPA03006686A (enExample) |
| NO (1) | NO334285B1 (enExample) |
| NZ (1) | NZ526655A (enExample) |
| PL (1) | PL215109B1 (enExample) |
| PT (1) | PT1355641E (enExample) |
| RU (1) | RU2257895C2 (enExample) |
| SK (1) | SK287632B6 (enExample) |
| WO (1) | WO2002062330A2 (enExample) |
| ZA (1) | ZA200304861B (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE602004003673T2 (de) * | 2004-03-25 | 2007-10-04 | Dompe' Pha.R.Ma S.P.A. | Verwendung von N-(2-Aryl-propionyl)-sulfonamiden zur Behandlung von Rückenmarkverletzungen |
| WO2006121995A2 (en) | 2005-05-09 | 2006-11-16 | Tap Pharmaceutical Products, Inc. | Methods for treating nephrolithiasis |
| CA2669935A1 (en) * | 2006-11-13 | 2008-05-29 | Takeda Pharmaceuticals North America, Inc. | Methods for preserving renal function using xanthine oxidoreductase inhibitors |
| EP2308484A1 (en) | 2009-10-06 | 2011-04-13 | Dompé S.p.a. | Inhibitors of cxcr1/2 as adjuvants in the transplant of pancreatic islets |
| EP2308485A1 (en) | 2009-10-06 | 2011-04-13 | Dompé S.p.a. | Sulfonamides for the prevention of diabetes |
| JP5978216B2 (ja) | 2010-09-10 | 2016-08-24 | タケダ ファーマシューティカルズ ユー．エス．エー． インコーポレイティド | テオフィリンとフェブキソスタットの併用療法のための方法 |
| US10561676B2 (en) * | 2013-08-02 | 2020-02-18 | Syntrix Biosystems Inc. | Method for treating cancer using dual antagonists of CXCR1 and CXCR2 |
| US10046002B2 (en) | 2013-08-02 | 2018-08-14 | Syntrix Biosystems Inc. | Method for treating cancer using chemokine antagonists |
| HUE065802T2 (hu) * | 2017-03-15 | 2024-06-28 | Numares Ag | Marker-készlet alkalmazása vesekilökõdés kockázatának meghatározására |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4879283A (en) * | 1985-10-03 | 1989-11-07 | Wisconsin Alumni Research Foundation | Solution for the preservation of organs |
| RU2008901C1 (ru) * | 1991-03-29 | 1994-03-15 | Донецкий государственный медицинский институт им.М.Горького | Способ фармакологической защиты децентрализованной почки |
| ATE257389T1 (de) * | 1992-09-17 | 2004-01-15 | Amgen Inc | Pharmazeutische zusammensetzungen mit interleukin-1 inhibitoren |
| IL110296A (en) * | 1993-07-16 | 1999-12-31 | Smithkline Beecham Corp | Imidazole compounds process for their preparation and pharmaceutical compositions containing them |
| JPH08231413A (ja) * | 1994-12-29 | 1996-09-10 | Mochida Pharmaceut Co Ltd | 臓器障害に基づく疾患の予防・治療剤 |
| IT1303249B1 (it) * | 1998-10-23 | 2000-11-06 | Dompe Spa | Alcune n-(2-aril-propionil)-solfonammidi e preparazionifarmaceutiche che le contengono. |
| US6355682B1 (en) * | 2001-05-11 | 2002-03-12 | Assa Weinberg | Treatment of acute renal failure by administration of N-acetylcysteine |
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