ITFO990015A1 - "dendrimeri polipeptidici quali trasportatori unimolecolari di farmaci e sostanze biologicamente attive". - Google Patents
"dendrimeri polipeptidici quali trasportatori unimolecolari di farmaci e sostanze biologicamente attive". Download PDFInfo
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- ITFO990015A1 ITFO990015A1 IT1999FO000015A ITFO990015A ITFO990015A1 IT FO990015 A1 ITFO990015 A1 IT FO990015A1 IT 1999FO000015 A IT1999FO000015 A IT 1999FO000015A IT FO990015 A ITFO990015 A IT FO990015A IT FO990015 A1 ITFO990015 A1 IT FO990015A1
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- GSNUFIFRDBKVIE-UHFFFAOYSA-N DMF Natural products CC1=CC=C(C)O1 GSNUFIFRDBKVIE-UHFFFAOYSA-N 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- 102000009123 Fibrin Human genes 0.000 description 1
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- 230000005526 G1 to G0 transition Effects 0.000 description 1
- OHJKXVLJWUPWQG-PNRHKHKDSA-N Heparinsodiumsalt Chemical compound O[C@@H]1[C@@H](NS(O)(=O)=O)[C@@H](O)O[C@H](COS(O)(=O)=O)[C@H]1O[C@H]1[C@H](OS(O)(=O)=O)[C@@H](O)[C@H](O)[C@H](C(O)=O)O1 OHJKXVLJWUPWQG-PNRHKHKDSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- 102000002704 Leucyl aminopeptidase Human genes 0.000 description 1
- 108010004098 Leucyl aminopeptidase Proteins 0.000 description 1
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 241000223960 Plasmodium falciparum Species 0.000 description 1
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- 210000001744 T-lymphocyte Anatomy 0.000 description 1
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- OAAKZKGKPMPJIF-UHFFFAOYSA-N [Cl].[I] Chemical compound [Cl].[I] OAAKZKGKPMPJIF-UHFFFAOYSA-N 0.000 description 1
- 238000010306 acid treatment Methods 0.000 description 1
- 239000003708 ampul Substances 0.000 description 1
- 150000008064 anhydrides Chemical class 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 description 1
- 239000012888 bovine serum Substances 0.000 description 1
- 229940098773 bovine serum albumin Drugs 0.000 description 1
- 210000004899 c-terminal region Anatomy 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
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- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 description 1
- 230000009089 cytolysis Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000010511 deprotection reaction Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 description 1
- 235000019621 digestibility Nutrition 0.000 description 1
- BGRWYRAHAFMIBJ-UHFFFAOYSA-N diisopropylcarbodiimide Natural products CC(C)NC(=O)NC(C)C BGRWYRAHAFMIBJ-UHFFFAOYSA-N 0.000 description 1
- 239000000539 dimer Substances 0.000 description 1
- 229960003638 dopamine Drugs 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 230000007515 enzymatic degradation Effects 0.000 description 1
- VFRSADQPWYCXDG-LEUCUCNGSA-N ethyl (2s,5s)-5-methylpyrrolidine-2-carboxylate;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.CCOC(=O)[C@@H]1CC[C@H](C)N1 VFRSADQPWYCXDG-LEUCUCNGSA-N 0.000 description 1
- 125000005313 fatty acid group Chemical group 0.000 description 1
- 229950003499 fibrin Drugs 0.000 description 1
- 229960000304 folic acid Drugs 0.000 description 1
- 235000019152 folic acid Nutrition 0.000 description 1
- 239000011724 folic acid Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 102000034238 globular proteins Human genes 0.000 description 1
- 108091005896 globular proteins Proteins 0.000 description 1
- YMAWOPBAYDPSLA-UHFFFAOYSA-N glycylglycine Chemical compound [NH3+]CC(=O)NCC([O-])=O YMAWOPBAYDPSLA-UHFFFAOYSA-N 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 238000005984 hydrogenation reaction Methods 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 210000004347 intestinal mucosa Anatomy 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 150000002605 large molecules Chemical class 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 125000003588 lysine group Chemical class [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 1
- 229910001629 magnesium chloride Inorganic materials 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 210000004379 membrane Anatomy 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 150000004702 methyl esters Chemical class 0.000 description 1
- 244000000010 microbial pathogen Species 0.000 description 1
- 230000003228 microsomal effect Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- FEMOMIGRRWSMCU-UHFFFAOYSA-N ninhydrin Chemical compound C1=CC=C2C(=O)C(O)(O)C(=O)C2=C1 FEMOMIGRRWSMCU-UHFFFAOYSA-N 0.000 description 1
- 231100000956 nontoxicity Toxicity 0.000 description 1
- 238000000655 nuclear magnetic resonance spectrum Methods 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 239000013307 optical fiber Substances 0.000 description 1
- 239000012044 organic layer Substances 0.000 description 1
- 239000012074 organic phase Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920000333 poly(propyleneimine) Polymers 0.000 description 1
- 239000004584 polyacrylic acid Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 229920002689 polyvinyl acetate Polymers 0.000 description 1
- 239000011118 polyvinyl acetate Substances 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 238000002953 preparative HPLC Methods 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000010453 quartz Substances 0.000 description 1
- 239000012088 reference solution Substances 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000001308 synthesis method Methods 0.000 description 1
- 229940126577 synthetic vaccine Drugs 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
- 230000034005 thiol-disulfide exchange Effects 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/641—Branched, dendritic or hypercomb peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (12)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT1999FO000015A ITFO990015A1 (it) | 1999-07-23 | 1999-07-23 | "dendrimeri polipeptidici quali trasportatori unimolecolari di farmaci e sostanze biologicamente attive". |
| CA002380178A CA2380178A1 (fr) | 1999-07-23 | 2000-07-21 | Dendrimeres polypeptidiques en tant que porteurs unimoleculaires d'agents de contraste d'imagerie diagnostique, de substances bioactives et de medicaments |
| JP2001512552A JP2003506326A (ja) | 1999-07-23 | 2000-07-21 | 診断イメージング造影剤、生物活性物質、および薬剤の単分子担体としてのポリペプチドデンドリマー |
| EP00949393A EP1200461A2 (fr) | 1999-07-23 | 2000-07-21 | Dendrimeres polypeptidiques en tant que porteurs unimoleculaires d'agents de contraste d'imagerie diagnostique, de substances bioactives et de medicaments |
| PCT/EP2000/007022 WO2001007469A2 (fr) | 1999-07-23 | 2000-07-21 | Dendrimeres polypeptidiques en tant que porteurs unimoleculaires d'agents de contraste d'imagerie diagnostique, de substances bioactives et de medicaments |
| NZ517231A NZ517231A (en) | 1999-07-23 | 2000-07-21 | Polypeptide dendrimers as unimolecular carriers of diagnostic imaging contrast agents, bioactive substances and drugs |
| AU62766/00A AU772167B2 (en) | 1999-07-23 | 2000-07-21 | Polypeptide dendrimers as unimolecular carriers of diagnostic imaging contrast agents, bioactive substances and drugs |
| PL00353273A PL353273A1 (en) | 1999-07-23 | 2000-07-21 | Polypeptide dendrimers as unimolecular carriers of diagnostic imaging contrast agents, bioactive substances and drugs |
| CN00810769A CN1364171A (zh) | 1999-07-23 | 2000-07-21 | 用作诊断显象造影剂、生物活性物质和药物的单分子载体的多肽树状聚物 |
| HU0201975A HUP0201975A3 (en) | 1999-07-23 | 2000-07-21 | Polypeptide dendrimers as unimolecular carriers of diagnostic imaging contrast agents, bioactive substances and drugs |
| NO20020333A NO20020333D0 (no) | 1999-07-23 | 2002-01-22 | Polypeptid-dendrimerer som unimolekyl¶re b¶rere av diagnostiske, billeddannende kontrastmidler, bioaktive stoffer oglegemidler |
| ZA200201089A ZA200201089B (en) | 1999-07-23 | 2002-02-07 | Polypeptide dendrimers as unimolecular carriers of diagnostic imaging contrast agents, bioactive substances and drugs. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT1999FO000015A ITFO990015A1 (it) | 1999-07-23 | 1999-07-23 | "dendrimeri polipeptidici quali trasportatori unimolecolari di farmaci e sostanze biologicamente attive". |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ITFO990015A1 true ITFO990015A1 (it) | 2001-01-23 |
Family
ID=11353680
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT1999FO000015A ITFO990015A1 (it) | 1999-07-23 | 1999-07-23 | "dendrimeri polipeptidici quali trasportatori unimolecolari di farmaci e sostanze biologicamente attive". |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP1200461A2 (fr) |
| JP (1) | JP2003506326A (fr) |
| CN (1) | CN1364171A (fr) |
| AU (1) | AU772167B2 (fr) |
| CA (1) | CA2380178A1 (fr) |
| HU (1) | HUP0201975A3 (fr) |
| IT (1) | ITFO990015A1 (fr) |
| NO (1) | NO20020333D0 (fr) |
| NZ (1) | NZ517231A (fr) |
| PL (1) | PL353273A1 (fr) |
| WO (1) | WO2001007469A2 (fr) |
| ZA (1) | ZA200201089B (fr) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR032941A1 (es) | 2001-03-05 | 2003-12-03 | Shell Int Research | Un procedimiento para preparar un aceite base lubricante y aceite base obtenido, con sus diversas utilizaciones |
| MY137259A (en) | 2001-03-05 | 2009-01-30 | Shell Int Research | Process to prepare a lubricating base oil and a gas oil. |
| AR032930A1 (es) | 2001-03-05 | 2003-12-03 | Shell Int Research | Procedimiento para preparar un aceite de base lubricante y gas oil |
| CN1558777A (zh) * | 2001-10-29 | 2004-12-29 | �Ϻ���ͨ��ѧ | 抗肿瘤的树枝状聚合物药物释放系统 |
| WO2004009739A2 (fr) | 2002-07-18 | 2004-01-29 | Shell Internationale Research Maatschappij B.V. | Procede de preparation d'une cire microcristalline et d'un combustible de distillat moyen |
| EP1525890A1 (fr) | 2003-10-02 | 2005-04-27 | Complex Biosystems GmbH | Complexes protéine-protéophore |
| EP2676691B1 (fr) | 2005-11-17 | 2016-07-06 | Zogenix, Inc. | Administration de préparations visqueuses par injection sans aiguille |
| HUP0700782A3 (en) * | 2007-12-05 | 2009-11-30 | Biostatin Gyogyszerkutato Fejl | Novel peptides and amino acid derivatives, pharmaceutical compositions containing the same and use of the compounds |
| AU2009241847B2 (en) | 2008-04-28 | 2014-07-10 | Zogenix, Inc. | Novel formulations for treatment of migraine |
| AU2009279365A1 (en) * | 2008-08-05 | 2010-02-11 | The University Of Queensland | Antigen-presenting scaffolds |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995000540A1 (fr) * | 1993-06-18 | 1995-01-05 | Robert Webber | Vecteur et immunogene de synthese |
| CN1246059A (zh) * | 1997-01-29 | 2000-03-01 | 奈科姆成像有限公司 | 聚合物 |
-
1999
- 1999-07-23 IT IT1999FO000015A patent/ITFO990015A1/it unknown
-
2000
- 2000-07-21 CA CA002380178A patent/CA2380178A1/fr not_active Abandoned
- 2000-07-21 HU HU0201975A patent/HUP0201975A3/hu unknown
- 2000-07-21 NZ NZ517231A patent/NZ517231A/en unknown
- 2000-07-21 AU AU62766/00A patent/AU772167B2/en not_active Ceased
- 2000-07-21 JP JP2001512552A patent/JP2003506326A/ja active Pending
- 2000-07-21 WO PCT/EP2000/007022 patent/WO2001007469A2/fr not_active Application Discontinuation
- 2000-07-21 PL PL00353273A patent/PL353273A1/xx not_active Application Discontinuation
- 2000-07-21 CN CN00810769A patent/CN1364171A/zh active Pending
- 2000-07-21 EP EP00949393A patent/EP1200461A2/fr not_active Withdrawn
-
2002
- 2002-01-22 NO NO20020333A patent/NO20020333D0/no not_active Application Discontinuation
- 2002-02-07 ZA ZA200201089A patent/ZA200201089B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN1364171A (zh) | 2002-08-14 |
| WO2001007469A2 (fr) | 2001-02-01 |
| NO20020333L (no) | 2002-01-22 |
| NZ517231A (en) | 2003-05-30 |
| JP2003506326A (ja) | 2003-02-18 |
| EP1200461A2 (fr) | 2002-05-02 |
| HUP0201975A2 (en) | 2002-10-28 |
| WO2001007469A3 (fr) | 2001-05-10 |
| HUP0201975A3 (en) | 2002-11-28 |
| PL353273A1 (en) | 2003-11-03 |
| CA2380178A1 (fr) | 2001-02-01 |
| ZA200201089B (en) | 2003-07-30 |
| AU6276600A (en) | 2001-02-13 |
| NO20020333D0 (no) | 2002-01-22 |
| AU772167B2 (en) | 2004-04-08 |
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