ITAL990010U1 - Nuova metodica di laboratorio per preparare gel e membrane piastriniche ottenute dal concentrato piastrinico. - Google Patents
Nuova metodica di laboratorio per preparare gel e membrane piastriniche ottenute dal concentrato piastrinico. Download PDFInfo
- Publication number
- ITAL990010U1 ITAL990010U1 IT1999AL000010U ITAL990010U ITAL990010U1 IT AL990010 U1 ITAL990010 U1 IT AL990010U1 IT 1999AL000010 U IT1999AL000010 U IT 1999AL000010U IT AL990010 U ITAL990010 U IT AL990010U IT AL990010 U1 ITAL990010 U1 IT AL990010U1
- Authority
- IT
- Italy
- Prior art keywords
- patient
- gel
- platelet
- procedure
- plate
- Prior art date
Links
- 239000012528 membrane Substances 0.000 title claims abstract description 11
- 238000011005 laboratory method Methods 0.000 title claims description 5
- 239000012141 concentrate Substances 0.000 title description 2
- 238000000034 method Methods 0.000 claims abstract description 21
- 108090000190 Thrombin Proteins 0.000 claims abstract description 6
- 229960004072 thrombin Drugs 0.000 claims abstract description 6
- 241000283690 Bos taurus Species 0.000 claims abstract description 5
- 210000004369 blood Anatomy 0.000 claims description 10
- 239000008280 blood Substances 0.000 claims description 10
- 238000002360 preparation method Methods 0.000 claims description 4
- 230000002364 anti-haemorrhagic effect Effects 0.000 claims description 2
- 108010046562 botropase Proteins 0.000 claims description 2
- 229940079593 drug Drugs 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 230000035876 healing Effects 0.000 claims description 2
- 238000011065 in-situ storage Methods 0.000 claims description 2
- 230000004927 fusion Effects 0.000 claims 1
- 230000017423 tissue regeneration Effects 0.000 claims 1
- 239000003634 thrombocyte concentrate Substances 0.000 abstract description 11
- 108010027612 Batroxobin Proteins 0.000 abstract description 6
- 229960002210 batroxobin Drugs 0.000 abstract description 6
- 239000012190 activator Substances 0.000 abstract 1
- 159000000007 calcium salts Chemical class 0.000 abstract 1
- 238000001994 activation Methods 0.000 description 6
- 210000002381 plasma Anatomy 0.000 description 6
- 210000004623 platelet-rich plasma Anatomy 0.000 description 5
- 230000004913 activation Effects 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 4
- 239000001110 calcium chloride Substances 0.000 description 4
- 229910001628 calcium chloride Inorganic materials 0.000 description 4
- 238000005119 centrifugation Methods 0.000 description 4
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 230000008901 benefit Effects 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000003102 growth factor Substances 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 239000008188 pellet Substances 0.000 description 2
- 238000005070 sampling Methods 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 230000029663 wound healing Effects 0.000 description 2
- 108010039209 Blood Coagulation Factors Proteins 0.000 description 1
- 102000015081 Blood Coagulation Factors Human genes 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 239000005312 bioglass Substances 0.000 description 1
- 239000003114 blood coagulation factor Substances 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 210000002805 bone matrix Anatomy 0.000 description 1
- 230000010478 bone regeneration Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 230000001054 cortical effect Effects 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 239000013067 intermediate product Substances 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 230000037353 metabolic pathway Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000003239 periodontal effect Effects 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 230000008467 tissue growth Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0057—Ingredients of undetermined constitution or reaction products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/19—Platelets; Megacaryocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/0005—Ingredients of undetermined constitution or reaction products thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Inorganic Chemistry (AREA)
- Molecular Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Gastroenterology & Hepatology (AREA)
- Materials Engineering (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Virology (AREA)
- Zoology (AREA)
- Dermatology (AREA)
- Surgery (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Materials For Medical Uses (AREA)
- Surgical Instruments (AREA)
- Compounds Of Unknown Constitution (AREA)
- External Artificial Organs (AREA)
Priority Applications (12)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT1999AL000010U ITAL990010U1 (it) | 1999-12-14 | 1999-12-14 | Nuova metodica di laboratorio per preparare gel e membrane piastriniche ottenute dal concentrato piastrinico. |
| PCT/EP2000/012661 WO2001043787A2 (en) | 1999-12-14 | 2000-12-13 | A process for preparing an autologous platelet gel and membrane thereof |
| AU25111/01A AU2511101A (en) | 1999-12-14 | 2000-12-13 | A process for preparing an autologous platelet gel and membranes thereof, and a kit for carrying out this process |
| CA2393315A CA2393315C (en) | 1999-12-14 | 2000-12-13 | A process for preparing an autologous platelet gel and membranes thereof, and a kit for carrying out this process |
| PT00988792T PT1239895E (pt) | 1999-12-14 | 2000-12-13 | Um processo para a preparacao de gel de plaquetas autologas |
| DK00988792T DK1239895T3 (da) | 1999-12-14 | 2000-12-13 | Fremgangsmåde til fremstilling af en gel af autologe blodplader |
| DE60002231T DE60002231T2 (de) | 1999-12-14 | 2000-12-13 | Verfahren zur herstellung eines gels von autologen blutplättchen |
| AT00988792T ATE237370T1 (de) | 1999-12-14 | 2000-12-13 | Verfahren zur herstellung eines gels von autologen blutplättchen |
| US10/129,827 US6841170B2 (en) | 1999-12-14 | 2000-12-13 | Process for preparing an autologous platelet gel and membrane thereof |
| JP2001544923A JP2003516815A (ja) | 1999-12-14 | 2000-12-13 | 自己血小板ゲルとその膜を調製する方法、およびこの方法を実施するためのキット |
| ES00988792T ES2197125T3 (es) | 1999-12-14 | 2000-12-13 | Proceso de elaboracion de un gel de plaquetas autologas y un equipo para realizar este proceso. |
| EP00988792A EP1239895B1 (en) | 1999-12-14 | 2000-12-13 | A process for preparing an autologous platelet gel |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT1999AL000010U ITAL990010U1 (it) | 1999-12-14 | 1999-12-14 | Nuova metodica di laboratorio per preparare gel e membrane piastriniche ottenute dal concentrato piastrinico. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ITAL990010U1 true ITAL990010U1 (it) | 2001-06-14 |
Family
ID=11333478
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT1999AL000010U ITAL990010U1 (it) | 1999-12-14 | 1999-12-14 | Nuova metodica di laboratorio per preparare gel e membrane piastriniche ottenute dal concentrato piastrinico. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6841170B2 (enExample) |
| EP (1) | EP1239895B1 (enExample) |
| JP (1) | JP2003516815A (enExample) |
| AT (1) | ATE237370T1 (enExample) |
| AU (1) | AU2511101A (enExample) |
| CA (1) | CA2393315C (enExample) |
| DE (1) | DE60002231T2 (enExample) |
| DK (1) | DK1239895T3 (enExample) |
| ES (1) | ES2197125T3 (enExample) |
| IT (1) | ITAL990010U1 (enExample) |
| PT (1) | PT1239895E (enExample) |
| WO (1) | WO2001043787A2 (enExample) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003017913A1 (en) * | 2001-08-27 | 2003-03-06 | The Cleveland Clinic Foundation | Compositions, methods and apparatus for surgical procedures |
| US7992725B2 (en) | 2002-05-03 | 2011-08-09 | Biomet Biologics, Llc | Buoy suspension fractionation system |
| US7832566B2 (en) | 2002-05-24 | 2010-11-16 | Biomet Biologics, Llc | Method and apparatus for separating and concentrating a component from a multi-component material including macroparticles |
| US20030205538A1 (en) | 2002-05-03 | 2003-11-06 | Randel Dorian | Methods and apparatus for isolating platelets from blood |
| US7845499B2 (en) | 2002-05-24 | 2010-12-07 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
| US20060278588A1 (en) | 2002-05-24 | 2006-12-14 | Woodell-May Jennifer E | Apparatus and method for separating and concentrating fluids containing multiple components |
| DE10392686T5 (de) | 2002-05-24 | 2005-07-07 | Biomet Mfg. Corp., Warsaw | Vorrichtung und Verfahren zum Trennen und Konzentrieren von Flüssigkeiten, welche mehrere Komponenten enthalten |
| ITMI20021917A1 (it) * | 2002-09-10 | 2004-03-11 | New Dawn Consultores E Servicos L Da | Attivatore per la formazione di gel piastrinico, gel di plasma povero di piastrine o gel di plasma ricco di piastrine. |
| ITRM20030467A1 (it) * | 2003-10-10 | 2005-04-11 | Advance Holdings Ltd | Contenitore monouso per la centrifugazione ed il trattamento di un materiale biologico fluido. |
| US20060095121A1 (en) * | 2004-10-28 | 2006-05-04 | Medtronic Vascular, Inc. | Autologous platelet gel on a stent graft |
| ES2426172T3 (es) * | 2005-02-07 | 2013-10-21 | Hanuman Llc | Dispositivo concentrador de plasma |
| US7694828B2 (en) | 2005-04-27 | 2010-04-13 | Biomet Manufacturing Corp. | Method and apparatus for producing autologous clotting components |
| US20070087061A1 (en) * | 2005-10-14 | 2007-04-19 | Medafor, Incorporated | Method and composition for creating and/or activating a platelet-rich gel by contact with a porous particulate material, for use in wound care, tissue adhesion, or as a matrix for delivery of therapeutic components |
| US20070086958A1 (en) * | 2005-10-14 | 2007-04-19 | Medafor, Incorporated | Formation of medically useful gels comprising microporous particles and methods of use |
| US8567609B2 (en) | 2006-05-25 | 2013-10-29 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
| ES2324438B1 (es) * | 2006-06-19 | 2010-05-25 | Lorente Alvarez-Beigbeder, S.L. | Metodo para la obtencion de plaquetas. |
| US20080255041A1 (en) * | 2007-04-11 | 2008-10-16 | Ebi, L.P. | Treatment of annulus fibrosis defects |
| US8328024B2 (en) | 2007-04-12 | 2012-12-11 | Hanuman, Llc | Buoy suspension fractionation system |
| US7806276B2 (en) | 2007-04-12 | 2010-10-05 | Hanuman, Llc | Buoy suspension fractionation system |
| EP2259774B1 (en) | 2008-02-27 | 2012-12-12 | Biomet Biologics, LLC | Methods and compositions for delivering interleukin-1 receptor antagonist |
| EP2254991B1 (en) | 2008-02-29 | 2018-08-22 | Biomet Manufacturing, LLC | A system and process for separating a material |
| ITFI20080070A1 (it) | 2008-04-04 | 2009-10-05 | Azienda Ospedaliero Universitaria Careggi | Matrice extracellulare comprendente fattori piastrinici. |
| US8187475B2 (en) | 2009-03-06 | 2012-05-29 | Biomet Biologics, Llc | Method and apparatus for producing autologous thrombin |
| US8313954B2 (en) | 2009-04-03 | 2012-11-20 | Biomet Biologics, Llc | All-in-one means of separating blood components |
| EP2470229B1 (en) | 2009-06-11 | 2017-08-23 | Universitat Autònoma De Barcelona | Use of gelled prp (platelet gel) for volumetric breast reconstruction |
| IT1394570B1 (it) | 2009-07-02 | 2012-07-05 | Fidia Farmaceutici | Materiale biologico adatto per la terapia dell osteoartrosi del danno dei legamenti e per il trattamento delle patologie delle articolazioni. |
| US9011800B2 (en) | 2009-07-16 | 2015-04-21 | Biomet Biologics, Llc | Method and apparatus for separating biological materials |
| US8591391B2 (en) | 2010-04-12 | 2013-11-26 | Biomet Biologics, Llc | Method and apparatus for separating a material |
| US9555171B2 (en) | 2010-09-30 | 2017-01-31 | Depuy Mitek, Llc | Methods and devices for collecting separate components of whole blood |
| US9642956B2 (en) | 2012-08-27 | 2017-05-09 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
| US10208095B2 (en) | 2013-03-15 | 2019-02-19 | Biomet Manufacturing, Llc | Methods for making cytokine compositions from tissues using non-centrifugal methods |
| US9895418B2 (en) | 2013-03-15 | 2018-02-20 | Biomet Biologics, Llc | Treatment of peripheral vascular disease using protein solutions |
| US9950035B2 (en) | 2013-03-15 | 2018-04-24 | Biomet Biologics, Llc | Methods and non-immunogenic compositions for treating inflammatory disorders |
| US20140271589A1 (en) | 2013-03-15 | 2014-09-18 | Biomet Biologics, Llc | Treatment of collagen defects using protein solutions |
| US10143725B2 (en) | 2013-03-15 | 2018-12-04 | Biomet Biologics, Llc | Treatment of pain using protein solutions |
| US9550028B2 (en) | 2014-05-06 | 2017-01-24 | Biomet Biologics, LLC. | Single step desiccating bead-in-syringe concentrating device |
| US20170369845A1 (en) * | 2014-12-31 | 2017-12-28 | Anthrogenesis Corporation | Methods for isolation of platelets |
| IT201700024672A1 (it) * | 2017-03-06 | 2018-09-06 | Caloprisco Gaetano Ditta Individuale | Metodo e sistema per preparare un kit medicale per curare lesioni tissutali di un paziente |
| US11767511B2 (en) | 2018-11-30 | 2023-09-26 | Cellphire, Inc. | Platelets as delivery agents |
| EP3887402A4 (en) | 2018-11-30 | 2022-10-26 | Cellphire, Inc. | PLATELETS AS RELEASING AGENT |
| US11529587B2 (en) | 2019-05-03 | 2022-12-20 | Cellphire, Inc. | Materials and methods for producing blood products |
| US20210308066A1 (en) | 2020-02-04 | 2021-10-07 | Cellphire, Inc. | Anti-fibrinolytic loaded platelets |
| CA3150936A1 (en) | 2019-08-16 | 2021-02-25 | Cellphire, Inc. | Thrombosomes as an antiplatelet agent reversal agent |
| US20220273724A1 (en) | 2021-02-17 | 2022-09-01 | Cellphire Inc. | Freeze-dried platelet derivative compositions for treating antiplatelet induced coagulopathy |
| CN114831770A (zh) * | 2022-05-20 | 2022-08-02 | 上海浦灵生物科技有限公司 | 一种肺动脉高压非人灵长类动物模型及其构建方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5585007A (en) * | 1994-12-07 | 1996-12-17 | Plasmaseal Corporation | Plasma concentrate and tissue sealant methods and apparatuses for making concentrated plasma and/or tissue sealant |
| US5733545A (en) * | 1995-03-03 | 1998-03-31 | Quantic Biomedical Partners | Platelet glue wound sealant |
| IT1284550B1 (it) | 1996-09-18 | 1998-05-21 | Flavio Tarantino | Procedimento per la preparazione di colla di fibrina autologa ad uso chirurgico |
-
1999
- 1999-12-14 IT IT1999AL000010U patent/ITAL990010U1/it unknown
-
2000
- 2000-12-13 AU AU25111/01A patent/AU2511101A/en not_active Abandoned
- 2000-12-13 CA CA2393315A patent/CA2393315C/en not_active Expired - Fee Related
- 2000-12-13 JP JP2001544923A patent/JP2003516815A/ja active Pending
- 2000-12-13 AT AT00988792T patent/ATE237370T1/de active
- 2000-12-13 DK DK00988792T patent/DK1239895T3/da active
- 2000-12-13 PT PT00988792T patent/PT1239895E/pt unknown
- 2000-12-13 ES ES00988792T patent/ES2197125T3/es not_active Expired - Lifetime
- 2000-12-13 EP EP00988792A patent/EP1239895B1/en not_active Expired - Lifetime
- 2000-12-13 US US10/129,827 patent/US6841170B2/en not_active Expired - Lifetime
- 2000-12-13 DE DE60002231T patent/DE60002231T2/de not_active Expired - Lifetime
- 2000-12-13 WO PCT/EP2000/012661 patent/WO2001043787A2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| DE60002231D1 (de) | 2003-05-22 |
| EP1239895B1 (en) | 2003-04-16 |
| WO2001043787A2 (en) | 2001-06-21 |
| CA2393315C (en) | 2010-01-26 |
| WO2001043787A3 (en) | 2001-12-13 |
| US20020172666A1 (en) | 2002-11-21 |
| AU2511101A (en) | 2001-06-25 |
| EP1239895A2 (en) | 2002-09-18 |
| PT1239895E (pt) | 2003-08-29 |
| DE60002231T2 (de) | 2004-04-29 |
| JP2003516815A (ja) | 2003-05-20 |
| ATE237370T1 (de) | 2003-05-15 |
| WO2001043787B1 (en) | 2002-01-10 |
| CA2393315A1 (en) | 2001-06-21 |
| DK1239895T3 (da) | 2003-07-21 |
| ES2197125T3 (es) | 2004-01-01 |
| US6841170B2 (en) | 2005-01-11 |
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