IT1292142B1 - Composizione farmaceutica in forma di microparticelle lipidiche solide atte alla somministrazione parenterale - Google Patents

Composizione farmaceutica in forma di microparticelle lipidiche solide atte alla somministrazione parenterale

Info

Publication number
IT1292142B1
IT1292142B1 IT97MI001385A ITMI971385A IT1292142B1 IT 1292142 B1 IT1292142 B1 IT 1292142B1 IT 97MI001385 A IT97MI001385 A IT 97MI001385A IT MI971385 A ITMI971385 A IT MI971385A IT 1292142 B1 IT1292142 B1 IT 1292142B1
Authority
IT
Italy
Prior art keywords
pharmaceutical composition
parenteral administration
solid lipid
lipid microparticles
microparticles suitable
Prior art date
Application number
IT97MI001385A
Other languages
English (en)
Italian (it)
Inventor
Maria Rosa Gasco
Original Assignee
Maria Rosa Gasco
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Maria Rosa Gasco filed Critical Maria Rosa Gasco
Publication of ITMI971385A0 publication Critical patent/ITMI971385A0/it
Priority to IT97MI001385A priority Critical patent/IT1292142B1/it
Priority to EP98929383A priority patent/EP0988031B1/en
Priority to AU79158/98A priority patent/AU7915898A/en
Priority to CA002294172A priority patent/CA2294172C/en
Priority to DE69812936T priority patent/DE69812936T2/de
Priority to US09/445,603 priority patent/US6238694B1/en
Priority to AT98929383T priority patent/ATE235897T1/de
Priority to PCT/EP1998/003110 priority patent/WO1998056362A1/en
Publication of ITMI971385A1 publication Critical patent/ITMI971385A1/it
Application granted granted Critical
Publication of IT1292142B1 publication Critical patent/IT1292142B1/it

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5123—Organic compounds, e.g. fats, sugars

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IT97MI001385A 1997-06-12 1997-06-12 Composizione farmaceutica in forma di microparticelle lipidiche solide atte alla somministrazione parenterale IT1292142B1 (it)

Priority Applications (8)

Application Number Priority Date Filing Date Title
IT97MI001385A IT1292142B1 (it) 1997-06-12 1997-06-12 Composizione farmaceutica in forma di microparticelle lipidiche solide atte alla somministrazione parenterale
DE69812936T DE69812936T2 (de) 1997-06-12 1998-05-27 Arzneimittel in form parenenteral verabreichbarer lipidmikropartikel
AU79158/98A AU7915898A (en) 1997-06-12 1998-05-27 Pharmaceutical composition in form of solid lipidic microparticles suitable to parenteral administration
CA002294172A CA2294172C (en) 1997-06-12 1998-05-27 Pharmaceutical composition in form of solid lipidic microparticles suitable to parenteral administration
EP98929383A EP0988031B1 (en) 1997-06-12 1998-05-27 Pharmaceutical composition in form of solid lipidic microparticles suitable to parenteral administration
US09/445,603 US6238694B1 (en) 1997-06-12 1998-05-27 Pharmaceutical composition in form of solid lipidic microparticles suitable to parenteral administration
AT98929383T ATE235897T1 (de) 1997-06-12 1998-05-27 Arzneimittel in form parenenteral verabreichbarer lipidmikropartikel
PCT/EP1998/003110 WO1998056362A1 (en) 1997-06-12 1998-05-27 Pharmaceutical composition in form of solid lipidic microparticles suitable to parenteral administration

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT97MI001385A IT1292142B1 (it) 1997-06-12 1997-06-12 Composizione farmaceutica in forma di microparticelle lipidiche solide atte alla somministrazione parenterale

Publications (3)

Publication Number Publication Date
ITMI971385A0 ITMI971385A0 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1997-06-12
ITMI971385A1 ITMI971385A1 (it) 1998-12-12
IT1292142B1 true IT1292142B1 (it) 1999-01-25

Family

ID=11377349

Family Applications (1)

Application Number Title Priority Date Filing Date
IT97MI001385A IT1292142B1 (it) 1997-06-12 1997-06-12 Composizione farmaceutica in forma di microparticelle lipidiche solide atte alla somministrazione parenterale

Country Status (8)

Country Link
US (1) US6238694B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP0988031B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) ATE235897T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU7915898A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA2294172C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE69812936T2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IT (1) IT1292142B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
WO (1) WO1998056362A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1296914B1 (it) 1997-12-01 1999-08-03 Maria Rosa Gasco Composizione farmaceutica comprendente microparticelle atte al passaggio transmucosale ed al superamento della barriera
IT1303787B1 (it) 1998-11-25 2001-02-23 Maria Rosa Gasco "nanosfere lipidiche solide atte ad una rapida internalizzazione nellecellule"
CA2395132A1 (en) * 2000-01-05 2001-07-12 Imarx Therapeutics, Inc. Pharmaceutical formulations for the delivery of drugs having low aqueous solubility
US7153525B1 (en) 2000-03-22 2006-12-26 The University Of Kentucky Research Foundation Microemulsions as precursors to solid nanoparticles
US20030096013A1 (en) * 2000-12-22 2003-05-22 Jane Werling Preparation of submicron sized particles with polymorph control
US20040256749A1 (en) * 2000-12-22 2004-12-23 Mahesh Chaubal Process for production of essentially solvent-free small particles
US6884436B2 (en) 2000-12-22 2005-04-26 Baxter International Inc. Method for preparing submicron particle suspensions
US7037528B2 (en) 2000-12-22 2006-05-02 Baxter International Inc. Microprecipitation method for preparing submicron suspensions
US7193084B2 (en) * 2000-12-22 2007-03-20 Baxter International Inc. Polymorphic form of itraconazole
US6977085B2 (en) 2000-12-22 2005-12-20 Baxter International Inc. Method for preparing submicron suspensions with polymorph control
US20050048126A1 (en) * 2000-12-22 2005-03-03 Barrett Rabinow Formulation to render an antimicrobial drug potent against organisms normally considered to be resistant to the drug
US9700866B2 (en) * 2000-12-22 2017-07-11 Baxter International Inc. Surfactant systems for delivery of organic compounds
US8067032B2 (en) 2000-12-22 2011-11-29 Baxter International Inc. Method for preparing submicron particles of antineoplastic agents
US7033348B2 (en) * 2001-04-10 2006-04-25 The Research Foundation Of The City University Of New York Gelatin based on Power-gel™ as solders for Cr4+laser tissue welding and sealing of lung air leak and fistulas in organs
US20060003012A9 (en) 2001-09-26 2006-01-05 Sean Brynjelsen Preparation of submicron solid particle suspensions by sonication of multiphase systems
BR0212833A (pt) * 2001-09-26 2004-10-13 Baxter Int Preparação de nanopartìculas de tamanho submìcron através de dispersão e de remoção de solvente ou de fase lìquida
US7112340B2 (en) * 2001-10-19 2006-09-26 Baxter International Inc. Compositions of and method for preparing stable particles in a frozen aqueous matrix
ATE505198T1 (de) 2002-02-28 2011-04-15 Heitland & Petre Internat Gmbh Mikro-/nanopartikel aus lipidhaltigen marinen organismen für pharmazie und kosmetik
WO2003077861A2 (en) * 2002-03-13 2003-09-25 Collagenex Pharmaceuticals, Inc. Water-based delivery systems
ITMI20022323A1 (it) * 2002-10-31 2004-05-01 Maria Rosa Gasco Composizioni farmaceutiche atte al trattamento di malattie oftalmiche.
JP2007520555A (ja) * 2004-02-05 2007-07-26 バクスター・インターナショナル・インコーポレイテッド 自己安定化剤の使用により調製された分散剤
US20060280787A1 (en) * 2005-06-14 2006-12-14 Baxter International Inc. Pharmaceutical formulation of the tubulin inhibitor indibulin for oral administration with improved pharmacokinetic properties, and process for the manufacture thereof
EP1906973A2 (en) * 2005-06-14 2008-04-09 Baxter International Inc. Pharmaceutical formulations for minimizing drug-drug interactions
US20070134341A1 (en) * 2005-11-15 2007-06-14 Kipp James E Compositions of lipoxygenase inhibitors
US20070154403A1 (en) * 2006-01-05 2007-07-05 Thomas Skold Oral, Pulmonary and Transmucosal Delivery Composition
WO2008080047A2 (en) * 2006-12-23 2008-07-03 Baxter International Inc. Magnetic separation of fine particles from compositions
US8722736B2 (en) * 2007-05-22 2014-05-13 Baxter International Inc. Multi-dose concentrate esmolol with benzyl alcohol
US8426467B2 (en) * 2007-05-22 2013-04-23 Baxter International Inc. Colored esmolol concentrate
US20080293814A1 (en) * 2007-05-22 2008-11-27 Deepak Tiwari Concentrate esmolol
ITTO20070411A1 (it) * 2007-06-08 2008-12-09 Univ Degli Studi Torino Metodo per la preparazione di micro e nanoparticelle lipidiche solide
US20090061009A1 (en) * 2007-08-29 2009-03-05 Joseph Schwarz Composition and Method of Treatment of Bacterial Infections
DE102008035442A1 (de) 2008-07-26 2010-01-28 Ernst-Moritz-Arndt-Universität Greifswald Zubereitungen aus Artemisia Annua, ihre Umwandlung in Mikro- und Nanopartikel und ihre Verwendung
WO2013105026A1 (en) * 2012-01-09 2013-07-18 Department Of Biotechnology (Dbt) A process for preparing solid lipid sustained release nanoparticles for delivery of vitamins
DE102013224627A1 (de) * 2013-11-29 2015-06-03 Andreas Lauterbach Pharmazeutische Formulierung mit Lipidmikropartikeln und Herstellungsverfahren
EP3148331B1 (en) * 2014-05-30 2020-12-23 OMS Investments, Inc. Methods of making nano-sized water-based dispersion compositions
CN107405305B (zh) 2015-01-20 2020-12-25 泰特拉德姆集团有限责任公司 提供粘膜和皮肤屏障恢复的通用局部药物递送载体和多因子组织保湿剂

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5985354A (en) * 1995-06-07 1999-11-16 Brown University Research Foundation Preparation of multiwall polymeric microcapsules from hydrophilic polymers
IT1240317B (it) * 1990-02-22 1993-12-07 Maria Rosa Gasco Microsfere lipidiche solide a stretto intervallo dimensionale e relativo procedimento di preparazione
US5145684A (en) * 1991-01-25 1992-09-08 Sterling Drug Inc. Surface modified drug nanoparticles
US5250236A (en) * 1991-08-05 1993-10-05 Gasco Maria R Method for producing solid lipid microspheres having a narrow size distribution
CA2091152C (en) * 1993-03-05 2005-05-03 Kirsten Westesen Solid lipid particles, particles of bioactive agents and methods for the manfuacture and use thereof
US5744155A (en) * 1993-08-13 1998-04-28 Friedman; Doron Bioadhesive emulsion preparations for enhanced drug delivery

Also Published As

Publication number Publication date
CA2294172A1 (en) 1998-12-17
DE69812936T2 (de) 2004-01-29
US6238694B1 (en) 2001-05-29
ITMI971385A0 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1997-06-12
DE69812936D1 (de) 2003-05-08
EP0988031A1 (en) 2000-03-29
EP0988031B1 (en) 2003-04-02
ATE235897T1 (de) 2003-04-15
WO1998056362A1 (en) 1998-12-17
AU7915898A (en) 1998-12-30
CA2294172C (en) 2007-01-09
ITMI971385A1 (it) 1998-12-12

Similar Documents

Publication Publication Date Title
IT1292142B1 (it) Composizione farmaceutica in forma di microparticelle lipidiche solide atte alla somministrazione parenterale
DK0857062T3 (da) Fremgangsmåde til fremstilling af multilags, faste lægemiddelformer til peroral eller rektal indgivelse
MX9701342A (es) Formulacion cosolvente de tirilazad para administracion parenteral.
PT1221918E (pt) Administracao de drogas sub-tenon
NO20022058L (no) Farmasöytiske sammensetninger
IS2537B (is) Lyfjablanda til inngjafar um húð
ES2195036T3 (es) Conectores de hidrazona ramificados.
BR0214469A (pt) 17alfa-alquil-17beta-óxi-estratrienos e produtos intermediários para sua preparação, aplicação dos 17alfa-alquil-17beta-óxi-estratrienos para a preparação de medicamentos bem como preparações farmacêuticas
PT840603E (pt) Composicao farmaceutica a base de ester etilico de levo-dopa
DE69231663D1 (de) Konjugate bestehend aus polysaccharid und protein
TR200000369T2 (tr) Romatizmal hastalıkların tedavisinde kullanılmak üzere kombine farmasötik preparatların üretilmesi.
TR199801861T2 (xx) Farmas�tik olarak yararl� bile�imler.
MY113203A (en) Lyophilizate of lipid complex of water insoluble camptothecins
DE60219307D1 (de) Oral anzuwendende arzneizusammensetzung enthaltend ein statinderivat
HUP9801241A2 (hu) Vastagbélbe beadható, azathioprine tartalmú készítmények és eljárás előállításukra
ES2191449T3 (es) Derivados de ciclopentabenzofurano y su uso.
HUP9701660A2 (hu) 10,13,15-trioxa-triciklo[9.2.1.1. 9.6]pentadekanon-származékok, eljárás ezek előállítására, és az e vegyületeket tartalmazó gyógyászati készítmények
NO20031410L (no) Anvendelse av distamycinderivater for fremstilling av medikamenter
BR0108958A (pt) Sistema de liberação controlada, administrado oralmente, para administração diária de ciprofloxacina
EA200501252A1 (ru) Липосомальная композиция, способ ее получения и лекарственное средство на ее основе (варианты)
NO20012518D0 (no) Fremgangsmåte ved fremstilling av legemidler i fast administrasjonsform
ATE296115T1 (de) Ortsspezifische arzneimittel verabreichung
PT1144420E (pt) Fosfatidilinositois sulfatados a sua preparacao e a sua utilizacao
BG105326A (bg) Нови бензоилгуанидинови производни с преимуществени свойства, метод за тяхното получаване и тяхнотоприложение при производството на лекарствени средства
DE50015195D1 (de) Feste paroxetin enthaltende zubereitungen

Legal Events

Date Code Title Description
0001 Granted