IT1264812B1 - Derivati benzossazinonici e benzotiazinonici terapeuticamente attivi - Google Patents

Derivati benzossazinonici e benzotiazinonici terapeuticamente attivi

Info

Publication number
IT1264812B1
IT1264812B1 IT93MI001678A ITMI931678A IT1264812B1 IT 1264812 B1 IT1264812 B1 IT 1264812B1 IT 93MI001678 A IT93MI001678 A IT 93MI001678A IT MI931678 A ITMI931678 A IT MI931678A IT 1264812 B1 IT1264812 B1 IT 1264812B1
Authority
IT
Italy
Prior art keywords
formula
therapeutically active
benzothiazinonic
benzossazinonic
derivatives
Prior art date
Application number
IT93MI001678A
Other languages
English (en)
Italian (it)
Inventor
Silvio Levi
Francesca Benedini
Giorgio Bertolini
Gianni Gromo
Jacques Mizrhai
Alberto Sala
Original Assignee
Italfarmaco Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Italfarmaco Spa filed Critical Italfarmaco Spa
Publication of ITMI931678A0 publication Critical patent/ITMI931678A0/it
Priority to IT93MI001678A priority Critical patent/IT1264812B1/it
Priority to JP7505529A priority patent/JPH09500878A/ja
Priority to PCT/EP1994/002354 priority patent/WO1995004048A1/en
Priority to FI960342A priority patent/FI960342A7/fi
Priority to HU9600165A priority patent/HUT74587A/hu
Priority to EP94924778A priority patent/EP0711286A1/en
Priority to CN94192889A priority patent/CN1128025A/zh
Priority to AU74945/94A priority patent/AU7494594A/en
Priority to CA002168099A priority patent/CA2168099A1/en
Priority to ZA945555A priority patent/ZA945555B/xx
Priority to IL11047394A priority patent/IL110473A0/xx
Priority to TW083106854A priority patent/TW277061B/zh
Publication of ITMI931678A1 publication Critical patent/ITMI931678A1/it
Priority to NO960308A priority patent/NO960308L/no
Application granted granted Critical
Publication of IT1264812B1 publication Critical patent/IT1264812B1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/20—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 4
    • C07D265/22—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/04—1,3-Thiazines; Hydrogenated 1,3-thiazines
    • C07D279/08—1,3-Thiazines; Hydrogenated 1,3-thiazines condensed with carbocyclic rings or ring systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
IT93MI001678A 1993-07-28 1993-07-28 Derivati benzossazinonici e benzotiazinonici terapeuticamente attivi IT1264812B1 (it)

Priority Applications (13)

Application Number Priority Date Filing Date Title
IT93MI001678A IT1264812B1 (it) 1993-07-28 1993-07-28 Derivati benzossazinonici e benzotiazinonici terapeuticamente attivi
CN94192889A CN1128025A (zh) 1993-07-28 1994-07-18 具有治疗活性的苯并噁嗪酮和苯并噻嗪酮
CA002168099A CA2168099A1 (en) 1993-07-28 1994-07-18 Benzoxazinones and benzothiazinones endowed with therapeutic activity
FI960342A FI960342A7 (fi) 1993-07-28 1994-07-18 Bentsoksatsinonit ja bentsotiatsinonit, joilla on terapeuttista aktiiv isuutta
HU9600165A HUT74587A (en) 1993-07-28 1994-07-18 Benzoxazinones and benzothiazinones and pharmaceutical compositions containing them
EP94924778A EP0711286A1 (en) 1993-07-28 1994-07-18 Benzoxazinones and benzothiazinones endowed with therapeutic activity
JP7505529A JPH09500878A (ja) 1993-07-28 1994-07-18 治療活性を有するベンゾキサジノン及びベンゾチアジノン
AU74945/94A AU7494594A (en) 1993-07-28 1994-07-18 Benzoxazinones and benzothiazinones endowed with therapeutic activity
PCT/EP1994/002354 WO1995004048A1 (en) 1993-07-28 1994-07-18 Benzoxazinones and benzothiazinones endowed with therapeutic activity
ZA945555A ZA945555B (en) 1993-07-28 1994-07-27 Benzoxazinones and benzothiazinones with therapeutic activity
IL11047394A IL110473A0 (en) 1993-07-28 1994-07-27 Benzoxazinones and benzothiazinones endowed with therapeutic activity
TW083106854A TW277061B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1993-07-28 1994-07-27
NO960308A NO960308L (no) 1993-07-28 1996-01-25 Terapeutisk aktive benzoksaziner og benzotioanoner

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT93MI001678A IT1264812B1 (it) 1993-07-28 1993-07-28 Derivati benzossazinonici e benzotiazinonici terapeuticamente attivi

Publications (3)

Publication Number Publication Date
ITMI931678A0 ITMI931678A0 (it) 1993-07-28
ITMI931678A1 ITMI931678A1 (it) 1995-01-28
IT1264812B1 true IT1264812B1 (it) 1996-10-10

Family

ID=11366700

Family Applications (1)

Application Number Title Priority Date Filing Date
IT93MI001678A IT1264812B1 (it) 1993-07-28 1993-07-28 Derivati benzossazinonici e benzotiazinonici terapeuticamente attivi

Country Status (13)

Country Link
EP (1) EP0711286A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPH09500878A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CN (1) CN1128025A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU7494594A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA2168099A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FI (1) FI960342A7 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HU (1) HUT74587A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IL (1) IL110473A0 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IT (1) IT1264812B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NO (1) NO960308L (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
TW (1) TW277061B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
WO (1) WO1995004048A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ZA (1) ZA945555B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6509334B1 (en) 1999-05-04 2003-01-21 American Home Products Corporation Cyclocarbamate derivatives as progesterone receptor modulators
CN102367239B (zh) * 2011-07-20 2015-10-28 沈阳药科大学 2-芳基-2,3-二氢-4h-1,3-苯并噻嗪-4-酮衍生物及其用途
JP6132915B2 (ja) * 2012-08-27 2017-05-24 ユニバーシティ オブ テネシー リサーチ ファウンデーション Ｌｐａ２受容体特異的安息香酸誘導体
ITMI20122221A1 (it) 2012-12-21 2014-06-22 C4T S C A R L Nuovi composti del 2,3-diidro-4h-1,3-benzossazin-4-one, metodo per prepararli e forma farmaceutica che li comprende
EA029415B1 (ru) * 2013-12-19 2018-03-30 Джилид Сайэнс, Инк. Производные 2-оксо-3,4-дигидро-2н-бензо[e][1,3]оксазина

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2443M (fr) * 1962-10-30 1964-04-06 Selvi & C Lab Bioterapico Thio-dérivés de benzo-oxazine ayant des propriétés antiphlogistiques, antipyrétiques et analgésiques.
US3459748A (en) * 1967-04-28 1969-08-05 Squibb & Sons Inc Hydroxyalkylene-substituted benzoxazines and benzothiazines
IT1136575B (it) * 1981-04-15 1986-09-03 Coli Farma Lab Esteri del 2-(2-ossietil)-2,3-diidro-h4-1,3-benzossazin-4-one ad attivita' analgesica e procedimento per la loro preparazione
IT1244472B (it) * 1990-12-14 1994-07-15 Italfarmaco Spa Benzossazinoni e benzotiazinoni ad attivita' cardiovascolare
FR2680172B1 (fr) * 1991-08-05 1993-11-19 Fabre Medicament Pierre Nouvelles piperazinylalcoyl-3 dihydro-2,3 4h-benzoxazine-1,3 ones-4 substituees, leur preparation et leur application en therapeutique.
IT1254884B (it) * 1992-04-16 1995-10-11 Italfarmaco Spa Benzossazinoni e benzotiazinoni ad attivita' cardiovascolare

Also Published As

Publication number Publication date
CA2168099A1 (en) 1995-02-09
ITMI931678A0 (it) 1993-07-28
NO960308D0 (no) 1996-01-25
EP0711286A1 (en) 1996-05-15
HU9600165D0 (en) 1996-03-28
FI960342L (fi) 1996-01-25
HUT74587A (en) 1997-01-28
FI960342A0 (fi) 1996-01-25
WO1995004048A1 (en) 1995-02-09
FI960342A7 (fi) 1996-01-25
ZA945555B (en) 1995-03-03
ITMI931678A1 (it) 1995-01-28
JPH09500878A (ja) 1997-01-28
CN1128025A (zh) 1996-07-31
NO960308L (no) 1996-03-13
TW277061B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1996-06-01
IL110473A0 (en) 1994-10-21
AU7494594A (en) 1995-02-28

Similar Documents

Publication Publication Date Title
SE8503922L (sv) Analgetiska 1,2-bensisotiazol-3-ylpiperazin-derivat
NO20013379D0 (no) 4-okso-1,4-dihydro-3-kinolinkarboksamider som antivirusmidler
NO954427L (no) Hiv-proteaseinhibitorer som er anvendbare for behandling av AIDS
AU537414B2 (en) Pyroglutamic acid derivatives
DK0887344T3 (da) Quinoliner og quinazoliner, som er nyttige ved terapi
AU560579B2 (en) N-aromatic-n:-cycloalkylalkanoyl-piperazines
DK0842661T3 (da) Anvendelse af estrogenagonister og -antagonister til fremstilling af et lægemiddel til behandling af atherosclerose, uafhængigt af lipidsænkning
ID26622A (id) Senyawa-senyawa pengganti 2-benzylamino-2-phenyl-acetamide
ATE115136T1 (de) 4-phenylphthalazin-derivate.
FI830831L (fi) Teofyllinyl-alkyl-oxadiazoler, foerfarande foer framstaellning daerav och farmaceutiska kompositioninnehaollande dessa
DK0875506T3 (da) Quinolin- og quinazolin-forbindelser, som er anvendelige til behandling
IT1264812B1 (it) Derivati benzossazinonici e benzotiazinonici terapeuticamente attivi
DK288686A (da) Farmaceutiske praeparater
SE8802412D0 (sv) Thiourea derivatives
DK0506434T3 (da) Thiazolidinon- og oxazolidinon-derivater, fremstilling deraf og deres anvendelse som vasodilaterende midler
ES455741A1 (es) Un procedimiento para la preparacion de nuevos derivados de 1,3-bencenodimetanol.
DE69413281D1 (de) Oral aktive Azolderivate
FI95796C (fi) Menetelmä yleisen kaavan I mukaisten lääkeaineina käyttökelpoisten 2,3-dihydro-4H-1,3-bentsoksatsinon-4-onien ja 2,3-dihydro-4H-bentsotiatsinon-4-onien nitro-oksijohdannaisten valmistamiseksi
NZ247249A (en) Benzoxazinone and benzothiazinone derivatives; medicaments and use
DK0492474T3 (da) 1,3-dioxolanderivater som cholesterol-sænkende midler
DK0469837T3 (da) Anvendelse af en forbindelse til fremstilling af et lægemiddel til sænkning af blodets urinsyreindhold
KR970706280A (ko) 5-HT1A 길항제로서의 비사이클릭 카복스아미드(Bicyclic carboxamides as 5-HT1 antagonists)
DE69016121D1 (de) 2-(2-Vinylpyrrolidinylthio)carbapenem-Derivate.
DK0784973T3 (da) Quinoxalinderivater til behandling af tinnitus
IT1270694B (it) Derivati fluorenil-idrossammici ad attivita' immunosoppressiva ed antiinfiammatoria

Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970729