IT1247138B - Composizione farmaceutica idrofila contenente ketoprofene sale di lisina per uso topico. - Google Patents
Composizione farmaceutica idrofila contenente ketoprofene sale di lisina per uso topico.Info
- Publication number
- IT1247138B IT1247138B ITMI910584A ITMI910584A IT1247138B IT 1247138 B IT1247138 B IT 1247138B IT MI910584 A ITMI910584 A IT MI910584A IT MI910584 A ITMI910584 A IT MI910584A IT 1247138 B IT1247138 B IT 1247138B
- Authority
- IT
- Italy
- Prior art keywords
- pharmaceutical composition
- lysine salt
- ketoprofene
- hydrophile
- composition containing
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 230000000699 topical effect Effects 0.000 title abstract 2
- 229960000991 ketoprofen Drugs 0.000 title 1
- 208000025747 Rheumatic disease Diseases 0.000 abstract 1
- VHIORVCHBUEWEP-ZSCHJXSPSA-N [(5s)-5-amino-5-carboxypentyl]azanium;2-(3-benzoylphenyl)propanoate Chemical compound NCCCC[C@H](N)C(O)=O.OC(=O)C(C)C1=CC=CC(C(=O)C=2C=CC=CC=2)=C1 VHIORVCHBUEWEP-ZSCHJXSPSA-N 0.000 abstract 1
- 238000010521 absorption reaction Methods 0.000 abstract 1
- 239000006260 foam Substances 0.000 abstract 1
- 230000002757 inflammatory effect Effects 0.000 abstract 1
- 210000001503 joint Anatomy 0.000 abstract 1
- 210000003041 ligament Anatomy 0.000 abstract 1
- 210000003205 muscle Anatomy 0.000 abstract 1
- 230000000552 rheumatic effect Effects 0.000 abstract 1
- 210000002435 tendon Anatomy 0.000 abstract 1
- 230000000472 traumatic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
- A61K9/122—Foams; Dry foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Abstract
Viene descritta una composizione farmaceutica idrofila sotto forma di schiuma contenente come principio attivo Ketoprofene sale di lisina alla concentrazione compresa tra 10 e 20% p/volume di soluzione che permette, per trattamento topico, l'assorbimento massimo del principio attivo.La schiuma viene utilmente impiegata nel trattamento locale di stati dolorosi e flogistici di natura reumatica o traumatica delle articolazioni, dei muscoli, dei tendini e dei legamenti.
Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI910584A IT1247138B (it) | 1991-03-06 | 1991-03-06 | Composizione farmaceutica idrofila contenente ketoprofene sale di lisina per uso topico. |
EP92103688A EP0502502B1 (en) | 1991-03-06 | 1992-03-04 | Topical composition containing ketoprofen lysinate |
DE69211036T DE69211036T2 (de) | 1991-03-06 | 1992-03-04 | Topisch anzuwendendes Arzneimittel enthaltend Ketoprofenlysinat |
DK92103688.5T DK0502502T3 (da) | 1991-03-06 | 1992-03-04 | Topisk præparat indeholdende ketoprofenlysinat |
ES92103688T ES2089260T3 (es) | 1991-03-06 | 1992-03-04 | Composicion topica que contiene lisinato de cetoprofeno. |
AT92103688T ATE138569T1 (de) | 1991-03-06 | 1992-03-04 | Topisch anzuwendendes arzneimittel enthaltend ketoprofenlysinat |
JP04814892A JP3356455B2 (ja) | 1991-03-06 | 1992-03-05 | ケトプロフェンリジン塩を含む局所用親水性医薬組成物 |
US08/199,972 US5614171A (en) | 1991-03-06 | 1994-02-22 | Hydrophilic pharmaceutical composition containing ketoprofen lysine salt for topical use |
US08/622,362 US5618516A (en) | 1991-03-06 | 1996-03-25 | Method of reducing subcutaneous inflammation by the topical application of a hydrophilic pharmaceutical composition containing ketoprofen lysine salt |
GR960402194T GR3020832T3 (en) | 1991-03-06 | 1996-08-21 | Topical composition containing ketoprofen lysinate |
HK98104272A HK1005167A1 (en) | 1991-03-06 | 1998-05-18 | Topical composition containing ketoprofen lysinate |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI910584A IT1247138B (it) | 1991-03-06 | 1991-03-06 | Composizione farmaceutica idrofila contenente ketoprofene sale di lisina per uso topico. |
Publications (3)
Publication Number | Publication Date |
---|---|
ITMI910584A0 ITMI910584A0 (it) | 1991-03-06 |
ITMI910584A1 ITMI910584A1 (it) | 1992-09-06 |
IT1247138B true IT1247138B (it) | 1994-12-12 |
Family
ID=11358896
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ITMI910584A IT1247138B (it) | 1991-03-06 | 1991-03-06 | Composizione farmaceutica idrofila contenente ketoprofene sale di lisina per uso topico. |
Country Status (10)
Country | Link |
---|---|
US (2) | US5614171A (it) |
EP (1) | EP0502502B1 (it) |
JP (1) | JP3356455B2 (it) |
AT (1) | ATE138569T1 (it) |
DE (1) | DE69211036T2 (it) |
DK (1) | DK0502502T3 (it) |
ES (1) | ES2089260T3 (it) |
GR (1) | GR3020832T3 (it) |
HK (1) | HK1005167A1 (it) |
IT (1) | IT1247138B (it) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU6290594A (en) * | 1993-03-09 | 1994-09-26 | Dompe Farmaceutici S.P.A. | Salts of 2-(3-benzoylphenyl)propionic acid with achiral and chiral organic bases and pharmaceutical compositions thereof |
US8512718B2 (en) | 2000-07-03 | 2013-08-20 | Foamix Ltd. | Pharmaceutical composition for topical application |
FR2814954B1 (fr) | 2000-10-09 | 2003-02-07 | Menarini France | Nouvelles compositions pharmaceutiques sous forme de pulverisation et les formes ainsi realises |
US7244703B2 (en) * | 2001-06-22 | 2007-07-17 | Bentley Pharmaceuticals, Inc. | Pharmaceutical compositions and methods for peptide treatment |
ES2189682B1 (es) * | 2001-12-11 | 2004-04-01 | Laboratorios Del Dr. Esteve, S.A. | Preparacion bebible que comprende ketoprofeno y su empleo en el tratamiento de procesos que cursan con fiebre, inflamacion y/o dolor, en un colectivo de animales, de forma simultanea. |
IL152486A0 (en) | 2002-10-25 | 2003-05-29 | Meir Eini | Alcohol-free cosmetic and pharmaceutical foam carrier |
WO2004037225A2 (en) | 2002-10-25 | 2004-05-06 | Foamix Ltd. | Cosmetic and pharmaceutical foam |
US20080138296A1 (en) | 2002-10-25 | 2008-06-12 | Foamix Ltd. | Foam prepared from nanoemulsions and uses |
US7820145B2 (en) * | 2003-08-04 | 2010-10-26 | Foamix Ltd. | Oleaginous pharmaceutical and cosmetic foam |
US8119150B2 (en) | 2002-10-25 | 2012-02-21 | Foamix Ltd. | Non-flammable insecticide composition and uses thereof |
US8119109B2 (en) | 2002-10-25 | 2012-02-21 | Foamix Ltd. | Foamable compositions, kits and methods for hyperhidrosis |
US9211259B2 (en) | 2002-11-29 | 2015-12-15 | Foamix Pharmaceuticals Ltd. | Antibiotic kit and composition and uses thereof |
US7704518B2 (en) * | 2003-08-04 | 2010-04-27 | Foamix, Ltd. | Foamable vehicle and pharmaceutical compositions thereof |
US8900554B2 (en) | 2002-10-25 | 2014-12-02 | Foamix Pharmaceuticals Ltd. | Foamable composition and uses thereof |
US7700076B2 (en) | 2002-10-25 | 2010-04-20 | Foamix, Ltd. | Penetrating pharmaceutical foam |
US8486376B2 (en) | 2002-10-25 | 2013-07-16 | Foamix Ltd. | Moisturizing foam containing lanolin |
US9668972B2 (en) * | 2002-10-25 | 2017-06-06 | Foamix Pharmaceuticals Ltd. | Nonsteroidal immunomodulating kit and composition and uses thereof |
US10117812B2 (en) | 2002-10-25 | 2018-11-06 | Foamix Pharmaceuticals Ltd. | Foamable composition combining a polar solvent and a hydrophobic carrier |
US20060233721A1 (en) * | 2002-10-25 | 2006-10-19 | Foamix Ltd. | Foam containing unique oil globules |
US9265725B2 (en) | 2002-10-25 | 2016-02-23 | Foamix Pharmaceuticals Ltd. | Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof |
US7575739B2 (en) | 2003-04-28 | 2009-08-18 | Foamix Ltd. | Foamable iodine composition |
US8795693B2 (en) | 2003-08-04 | 2014-08-05 | Foamix Ltd. | Compositions with modulating agents |
US8486374B2 (en) | 2003-08-04 | 2013-07-16 | Foamix Ltd. | Hydrophilic, non-aqueous pharmaceutical carriers and compositions and uses |
DE602004028284D1 (de) * | 2003-12-08 | 2010-09-02 | Cpex Pharmaceuticals Inc | Pharmazeutische zusammensetzungen und verfahren für die insulinbehandlung |
JP2005310310A (ja) * | 2004-04-23 | 2005-11-04 | Sanyo Electric Co Ltd | トラッキングバランス調整装置 |
JP2008540508A (ja) * | 2005-05-09 | 2008-11-20 | フォーミックス エルティーディー. | 起泡性ビヒクル及びその医薬組成物 |
US20080152596A1 (en) * | 2005-07-19 | 2008-06-26 | Foamix Ltd. | Polypropylene glycol foamable vehicle and pharmaceutical compositions thereof |
WO2009007785A2 (en) * | 2006-11-14 | 2009-01-15 | Foamix Ltd. | Stable non-alcoholic foamable pharmaceutical emulsion compositions with an unctuous emollient and their uses |
US8010188B2 (en) | 2006-11-14 | 2011-08-30 | Kagoshima University | Drug injecting device |
US20080260655A1 (en) * | 2006-11-14 | 2008-10-23 | Dov Tamarkin | Substantially non-aqueous foamable petrolatum based pharmaceutical and cosmetic compositions and their uses |
PL1986473T3 (pl) * | 2007-04-03 | 2017-07-31 | Tsinghua University | Organiczne urządzenie elektroluminescencyjne |
US8636982B2 (en) | 2007-08-07 | 2014-01-28 | Foamix Ltd. | Wax foamable vehicle and pharmaceutical compositions thereof |
US9439857B2 (en) | 2007-11-30 | 2016-09-13 | Foamix Pharmaceuticals Ltd. | Foam containing benzoyl peroxide |
WO2009090495A2 (en) | 2007-12-07 | 2009-07-23 | Foamix Ltd. | Oil and liquid silicone foamable carriers and formulations |
US8518376B2 (en) | 2007-12-07 | 2013-08-27 | Foamix Ltd. | Oil-based foamable carriers and formulations |
EP2242476A2 (en) | 2008-01-14 | 2010-10-27 | Foamix Ltd. | Poloxamer foamable pharmaceutical compositions with active agents and/or therapeutic cells and uses |
JP4879928B2 (ja) * | 2008-03-25 | 2012-02-22 | 帝國製薬株式会社 | ケトプロフェンリジン塩を含有する水性貼付剤 |
WO2010125470A2 (en) | 2009-04-28 | 2010-11-04 | Foamix Ltd. | Foamable vehicle and pharmaceutical compositions comprising aprotic polar solvents and uses thereof |
CA2769677A1 (en) | 2009-07-29 | 2011-02-03 | Foamix Ltd. | Non surface active agent non polymeric agent hydro-alcoholic foamable compositions, breakable foams and their uses |
CA2769625C (en) | 2009-07-29 | 2017-04-11 | Foamix Ltd. | Non surfactant hydro-alcoholic foamable compositions, breakable foams and their uses |
US9849142B2 (en) | 2009-10-02 | 2017-12-26 | Foamix Pharmaceuticals Ltd. | Methods for accelerated return of skin integrity and for the treatment of impetigo |
CN102686205A (zh) | 2009-10-02 | 2012-09-19 | 弗艾米克斯有限公司 | 局部四环素组合物 |
US8174881B2 (en) | 2009-11-24 | 2012-05-08 | Micron Technology, Inc. | Techniques for reducing disturbance in a semiconductor device |
US9012402B1 (en) | 2014-06-11 | 2015-04-21 | James Blanchard | Gel for topical delivery of NSAIDs to provide relief of musculoskeletal pain and methods for its preparation |
US10398641B2 (en) | 2016-09-08 | 2019-09-03 | Foamix Pharmaceuticals Ltd. | Compositions and methods for treating rosacea and acne |
US10821075B1 (en) | 2017-07-12 | 2020-11-03 | James Blanchard | Compositions for topical application of a medicaments onto a mammalian body surface |
WO2019104213A1 (en) * | 2017-11-22 | 2019-05-31 | Board Of Regents, The University Of Texas System | Antibiofilm formulations and use thereof |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4282216A (en) * | 1977-04-20 | 1981-08-04 | Johnson & Johnson | Topical anti-inflammatory drug therapy |
IT1104556B (it) * | 1977-05-12 | 1985-10-21 | Medea Res Srl | Sale di lisina dell'acido meta-benzoil-idratropico,processo per la sua preparazione e composizione farmaceutiche che lo contengono |
JPS5810517A (ja) * | 1981-07-13 | 1983-01-21 | Santen Pharmaceut Co Ltd | 非ステロイド系消炎剤を主成分とする点眼剤 |
JPS59190912A (ja) * | 1983-04-15 | 1984-10-29 | Hokuriku Seiyaku Co Ltd | 消炎鎮痛クリ−ム剤 |
DE3328401A1 (de) * | 1983-08-05 | 1985-02-21 | Merckle GmbH, 7902 Blaubeuren | Injizierbare loesung zur behandlung von entzuendungen |
DE3522550A1 (de) * | 1985-06-24 | 1987-01-02 | Klinge Co Chem Pharm Fab | Aufspruehbare pharmazeutische zubereitung fuer die topische anwendung |
US4837026A (en) * | 1985-10-03 | 1989-06-06 | Rajakhyaksha Vithal J | Transdermal and systemic preparation and method |
JPH0778019B2 (ja) * | 1986-11-08 | 1995-08-23 | 久光製薬株式会社 | 泡状エアゾ−ル消炎鎮痛製剤 |
US4954332A (en) * | 1987-10-22 | 1990-09-04 | The Procter & Gamble Company | Photoprotection compositions comprising tocopherol sorbate and an anti-inflammatory agent |
US5158761A (en) * | 1989-04-05 | 1992-10-27 | Toko Yakuhin Kogyo Kabushiki Kaisha | Spray gel base and spray gel preparation using thereof |
AU629670B2 (en) * | 1989-07-28 | 1992-10-08 | Hisamitsu Pharmaceutical Co., Inc. | Foamed aerosol preparation |
FR2660555B1 (fr) * | 1990-04-06 | 1994-09-16 | Rhone Poulenc Sante | Gelule huileuse de ketoprofene. |
-
1991
- 1991-03-06 IT ITMI910584A patent/IT1247138B/it active IP Right Grant
-
1992
- 1992-03-04 EP EP92103688A patent/EP0502502B1/en not_active Expired - Lifetime
- 1992-03-04 ES ES92103688T patent/ES2089260T3/es not_active Expired - Lifetime
- 1992-03-04 DE DE69211036T patent/DE69211036T2/de not_active Expired - Lifetime
- 1992-03-04 DK DK92103688.5T patent/DK0502502T3/da active
- 1992-03-04 AT AT92103688T patent/ATE138569T1/de active
- 1992-03-05 JP JP04814892A patent/JP3356455B2/ja not_active Expired - Fee Related
-
1994
- 1994-02-22 US US08/199,972 patent/US5614171A/en not_active Expired - Lifetime
-
1996
- 1996-03-25 US US08/622,362 patent/US5618516A/en not_active Expired - Lifetime
- 1996-08-21 GR GR960402194T patent/GR3020832T3/el unknown
-
1998
- 1998-05-18 HK HK98104272A patent/HK1005167A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DK0502502T3 (da) | 1996-10-21 |
US5618516A (en) | 1997-04-08 |
US5614171A (en) | 1997-03-25 |
ATE138569T1 (de) | 1996-06-15 |
ITMI910584A0 (it) | 1991-03-06 |
HK1005167A1 (en) | 1998-12-24 |
DE69211036D1 (de) | 1996-07-04 |
EP0502502A1 (en) | 1992-09-09 |
JP3356455B2 (ja) | 2002-12-16 |
JPH0578241A (ja) | 1993-03-30 |
EP0502502B1 (en) | 1996-05-29 |
ITMI910584A1 (it) | 1992-09-06 |
ES2089260T3 (es) | 1996-10-01 |
DE69211036T2 (de) | 1997-01-16 |
GR3020832T3 (en) | 1996-11-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
0001 | Granted | ||
TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19950323 |