IT1238080B - Combinazione di un inibitore della hmg coa reduttasi e di un inibitoredella squalene sintetasi per fare abbassare il colesterolo nel siero - Google Patents

Combinazione di un inibitore della hmg coa reduttasi e di un inibitoredella squalene sintetasi per fare abbassare il colesterolo nel siero

Info

Publication number
IT1238080B
IT1238080B IT01922090A IT1922090A IT1238080B IT 1238080 B IT1238080 B IT 1238080B IT 01922090 A IT01922090 A IT 01922090A IT 1922090 A IT1922090 A IT 1922090A IT 1238080 B IT1238080 B IT 1238080B
Authority
IT
Italy
Prior art keywords
inhibitor
synthetase
combination
coa reductase
serum cholesterol
Prior art date
Application number
IT01922090A
Other languages
English (en)
Other versions
IT9019220A0 (it
IT9019220A1 (it
Original Assignee
Squibb & Sons Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc
Publication of IT9019220A0 publication Critical patent/IT9019220A0/it
Publication of IT9019220A1 publication Critical patent/IT9019220A1/it
Application granted granted Critical
Publication of IT1238080B publication Critical patent/IT1238080B/it

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IT01922090A 1989-02-01 1990-02-01 Combinazione di un inibitore della hmg coa reduttasi e di un inibitoredella squalene sintetasi per fare abbassare il colesterolo nel siero IT1238080B (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US30534389A 1989-02-01 1989-02-01

Publications (3)

Publication Number Publication Date
IT9019220A0 IT9019220A0 (it) 1990-02-01
IT9019220A1 IT9019220A1 (it) 1990-08-02
IT1238080B true IT1238080B (it) 1993-07-05

Family

ID=23180410

Family Applications (1)

Application Number Title Priority Date Filing Date
IT01922090A IT1238080B (it) 1989-02-01 1990-02-01 Combinazione di un inibitore della hmg coa reduttasi e di un inibitoredella squalene sintetasi per fare abbassare il colesterolo nel siero

Country Status (6)

Country Link
JP (1) JPH02235821A (it)
CA (1) CA2007643A1 (it)
DE (1) DE4002836C2 (it)
FR (1) FR2642311B1 (it)
GB (1) GB2227662B (it)
IT (1) IT1238080B (it)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05239075A (ja) * 1991-08-27 1993-09-17 Eisai Co Ltd 含リンイソプレノイド誘導体
US5719303A (en) 1993-03-08 1998-02-17 Eisai Co., Ltd. Phosphonic acid derivatives
WO2000067737A2 (en) * 1999-05-07 2000-11-16 The Brigham And Women's Hospital, Inc. USE OF HMGCoA REDUCTASE INHIBITORS IN THE PREVENTION OF DISEASES WHOSE PATHOGENESIS IS DEPENDENT ON NEOVASCULARIZATION
DE10038043B4 (de) * 2000-08-02 2006-09-07 Walter, Michael, Dr. Phamakologisch wirksame Substanz zur Behandlung kardiovaskulärer Erkrankungen
AUPR549901A0 (en) 2001-06-06 2001-07-12 Vital Health Sciences Pty Ltd Topical formulation containing tocopheryl phosphates
CN1547475B (zh) 2001-07-27 2010-12-15 生命健康科学有限公司 含电子转移试剂的磷酸酯衍生物的皮肤制剂
AU2002950713A0 (en) 2002-08-09 2002-09-12 Vital Health Sciences Pty Ltd Carrier
AU2003901812A0 (en) * 2003-04-15 2003-05-01 Vital Health Sciences Pty Ltd Phosphates of secondary alcohols
ATE495730T1 (de) 2004-03-03 2011-02-15 Vital Health Sciences Pty Ltd Alkaloid-formulierungen
TW200714280A (en) * 2005-06-01 2007-04-16 Takeda Pharmaceuticals Co Novel method of treating hyperlipidemia
MX2007015949A (es) 2005-06-17 2008-03-07 Vital Health Sciences Pty Ltd Un vehiculo que comprende uno o mas derivados de fosfato de di- y/o mono-(agentes de transferencia de electrones) o complejos de los mismos.
EP2531047A4 (en) 2010-02-05 2014-03-19 Phosphagenics Ltd CARRIER WITH AN UNINUTRALIZED TOCOPHERYL PHOSPHATE
CA2794734C (en) 2010-03-30 2017-12-12 Phosphagenics Limited Transdermal delivery patch
US9561243B2 (en) 2011-03-15 2017-02-07 Phosphagenics Limited Composition comprising non-neutralised tocol phosphate and a vitamin A compound
CN108601732A (zh) 2015-12-09 2018-09-28 磷肌酸有限公司 药物制剂
WO2018112512A1 (en) 2016-12-21 2018-06-28 Phosphagenics Limited Process

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU610591B2 (en) * 1987-05-22 1991-05-23 E.R. Squibb & Sons, Inc. Phosphorus-containing hmg-coa reductase inhibitors, new intermediates and method
US4871721A (en) * 1988-01-11 1989-10-03 E. R. Squibb & Sons, Inc. Phosphorus-containing squalene synthetase inhibitors
CA2003478A1 (en) * 1988-12-12 1990-06-12 Leonard G. Dennick Combination of an hmg coa reductase inhibitor and other type of serum cholesterol reducing agent and method for lowering serum cholesterol using such combination

Also Published As

Publication number Publication date
CA2007643A1 (en) 1990-08-01
GB2227662A (en) 1990-08-08
IT9019220A0 (it) 1990-02-01
FR2642311A1 (fr) 1990-08-03
DE4002836C2 (de) 1998-08-27
GB9002016D0 (en) 1990-03-28
DE4002836A1 (de) 1990-08-02
GB2227662B (en) 1993-03-17
IT9019220A1 (it) 1990-08-02
FR2642311B1 (fr) 1991-10-25
JPH02235821A (ja) 1990-09-18

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Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970227