GB2227662B - Lowering serum cholesterol using a hmg coa reductase inhibitor and a squaline synthetase inhibitor - Google Patents

Lowering serum cholesterol using a hmg coa reductase inhibitor and a squaline synthetase inhibitor

Info

Publication number
GB2227662B
GB2227662B GB9002016A GB9002016A GB2227662B GB 2227662 B GB2227662 B GB 2227662B GB 9002016 A GB9002016 A GB 9002016A GB 9002016 A GB9002016 A GB 9002016A GB 2227662 B GB2227662 B GB 2227662B
Authority
GB
United Kingdom
Prior art keywords
inhibitor
squaline
coa reductase
serum cholesterol
hmg coa
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
GB9002016A
Other versions
GB2227662A (en
GB9002016D0 (en
Inventor
Donald S Karanewsky
Scott Adams Biller
Eric M Gordon
William A Scott
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Publication of GB9002016D0 publication Critical patent/GB9002016D0/en
Publication of GB2227662A publication Critical patent/GB2227662A/en
Application granted granted Critical
Publication of GB2227662B publication Critical patent/GB2227662B/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
GB9002016A 1989-02-01 1990-01-30 Lowering serum cholesterol using a hmg coa reductase inhibitor and a squaline synthetase inhibitor Expired - Fee Related GB2227662B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US30534389A 1989-02-01 1989-02-01

Publications (3)

Publication Number Publication Date
GB9002016D0 GB9002016D0 (en) 1990-03-28
GB2227662A GB2227662A (en) 1990-08-08
GB2227662B true GB2227662B (en) 1993-03-17

Family

ID=23180410

Family Applications (1)

Application Number Title Priority Date Filing Date
GB9002016A Expired - Fee Related GB2227662B (en) 1989-02-01 1990-01-30 Lowering serum cholesterol using a hmg coa reductase inhibitor and a squaline synthetase inhibitor

Country Status (6)

Country Link
JP (1) JPH02235821A (en)
CA (1) CA2007643A1 (en)
DE (1) DE4002836C2 (en)
FR (1) FR2642311B1 (en)
GB (1) GB2227662B (en)
IT (1) IT1238080B (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7648710B2 (en) 2001-06-06 2010-01-19 Vital Health Sciences Pty Ltd. Formulation containing phosphate derivatives of electron transfer agents
US8008345B2 (en) 2001-07-27 2011-08-30 Vital Health Sciences Pty. Ltd. Dermal therapy using phosphate derivatives of electron transfer agents
US8529947B2 (en) 2004-03-03 2013-09-10 Vital Health Sciences Pty. Ltd. Alkaloid formulations
US8652511B2 (en) 2010-03-30 2014-02-18 Phosphagenics Limited Transdermal delivery patch
US8841342B2 (en) 2002-08-09 2014-09-23 Vital Health Sciences Pty. Ltd. Carrier
US9168216B2 (en) 2005-06-17 2015-10-27 Vital Health Sciences Pty. Ltd. Carrier comprising one or more di and/or mono-(electron transfer agent) phosphate derivatives or complexes thereof
US9561243B2 (en) 2011-03-15 2017-02-07 Phosphagenics Limited Composition comprising non-neutralised tocol phosphate and a vitamin A compound

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05239075A (en) * 1991-08-27 1993-09-17 Eisai Co Ltd Phosphorus-containing isoprenoid derivative
US5719303A (en) 1993-03-08 1998-02-17 Eisai Co., Ltd. Phosphonic acid derivatives
WO2000067737A2 (en) * 1999-05-07 2000-11-16 The Brigham And Women's Hospital, Inc. USE OF HMGCoA REDUCTASE INHIBITORS IN THE PREVENTION OF DISEASES WHOSE PATHOGENESIS IS DEPENDENT ON NEOVASCULARIZATION
DE10038043B4 (en) * 2000-08-02 2006-09-07 Walter, Michael, Dr. Phamacologically active substance for the treatment of cardiovascular diseases
AU2003901812A0 (en) * 2003-04-15 2003-05-01 Vital Health Sciences Pty Ltd Phosphates of secondary alcohols
TW200714280A (en) * 2005-06-01 2007-04-16 Takeda Pharmaceuticals Co Novel method of treating hyperlipidemia
EP2531047A4 (en) 2010-02-05 2014-03-19 Phosphagenics Ltd Carrier comprising non-neutralised tocopheryl phosphate
CN108601732A (en) 2015-12-09 2018-09-28 磷肌酸有限公司 pharmaceutical preparation
WO2018112512A1 (en) 2016-12-21 2018-06-28 Phosphagenics Limited Process

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0373507A1 (en) * 1988-12-12 1990-06-20 E.R. SQUIBB & SONS, INC. Combination of an HMG CoA reductase inhibitor and other type of serum cholesterol reducing agent and method for lowering serum cholesterol using such combination

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU610591B2 (en) * 1987-05-22 1991-05-23 E.R. Squibb & Sons, Inc. Phosphorus-containing hmg-coa reductase inhibitors, new intermediates and method
US4871721A (en) * 1988-01-11 1989-10-03 E. R. Squibb & Sons, Inc. Phosphorus-containing squalene synthetase inhibitors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0373507A1 (en) * 1988-12-12 1990-06-20 E.R. SQUIBB & SONS, INC. Combination of an HMG CoA reductase inhibitor and other type of serum cholesterol reducing agent and method for lowering serum cholesterol using such combination

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8173145B2 (en) 2000-11-14 2012-05-08 Vital Health Sciences Pty. Ltd. Formulation containing phosphate derivatives of electron transfer agents
US7648710B2 (en) 2001-06-06 2010-01-19 Vital Health Sciences Pty Ltd. Formulation containing phosphate derivatives of electron transfer agents
US8008345B2 (en) 2001-07-27 2011-08-30 Vital Health Sciences Pty. Ltd. Dermal therapy using phosphate derivatives of electron transfer agents
US8841342B2 (en) 2002-08-09 2014-09-23 Vital Health Sciences Pty. Ltd. Carrier
US8529947B2 (en) 2004-03-03 2013-09-10 Vital Health Sciences Pty. Ltd. Alkaloid formulations
US9168216B2 (en) 2005-06-17 2015-10-27 Vital Health Sciences Pty. Ltd. Carrier comprising one or more di and/or mono-(electron transfer agent) phosphate derivatives or complexes thereof
US8652511B2 (en) 2010-03-30 2014-02-18 Phosphagenics Limited Transdermal delivery patch
US9314527B2 (en) 2010-03-30 2016-04-19 Phosphagenics Limited Transdermal delivery patch
US9561243B2 (en) 2011-03-15 2017-02-07 Phosphagenics Limited Composition comprising non-neutralised tocol phosphate and a vitamin A compound

Also Published As

Publication number Publication date
CA2007643A1 (en) 1990-08-01
GB2227662A (en) 1990-08-08
IT9019220A0 (en) 1990-02-01
FR2642311A1 (en) 1990-08-03
DE4002836C2 (en) 1998-08-27
GB9002016D0 (en) 1990-03-28
DE4002836A1 (en) 1990-08-02
IT9019220A1 (en) 1990-08-02
IT1238080B (en) 1993-07-05
FR2642311B1 (en) 1991-10-25
JPH02235821A (en) 1990-09-18

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 20050130