IT1199374B - Processo per la preparazione di pirido-imidazo-rifamicine - Google Patents

Processo per la preparazione di pirido-imidazo-rifamicine

Info

Publication number
IT1199374B
IT1199374B IT03463/84A IT346384A IT1199374B IT 1199374 B IT1199374 B IT 1199374B IT 03463/84 A IT03463/84 A IT 03463/84A IT 346384 A IT346384 A IT 346384A IT 1199374 B IT1199374 B IT 1199374B
Authority
IT
Italy
Prior art keywords
rifamicine
pirido
imidazo
preparation
Prior art date
Application number
IT03463/84A
Other languages
English (en)
Italian (it)
Other versions
IT8403463A0 (it
Inventor
Cannata Vincenzo
Franco Tomagnone G
Piani Silvano
Marchi Egidio
Original Assignee
Alfa Farmaceutici Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alfa Farmaceutici Spa filed Critical Alfa Farmaceutici Spa
Publication of IT8403463A0 publication Critical patent/IT8403463A0/it
Priority to IT03463/84A priority Critical patent/IT1199374B/it
Priority to EP85104790A priority patent/EP0161534B1/en
Priority to ZA852971A priority patent/ZA852971B/xx
Priority to AT85104790T priority patent/ATE46512T1/de
Priority to DE8585104790T priority patent/DE3573120D1/de
Priority to PH32186A priority patent/PH22007A/en
Priority to US06/727,521 priority patent/US4557866A/en
Priority to CA000480321A priority patent/CA1215708A/en
Priority to PT80446A priority patent/PT80446B/pt
Priority to GR851144A priority patent/GR851144B/el
Priority to JP60102528A priority patent/JPS60252483A/ja
Priority to DK214685A priority patent/DK162647C/da
Priority to ES543115A priority patent/ES8603489A1/es
Priority to NO851921A priority patent/NO164242C/no
Priority to FI851907A priority patent/FI81101C/fi
Priority to IE119185A priority patent/IE58392B1/en
Priority to AU42515/85A priority patent/AU568934B2/en
Priority to AR85300385A priority patent/AR241913A1/es
Application granted granted Critical
Publication of IT1199374B publication Critical patent/IT1199374B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IT03463/84A 1984-05-15 1984-05-15 Processo per la preparazione di pirido-imidazo-rifamicine IT1199374B (it)

Priority Applications (18)

Application Number Priority Date Filing Date Title
IT03463/84A IT1199374B (it) 1984-05-15 1984-05-15 Processo per la preparazione di pirido-imidazo-rifamicine
EP85104790A EP0161534B1 (en) 1984-05-15 1985-04-19 New process for the synthesis of pyrido-imidazo-refamycins
ZA852971A ZA852971B (en) 1984-05-15 1985-04-19 New process for the synthesis of pyrido-imidazo rifamycins
AT85104790T ATE46512T1 (de) 1984-05-15 1985-04-19 Verfahren zur synthese von pyridoimidazorifamycin.
DE8585104790T DE3573120D1 (en) 1984-05-15 1985-04-19 New process for the synthesis of pyrido-imidazo-refamycins
PH32186A PH22007A (en) 1984-05-15 1985-04-25 A new process for the synthesis of pyridoimidazorifaycins
US06/727,521 US4557866A (en) 1984-05-15 1985-04-26 Process for the synthesis of pyrido-imidazo rifamycins
CA000480321A CA1215708A (en) 1984-05-15 1985-04-29 New process for the synthesis of pyrido-imidazo- rifamycins
PT80446A PT80446B (pt) 1984-05-15 1985-05-13 Novo processo para a sintese de pirido-imidazo-rifamicinas
GR851144A GR851144B (esLanguage) 1984-05-15 1985-05-13
JP60102528A JPS60252483A (ja) 1984-05-15 1985-05-14 ピリド‐イミダゾリフアマイシンの新規製造法
DK214685A DK162647C (da) 1984-05-15 1985-05-14 Fremgangsmaade til fremstilling af pyrido-imidazorifamyciner
ES543115A ES8603489A1 (es) 1984-05-15 1985-05-14 Un nuevo procedimiento para la preparacion de pirido-imidazorifamicinas
NO851921A NO164242C (no) 1984-05-15 1985-05-14 Fremgangsmaate for fremstilling av pyrido-imidazo-rifamycin-derivater.
FI851907A FI81101C (fi) 1984-05-15 1985-05-14 Nytt foerfarande foer syntetisering av pyridoimidazorifamyciner.
IE119185A IE58392B1 (en) 1984-05-15 1985-05-14 A new process for the synthesis of pyrido-imidazo-rifamycins
AU42515/85A AU568934B2 (en) 1984-05-15 1985-05-15 New process for the synthesis of pyrido-imidazo-rifamycins
AR85300385A AR241913A1 (es) 1984-05-15 1985-05-15 Un nuevo procedimiento para la preparacion de rifamicinas pirido-imidazo.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT03463/84A IT1199374B (it) 1984-05-15 1984-05-15 Processo per la preparazione di pirido-imidazo-rifamicine

Publications (2)

Publication Number Publication Date
IT8403463A0 IT8403463A0 (it) 1984-05-15
IT1199374B true IT1199374B (it) 1988-12-30

Family

ID=11107845

Family Applications (1)

Application Number Title Priority Date Filing Date
IT03463/84A IT1199374B (it) 1984-05-15 1984-05-15 Processo per la preparazione di pirido-imidazo-rifamicine

Country Status (18)

Country Link
US (1) US4557866A (esLanguage)
EP (1) EP0161534B1 (esLanguage)
JP (1) JPS60252483A (esLanguage)
AR (1) AR241913A1 (esLanguage)
AT (1) ATE46512T1 (esLanguage)
AU (1) AU568934B2 (esLanguage)
CA (1) CA1215708A (esLanguage)
DE (1) DE3573120D1 (esLanguage)
DK (1) DK162647C (esLanguage)
ES (1) ES8603489A1 (esLanguage)
FI (1) FI81101C (esLanguage)
GR (1) GR851144B (esLanguage)
IE (1) IE58392B1 (esLanguage)
IT (1) IT1199374B (esLanguage)
NO (1) NO164242C (esLanguage)
PH (1) PH22007A (esLanguage)
PT (1) PT80446B (esLanguage)
ZA (1) ZA852971B (esLanguage)

Families Citing this family (62)

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US6861053B1 (en) 1999-08-11 2005-03-01 Cedars-Sinai Medical Center Methods of diagnosing or treating irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth
US7048906B2 (en) 1995-05-17 2006-05-23 Cedars-Sinai Medical Center Methods of diagnosing and treating small intestinal bacterial overgrowth (SIBO) and SIBO-related conditions
AU2002364162A1 (en) * 2001-12-13 2003-06-30 Activbiotics, Inc. Sulfhydryl rifamycins and uses thereof
US7902206B2 (en) 2003-11-07 2011-03-08 Alfa Wassermann, S.P.A. Polymorphic forms α, β and γ of rifaximin
ITMI20032144A1 (it) * 2003-11-07 2005-05-08 Alfa Wassermann Spa Forme polimorfe di rifaximina, processi per ottenerle e
US7906542B2 (en) 2004-11-04 2011-03-15 Alfa Wassermann, S.P.A. Pharmaceutical compositions comprising polymorphic forms α, β, and γ of rifaximin
US20080262024A1 (en) * 2003-11-07 2008-10-23 Giuseppe Claudio Viscomi Rifaximin compositions and method of use
US7923553B2 (en) 2003-11-07 2011-04-12 Alfa Wassermann, S.P.A. Processes for the production of polymorphic forms of rifaximin
US20060210492A1 (en) * 2005-03-02 2006-09-21 Kodsi Robert E Use of rifaximin for treatment and prevention of periodontal conditions
US8003118B2 (en) * 2005-03-02 2011-08-23 Kodsi Robert E Use of rifaximin for the prevention of aspiration pneumonia and/or sepsis
US20060210483A1 (en) * 2005-03-02 2006-09-21 Kodsi Robert E Non-systemic antibiotic formulations and related method of use and treatment of upper respiratory infections
PL1698630T3 (pl) * 2005-03-03 2014-12-31 Alfasigma Spa Nowe postacie polimorficzne rifaksyminy,sposoby ich wytwarzania i ich zastosowanie w preparatach leczniczych
ITBO20050123A1 (it) * 2005-03-07 2005-06-06 Alfa Wassermann Spa Formulazioni farmaceutiche gastroresistenti contenenti rifaximina
CN103263668A (zh) 2006-03-09 2013-08-28 萨利克斯药品公司 利福昔明抗直肠功能障碍制剂
SI2054066T1 (sl) 2006-08-02 2015-08-31 Salix Pharmaceuticals, Inc. Postopki za zdravljenje radiacijskega enteritisa
ITMI20061692A1 (it) 2006-09-05 2008-03-06 Alfa Wassermann Spa Uso di polioli per ottenere forme polimorfe stabili di rifaximina
US8633234B2 (en) * 2006-09-22 2014-01-21 Cipla Limited Rifaximin
US20080161337A1 (en) * 2007-01-03 2008-07-03 Leonard Weinstock Use of Rifaximin for the Treatment of Chronic Prostatitis
US20080159987A1 (en) * 2007-01-03 2008-07-03 Leonard Weinstock Use of Rifaximin for the Treatment of Restless Legs Syndrome
ITMI20071241A1 (it) * 2007-06-20 2008-12-21 Solmag S P A Processo per la preparazione di rifaximina amorfa e rifaximina amorfa cosi' ottenuta
US7709634B2 (en) 2007-09-20 2010-05-04 Apotex Pharmachem Inc. Amorphous form of rifaximin and processes for its preparation
CN102015725B (zh) 2008-02-25 2014-10-22 萨利克斯药品有限公司 利福昔明的多种形式及其用途
US8486956B2 (en) 2008-02-25 2013-07-16 Salix Pharmaceuticals, Ltd Forms of rifaximin and uses thereof
EP3563850A1 (en) 2008-02-26 2019-11-06 Salix Pharmaceuticals, Ltd. Methods for treating bowel diseases
US11779571B2 (en) 2008-02-26 2023-10-10 Salix Pharmaceuticals, Inc. Methods for treating irritable bowel syndrome (IBS)
HRP20140939T1 (hr) 2008-05-07 2014-11-21 Salix Pharmaceuticals, Ltd. Davanje preparata za äśišä†enje crijeva i antibiotika za lijeäśenje bolesti crijeva
CN101585843B (zh) * 2008-05-21 2011-07-06 重庆赛诺生物药业股份有限公司 一种利福昔明的制备工艺
US12285414B2 (en) 2008-10-02 2025-04-29 Salix Pharmaceuticals, Inc. Methods of treating hepatic encephalopathy
US20110035232A1 (en) 2008-10-02 2011-02-10 Salix Pharmaceuticals, Ltd. Methods of treating hepatic encephalopathy
ES2972135T3 (es) 2008-10-02 2024-06-11 Salix Pharmaceuticals Inc Tratamiento de encefalopatía hepática usando rifaximina
US7928115B2 (en) 2008-10-02 2011-04-19 Salix Pharmaceuticals, Ltd. Methods of treating travelers diarrhea and hepatic encephalopathy
CA2745980C (en) 2008-12-10 2017-10-31 Cipla Limited Rifaximin complexes
IT1397617B1 (it) * 2009-04-20 2013-01-18 Alfa Wassermann Spa Nuovi derivati della rifamicina
NZ596851A (en) 2009-06-02 2013-10-25 Salix Pharmaceuticals Ltd Methods of treating hepatic encephalopathy
KR20120062897A (ko) 2009-09-13 2012-06-14 샐릭스 파마슈티컬스 리미티드 과민성 장 증후군(ｉｂｓ)의 치료방법
MX2012005883A (es) 2009-11-23 2012-10-09 Cipla Ltd Composicion topica en espuma.
EP2401282B2 (en) 2009-12-28 2017-01-04 Silvio Massimo Lavagna Method for the production of amorphous rifaximin
AU2011218129A1 (en) 2010-02-18 2012-08-23 Board Of Regents Of The University Of Texas System Methods for treating infection
IT1398550B1 (it) 2010-03-05 2013-03-01 Alfa Wassermann Spa Formulazioni comprendenti rifaximina utili per ottenere un effetto prolungato nel tempo
US8883795B2 (en) * 2010-06-16 2014-11-11 Apotex Pharmachem Inc. Polymorphic forms of Rifaximin
GEAP202112996A (en) 2010-07-12 2021-09-10 Salix Pharmaceuticals Ltd Us Formulations of rifaximin and uses thereof
WO2012035544A2 (en) 2010-09-13 2012-03-22 Sequent Scientific Ltd. A novel polymorphic form of rifaximin and process for its preparation
EP2672970B1 (en) 2011-02-11 2018-08-01 Salix Pharmaceuticals, Ltd. Forms of rifaximin and uses thereof
WO2012150561A1 (en) 2011-05-02 2012-11-08 Ranbaxy Laboratories Limited Rifaximin dimethylformamide solvate
WO2012155981A1 (en) 2011-05-19 2012-11-22 Friulchem Spa New process for the synthesis of rifaximin and a new pseudo-crystalline form of rifaximin obtained thereby
ITBO20110461A1 (it) 2011-07-29 2013-01-30 Alfa Wassermann Spa Composizioni farmaceutiche comprendenti rifaximina, processi per la loro preparazione e loro uso nel trattamento di infezioni vaginali.
US20130184302A1 (en) 2011-11-02 2013-07-18 Enoch Bortey Methods for treating irritable bowel syndrome (ibs) and infections
US9359374B2 (en) 2012-06-13 2016-06-07 Apotex Pharmachem Inc. Polymorphic forms of rifaximin
ITBO20120368A1 (it) 2012-07-06 2014-01-07 Alfa Wassermann Spa Composizioni comprendenti rifaximina e amminoacidi, cristalli di rifaximina derivanti da tali composizioni e loro uso.
EP2971062A2 (en) 2013-03-15 2016-01-20 ALFA WASSERMANN S.p.A. Method for diagnosing vaginal infections
CA2897758A1 (en) 2013-03-15 2014-09-18 Alfa Wassermann S.P.A. Rifaximin for use in the treating of vaginal infections
US20140308350A1 (en) 2013-04-12 2014-10-16 Alfa Wassermann S.P.A. Nsaid administration and related compositions, methods and systems
US9018225B1 (en) 2013-07-26 2015-04-28 Novel Laboratories Rifaximin crystalline forms and methods of preparation thereof
ITMI20131307A1 (it) 2013-08-02 2015-02-02 A M S A Anonima Materie Sint & Affini S P A Processo per la preparazione di refaximina k
CN103509038B (zh) * 2013-09-30 2016-01-20 浙江思贤制药有限公司 一种新晶型利福昔明ζ及其制备方法
ES2621557T3 (es) 2014-03-31 2017-07-04 Euticals S.P.A. Mezcla polimórfica de rifaximina y su uso para la preparación de formulaciones sólidas
JP6693946B2 (ja) 2014-05-04 2020-05-13 サリックス ファーマスーティカルズ，インコーポレーテッド Ｉｂｓ微生物叢及びその使用
US9938298B2 (en) 2014-05-12 2018-04-10 Alfa Wassermann S.P.A. Solvated crystal form of rifaximin, production, compositions and uses thereof
EP2982764A1 (en) 2014-08-05 2016-02-10 ALFA WASSERMANN S.p.A. Identification of vaginal bacteria
US9988398B2 (en) 2016-06-07 2018-06-05 Cadila Healthcare Limited Crystalline form of rifaximin and process for its preparation
CA3038312A1 (en) 2016-09-30 2018-04-05 Salix Pharmaceuticals, Inc. Solid dispersion forms of rifaximin
WO2019003076A1 (en) * 2017-06-26 2019-01-03 Biofer S.P.A. PYRIDO-IMIDAZO-RIFAMYCIN DERIVATIVES AS ANTIBACTERIAL AGENT

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1154655B (it) * 1980-05-22 1987-01-21 Alfa Farmaceutici Spa Derivati imidazo-rifamicinici metodi per la loro preparazione e loro uso come sostanza ad azione antibatterica

Also Published As

Publication number Publication date
US4557866A (en) 1985-12-10
GR851144B (esLanguage) 1985-11-25
IE851191L (en) 1985-11-15
ATE46512T1 (de) 1989-10-15
JPH0469634B2 (esLanguage) 1992-11-06
PT80446A (en) 1985-06-01
PH22007A (en) 1988-05-02
ES543115A0 (es) 1986-01-01
DK214685A (da) 1985-11-16
FI81101C (fi) 1990-09-10
FI81101B (fi) 1990-05-31
AR241913A1 (es) 1993-01-29
NO164242B (no) 1990-06-05
DK162647B (da) 1991-11-25
DK214685D0 (da) 1985-05-14
ES8603489A1 (es) 1986-01-01
ZA852971B (en) 1985-12-24
JPS60252483A (ja) 1985-12-13
EP0161534A2 (en) 1985-11-21
IT8403463A0 (it) 1984-05-15
EP0161534B1 (en) 1989-09-20
PT80446B (pt) 1987-11-11
AU4251585A (en) 1985-11-21
IE58392B1 (en) 1993-09-08
NO851921L (no) 1985-11-18
CA1215708A (en) 1986-12-23
NO164242C (no) 1990-09-12
AU568934B2 (en) 1988-01-14
EP0161534A3 (en) 1987-03-04
FI851907L (fi) 1985-11-16
DK162647C (da) 1992-04-13
DE3573120D1 (en) 1989-10-26
FI851907A0 (fi) 1985-05-14

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Legal Events

Date Code Title Description
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19940505