IT1190755B - Procedimento per la preparazione di derivati di 2-dietilamino-1-metiletil cis-1-idrossi-(bicicloesil)-2-carbossilato - Google Patents

Procedimento per la preparazione di derivati di 2-dietilamino-1-metiletil cis-1-idrossi-(bicicloesil)-2-carbossilato

Info

Publication number
IT1190755B
IT1190755B IT20538/82A IT2053882A IT1190755B IT 1190755 B IT1190755 B IT 1190755B IT 20538/82 A IT20538/82 A IT 20538/82A IT 2053882 A IT2053882 A IT 2053882A IT 1190755 B IT1190755 B IT 1190755B
Authority
IT
Italy
Prior art keywords
bicyclohesyl
diethylamine
hydroxy
procedure
preparation
Prior art date
Application number
IT20538/82A
Other languages
English (en)
Other versions
IT8220538A0 (it
Inventor
Franco Sbarbaro
Original Assignee
Guidotti Internationale Sa Hol
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guidotti Internationale Sa Hol filed Critical Guidotti Internationale Sa Hol
Publication of IT8220538A0 publication Critical patent/IT8220538A0/it
Priority to IT20538/82A priority Critical patent/IT1190755B/it
Priority to PH28721A priority patent/PH23299A/en
Priority to EP83103129A priority patent/EP0091078B1/en
Priority to DK143083A priority patent/DK164046C/da
Priority to DE8383103129T priority patent/DE3367909D1/de
Priority to NO831180A priority patent/NO161218C/no
Priority to AT83103129T priority patent/ATE23854T1/de
Priority to AR83292613A priority patent/AR243863A1/es
Priority to ES521183A priority patent/ES8405359A1/es
Priority to MX778683A priority patent/MX155043A/es
Priority to CA000424888A priority patent/CA1214470A/en
Priority to FI831118A priority patent/FI77648C/fi
Priority to AU13121/83A priority patent/AU570201B2/en
Priority to GR70954A priority patent/GR78791B/el
Priority to PT76491A priority patent/PT76491B/pt
Priority to IN388/CAL/83A priority patent/IN158129B/en
Priority to KR1019830001320A priority patent/KR910002686B1/ko
Priority to JP58058566A priority patent/JPS591452A/ja
Priority to IL68281A priority patent/IL68281A/xx
Application granted granted Critical
Publication of IT1190755B publication Critical patent/IT1190755B/it
Priority to US07/318,520 priority patent/US5011974A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/24—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups or amino groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/02—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C219/04—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C219/12—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the hydroxy groups esterified by a carboxylic acid having the esterifying carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IT20538/82A 1982-04-01 1982-04-01 Procedimento per la preparazione di derivati di 2-dietilamino-1-metiletil cis-1-idrossi-(bicicloesil)-2-carbossilato IT1190755B (it)

Priority Applications (20)

Application Number Priority Date Filing Date Title
IT20538/82A IT1190755B (it) 1982-04-01 1982-04-01 Procedimento per la preparazione di derivati di 2-dietilamino-1-metiletil cis-1-idrossi-(bicicloesil)-2-carbossilato
PH28721A PH23299A (en) 1982-04-01 1983-03-29 A process for the preparation of derivatives of 2-diethylamino-1-methyl ethyl-cis-1-hydroxy-(bicyclohexyl)-2-carboxylate
EP83103129A EP0091078B1 (en) 1982-04-01 1983-03-29 A process for the preparation of derivatives of 2-diethylamino-1-methyl ethyl cis-1-hydroxy-(bicyclohexyl)-2-carboxylate
DK143083A DK164046C (da) 1982-04-01 1983-03-29 Fremgangsmaade til fremstilling af farmaceutisk acceptable salte af 2-diethylamino-1-methylethyl-cis-1-hydroxy-(bicyclohexyl)-2-carboxylat
DE8383103129T DE3367909D1 (en) 1982-04-01 1983-03-29 A process for the preparation of derivatives of 2-diethylamino-1-methyl ethyl cis-1-hydroxy-(bicyclohexyl)-2-carboxylate
NO831180A NO161218C (no) 1982-04-01 1983-03-29 Fremgangsm te for fremstilling av terapeutisk aktivr av 2-dietylamino-1-metyletyl-cis-1-hydroksy-(bisykloheksyl)-2-karboksylat.
AT83103129T ATE23854T1 (de) 1982-04-01 1983-03-29 Verfahren zur herstellung von derivaten des 2diethylamino-1-methylesters der cis-1hydroxy(bicyclohexyl)-2-carbons|ure.
CA000424888A CA1214470A (en) 1982-04-01 1983-03-30 Process for the preparation of derivatives of 2- diethylamino-1-methyl ethyl cis-1-hydroxy- (bicyclohexyl)-2-carboxylate
ES521183A ES8405359A1 (es) 1982-04-01 1983-03-30 Procedimiento para preparar derivados farmaceuticamente aceptables de 2-dietilamino-metiletil-cis-1-hidroxi-(biciclohexil)-2-carboxilato.
MX778683A MX155043A (es) 1982-04-01 1983-03-30 Procedimiento para preparar sales de cis-1-hidroxi(biciclohexil)-2-carboxilato de 2-dietilamino-1-metiletilo
AR83292613A AR243863A1 (es) 1982-04-01 1983-03-30 Procedimiento para la preparacion de sales de acidos farmaceuticamente aceptables de cis-1-hidroxi-(bici-clohexil)-2-carboxilato de 2-dietilamino-1-metiletilo.
PT76491A PT76491B (en) 1982-04-01 1983-03-31 Process for the preparation of derivatives of 2-diethylamino-1-methyl ethyl cis-1-hidroxy-(bicyclohexyl)-2-carboxilate
AU13121/83A AU570201B2 (en) 1982-04-01 1983-03-31 2-diethylamino-1-methylethyl cis-1-hydroxy-(bicylohexyl) -2-carboxylate
GR70954A GR78791B (it) 1982-04-01 1983-03-31
FI831118A FI77648C (fi) 1982-04-01 1983-03-31 Foerfaranden foer framstaellning av citrat, maleat, fumarat och pamoat av 2-dietylamino-1-metyletyl-cis-1- hydroxi(bicyklohexyl)-2-karboxylat samt vid foerfarandena anvaent fosfatsalt.
IN388/CAL/83A IN158129B (it) 1982-04-01 1983-03-31
KR1019830001320A KR910002686B1 (ko) 1982-04-01 1983-03-31 2-디에틸아미노-1-메틸에틸 시스-1-히드록시-(비시클로헥실)-2-카르복실산염 유도체의 제조방법
JP58058566A JPS591452A (ja) 1982-04-01 1983-04-01 ２―ジエチルアミノ―１―メチルエチル・シス―１―ヒドロキシ―（ビシクロヘキシル）―２―カルボキシレートの誘導体の製造方法
IL68281A IL68281A (en) 1982-04-01 1983-04-01 Citrate,maleate,fumarate and pamoate salts of 2-diethylamino-1-methyl-ethyl cis-1-hydroxy-(bicyclohexyl)-2-carboxylate and process for the preparation thereof
US07/318,520 US5011974A (en) 1982-04-01 1989-03-01 Process for the preparation of derivative of 2-diethylamino-1-methylethyl-1-hydroxy-(bicyclohexyl)-2-carboxylate

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT20538/82A IT1190755B (it) 1982-04-01 1982-04-01 Procedimento per la preparazione di derivati di 2-dietilamino-1-metiletil cis-1-idrossi-(bicicloesil)-2-carbossilato

Publications (2)

Publication Number Publication Date
IT8220538A0 IT8220538A0 (it) 1982-04-01
IT1190755B true IT1190755B (it) 1988-02-24

Family

ID=11168449

Family Applications (1)

Application Number Title Priority Date Filing Date
IT20538/82A IT1190755B (it) 1982-04-01 1982-04-01 Procedimento per la preparazione di derivati di 2-dietilamino-1-metiletil cis-1-idrossi-(bicicloesil)-2-carbossilato

Country Status (19)

Country Link
US (1) US5011974A (it)
EP (1) EP0091078B1 (it)
JP (1) JPS591452A (it)
KR (1) KR910002686B1 (it)
AR (1) AR243863A1 (it)
AT (1) ATE23854T1 (it)
AU (1) AU570201B2 (it)
CA (1) CA1214470A (it)
DE (1) DE3367909D1 (it)
DK (1) DK164046C (it)
ES (1) ES8405359A1 (it)
FI (1) FI77648C (it)
GR (1) GR78791B (it)
IL (1) IL68281A (it)
IN (1) IN158129B (it)
IT (1) IT1190755B (it)
NO (1) NO161218C (it)
PH (1) PH23299A (it)
PT (1) PT76491B (it)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106631760B (zh) * 2015-10-29 2019-05-28 上海医药工业研究院 顺-1-羟基-[1,1’-双(环己烷)]-2-羧酸的制备工艺

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3156725A (en) * 1962-04-18 1964-11-10 Smith Kline French Lab Substituted 2-phenoxy and phenylthio-cyclopropylamines
NL296693A (it) * 1962-08-16
AU423221B2 (en) * 1967-07-29 1972-04-14 LABORATORIO GUIDOTTI & C. Sp. A 2 hydroxycyclohexanecarboxylic substituted acids, basic esters thereof and salts showing a choleretic and antispastic activity
AT288348B (de) * 1967-09-20 1971-02-25 Guidotti & C Spa Labor Verfahren zur Herstellung von neuen basischen Estern der 2-Phenyl- oder 2-Cyclohexyl-2-hydroxycyclohexancarbonsäure sowie von deren Säureadditions- und quaternären Salzen
US3700675A (en) * 1970-09-11 1972-10-24 Luigi Turbanti Ester of 2-hydroxy-cyclohexane-2-substituted carboxylic acids
IT1100581B (it) * 1978-11-24 1985-09-28 Lab Guidotti & C Spa Procedimento per la fabbricazione di esteri easici di acidi idrossicicicloesancarbossilici sostituti

Also Published As

Publication number Publication date
DE3367909D1 (en) 1987-01-15
DK143083D0 (da) 1983-03-29
PH23299A (en) 1989-06-30
JPS591452A (ja) 1984-01-06
AU570201B2 (en) 1988-03-10
AU1312183A (en) 1983-10-06
GR78791B (it) 1984-10-02
PT76491B (en) 1985-12-10
PT76491A (en) 1983-04-01
EP0091078B1 (en) 1986-11-26
US5011974A (en) 1991-04-30
NO161218B (no) 1989-04-10
AR243863A1 (es) 1993-09-30
DK164046B (da) 1992-05-04
IL68281A0 (en) 1983-07-31
FI77648C (fi) 1989-04-10
NO831180L (no) 1983-10-03
IL68281A (en) 1987-09-16
FI831118A0 (fi) 1983-03-31
CA1214470A (en) 1986-11-25
ES521183A0 (es) 1984-06-01
IT8220538A0 (it) 1982-04-01
ES8405359A1 (es) 1984-06-01
FI77648B (fi) 1988-12-30
JPH0480899B2 (it) 1992-12-21
DK164046C (da) 1992-10-12
ATE23854T1 (de) 1986-12-15
KR840004061A (ko) 1984-10-06
NO161218C (no) 1989-07-19
IN158129B (it) 1986-09-13
KR910002686B1 (ko) 1991-05-03
DK143083A (da) 1983-10-02
EP0091078A1 (en) 1983-10-12
FI831118L (fi) 1983-10-02

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Effective date: 19970506