IT1187750B - Procedimento per la preparazione di compresse,anche a rilascio prolungato,di iscsorbide-5-mononitrato stabilizzato e formulazioni cosi' ottenute - Google Patents

Procedimento per la preparazione di compresse,anche a rilascio prolungato,di iscsorbide-5-mononitrato stabilizzato e formulazioni cosi' ottenute

Info

Publication number
IT1187750B
IT1187750B IT22493/85A IT2249385A IT1187750B IT 1187750 B IT1187750 B IT 1187750B IT 22493/85 A IT22493/85 A IT 22493/85A IT 2249385 A IT2249385 A IT 2249385A IT 1187750 B IT1187750 B IT 1187750B
Authority
IT
Italy
Prior art keywords
mononitrate
tablets
iscsorbide
formulations
stabilized
Prior art date
Application number
IT22493/85A
Other languages
English (en)
Italian (it)
Other versions
IT8522493A0 (it
Inventor
Piergiorgio Rossi
Massimo Calanchi
Original Assignee
Eurand Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eurand Spa filed Critical Eurand Spa
Publication of IT8522493A0 publication Critical patent/IT8522493A0/it
Priority to IT22493/85A priority Critical patent/IT1187750B/it
Priority to ES198686201705T priority patent/ES2035819T3/es
Priority to DE8686201705T priority patent/DE3683342D1/de
Priority to EP86201705A priority patent/EP0219161B1/en
Priority to AT86201705T priority patent/ATE71290T1/de
Priority to AU63831/86A priority patent/AU591185B2/en
Priority to JP61241570A priority patent/JPS62123114A/ja
Priority to US06/918,385 priority patent/US4812316A/en
Priority to ZA867768A priority patent/ZA867768B/xx
Priority to CA000520377A priority patent/CA1285489C/en
Application granted granted Critical
Publication of IT1187750B publication Critical patent/IT1187750B/it
Priority to GR920400639T priority patent/GR3004285T3/el
Priority to HK12295A priority patent/HK12295A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IT22493/85A 1985-10-15 1985-10-15 Procedimento per la preparazione di compresse,anche a rilascio prolungato,di iscsorbide-5-mononitrato stabilizzato e formulazioni cosi' ottenute IT1187750B (it)

Priority Applications (12)

Application Number Priority Date Filing Date Title
IT22493/85A IT1187750B (it) 1985-10-15 1985-10-15 Procedimento per la preparazione di compresse,anche a rilascio prolungato,di iscsorbide-5-mononitrato stabilizzato e formulazioni cosi' ottenute
ES198686201705T ES2035819T3 (es) 1985-10-15 1986-10-02 Procedimiento para la preparacion de tabletas de isosorbido-5-moninitrato de liberacion sostenida y las formulaciones obtenidas.
DE8686201705T DE3683342D1 (de) 1985-10-15 1986-10-02 Verfahren zur herstellung von tabletten von isosorbid-5-mononitrat mit verzoegerter abgabe und so erhaltene zusammensetzungen.
EP86201705A EP0219161B1 (en) 1985-10-15 1986-10-02 Process for the preparation of stabilized isosorbide-5-mononitrate tablets, being also of sustained release, and formulations thus obtained
AT86201705T ATE71290T1 (de) 1985-10-15 1986-10-02 Verfahren zur herstellung von tabletten von isosorbid-5-mononitrat mit verzoegerter abgabe und so erhaltene zusammensetzungen.
JP61241570A JPS62123114A (ja) 1985-10-15 1986-10-13 安定化されたイソソルビド−５−モノニトレ−ト錠剤及びその製造方法
AU63831/86A AU591185B2 (en) 1985-10-15 1986-10-13 Process for the preparation of stabilized isosorbide-5-mononitrate tablets, being also of sustained release, and formulations thus obtained
US06/918,385 US4812316A (en) 1985-10-15 1986-10-14 Process for the preparation of stabilized isosorbide-5-mononitrate tablets, being also of sustained release, and formulations thus obtained
ZA867768A ZA867768B (en) 1985-10-15 1986-10-14 Process for the preparation of stabilized isosorbide-5-mononitrate tablets,being also of sustained release,and formulation thus obtained
CA000520377A CA1285489C (en) 1985-10-15 1986-10-14 Process for the preparation of stabilized isosorbide- 5-mononitrate tablets, being also of sustained release, and formulations thus obtained
GR920400639T GR3004285T3 (cg-RX-API-DMAC10.html) 1985-10-15 1992-04-07
HK12295A HK12295A (en) 1985-10-15 1995-01-26 Process for the preparation of stabilized isosorbide-5-mononitrate tablets, being also of sustained release, and formulations thus obtained

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT22493/85A IT1187750B (it) 1985-10-15 1985-10-15 Procedimento per la preparazione di compresse,anche a rilascio prolungato,di iscsorbide-5-mononitrato stabilizzato e formulazioni cosi' ottenute

Publications (2)

Publication Number Publication Date
IT8522493A0 IT8522493A0 (it) 1985-10-15
IT1187750B true IT1187750B (it) 1987-12-23

Family

ID=11197007

Family Applications (1)

Application Number Title Priority Date Filing Date
IT22493/85A IT1187750B (it) 1985-10-15 1985-10-15 Procedimento per la preparazione di compresse,anche a rilascio prolungato,di iscsorbide-5-mononitrato stabilizzato e formulazioni cosi' ottenute

Country Status (12)

Country Link
US (1) US4812316A (cg-RX-API-DMAC10.html)
EP (1) EP0219161B1 (cg-RX-API-DMAC10.html)
JP (1) JPS62123114A (cg-RX-API-DMAC10.html)
AT (1) ATE71290T1 (cg-RX-API-DMAC10.html)
AU (1) AU591185B2 (cg-RX-API-DMAC10.html)
CA (1) CA1285489C (cg-RX-API-DMAC10.html)
DE (1) DE3683342D1 (cg-RX-API-DMAC10.html)
ES (1) ES2035819T3 (cg-RX-API-DMAC10.html)
GR (1) GR3004285T3 (cg-RX-API-DMAC10.html)
HK (1) HK12295A (cg-RX-API-DMAC10.html)
IT (1) IT1187750B (cg-RX-API-DMAC10.html)
ZA (1) ZA867768B (cg-RX-API-DMAC10.html)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE64726B1 (en) * 1987-11-20 1995-08-23 Elan Corp Plc Pharmaceutical formulations for preventing drug tolerance
IT1237638B (it) * 1989-10-25 1993-06-12 Ghirardi Paolo E. Impiego dell'isosorbide 2-mononitrato per la preparazione di composi- zioni farmaceutiche atte al trattamento dell'angina pectoris
FR2666506A1 (fr) * 1990-09-07 1992-03-13 Pf Medicament Comprime a liberation prolongee a base de 5-mononitrate d'isosorbide et son procede de preparation.
FR2677886B1 (fr) * 1991-06-18 1995-03-31 Adir Comprime matriciel permettant la liberation prolongee d'indapamide apres administration par voie orale.
IT1251114B (it) * 1991-07-26 1995-05-04 Farcon Ag Forme farmaceutiche antivirali per applicazione vaginale
DE4313726A1 (de) * 1993-04-27 1994-11-03 Byk Nederland Bv Feste Darreichungsform
US6818229B1 (en) 1993-09-20 2004-11-16 Kos Pharmaceuticals, Inc. Intermediate release nicotinic acid compositions for treating hyperlipidemia
US6080428A (en) 1993-09-20 2000-06-27 Bova; David J. Nicotinic acid compositions for treating hyperlipidemia and related methods therefor
US6676967B1 (en) * 1993-09-20 2004-01-13 Kos Pharmaceuticals, Inc. Methods for reducing flushing in individuals being treated with nicotinic acid for hyperlipidemia
US6746691B2 (en) 1993-09-20 2004-06-08 Kos Pharmaceuticals, Inc. Intermediate release nicotinic acid compositions for treating hyperlipidemia having unique biopharmaceutical characteristics
US20060263428A1 (en) * 1993-09-20 2006-11-23 Eugenio Cefali Methods for treating hyperlipidemia with intermediate release nicotinic acid compositions having unique biopharmaceutical characteristics
US6129930A (en) 1993-09-20 2000-10-10 Bova; David J. Methods and sustained release nicotinic acid compositions for treating hyperlipidemia at night
DE19515972A1 (de) * 1995-05-02 1996-11-07 Bayer Ag Arzneizubereitungen mit kontrollierter Freisetzung und Verfahren zu ihrer Herstellung
US5900425A (en) * 1995-05-02 1999-05-04 Bayer Aktiengesellschaft Pharmaceutical preparations having controlled release of active compound and processes for their preparation
AU3861397A (en) * 1996-08-02 1998-02-25 Cal International Limited Controlled release tablet formulation of isosorbide-5-mononitrate
US5851555A (en) * 1997-08-15 1998-12-22 Fuisz Technologies Ltd. Controlled release dosage forms containing water soluble drugs
US6562974B2 (en) 2000-02-01 2003-05-13 The Procter & Gamble Company Process for making geminal bisphosphonates
PE20011061A1 (es) 2000-02-01 2001-11-20 Procter & Gamble Cristalizacion selectiva del acido 3-piridil-1-hidroxi-etiliden-1,1-bisfosfonico sodio como el hemipentahidrato o el monohidrato
JP4696210B2 (ja) * 2000-06-07 2011-06-08 トーアエイヨー株式会社 イソソルビド‐５‐モノニトレートを有効成分とする徐放性錠剤及びその製造方法
JP4840549B2 (ja) * 2000-11-20 2011-12-21 トーアエイヨー株式会社 安定な血管拡張剤及びその製造方法
US7008979B2 (en) * 2002-04-30 2006-03-07 Hydromer, Inc. Coating composition for multiple hydrophilic applications
US20040109889A1 (en) * 2002-12-04 2004-06-10 Bunick Frank J. Surface treatment composition for soft substrates
JP5079713B2 (ja) * 2006-03-16 2012-11-21 グライコロジック リミテッド 満腹を誘発するための、好ましく加工されたデンプンを含む胃内ラフト組成物
CN111068644B (zh) * 2019-12-20 2023-01-03 中海油天津化工研究设计院有限公司 一种均四甲苯氧化制均酐催化剂及其制备方法
CN115487162B (zh) * 2022-10-13 2023-10-13 山东力诺制药有限公司 一种单硝酸异山梨酯缓释片的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2301664C3 (de) * 1973-01-13 1979-07-12 Byk Gulden Lomberg Chemische Fabrik Gmbh, 7750 Konstanz Oral verabreichbares, Nitroglycerin enthaltendes Arzneimittel
US3972995A (en) * 1975-04-14 1976-08-03 American Home Products Corporation Dosage form
US4291015A (en) * 1979-08-14 1981-09-22 Key Pharmaceuticals, Inc. Polymeric diffusion matrix containing a vasodilator
IL61721A (en) * 1980-12-16 1984-03-30 Blank Izhak Nitroglycerin preparations
US4369172A (en) * 1981-12-18 1983-01-18 Forest Laboratories Inc. Prolonged release therapeutic compositions based on hydroxypropylmethylcellulose
DE3325652A1 (de) * 1983-07-15 1985-01-24 Dr. Rentschler Arzneimittel Gmbh & Co, 7958 Laupheim Feste, stabile isosorbid-5-mononitrat enthaltende arzneimittelzubereitungen und verfahren zu ihrer herstellung
JPS60181052A (ja) * 1984-02-29 1985-09-14 Tooa Eiyoo Kk 安定なイソソルビド硝酸エステル組成物及びその製造法

Also Published As

Publication number Publication date
JPS62123114A (ja) 1987-06-04
JPH0524888B2 (cg-RX-API-DMAC10.html) 1993-04-09
HK12295A (en) 1995-02-03
AU591185B2 (en) 1989-11-30
ZA867768B (en) 1987-06-24
ES2035819T3 (es) 1993-05-01
CA1285489C (en) 1991-07-02
EP0219161B1 (en) 1992-01-08
EP0219161A3 (en) 1988-01-13
US4812316A (en) 1989-03-14
EP0219161A2 (en) 1987-04-22
IT8522493A0 (it) 1985-10-15
GR3004285T3 (cg-RX-API-DMAC10.html) 1993-03-31
DE3683342D1 (de) 1992-02-20
AU6383186A (en) 1987-04-16
ATE71290T1 (de) 1992-01-15

Similar Documents

Publication Publication Date Title
AU591185B2 (en) Process for the preparation of stabilized isosorbide-5-mononitrate tablets, being also of sustained release, and formulations thus obtained
IT8522494A0 (it) Procedimento per la preparazione di formulazioni solide di nifedipina ad elevata biodisponibilita' e ad effetto prolungato e formulazioni cosi' ottenute.
DE68915695D1 (de) Zubereitungen mit kontrollierter Wirkstoffabgabe.
GR3006518T3 (cg-RX-API-DMAC10.html)
NO863061D0 (no) Fremgangsmaate for fremstilling av fysiologisk aktive fenoksyeddiksyrederivater.
EG17753A (en) Novel pharmacological compounds
MY103225A (en) Phenyl carbamate
IL91276A0 (en) Pharmaceutical compositions containing alpha-amino boronic acid derivatives,for the prophylaxis and treatment of virus diseases
JPS51148013A (en) Stable insulin preparation for nosal administration
EP0341707A3 (en) Phenylethanol ester of ortho-cinnamic acid, its preparation and use as fragrance compound
ES478967A1 (es) Un procedimiento para preparar compuestos de acido 3-cefem-4-carboxilico disustituido en las posiciones 3 y 7.
FI853859L (fi) Amidderivat.
GB2021409A (en) Pharmaceutical composition
EP0209843A3 (en) Benzylpiperazine compound, preparation thereof, pharmaceutical composition, and use
MY101266A (en) Pharmaceutical formulations
IT8521528A0 (it) Composizioni farmaceutiche e cosmetiche contenenti come ingrediente attivo diidrossi-1,8fenil-10 antrone-9, e procedimentodi preparazione dell'ingrediente attivo.
JPS5318529A (en) Optically active mandelic acid phenylglycinol salt and its preparation
JPS53127432A (en) Novel physiologically active substance, anthglutin, and its preparation
IT1230719B (it) Procedimento per la produzione di polvere di lombrichi secca e preparazioni anti iperlipemiche, anti diabetiche, anti ipertensive ed anti ipotensive contenenti, come ingrediente attivo, polvere secca di lombrichi.
FI802543A7 (fi) Kestovalmiste jolla on pidennetty tehoaineen luovutus.
SG103391G (en) Pharmaceutical formulations with controlled release of the active substance
PH21338A (en) Novel compound, its production and insecticidal and acaricidal composition containing it as an active ingredient
JPS51136886A (en) New biologica lly active substance, ml-236c, and its preparation
DE3563416D1 (en) Hexetidin-containing therapeutically active agent, method for its preparation and its use as a vaginal disinfectant
NO863005D0 (no) Fremgangsmaate for fremstilling av terapeutisk aktive 1,4,5,6,7,8-heksahydro-2-alkyl-4-aryl-5-okso-1,7-naftyridin-3-karboksylsyreesterderivater.