IT1178792B - Acilammino mitosani ad attivita'antitumorale e relativo procedimento di preparazione - Google Patents

Acilammino mitosani ad attivita'antitumorale e relativo procedimento di preparazione

Info

Publication number
IT1178792B
IT1178792B IT24227/84A IT2422784A IT1178792B IT 1178792 B IT1178792 B IT 1178792B IT 24227/84 A IT24227/84 A IT 24227/84A IT 2422784 A IT2422784 A IT 2422784A IT 1178792 B IT1178792 B IT 1178792B
Authority
IT
Italy
Prior art keywords
mitosani
acilamino
tumor activity
preparation procedure
related preparation
Prior art date
Application number
IT24227/84A
Other languages
English (en)
Other versions
IT8424227A0 (it
Inventor
Kaneko Takushi
She Lai Wong Henry
Terrence William Dolye
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of IT8424227A0 publication Critical patent/IT8424227A0/it
Application granted granted Critical
Publication of IT1178792B publication Critical patent/IT1178792B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IT24227/84A 1983-12-23 1984-12-21 Acilammino mitosani ad attivita'antitumorale e relativo procedimento di preparazione IT1178792B (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/564,806 US4642352A (en) 1983-12-23 1983-12-23 Acylamino mitosanes

Publications (2)

Publication Number Publication Date
IT8424227A0 IT8424227A0 (it) 1984-12-21
IT1178792B true IT1178792B (it) 1987-09-16

Family

ID=24255968

Family Applications (1)

Application Number Title Priority Date Filing Date
IT24227/84A IT1178792B (it) 1983-12-23 1984-12-21 Acilammino mitosani ad attivita'antitumorale e relativo procedimento di preparazione

Country Status (32)

Country Link
US (1) US4642352A (it)
JP (1) JPS60169481A (it)
KR (1) KR910009329B1 (it)
AR (1) AR244231A1 (it)
AT (1) AT386828B (it)
AU (1) AU561376B2 (it)
BE (1) BE901377A (it)
CA (1) CA1239645A (it)
CH (1) CH665641A5 (it)
DD (1) DD228259A5 (it)
DE (1) DE3447003C2 (it)
DK (1) DK169477B1 (it)
ES (1) ES538804A0 (it)
FI (1) FI81099C (it)
FR (1) FR2557112B1 (it)
GB (1) GB2151627B (it)
GR (1) GR82567B (it)
HU (1) HU193245B (it)
IE (1) IE57835B1 (it)
IL (1) IL73876A (it)
IT (1) IT1178792B (it)
LU (1) LU85711A1 (it)
MY (1) MY100976A (it)
NL (1) NL8403852A (it)
NO (1) NO163570C (it)
NZ (1) NZ210254A (it)
OA (1) OA07911A (it)
PT (1) PT79741B (it)
SE (1) SE8406577L (it)
SU (1) SU1364239A3 (it)
YU (1) YU45688B (it)
ZA (1) ZA849907B (it)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4487769A (en) * 1982-06-04 1984-12-11 Bristol-Myers Company Amidines
NZ206932A (en) * 1983-02-07 1987-08-31 University Patents Inc Certain 6-(heterocyclyl or amino) mitosanes and pharmaceutical compositions
US4803212A (en) * 1983-04-11 1989-02-07 Bristol-Myers Company Amino disulfides
FR2571373A1 (fr) * 1984-10-09 1986-04-11 Bristol Myers Co Procede de preparation de derives n7-substitues de la mitomycine c
CA1282069C (en) * 1985-09-12 1991-03-26 Damon L. Meyer Antibody complexes of hapten-modified diagnostic or therapeutic agents
JPS6354380A (ja) * 1986-08-26 1988-03-08 Kyowa Hakko Kogyo Co Ltd マイトマイシン誘導体
ZA886812B (en) * 1987-11-23 1989-07-26 Bristol Myers Co Anti-tumor prodrugs
US4874779A (en) * 1988-06-29 1989-10-17 Bristol-Myers Company Mitomycin phosphate derivatives
US5214804A (en) * 1992-01-27 1993-06-01 Carey Michael J Protective mask with scarf

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US27384A (en) * 1860-03-06 Slide-valve for steam-engines
BE655399A (it) *
CA771155A (en) * 1967-11-07 Matsui Masanao Phosphorus-containing derivatives of mitomycin c
US3660578A (en) * 1957-04-06 1972-05-02 Kyowa Hakko Kogyo Kk Mitomycin c
NL129868C (it) * 1963-06-07
DE1570029A1 (de) * 1964-07-09 1970-04-09 Kyowa Hakko Kogyo Kk Verfahren zur Herstellung von Mitosanverbindungen
US3420846A (en) * 1964-08-25 1969-01-07 Kyowa Hakko Kogyo Kk 7-substituted mitomycin a
US3332944A (en) * 1964-11-02 1967-07-25 American Cyanamid Co Antibiotic derivatives of mitomycins a, b, c and porfiromycin
FR1540921A (fr) * 1965-05-18 1968-10-04 Kyowa Hakko Kogyo Kk Procédé de préparation de dérivés de thio-urée de la mitomycine c
US3410867A (en) * 1965-11-22 1968-11-12 Kyowa Hakko Kogyo Kk Mitomycin derivatives
JPS5439098A (en) * 1977-08-31 1979-03-24 Kyowa Hakko Kogyo Co Ltd Mitomycin c derivatives
DE2966984D1 (en) * 1978-07-18 1984-06-20 Kyowa Hakko Kogyo Kk New mitomycins and processes for production thereof
US4268676A (en) * 1979-12-05 1981-05-19 University Patents, Inc. Mitomycin analogs
US4444768A (en) * 1980-03-04 1984-04-24 Ciba-Geigy Corporation Pyrimido[1,6-a]indoles, pharmaceutical preparations containing them, and methods of treating pain and inflammation with them
NZ199617A (en) * 1981-05-15 1985-08-30 University Patents Inc Azirino(2',3',:3,4)pyrrolo(1,2-a)indole-4,7-dione derivatives and pharmaceutical compositions
JPS58201791A (ja) 1982-05-19 1983-11-24 Katsuo Unno ヘマトポルフイリン誘導体
US4487769A (en) * 1982-06-04 1984-12-11 Bristol-Myers Company Amidines

Also Published As

Publication number Publication date
DK621484D0 (da) 1984-12-21
IE57835B1 (en) 1993-04-21
HU193245B (en) 1987-08-28
KR850004762A (ko) 1985-07-27
ES8603485A1 (es) 1985-12-16
PT79741A (en) 1985-01-01
DE3447003A1 (de) 1985-07-04
NO163570C (no) 1990-06-20
DE3447003C2 (de) 1994-11-17
OA07911A (fr) 1986-11-20
NZ210254A (en) 1988-02-29
GB2151627A (en) 1985-07-24
SE8406577L (sv) 1985-06-24
SE8406577D0 (sv) 1984-12-21
IL73876A (en) 1991-08-16
BE901377A (fr) 1985-06-21
HUT37434A (en) 1985-12-28
MY100976A (en) 1991-06-15
IL73876A0 (en) 1985-03-31
FR2557112B1 (fr) 1987-02-13
NO845100L (no) 1985-06-24
LU85711A1 (fr) 1985-09-12
CA1239645A (en) 1988-07-26
FI81099C (fi) 1990-09-10
NL8403852A (nl) 1985-07-16
FI845037L (fi) 1985-06-24
ES538804A0 (es) 1985-12-16
PT79741B (en) 1987-01-16
NO163570B (no) 1990-03-12
DK621484A (da) 1985-06-24
IE843318L (en) 1985-06-23
US4642352A (en) 1987-02-10
CH665641A5 (de) 1988-05-31
AR244231A1 (es) 1993-10-29
FI81099B (fi) 1990-05-31
DK169477B1 (da) 1994-11-07
GB2151627B (en) 1988-03-30
AU561376B2 (en) 1987-05-07
GR82567B (en) 1985-04-23
FR2557112A1 (fr) 1985-06-28
GB8432513D0 (en) 1985-02-06
YU45688B (sh) 1992-07-20
AU3571084A (en) 1985-06-27
IT8424227A0 (it) 1984-12-21
DD228259A5 (de) 1985-10-09
KR910009329B1 (ko) 1991-11-11
YU215284A (en) 1990-06-30
AT386828B (de) 1988-10-25
JPH0471076B2 (it) 1992-11-12
ATA407484A (de) 1988-03-15
ZA849907B (en) 1985-08-28
FI845037A0 (fi) 1984-12-19
JPS60169481A (ja) 1985-09-02
SU1364239A3 (ru) 1987-12-30

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