IT1177017B - Processo per la preparazione dell'acido 2(4-flurofenil)alfa-metil-5-benzox azoloacetico - Google Patents
Processo per la preparazione dell'acido 2(4-flurofenil)alfa-metil-5-benzox azoloaceticoInfo
- Publication number
- IT1177017B IT1177017B IT23264/84A IT2326484A IT1177017B IT 1177017 B IT1177017 B IT 1177017B IT 23264/84 A IT23264/84 A IT 23264/84A IT 2326484 A IT2326484 A IT 2326484A IT 1177017 B IT1177017 B IT 1177017B
- Authority
- IT
- Italy
- Prior art keywords
- acid
- fluorophenyl
- methyl
- benzoxazole
- azoloacetic
- Prior art date
Links
- 239000002253 acid Substances 0.000 title abstract 2
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 abstract 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 abstract 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 2
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 abstract 2
- AOZKIUFHHMUPGU-UHFFFAOYSA-N 2-(3-amino-4-hydroxyphenyl)acetic acid Chemical compound NC1=CC(CC(O)=O)=CC=C1O AOZKIUFHHMUPGU-UHFFFAOYSA-N 0.000 abstract 1
- KBFHXGWZGIITPB-UHFFFAOYSA-N 2-[2-(4-fluorophenyl)-1,3-benzoxazol-5-yl]acetic acid Chemical compound N=1C2=CC(CC(=O)O)=CC=C2OC=1C1=CC=C(F)C=C1 KBFHXGWZGIITPB-UHFFFAOYSA-N 0.000 abstract 1
- CZKLEJHVLCMVQR-UHFFFAOYSA-N 4-fluorobenzoyl chloride Chemical compound FC1=CC=C(C(Cl)=O)C=C1 CZKLEJHVLCMVQR-UHFFFAOYSA-N 0.000 abstract 1
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 abstract 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 abstract 1
- WYACBZDAHNBPPB-UHFFFAOYSA-N diethyl oxalate Chemical compound CCOC(=O)C(=O)OCC WYACBZDAHNBPPB-UHFFFAOYSA-N 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 235000019441 ethanol Nutrition 0.000 abstract 1
- 238000005984 hydrogenation reaction Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- KHPXUQMNIQBQEV-UHFFFAOYSA-L oxaloacetate(2-) Chemical compound [O-]C(=O)CC(=O)C([O-])=O KHPXUQMNIQBQEV-UHFFFAOYSA-L 0.000 abstract 1
- 229910000027 potassium carbonate Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D263/57—Aryl or substituted aryl radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT23264/84A IT1177017B (it) | 1984-10-22 | 1984-10-22 | Processo per la preparazione dell'acido 2(4-flurofenil)alfa-metil-5-benzox azoloacetico |
| EP85112699A EP0182061B1 (en) | 1984-10-22 | 1985-10-07 | New process for preparing 2(4-fluorophenyl) alpha methyl-5-benzoxazole acetic acid |
| AT85112699T ATE70832T1 (de) | 1984-10-22 | 1985-10-07 | Verfahren zur herstellung von 2-(4-fluorphenyl)alpha-methyl-5-benzoxazolessigs|ure. |
| US06/784,892 US4652654A (en) | 1984-10-22 | 1985-10-07 | Process for preparing 2(4-fluorophenyl)alpha-methyl-5-benzoxazole acetic acid |
| DE8585112699T DE3585022D1 (de) | 1984-10-22 | 1985-10-07 | Verfahren zur herstellung von 2-(4-fluorphenyl)-alpha-methyl-5-benzoxazolessigsaeure. |
| JP60231423A JPS61100574A (ja) | 1984-10-22 | 1985-10-18 | ２（４‐フルオロフエニル）α‐メチル‐５‐ベンゾオキサゾール酢酸の製造方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT23264/84A IT1177017B (it) | 1984-10-22 | 1984-10-22 | Processo per la preparazione dell'acido 2(4-flurofenil)alfa-metil-5-benzox azoloacetico |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| IT8423264A0 IT8423264A0 (it) | 1984-10-22 |
| IT8423264A1 IT8423264A1 (it) | 1986-04-22 |
| IT1177017B true IT1177017B (it) | 1987-08-26 |
Family
ID=11205428
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT23264/84A IT1177017B (it) | 1984-10-22 | 1984-10-22 | Processo per la preparazione dell'acido 2(4-flurofenil)alfa-metil-5-benzox azoloacetico |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US4652654A (en, 2012) |
| EP (1) | EP0182061B1 (en, 2012) |
| JP (1) | JPS61100574A (en, 2012) |
| AT (1) | ATE70832T1 (en, 2012) |
| DE (1) | DE3585022D1 (en, 2012) |
| IT (1) | IT1177017B (en, 2012) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1233836B (it) * | 1988-01-13 | 1992-04-21 | Euroresearch Srl | Sali idrosolubili dell'acido (+)2-(4 fluorofenil)-alfa-metil-5 benzoxazolo acetato. |
| GB9312853D0 (en) * | 1993-06-22 | 1993-08-04 | Euro Celtique Sa | Chemical compounds |
| US5922751A (en) * | 1994-06-24 | 1999-07-13 | Euro-Celtique, S.A. | Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same |
| US5591776A (en) * | 1994-06-24 | 1997-01-07 | Euro-Celtique, S.A. | Pheynl or benzyl-substituted rolipram-based compounds for and method of inhibiting phosphodiesterase IV |
| US6372770B1 (en) | 1994-10-12 | 2002-04-16 | Euro-Celtique, S.A. | Benzoxazoles |
| US5665737B1 (en) * | 1994-10-12 | 1999-02-16 | Euro Celtique Sa | Substituted benzoxazoles |
| CA2202273A1 (en) * | 1994-10-12 | 1996-04-25 | David J. Cavalla | Novel benzoxazoles |
| AU4527896A (en) * | 1994-12-13 | 1996-07-03 | Euro-Celtique S.A. | Aryl thioxanthines |
| AU4527996A (en) * | 1994-12-13 | 1996-07-03 | Euro-Celtique S.A. | Trisubstituted thioxanthines |
| US6025361A (en) * | 1994-12-13 | 2000-02-15 | Euro-Celtique, S.A. | Trisubstituted thioxanthines |
| US6166041A (en) * | 1995-10-11 | 2000-12-26 | Euro-Celtique, S.A. | 2-heteroaryl and 2-heterocyclic benzoxazoles as PDE IV inhibitors for the treatment of asthma |
| US6075016A (en) * | 1996-04-10 | 2000-06-13 | Euro-Celtique S.A. | 6,5-fused aromatic ring systems having enhanced phosphodiesterase IV inhibitory activity |
| US5864037A (en) * | 1996-06-06 | 1999-01-26 | Euro-Celtique, S.A. | Methods for the synthesis of chemical compounds having PDE-IV inhibitory activity |
| US5744473A (en) * | 1996-09-16 | 1998-04-28 | Euro-Celtique, S.A. | PDE IV inhibitors: "bis-compounds" |
| CN1222513C (zh) * | 1997-02-03 | 2005-10-12 | 富士写真菲林株式会社 | 卤化银彩色照相感光材料和其中所用的菲尼酮化合物以及这类化合物的制备方法 |
| WO2010130718A1 (en) * | 2009-05-15 | 2010-11-18 | Sanofi-Aventis | Process for the preparation of a compound useful as an inhibitor of tafia |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1435721A (en) * | 1972-05-18 | 1976-05-12 | Lilly Industries Ltd | Benzoxazole derivatives |
| US3962452A (en) * | 1972-05-18 | 1976-06-08 | Lilly Industries, Ltd. | Benzoxazole derivatives as therapeutics |
| US4025636A (en) * | 1973-10-23 | 1977-05-24 | Lilly Industries, Ltd. | 2-(Optionally substituted)phenyl-5 or 6-substituted benzoxazoles |
-
1984
- 1984-10-22 IT IT23264/84A patent/IT1177017B/it active
-
1985
- 1985-10-07 EP EP85112699A patent/EP0182061B1/en not_active Expired - Lifetime
- 1985-10-07 DE DE8585112699T patent/DE3585022D1/de not_active Expired - Fee Related
- 1985-10-07 AT AT85112699T patent/ATE70832T1/de not_active IP Right Cessation
- 1985-10-07 US US06/784,892 patent/US4652654A/en not_active Expired - Lifetime
- 1985-10-18 JP JP60231423A patent/JPS61100574A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0368026B2 (en, 2012) | 1991-10-25 |
| IT8423264A0 (it) | 1984-10-22 |
| ATE70832T1 (de) | 1992-01-15 |
| EP0182061B1 (en) | 1991-12-27 |
| US4652654A (en) | 1987-03-24 |
| DE3585022D1 (de) | 1992-02-06 |
| EP0182061A1 (en) | 1986-05-28 |
| JPS61100574A (ja) | 1986-05-19 |
| IT8423264A1 (it) | 1986-04-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IT1177017B (it) | Processo per la preparazione dell'acido 2(4-flurofenil)alfa-metil-5-benzox azoloacetico | |
| IT8520869A0 (it) | Procedimento di fermentazione per produrre acido ialuronico. | |
| DE69809962D1 (de) | Verfahren zur herstellung von hydroxysubstituierten gamma-butyrolactonen | |
| IT8567583A1 (it) | Procedimento per la produzione di esteri dell'acido acrilico e metacrilico mediante esterificazione. | |
| IT8822798A0 (it) | Esteri dell'acido 3,6-diidro-1,5(2h)-pirimidincarbossilico | |
| IT7824903A0 (it) | Processo per la preparazione di esteri dell'acido ossalico. | |
| ES2062205T3 (es) | Metodo para producir 2,2-dimetil-3-hidroxipropil-2,2-dimetil-3-hidroxipropionato. | |
| MY106374A (en) | Process and intermediates for 2r-benzyl- chroman-6-carbaldehyde. | |
| ES556648A0 (es) | Un procedimiento para preparar ester isopropilidenico ciclico de acido malonico | |
| DE69211936D1 (de) | Verfahren zur Herstellung von niedrigem Alkyl-2-oxo-L-Gulonat | |
| ATE207139T1 (de) | Verfahren zur herstellung von butantetracarbonsäure | |
| DE3473438D1 (en) | Process for the production of alpha, beta-ethylenically unsaturated esters | |
| KR100214903B1 (en) | Process for producing aminomethanephosphonic acid and aminomethylphosphinic acids | |
| IT1173369B (it) | Processo per la preparazione di acidi alfa-arilalcanoici otticamente attivi | |
| PL255065A1 (en) | Method of obtaining /4s/-6-fluoro-spiro-/chromano-4,4'-imidazolidin/-dione-2',5' or its /2r/-methyl derivative | |
| ATE4118T1 (de) | Verfahren zur herstellung von 17 alpha-hydroxyund 17a alpha-hydroxy-d-homo-etiocarbonsaeuren. | |
| ES483482A1 (es) | Un procedimiento para la preparacion de derivados de carba- zol | |
| ES518419A0 (es) | Procedimiento para la preparacion de acido 1-(para-clorobenzoil)-5-metoxi-2-metilindol-3-acetoxiacetico. | |
| CA2029085A1 (en) | Process for preparing butanetetracarboxylic acid | |
| IT8521530A0 (it) | Processo per produrre acido cinnamico. | |
| ES8305326A1 (es) | "procedimiento para la preparacion de l-prolina". | |
| ATE47427T1 (de) | Verfahren zur herstellung von arphamenin mit hoher ausbeute. | |
| ATE130839T1 (de) | Verfahren zur herstellung von carboxylierten 2- allylphenolen. | |
| IT1113932B (it) | Processo per la idrogenazione stereoselettiva dell'acido 2i(6'-metossi-2'-naftil)-acrilico | |
| ATE178581T1 (de) | Verfahren zur herstellung von optisch aktiven 2- halogenpropionsäuren |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19971029 |