ATE70832T1 - Verfahren zur herstellung von 2-(4-fluorphenyl)alpha-methyl-5-benzoxazolessigs|ure. - Google Patents
Verfahren zur herstellung von 2-(4-fluorphenyl)alpha-methyl-5-benzoxazolessigs|ure.Info
- Publication number
- ATE70832T1 ATE70832T1 AT85112699T AT85112699T ATE70832T1 AT E70832 T1 ATE70832 T1 AT E70832T1 AT 85112699 T AT85112699 T AT 85112699T AT 85112699 T AT85112699 T AT 85112699T AT E70832 T1 ATE70832 T1 AT E70832T1
- Authority
- AT
- Austria
- Prior art keywords
- fluorophenyl
- benzoxazole
- methyl
- reacted
- acid
- Prior art date
Links
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 abstract 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 abstract 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 2
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 abstract 2
- AOZKIUFHHMUPGU-UHFFFAOYSA-N 2-(3-amino-4-hydroxyphenyl)acetic acid Chemical compound NC1=CC(CC(O)=O)=CC=C1O AOZKIUFHHMUPGU-UHFFFAOYSA-N 0.000 abstract 1
- KBFHXGWZGIITPB-UHFFFAOYSA-N 2-[2-(4-fluorophenyl)-1,3-benzoxazol-5-yl]acetic acid Chemical compound N=1C2=CC(CC(=O)O)=CC=C2OC=1C1=CC=C(F)C=C1 KBFHXGWZGIITPB-UHFFFAOYSA-N 0.000 abstract 1
- CZKLEJHVLCMVQR-UHFFFAOYSA-N 4-fluorobenzoyl chloride Chemical compound FC1=CC=C(C(Cl)=O)C=C1 CZKLEJHVLCMVQR-UHFFFAOYSA-N 0.000 abstract 1
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 abstract 1
- WYACBZDAHNBPPB-UHFFFAOYSA-N diethyl oxalate Chemical compound CCOC(=O)C(=O)OCC WYACBZDAHNBPPB-UHFFFAOYSA-N 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 235000019441 ethanol Nutrition 0.000 abstract 1
- 238000005984 hydrogenation reaction Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- KHPXUQMNIQBQEV-UHFFFAOYSA-L oxaloacetate(2-) Chemical compound [O-]C(=O)CC(=O)C([O-])=O KHPXUQMNIQBQEV-UHFFFAOYSA-L 0.000 abstract 1
- 229910000027 potassium carbonate Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D263/57—Aryl or substituted aryl radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT23264/84A IT1177017B (it) | 1984-10-22 | 1984-10-22 | Processo per la preparazione dell'acido 2(4-flurofenil)alfa-metil-5-benzox azoloacetico |
| EP85112699A EP0182061B1 (en) | 1984-10-22 | 1985-10-07 | New process for preparing 2(4-fluorophenyl) alpha methyl-5-benzoxazole acetic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE70832T1 true ATE70832T1 (de) | 1992-01-15 |
Family
ID=11205428
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT85112699T ATE70832T1 (de) | 1984-10-22 | 1985-10-07 | Verfahren zur herstellung von 2-(4-fluorphenyl)alpha-methyl-5-benzoxazolessigs|ure. |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US4652654A (en, 2012) |
| EP (1) | EP0182061B1 (en, 2012) |
| JP (1) | JPS61100574A (en, 2012) |
| AT (1) | ATE70832T1 (en, 2012) |
| DE (1) | DE3585022D1 (en, 2012) |
| IT (1) | IT1177017B (en, 2012) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1233836B (it) * | 1988-01-13 | 1992-04-21 | Euroresearch Srl | Sali idrosolubili dell'acido (+)2-(4 fluorofenil)-alfa-metil-5 benzoxazolo acetato. |
| GB9312853D0 (en) * | 1993-06-22 | 1993-08-04 | Euro Celtique Sa | Chemical compounds |
| US5922751A (en) * | 1994-06-24 | 1999-07-13 | Euro-Celtique, S.A. | Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same |
| US5591776A (en) * | 1994-06-24 | 1997-01-07 | Euro-Celtique, S.A. | Pheynl or benzyl-substituted rolipram-based compounds for and method of inhibiting phosphodiesterase IV |
| US5665737B1 (en) * | 1994-10-12 | 1999-02-16 | Euro Celtique Sa | Substituted benzoxazoles |
| US6372770B1 (en) | 1994-10-12 | 2002-04-16 | Euro-Celtique, S.A. | Benzoxazoles |
| DE69531623T2 (de) * | 1994-10-12 | 2004-06-17 | Euroceltique S.A. | Neue benzoxazole |
| DE69531555T2 (de) * | 1994-12-13 | 2004-06-17 | Euroceltique S.A. | Dreifachsubstituierte thioxanthine |
| JPH10508032A (ja) * | 1994-12-13 | 1998-08-04 | ユーロ−セルティーク，エス．エイ． | アリールチオキサンチン類 |
| US6025361A (en) * | 1994-12-13 | 2000-02-15 | Euro-Celtique, S.A. | Trisubstituted thioxanthines |
| US6166041A (en) * | 1995-10-11 | 2000-12-26 | Euro-Celtique, S.A. | 2-heteroaryl and 2-heterocyclic benzoxazoles as PDE IV inhibitors for the treatment of asthma |
| US6075016A (en) * | 1996-04-10 | 2000-06-13 | Euro-Celtique S.A. | 6,5-fused aromatic ring systems having enhanced phosphodiesterase IV inhibitory activity |
| US5864037A (en) | 1996-06-06 | 1999-01-26 | Euro-Celtique, S.A. | Methods for the synthesis of chemical compounds having PDE-IV inhibitory activity |
| US5744473A (en) * | 1996-09-16 | 1998-04-28 | Euro-Celtique, S.A. | PDE IV inhibitors: "bis-compounds" |
| DE69834601T2 (de) * | 1997-02-03 | 2007-05-03 | Fuji Photo Film Co., Ltd., Minami-Ashigara | Silberhalogenid enthaltendes farbphotographisches material, phenidonverbindungen zu seiner herstellung und verfahren zur herstellung dieser phenidonverbindungen |
| ES2431068T3 (es) * | 2009-05-15 | 2013-11-25 | Sanofi | Proceso para la preparación de un compuesto útil como un inhibidor de TAFIa |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3962452A (en) * | 1972-05-18 | 1976-06-08 | Lilly Industries, Ltd. | Benzoxazole derivatives as therapeutics |
| GB1435721A (en) * | 1972-05-18 | 1976-05-12 | Lilly Industries Ltd | Benzoxazole derivatives |
| US4025636A (en) * | 1973-10-23 | 1977-05-24 | Lilly Industries, Ltd. | 2-(Optionally substituted)phenyl-5 or 6-substituted benzoxazoles |
-
1984
- 1984-10-22 IT IT23264/84A patent/IT1177017B/it active
-
1985
- 1985-10-07 US US06/784,892 patent/US4652654A/en not_active Expired - Lifetime
- 1985-10-07 EP EP85112699A patent/EP0182061B1/en not_active Expired - Lifetime
- 1985-10-07 DE DE8585112699T patent/DE3585022D1/de not_active Expired - Fee Related
- 1985-10-07 AT AT85112699T patent/ATE70832T1/de not_active IP Right Cessation
- 1985-10-18 JP JP60231423A patent/JPS61100574A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0368026B2 (en, 2012) | 1991-10-25 |
| DE3585022D1 (de) | 1992-02-06 |
| EP0182061B1 (en) | 1991-12-27 |
| JPS61100574A (ja) | 1986-05-19 |
| IT8423264A1 (it) | 1986-04-22 |
| IT8423264A0 (it) | 1984-10-22 |
| US4652654A (en) | 1987-03-24 |
| EP0182061A1 (en) | 1986-05-28 |
| IT1177017B (it) | 1987-08-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEFA | Change of the company name | ||
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |