IT1172225B - Derivati della 4-ammino-6,7-dimetossi-2-piperazinil-chinazolina, loro preparazione ed impiego - Google Patents

Derivati della 4-ammino-6,7-dimetossi-2-piperazinil-chinazolina, loro preparazione ed impiego

Info

Publication number
IT1172225B
IT1172225B IT67213/81A IT6721381A IT1172225B IT 1172225 B IT1172225 B IT 1172225B IT 67213/81 A IT67213/81 A IT 67213/81A IT 6721381 A IT6721381 A IT 6721381A IT 1172225 B IT1172225 B IT 1172225B
Authority
IT
Italy
Prior art keywords
dimetoxy
chinazoline
piperazinyl
derivatives
amino
Prior art date
Application number
IT67213/81A
Other languages
English (en)
Italian (it)
Other versions
IT8167213A0 (it
Inventor
Sato Yasunobu
Fukumi Hiroshi
Koike Hiroyuki
Nishino Hiroshi
Original Assignee
Sankyo Co Ltd Td
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP1677580A external-priority patent/JPS56113770A/ja
Priority claimed from JP5275480A external-priority patent/JPS56150072A/ja
Priority claimed from JP9610780A external-priority patent/JPS5721385A/ja
Priority claimed from JP9610680A external-priority patent/JPS5721384A/ja
Application filed by Sankyo Co Ltd Td filed Critical Sankyo Co Ltd Td
Publication of IT8167213A0 publication Critical patent/IT8167213A0/it
Application granted granted Critical
Publication of IT1172225B publication Critical patent/IT1172225B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IT67213/81A 1980-02-13 1981-02-13 Derivati della 4-ammino-6,7-dimetossi-2-piperazinil-chinazolina, loro preparazione ed impiego IT1172225B (it)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP1677580A JPS56113770A (en) 1980-02-13 1980-02-13 Novel quinazoline derivative and its preparation
JP5275480A JPS56150072A (en) 1980-04-21 1980-04-21 Novel quinazoline derivative and its preparation
JP9610780A JPS5721385A (en) 1980-07-14 1980-07-14 Novel aminoquinazoline derivative and its preparation
JP9610680A JPS5721384A (en) 1980-07-14 1980-07-14 Novel aminoquinazoline derivative and its preparation

Publications (2)

Publication Number Publication Date
IT8167213A0 IT8167213A0 (it) 1981-02-13
IT1172225B true IT1172225B (it) 1987-06-18

Family

ID=27456647

Family Applications (1)

Application Number Title Priority Date Filing Date
IT67213/81A IT1172225B (it) 1980-02-13 1981-02-13 Derivati della 4-ammino-6,7-dimetossi-2-piperazinil-chinazolina, loro preparazione ed impiego

Country Status (9)

Country Link
US (1) US4426382A (enrdf_load_stackoverflow)
CA (1) CA1154765A (enrdf_load_stackoverflow)
CH (1) CH644857A5 (enrdf_load_stackoverflow)
DE (1) DE3105330A1 (enrdf_load_stackoverflow)
ES (1) ES8207169A1 (enrdf_load_stackoverflow)
FR (1) FR2475548A1 (enrdf_load_stackoverflow)
GB (1) GB2068961B (enrdf_load_stackoverflow)
IT (1) IT1172225B (enrdf_load_stackoverflow)
NL (1) NL191208C (enrdf_load_stackoverflow)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS236097B1 (en) * 1983-06-01 1985-05-15 Jan Koenig Acylderivatives of 2-piperazinochinazoline and method of their preparation
DE3346675A1 (de) * 1983-12-23 1985-07-04 Beiersdorf Ag, 2000 Hamburg Substituierte 1-(4-amino-6,7-dialkoxy-chinazolinyl)-4- cyclohexenyl-derivate des piperazins und homopiperazins, verfahren zu ihrer herstellung und ihre verwendung sowie diese verbindungen enthaltende zubereitungen und zwischenprodukte
JPH0647540B2 (ja) * 1985-07-16 1994-06-22 エーザイ株式会社 虚血性心疾患・不整脈治療・予防剤
IT1270993B (it) * 1994-03-18 1997-05-26 Recordati Chem Pharm Derivati chinzolilamminici attivi come alfa-antagonisti
TWI350168B (en) 2004-05-07 2011-10-11 Incyte Corp Amido compounds and their use as pharmaceuticals
WO2007126935A2 (en) * 2006-03-29 2007-11-08 Merck & Co., Inc. Diazepan orexin receptor antagonists
PE20081229A1 (es) * 2006-12-01 2008-08-28 Merck & Co Inc Antagonistas de receptor de orexina de diazepam sustituido
EP2155689B1 (en) 2007-05-31 2015-07-08 Boehringer Ingelheim International GmbH Ccr2 receptor antagonists and uses thereof
US20090325964A1 (en) * 2008-05-23 2009-12-31 Wyeth Piperazine Metabotropic Glutamate Receptor 5 (MGLUR5) Negative Allosteric Modulators For Anxiety/Depression
EP2379525B1 (en) 2008-12-19 2015-07-29 Boehringer Ingelheim International GmbH Cyclic pyrimidin-4-carboxamides as ccr2 receptor antagonists for treatment of inflammation, asthma and copd
PT3091012T (pt) 2009-12-17 2018-06-27 Centrexion Therapeutics Corp Antagonistas do receptor ccr2 e suas utilizações
US8946218B2 (en) 2010-05-12 2015-02-03 Boehringer Ingelheim International Gmbh CCR2 receptor antagonists, method for producing the same, and use thereof as medicaments
JP2013526507A (ja) 2010-05-12 2013-06-24 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規ｃｃｒ２受容体アンタゴニスト、その製造方法及び薬物としてのその使用
JP5647339B2 (ja) 2010-05-17 2014-12-24 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｃｒ２アンタゴニスト及びこれらの使用
EP2576542B1 (en) 2010-05-25 2015-04-22 Boehringer Ingelheim International GmbH Cyclic amide derivatives of pyridazine-3-carboxylic acids and their use in the treatment of pulmonary, pain, immune related and cardiovascular diseases
EP2576538B1 (en) 2010-06-01 2015-10-28 Boehringer Ingelheim International GmbH New CCR2 antagonists
JP5786258B2 (ja) 2011-07-15 2015-09-30 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規かつ選択的なｃｃｒ２拮抗薬
AU2013241854B2 (en) * 2012-03-28 2017-11-02 Intervet International B.V. Heteroaryl compounds with cyclic bridging unit for use in the treatment helminth infection
KR20150033652A (ko) 2012-06-20 2015-04-01 노파르티스 아게 보체 경로 조절제 및 그의 용도
WO2015095111A1 (en) 2013-12-18 2015-06-25 Merck Sharp & Dohme Corp. Diazepane orexin receptor antagonists
CA2990460C (en) 2015-07-02 2023-10-17 Centrexion Therapeutics Corporation (4-((3r,4r)-3-methoxytetrahydro-pyran-4-ylamino)piperidin-1-yl)(5-methyl-6-(((2r,6s)-6-(p-tolyl)tetrahydro-2h-pyran-2-yl)methylamino)pyrimidin-4-yl)methanone citrate
WO2019010180A1 (en) * 2017-07-06 2019-01-10 Case Western Reserve University PEPTIDE AND SMALL MOLECULE AGONISTS OF EPHA AND USES THEREOF

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3511836A (en) * 1967-12-13 1970-05-12 Pfizer & Co C 2,4,6,7-tetra substituted quinazolines
US3663706A (en) 1969-09-29 1972-05-16 Pfizer Use of 2,4-diaminoquinazolines as hypotensive agents
JPS536156B2 (enrdf_load_stackoverflow) * 1972-10-30 1978-03-04
US3935213A (en) 1973-12-05 1976-01-27 Pfizer Inc. Process for hypotensive 4-amino-2-(piperazin-1-yl) quinazoline derivatives
US4060615A (en) * 1976-02-18 1977-11-29 Mead Johnson & Company 2-Piperazinyl-6,7-dimethoxyquinazolines
US4001237A (en) * 1976-02-18 1977-01-04 Bristol-Myers Company Oxazole, isoxazole, thiazole and isothiazole amides
US4189484A (en) * 1977-11-08 1980-02-19 Mitsubishi Yuka Pharmaceutical Co., Ltd. Antihypertensive quinazoline derivatives
US4287341A (en) 1979-11-01 1981-09-01 Pfizer Inc. Alkoxy-substituted-6-chloro-quinazoline-2,4-diones
JPS5728576A (en) * 1980-07-24 1982-02-16 Toshiba Corp Inverter device

Also Published As

Publication number Publication date
DE3105330C2 (enrdf_load_stackoverflow) 1991-07-25
NL191208C (nl) 1995-03-16
FR2475548A1 (fr) 1981-08-14
GB2068961A (en) 1981-08-19
IT8167213A0 (it) 1981-02-13
NL191208B (nl) 1994-10-17
NL8100726A (nl) 1981-09-16
ES499377A0 (es) 1982-09-01
GB2068961B (en) 1983-11-30
DE3105330A1 (de) 1981-12-17
CA1154765A (en) 1983-10-04
ES8207169A1 (es) 1982-09-01
FR2475548B1 (enrdf_load_stackoverflow) 1983-06-24
CH644857A5 (de) 1984-08-31
US4426382A (en) 1984-01-17

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Effective date: 19950227