IT1165954B - 2'-deossi-5(2-alogenovinil)-uridina e suo metodo di preparazione in specie per trattamento di infezioni da erpes - Google Patents
2'-deossi-5(2-alogenovinil)-uridina e suo metodo di preparazione in specie per trattamento di infezioni da erpesInfo
- Publication number
- IT1165954B IT1165954B IT09403/79A IT940379A IT1165954B IT 1165954 B IT1165954 B IT 1165954B IT 09403/79 A IT09403/79 A IT 09403/79A IT 940379 A IT940379 A IT 940379A IT 1165954 B IT1165954 B IT 1165954B
- Authority
- IT
- Italy
- Prior art keywords
- deossi
- erpes
- halogenovinyl
- uridine
- infections
- Prior art date
Links
- 208000015181 infectious disease Diseases 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 229940045145 uridine Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB16158/78A GB1601020A (en) | 1978-04-24 | 1978-04-24 | 2'-deoxy-5 (2-halogenovinyl)-uridines |
Publications (2)
Publication Number | Publication Date |
---|---|
IT7909403A0 IT7909403A0 (it) | 1979-04-23 |
IT1165954B true IT1165954B (it) | 1987-04-29 |
Family
ID=10072234
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT09403/79A IT1165954B (it) | 1978-04-24 | 1979-04-23 | 2'-deossi-5(2-alogenovinil)-uridina e suo metodo di preparazione in specie per trattamento di infezioni da erpes |
Country Status (11)
Country | Link |
---|---|
US (1) | US4424211A (it) |
JP (1) | JPS554364A (it) |
BE (1) | BE875773A (it) |
CA (1) | CA1117108A (it) |
CH (1) | CH643273A5 (it) |
DE (1) | DE2915254A1 (it) |
FR (1) | FR2432526A1 (it) |
GB (1) | GB1601020A (it) |
IT (1) | IT1165954B (it) |
NL (1) | NL192793C (it) |
SE (1) | SE445832B (it) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5687599A (en) * | 1979-12-19 | 1981-07-16 | Yamasa Shoyu Co Ltd | E 55 22halogenovinyl arabinofuranosyluracil and its preparation |
US4383990A (en) * | 1980-10-01 | 1983-05-17 | Beecham Group Limited | Antiviral agents, their preparation and use |
EP0060099A1 (en) * | 1981-03-11 | 1982-09-15 | Beecham Group Plc | Antiviral agents, their preparation and use |
NZ199764A (en) * | 1981-03-20 | 1984-08-24 | Beecham Group Plc | 5-(2-halogenovinyl)-2'-deoxyuridine derivatives and pharmaceutical compositions |
EP0072137A1 (en) * | 1981-08-01 | 1983-02-16 | Beecham Group Plc | Antiviral deoxyuridine compounds |
HU183567B (en) * | 1981-09-07 | 1984-05-28 | Mta Koezponti Kemiai Kutato In | Process for preparing /e/-5-/2-bromo-vinyl/-uridine and derivatives thereof |
EP0082667A1 (en) * | 1981-12-18 | 1983-06-29 | Beecham Group Plc | Pharmaceutical compositions |
DE3362994D1 (en) * | 1982-02-12 | 1986-05-22 | Atomic Energy Authority Uk | Laser pipe welder/cutter |
EP0095292A1 (en) * | 1982-05-22 | 1983-11-30 | Beecham Group Plc | 5-(2-halogenovinyl)-2'-deoxyuridine derivatives, processes for their preparation, pharmaceutical compositions containing them, and their use in treating viral infections" |
EP0095294A1 (en) * | 1982-05-22 | 1983-11-30 | Beecham Group Plc | Deoxyuridine compounds, methods for preparing them and their use in medicine |
EP0097039A1 (en) * | 1982-06-16 | 1983-12-28 | Beecham Group Plc | 5-(E-2-halovinyl)-2'-deoxyuridine derivatives, processes for their preparation, pharmaceutical compositions containing them, and their use in treating viral infections |
HU187736B (en) * | 1982-08-04 | 1986-02-28 | Mta Koezponti Kemiai Kutato Intezet,Hu | Process for producing /e/ -5-/2-bromovinyl/-2-comma above-deoxyuridine and o-acyl derivatives |
FR2531962B1 (fr) * | 1982-08-17 | 1986-11-14 | Sandoz Sa | Nouveaux derives de la desoxyuridine, leur preparation et leur utilisation comme medicaments |
EP0104066B1 (en) * | 1982-09-17 | 1988-08-10 | Glaxo Group Limited | 5-halovinyl-2'-deoxyuridine derivatives |
EP0104857A1 (en) * | 1982-09-28 | 1984-04-04 | Beecham Group Plc | Deoxyuridine compounds, methods for preparing them and their use in medicine |
US4658044A (en) * | 1983-09-16 | 1987-04-14 | Glaxo Group Limited | Intermediates for uracil derivatives |
JPS62500239A (ja) * | 1984-09-24 | 1987-01-29 | ピイシーアール,インコーポレイテッド | 2−デオキシウリジンの製造方法 |
GB8517402D0 (en) | 1985-07-10 | 1985-08-14 | Wellcome Found | Treatment of viral infections |
GB8629892D0 (en) * | 1986-12-15 | 1987-01-28 | Wellcome Found | Antiviral compounds |
US5215971A (en) * | 1986-12-19 | 1993-06-01 | Medivir Ab | Antiviral pharmaceutical composition comprising 5-substituted pyrimidine nucleosides |
SE8605503D0 (sv) * | 1986-12-19 | 1986-12-19 | Astra Laekemedel Ab | Novel medicinal use |
US4863927A (en) * | 1987-05-11 | 1989-09-05 | Merck & Co., Inc. | 1-(2-hydroxymethyl)cycloalkylmethyl)-5-substituted uracils |
JPH0217199A (ja) * | 1988-07-05 | 1990-01-22 | Japan Tobacco Inc | 2’−デオキシ−β−アデノシンの製造方法 |
JPH0217198A (ja) * | 1988-07-05 | 1990-01-22 | Japan Tobacco Inc | 2’−デオキシ−β−シチジン誘導体およびその塩の製造法 |
EP0428623A4 (en) * | 1988-08-10 | 1993-12-08 | Stephen Leslie Sacks | Production of radioiodinated 1--g(b)-d-arabinofuranosyl)-5(e)-(2-iodovinyl)uracil, and uses thereof, and related analogues incorporating alternative halogen radionuclides, the general radiohalogenation precursors, 1-(2,3,5-tri-o-acetyl--g(b)-d-arabinofuranosyl)-5(z and e)-(2-trimethylsilylvinyl)urac |
EA005497B1 (ru) * | 2001-01-03 | 2005-02-24 | Берлин Хеми Аг | Применение фармацевтической композиции, содержащей бривудин, для лечения герпесвирусных инфекций |
DE10109657A1 (de) * | 2001-02-28 | 2002-09-05 | Menarini Ricerche Spa | Verfahren zur Herstellung von (E)-5-(2-Bromvinyl)-2`-desoxyuridin |
JP4651942B2 (ja) * | 2001-12-20 | 2011-03-16 | フアーマセツト・インコーポレイテッド | Ebv及びkhsv感染並びにそれに伴う異常細胞増殖の治療 |
CN102432655A (zh) * | 2011-10-28 | 2012-05-02 | 河南师范大学 | 一种合成5-((e)-2-溴乙烯基)-2′-脱氧尿嘧啶核苷(溴呋啶)的方法 |
EP3792271A1 (en) | 2019-09-13 | 2021-03-17 | Aurobindo Pharma Limited | A process for the preparation of brivudine |
WO2021209563A1 (en) | 2020-04-16 | 2021-10-21 | Som Innovation Biotech, S.A. | Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SU452961A3 (ru) | 1969-04-11 | 1974-12-05 | Шеринг Аг. (Фирма) | Способ получени пиримидиннуклеозидов |
DE2012888C3 (de) | 1970-03-14 | 1981-04-02 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Verfahren zur Herstellung von 5-Azapyrimidinnucleosiden |
DE2122991C2 (de) | 1971-05-04 | 1982-06-09 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Verfahren zur Herstellung von Cytosin- und 6-Azacytosinnucleosiden |
US4093715A (en) | 1977-04-28 | 1978-06-06 | Research Corporation | 5-Iodo-5'-amino-2',5'-dideoxycytidine and the pharmaceutically acceptable salts thereof |
US4093716A (en) | 1977-04-28 | 1978-06-06 | Research Corporation | Compositions containing 5-amino-5-deoxythymidine and pharmaceutically acceptable salts thereof |
DE2721466A1 (de) | 1977-05-12 | 1978-11-16 | Robugen Gmbh | Verfahren zur herstellung von 2'-desoxyribofuranosylnucleosiden |
-
1978
- 1978-04-24 GB GB16158/78A patent/GB1601020A/en not_active Expired
-
1979
- 1979-04-14 DE DE19792915254 patent/DE2915254A1/de active Granted
- 1979-04-18 NL NL7903029A patent/NL192793C/nl not_active IP Right Cessation
- 1979-04-19 CH CH367179A patent/CH643273A5/de not_active IP Right Cessation
- 1979-04-23 CA CA000326164A patent/CA1117108A/en not_active Expired
- 1979-04-23 FR FR7910230A patent/FR2432526A1/fr active Granted
- 1979-04-23 SE SE7903541A patent/SE445832B/sv not_active IP Right Cessation
- 1979-04-23 IT IT09403/79A patent/IT1165954B/it active
- 1979-04-23 BE BE1/9368A patent/BE875773A/xx not_active IP Right Cessation
- 1979-04-24 JP JP5133379A patent/JPS554364A/ja active Granted
-
1981
- 1981-12-21 US US06/332,757 patent/US4424211A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
SE7903541L (sv) | 1979-10-25 |
CH643273A5 (de) | 1984-05-30 |
NL7903029A (nl) | 1979-10-26 |
BE875773A (nl) | 1979-10-23 |
GB1601020A (en) | 1981-10-21 |
FR2432526A1 (fr) | 1980-02-29 |
NL192793C (nl) | 1998-02-03 |
FR2432526B1 (it) | 1982-10-08 |
JPS642599B2 (it) | 1989-01-18 |
DE2915254C2 (it) | 1990-07-12 |
JPS554364A (en) | 1980-01-12 |
NL192793B (nl) | 1997-10-01 |
SE445832B (sv) | 1986-07-21 |
US4424211A (en) | 1984-01-03 |
DE2915254A1 (de) | 1979-11-15 |
CA1117108A (en) | 1982-01-26 |
IT7909403A0 (it) | 1979-04-23 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19980429 |