IT1108491B - Derivati di amminotiazoli particolarment utili come immunostimolanti e procedimento per la loro preparazione - Google Patents
Derivati di amminotiazoli particolarment utili come immunostimolanti e procedimento per la loro preparazioneInfo
- Publication number
- IT1108491B IT1108491B IT69340/78A IT6934078A IT1108491B IT 1108491 B IT1108491 B IT 1108491B IT 69340/78 A IT69340/78 A IT 69340/78A IT 6934078 A IT6934078 A IT 6934078A IT 1108491 B IT1108491 B IT 1108491B
- Authority
- IT
- Italy
- Prior art keywords
- amminothiazoles
- immunostimulants
- derivatives
- procedure
- preparation
- Prior art date
Links
- 229960001438 immunostimulant agent Drugs 0.000 title 1
- 239000003022 immunostimulating agent Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/40—Unsubstituted amino or imino radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7731687A FR2406634A1 (fr) | 1977-10-19 | 1977-10-19 | Immunostimulants derives d'amino thiazoles |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IT7869340A0 IT7869340A0 (it) | 1978-10-10 |
| IT1108491B true IT1108491B (it) | 1985-12-09 |
Family
ID=9196775
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT69340/78A IT1108491B (it) | 1977-10-19 | 1978-10-10 | Derivati di amminotiazoli particolarment utili come immunostimolanti e procedimento per la loro preparazione |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US4225610A (enrdf_load_stackoverflow) |
| EP (1) | EP0001727B1 (enrdf_load_stackoverflow) |
| JP (1) | JPS5461172A (enrdf_load_stackoverflow) |
| CA (1) | CA1132574A (enrdf_load_stackoverflow) |
| DE (1) | DE2861318D1 (enrdf_load_stackoverflow) |
| ES (1) | ES474229A1 (enrdf_load_stackoverflow) |
| FR (1) | FR2406634A1 (enrdf_load_stackoverflow) |
| IL (1) | IL55770A (enrdf_load_stackoverflow) |
| IT (1) | IT1108491B (enrdf_load_stackoverflow) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57188578A (en) * | 1981-05-18 | 1982-11-19 | Mitsui Toatsu Chem Inc | N-(4-phenyl-2-thiazolyl)carbamic acid derivative and medicinal composition containing the same |
| WO1982002384A1 (en) * | 1981-01-08 | 1982-07-22 | Sakano Isao | Their preparation,and medicinal composition containing same |
| JPS57118574A (en) * | 1981-01-13 | 1982-07-23 | Mitsui Toatsu Chem Inc | N-(4-phenylthiazol-2-yl)carbamate derivative, its preparation and medicinal composition containing the same |
| JPS57116056A (en) * | 1981-01-08 | 1982-07-19 | Mitsui Toatsu Chem Inc | N-(4-phenyl-2-thiazolyl)carbamate derivative, its preparation and medicinal composition containing the same |
| JPS57136579A (en) * | 1981-01-21 | 1982-08-23 | Mitsui Toatsu Chem Inc | Thiazolylurea derivative, its preparation, and pharmaceutical composition containing the same |
| JPS57118573A (en) * | 1981-01-12 | 1982-07-23 | Mitsui Toatsu Chem Inc | N-(2-thiazolyl)carbamate derivative, its preparation, and drug composition comprising it |
| JPS57118575A (en) * | 1981-01-13 | 1982-07-23 | Mitsui Toatsu Chem Inc | Disubstituted aminothiazole derivative, its preparation and medicinal composition |
| JPS57116067A (en) * | 1981-01-12 | 1982-07-19 | Sankyo Kagaku Kk | Novel 8-quinolinesulfonyl derivative, its synthesis and use |
| EP0069154B1 (en) * | 1981-01-13 | 1986-10-15 | Mitsui Toatsu Kagaku Kabushiki Kaisha | Novel thiazole compounds, process for their preparation, and medicinal composition containing same |
| WO1982002386A1 (en) * | 1981-01-13 | 1982-07-22 | Sakano Isao | Aminothiazole derivatives,process for their preparation,and medicinal composition containing same |
| JPS57154175A (en) * | 1981-03-16 | 1982-09-22 | Mitsui Toatsu Chem Inc | 2-thiazoleamine derivative, its preparation, and drug composition comprising it |
| DE3503773A1 (de) * | 1985-02-05 | 1986-08-07 | Basf Ag, 6700 Ludwigshafen | Thiazolylamide, verfahren zu ihrer herstellung und ihre verwendung zur bekaempfung unerwuenschten pflanzenwuchses |
| US4914112A (en) * | 1986-06-03 | 1990-04-03 | Sumitomo Pharmaceuticals Company, Limited | Aminoazole derivatives and their production and use |
| JPS63152368A (ja) * | 1986-06-03 | 1988-06-24 | Sumitomo Pharmaceut Co Ltd | 新規なアミノアゾ−ル誘導体およびその酸付加塩 |
| US5180731A (en) * | 1986-06-03 | 1993-01-19 | Sumitomo Pharmaceuticals Company, Limited | Aminoazole derivatives and their production and use |
| JPH075579B2 (ja) * | 1986-09-01 | 1995-01-25 | 吉富製薬株式会社 | アミノチアゾ−ル化合物 |
| DE3864248D1 (de) * | 1987-12-14 | 1991-09-19 | Sawai Seiyaku Kk | Carboxamide mit tetrazol- und thiazol-ringen und ihre anwendung. |
| US4874864A (en) * | 1988-05-24 | 1989-10-17 | Pfizer Inc. | Benzamide protease inhibitors |
| WO1999015524A1 (en) * | 1997-09-23 | 1999-04-01 | Fujisawa Pharmaceutical Co., Ltd. | Thiazole derivatives |
| US20030055263A1 (en) * | 2001-07-11 | 2003-03-20 | Boehringer Ingelheim Pharma Kg | Carboxylic acid derivatives, medicaments comprising these compounds, their use and processes for their production |
| DE10133665A1 (de) * | 2001-07-11 | 2003-01-30 | Boehringer Ingelheim Pharma | Carbonsäurederivate, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Herstellung |
| FR2854158B1 (fr) | 2003-04-25 | 2006-11-17 | Sanofi Synthelabo | Derives de 2-acylamino-4-phenylethiazole, leur preparation et leur application en therapeutique |
| FR2872813B1 (fr) | 2004-07-09 | 2007-01-19 | Sanofi Synthelabo | Derives de 2-carbamide-4-phenylthiazole, leur preparation et leur application en therapeutique |
| FR2876692B1 (fr) | 2004-10-19 | 2007-02-23 | Sanofi Aventis Sa | Derives de 2-amido-4-phenylthiazole, leur preparation et leur application en therapeutique |
| FR2895989B1 (fr) | 2006-01-06 | 2010-04-30 | Sanofi Aventis | Derives de 2-carbamide-4-phenylthiazole, leur preparation et leur application en therapeutique |
| GB0905525D0 (en) * | 2009-03-31 | 2009-05-13 | Univ Leiden | Compounds and uses |
| CN102166214B (zh) * | 2011-03-02 | 2012-12-12 | 华中科技大学同济医学院附属同济医院 | 氨基噻唑类MyD88特异性抑制剂在医学上的用途 |
| CN102336720B (zh) * | 2011-03-02 | 2016-01-13 | 华中科技大学 | 2-氨基噻唑衍生物及制备方法和应用 |
| WO2019169135A1 (en) * | 2018-02-28 | 2019-09-06 | University Of Southern California | Compositions and methods for modulating inflammatory and degenerative disorder |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3499910A (en) * | 1967-05-08 | 1970-03-10 | Mobil Oil Corp | Monohalophenylthiazolyl ureas |
| DE2132431A1 (de) * | 1971-06-30 | 1973-01-11 | Riedel De Haen Ag | 4-phenyl-thiazolderivate enthaltende pharmazeutische praeparate |
| US4134984A (en) * | 1975-11-18 | 1979-01-16 | John Wyeth & Brother Limited | Thiazole compositions |
-
1977
- 1977-10-19 FR FR7731687A patent/FR2406634A1/fr active Granted
-
1978
- 1978-09-26 EP EP78400112A patent/EP0001727B1/fr not_active Expired
- 1978-09-26 DE DE7878400112T patent/DE2861318D1/de not_active Expired
- 1978-10-10 IT IT69340/78A patent/IT1108491B/it active
- 1978-10-16 ES ES474229A patent/ES474229A1/es not_active Expired
- 1978-10-18 CA CA313,712A patent/CA1132574A/fr not_active Expired
- 1978-10-19 IL IL55770A patent/IL55770A/xx unknown
- 1978-10-19 JP JP12792178A patent/JPS5461172A/ja active Granted
- 1978-10-19 US US05/952,739 patent/US4225610A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE2861318D1 (en) | 1982-01-14 |
| CA1132574A (fr) | 1982-09-28 |
| EP0001727B1 (fr) | 1981-11-11 |
| IT7869340A0 (it) | 1978-10-10 |
| ES474229A1 (es) | 1979-04-01 |
| IL55770A0 (en) | 1978-12-17 |
| JPS5461172A (en) | 1979-05-17 |
| US4225610A (en) | 1980-09-30 |
| EP0001727A2 (fr) | 1979-05-02 |
| IL55770A (en) | 1982-02-28 |
| JPS6116275B2 (enrdf_load_stackoverflow) | 1986-04-28 |
| EP0001727A3 (en) | 1979-05-30 |
| FR2406634A1 (fr) | 1979-05-18 |
| FR2406634B1 (enrdf_load_stackoverflow) | 1982-09-03 |
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