DE2861318D1 - New derivatives of 4-phenyl-2-(2',2',2-trichlorethoxycarboxamido)-thiazole useful as medicaments, pharmaceutical compositions containing them and process for the preparation of these compounds - Google Patents

New derivatives of 4-phenyl-2-(2',2',2-trichlorethoxycarboxamido)-thiazole useful as medicaments, pharmaceutical compositions containing them and process for the preparation of these compounds

Info

Publication number
DE2861318D1
DE2861318D1 DE7878400112T DE2861318T DE2861318D1 DE 2861318 D1 DE2861318 D1 DE 2861318D1 DE 7878400112 T DE7878400112 T DE 7878400112T DE 2861318 T DE2861318 T DE 2861318T DE 2861318 D1 DE2861318 D1 DE 2861318D1
Authority
DE
Germany
Prior art keywords
trichlorethoxycarboxamido
medicaments
phenyl
compounds
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE7878400112T
Other languages
English (en)
Inventor
Jean-Pierre Tarayre
Henri Cousse
Gilbert Mouzin
Henri Lauressergues
Silvano Casadio
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pierre Fabre SA
Original Assignee
Pierre Fabre SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pierre Fabre SA filed Critical Pierre Fabre SA
Application granted granted Critical
Publication of DE2861318D1 publication Critical patent/DE2861318D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/40—Unsubstituted amino or imino radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE7878400112T 1977-10-19 1978-09-26 New derivatives of 4-phenyl-2-(2',2',2-trichlorethoxycarboxamido)-thiazole useful as medicaments, pharmaceutical compositions containing them and process for the preparation of these compounds Expired DE2861318D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7731687A FR2406634A1 (fr) 1977-10-19 1977-10-19 Immunostimulants derives d'amino thiazoles

Publications (1)

Publication Number Publication Date
DE2861318D1 true DE2861318D1 (en) 1982-01-14

Family

ID=9196775

Family Applications (1)

Application Number Title Priority Date Filing Date
DE7878400112T Expired DE2861318D1 (en) 1977-10-19 1978-09-26 New derivatives of 4-phenyl-2-(2',2',2-trichlorethoxycarboxamido)-thiazole useful as medicaments, pharmaceutical compositions containing them and process for the preparation of these compounds

Country Status (9)

Country Link
US (1) US4225610A (de)
EP (1) EP0001727B1 (de)
JP (1) JPS5461172A (de)
CA (1) CA1132574A (de)
DE (1) DE2861318D1 (de)
ES (1) ES474229A1 (de)
FR (1) FR2406634A1 (de)
IL (1) IL55770A (de)
IT (1) IT1108491B (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57118574A (en) * 1981-01-13 1982-07-23 Mitsui Toatsu Chem Inc N-(4-phenylthiazol-2-yl)carbamate derivative, its preparation and medicinal composition containing the same
JPS57136579A (en) * 1981-01-21 1982-08-23 Mitsui Toatsu Chem Inc Thiazolylurea derivative, its preparation, and pharmaceutical composition containing the same
JPS57116056A (en) * 1981-01-08 1982-07-19 Mitsui Toatsu Chem Inc N-(4-phenyl-2-thiazolyl)carbamate derivative, its preparation and medicinal composition containing the same
JPS57118573A (en) * 1981-01-12 1982-07-23 Mitsui Toatsu Chem Inc N-(2-thiazolyl)carbamate derivative, its preparation, and drug composition comprising it
JPS57188578A (en) * 1981-05-18 1982-11-19 Mitsui Toatsu Chem Inc N-(4-phenyl-2-thiazolyl)carbamic acid derivative and medicinal composition containing the same
WO1982002384A1 (en) * 1981-01-08 1982-07-22 Sakano Isao Their preparation,and medicinal composition containing same
JPS57118575A (en) * 1981-01-13 1982-07-23 Mitsui Toatsu Chem Inc Disubstituted aminothiazole derivative, its preparation and medicinal composition
JPS57116067A (en) * 1981-01-12 1982-07-19 Sankyo Kagaku Kk Novel 8-quinolinesulfonyl derivative, its synthesis and use
WO1982002386A1 (en) * 1981-01-13 1982-07-22 Sakano Isao Aminothiazole derivatives,process for their preparation,and medicinal composition containing same
WO1982002383A1 (en) * 1981-01-13 1982-07-22 Sakano Isao Novel thiazole compounds,process for their preparation,and medicinal composition containing same
JPS57154175A (en) * 1981-03-16 1982-09-22 Mitsui Toatsu Chem Inc 2-thiazoleamine derivative, its preparation, and drug composition comprising it
DE3503773A1 (de) * 1985-02-05 1986-08-07 Basf Ag, 6700 Ludwigshafen Thiazolylamide, verfahren zu ihrer herstellung und ihre verwendung zur bekaempfung unerwuenschten pflanzenwuchses
US4914112A (en) * 1986-06-03 1990-04-03 Sumitomo Pharmaceuticals Company, Limited Aminoazole derivatives and their production and use
US5180731A (en) * 1986-06-03 1993-01-19 Sumitomo Pharmaceuticals Company, Limited Aminoazole derivatives and their production and use
JPS63152368A (ja) * 1986-06-03 1988-06-24 Sumitomo Pharmaceut Co Ltd 新規なアミノアゾ−ル誘導体およびその酸付加塩
JPH075579B2 (ja) * 1986-09-01 1995-01-25 吉富製薬株式会社 アミノチアゾ−ル化合物
EP0321115B1 (de) * 1987-12-14 1991-08-14 Sawai Pharmaceutical Co., Ltd. Carboxamide mit Tetrazol- und Thiazol-Ringen und ihre Anwendung
US4874864A (en) * 1988-05-24 1989-10-17 Pfizer Inc. Benzamide protease inhibitors
WO1999015524A1 (en) * 1997-09-23 1999-04-01 Fujisawa Pharmaceutical Co., Ltd. Thiazole derivatives
DE10133665A1 (de) * 2001-07-11 2003-01-30 Boehringer Ingelheim Pharma Carbonsäurederivate, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Herstellung
US20030055263A1 (en) * 2001-07-11 2003-03-20 Boehringer Ingelheim Pharma Kg Carboxylic acid derivatives, medicaments comprising these compounds, their use and processes for their production
FR2854158B1 (fr) 2003-04-25 2006-11-17 Sanofi Synthelabo Derives de 2-acylamino-4-phenylethiazole, leur preparation et leur application en therapeutique
FR2872813B1 (fr) 2004-07-09 2007-01-19 Sanofi Synthelabo Derives de 2-carbamide-4-phenylthiazole, leur preparation et leur application en therapeutique
FR2876692B1 (fr) * 2004-10-19 2007-02-23 Sanofi Aventis Sa Derives de 2-amido-4-phenylthiazole, leur preparation et leur application en therapeutique
FR2895989B1 (fr) * 2006-01-06 2010-04-30 Sanofi Aventis Derives de 2-carbamide-4-phenylthiazole, leur preparation et leur application en therapeutique
GB0905525D0 (en) * 2009-03-31 2009-05-13 Univ Leiden Compounds and uses
CN102336720B (zh) * 2011-03-02 2016-01-13 华中科技大学 2-氨基噻唑衍生物及制备方法和应用
CN102166214B (zh) * 2011-03-02 2012-12-12 华中科技大学同济医学院附属同济医院 氨基噻唑类MyD88特异性抑制剂在医学上的用途
CA3090545A1 (en) * 2018-02-28 2019-09-06 University Of Southern California Compositions and methods for modulating inflammatory and degenerative disorder

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3499910A (en) * 1967-05-08 1970-03-10 Mobil Oil Corp Monohalophenylthiazolyl ureas
DE2132431A1 (de) * 1971-06-30 1973-01-11 Riedel De Haen Ag 4-phenyl-thiazolderivate enthaltende pharmazeutische praeparate
US4134984A (en) * 1975-11-18 1979-01-16 John Wyeth & Brother Limited Thiazole compositions

Also Published As

Publication number Publication date
FR2406634B1 (de) 1982-09-03
JPS5461172A (en) 1979-05-17
IL55770A0 (en) 1978-12-17
ES474229A1 (es) 1979-04-01
US4225610A (en) 1980-09-30
EP0001727A3 (en) 1979-05-30
EP0001727A2 (de) 1979-05-02
CA1132574A (fr) 1982-09-28
EP0001727B1 (de) 1981-11-11
IT7869340A0 (it) 1978-10-10
IT1108491B (it) 1985-12-09
FR2406634A1 (fr) 1979-05-18
IL55770A (en) 1982-02-28
JPS6116275B2 (de) 1986-04-28

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Legal Events

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8339 Ceased/non-payment of the annual fee