IL55770A - 4-phenyl-2-acylaminothiazole derivatives,their preparation and immunostimulant compositions containing them - Google Patents

4-phenyl-2-acylaminothiazole derivatives,their preparation and immunostimulant compositions containing them

Info

Publication number
IL55770A
IL55770A IL55770A IL5577078A IL55770A IL 55770 A IL55770 A IL 55770A IL 55770 A IL55770 A IL 55770A IL 5577078 A IL5577078 A IL 5577078A IL 55770 A IL55770 A IL 55770A
Authority
IL
Israel
Prior art keywords
phenyl
preparation
compositions containing
acylaminothiazole derivatives
immunostimulant compositions
Prior art date
Application number
IL55770A
Other languages
English (en)
Other versions
IL55770A0 (en
Inventor
Jean P Tarayre
Henri Cousse
Gilbert Mouzin
Henri Lauressergues
Silvano Casadio
Original Assignee
Fabre Sa Pierre
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fabre Sa Pierre filed Critical Fabre Sa Pierre
Publication of IL55770A0 publication Critical patent/IL55770A0/xx
Publication of IL55770A publication Critical patent/IL55770A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/40—Unsubstituted amino or imino radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL55770A 1977-10-19 1978-10-19 4-phenyl-2-acylaminothiazole derivatives,their preparation and immunostimulant compositions containing them IL55770A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7731687A FR2406634A1 (fr) 1977-10-19 1977-10-19 Immunostimulants derives d'amino thiazoles

Publications (2)

Publication Number Publication Date
IL55770A0 IL55770A0 (en) 1978-12-17
IL55770A true IL55770A (en) 1982-02-28

Family

ID=9196775

Family Applications (1)

Application Number Title Priority Date Filing Date
IL55770A IL55770A (en) 1977-10-19 1978-10-19 4-phenyl-2-acylaminothiazole derivatives,their preparation and immunostimulant compositions containing them

Country Status (9)

Country Link
US (1) US4225610A (xx)
EP (1) EP0001727B1 (xx)
JP (1) JPS5461172A (xx)
CA (1) CA1132574A (xx)
DE (1) DE2861318D1 (xx)
ES (1) ES474229A1 (xx)
FR (1) FR2406634A1 (xx)
IL (1) IL55770A (xx)
IT (1) IT1108491B (xx)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57118573A (en) * 1981-01-12 1982-07-23 Mitsui Toatsu Chem Inc N-(2-thiazolyl)carbamate derivative, its preparation, and drug composition comprising it
EP0068033B1 (en) * 1981-01-08 1985-07-10 Mitsui Toatsu Kagaku Kabushiki Kaisha N-(4-phenyl-2-thiazolyl)carbamate derivatives, process for their preparation, and medicinal composition containing same
JPS57116056A (en) * 1981-01-08 1982-07-19 Mitsui Toatsu Chem Inc N-(4-phenyl-2-thiazolyl)carbamate derivative, its preparation and medicinal composition containing the same
JPS57118574A (en) * 1981-01-13 1982-07-23 Mitsui Toatsu Chem Inc N-(4-phenylthiazol-2-yl)carbamate derivative, its preparation and medicinal composition containing the same
JPS57136579A (en) * 1981-01-21 1982-08-23 Mitsui Toatsu Chem Inc Thiazolylurea derivative, its preparation, and pharmaceutical composition containing the same
JPS57118575A (en) * 1981-01-13 1982-07-23 Mitsui Toatsu Chem Inc Disubstituted aminothiazole derivative, its preparation and medicinal composition
JPS57188578A (en) * 1981-05-18 1982-11-19 Mitsui Toatsu Chem Inc N-(4-phenyl-2-thiazolyl)carbamic acid derivative and medicinal composition containing the same
JPS57116067A (en) * 1981-01-12 1982-07-19 Sankyo Kagaku Kk Novel 8-quinolinesulfonyl derivative, its synthesis and use
WO1982002386A1 (en) * 1981-01-13 1982-07-22 Sakano Isao Aminothiazole derivatives,process for their preparation,and medicinal composition containing same
US4501750A (en) * 1981-01-13 1985-02-26 Mitsui Toatsu Kaguku Kabushiki Kaisha Thiazole compounds, a process for preparing same and a pharmaceutical composition containing the thiazole compounds
JPS57154175A (en) * 1981-03-16 1982-09-22 Mitsui Toatsu Chem Inc 2-thiazoleamine derivative, its preparation, and drug composition comprising it
DE3503773A1 (de) * 1985-02-05 1986-08-07 Basf Ag, 6700 Ludwigshafen Thiazolylamide, verfahren zu ihrer herstellung und ihre verwendung zur bekaempfung unerwuenschten pflanzenwuchses
US4914112A (en) * 1986-06-03 1990-04-03 Sumitomo Pharmaceuticals Company, Limited Aminoazole derivatives and their production and use
US5180731A (en) * 1986-06-03 1993-01-19 Sumitomo Pharmaceuticals Company, Limited Aminoazole derivatives and their production and use
JPS63152368A (ja) * 1986-06-03 1988-06-24 Sumitomo Pharmaceut Co Ltd 新規なアミノアゾ−ル誘導体およびその酸付加塩
JPH075579B2 (ja) * 1986-09-01 1995-01-25 吉富製薬株式会社 アミノチアゾ−ル化合物
EP0321115B1 (en) * 1987-12-14 1991-08-14 Sawai Pharmaceutical Co., Ltd. Carboxamide derivatives having tetrazole and thiazole rings and their use
US4874864A (en) * 1988-05-24 1989-10-17 Pfizer Inc. Benzamide protease inhibitors
WO1999015524A1 (en) * 1997-09-23 1999-04-01 Fujisawa Pharmaceutical Co., Ltd. Thiazole derivatives
DE10133665A1 (de) * 2001-07-11 2003-01-30 Boehringer Ingelheim Pharma Carbonsäurederivate, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Herstellung
US20030055263A1 (en) * 2001-07-11 2003-03-20 Boehringer Ingelheim Pharma Kg Carboxylic acid derivatives, medicaments comprising these compounds, their use and processes for their production
FR2854158B1 (fr) * 2003-04-25 2006-11-17 Sanofi Synthelabo Derives de 2-acylamino-4-phenylethiazole, leur preparation et leur application en therapeutique
FR2872813B1 (fr) 2004-07-09 2007-01-19 Sanofi Synthelabo Derives de 2-carbamide-4-phenylthiazole, leur preparation et leur application en therapeutique
FR2876692B1 (fr) * 2004-10-19 2007-02-23 Sanofi Aventis Sa Derives de 2-amido-4-phenylthiazole, leur preparation et leur application en therapeutique
FR2895989B1 (fr) * 2006-01-06 2010-04-30 Sanofi Aventis Derives de 2-carbamide-4-phenylthiazole, leur preparation et leur application en therapeutique
GB0905525D0 (en) * 2009-03-31 2009-05-13 Univ Leiden Compounds and uses
CN102166214B (zh) * 2011-03-02 2012-12-12 华中科技大学同济医学院附属同济医院 氨基噻唑类MyD88特异性抑制剂在医学上的用途
CN102336720B (zh) * 2011-03-02 2016-01-13 华中科技大学 2-氨基噻唑衍生物及制备方法和应用
WO2019169135A1 (en) 2018-02-28 2019-09-06 University Of Southern California Compositions and methods for modulating inflammatory and degenerative disorder

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3499910A (en) * 1967-05-08 1970-03-10 Mobil Oil Corp Monohalophenylthiazolyl ureas
DE2132431A1 (de) * 1971-06-30 1973-01-11 Riedel De Haen Ag 4-phenyl-thiazolderivate enthaltende pharmazeutische praeparate
US4134984A (en) * 1975-11-18 1979-01-16 John Wyeth & Brother Limited Thiazole compositions

Also Published As

Publication number Publication date
ES474229A1 (es) 1979-04-01
IT7869340A0 (it) 1978-10-10
FR2406634B1 (xx) 1982-09-03
JPS5461172A (en) 1979-05-17
IT1108491B (it) 1985-12-09
US4225610A (en) 1980-09-30
IL55770A0 (en) 1978-12-17
EP0001727A2 (fr) 1979-05-02
CA1132574A (fr) 1982-09-28
FR2406634A1 (fr) 1979-05-18
JPS6116275B2 (xx) 1986-04-28
EP0001727A3 (en) 1979-05-30
DE2861318D1 (en) 1982-01-14
EP0001727B1 (fr) 1981-11-11

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