IS5990A - Nýjar amidínbensýlamínafleiður og notkun þeirra sem þrombínhemlar - Google Patents

Nýjar amidínbensýlamínafleiður og notkun þeirra sem þrombínhemlar

Info

Publication number
IS5990A
IS5990A IS5990A IS5990A IS5990A IS 5990 A IS5990 A IS 5990A IS 5990 A IS5990 A IS 5990A IS 5990 A IS5990 A IS 5990A IS 5990 A IS5990 A IS 5990A
Authority
IS
Iceland
Prior art keywords
thrombin inhibitors
benzylamine derivatives
new amidine
amidine
new
Prior art date
Application number
IS5990A
Other languages
English (en)
Inventor
Inghardt Tord
Nyström Jan-Erik
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE9900071A external-priority patent/SE9900071D0/xx
Priority claimed from SE9904228A external-priority patent/SE9904228D0/xx
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of IS5990A publication Critical patent/IS5990A/is

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IS5990A 1999-01-13 2001-07-05 Nýjar amidínbensýlamínafleiður og notkun þeirra sem þrombínhemlar IS5990A (is)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE9900071A SE9900071D0 (sv) 1999-01-13 1999-01-13 New compounds
SE9904228A SE9904228D0 (sv) 1999-11-22 1999-11-22 New compounds
PCT/SE2000/000052 WO2000042059A1 (en) 1999-01-13 2000-01-13 New amidinobenzylamine derivatives and their use as thrombin inhibitors

Publications (1)

Publication Number Publication Date
IS5990A true IS5990A (is) 2001-07-05

Family

ID=26663479

Family Applications (1)

Application Number Title Priority Date Filing Date
IS5990A IS5990A (is) 1999-01-13 2001-07-05 Nýjar amidínbensýlamínafleiður og notkun þeirra sem þrombínhemlar

Country Status (22)

Country Link
US (1) US6599894B1 (is)
EP (1) EP1150996B1 (is)
JP (1) JP2002535250A (is)
KR (1) KR100639274B1 (is)
CN (1) CN1170842C (is)
AU (1) AU764121B2 (is)
BR (1) BR0007453A (is)
CA (1) CA2355792A1 (is)
CY (1) CY1107149T1 (is)
CZ (1) CZ20012529A3 (is)
DE (1) DE60037183T2 (is)
DK (1) DK1150996T3 (is)
EE (1) EE200100371A (is)
ES (1) ES2295004T3 (is)
IL (1) IL143987A (is)
IS (1) IS5990A (is)
NO (1) NO20013319L (is)
NZ (1) NZ512714A (is)
PL (1) PL349769A1 (is)
PT (1) PT1150996E (is)
TR (1) TR200102037T2 (is)
WO (1) WO2000042059A1 (is)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0001803D0 (sv) * 2000-05-16 2000-05-16 Astrazeneca Ab New compounds i
AU2001280395B2 (en) * 2000-08-16 2005-11-24 Astrazeneca Ab New amidino derivatives and their use as thrombin inhibitors
US6433186B1 (en) 2000-08-16 2002-08-13 Astrazeneca Ab Amidino derivatives and their use as thormbin inhibitors
SE0102921D0 (sv) 2001-08-30 2001-08-30 Astrazeneca Ab Pharmaceutically useful compounds
US7129233B2 (en) 2000-12-01 2006-10-31 Astrazeneca Ab Mandelic acid derivatives and their use as thrombin inhibitors
AR035216A1 (es) * 2000-12-01 2004-05-05 Astrazeneca Ab Derivados de acido mandelico ,derivados farmaceuticamente aceptables, uso de estos derivados para la fabricacion de medicamentos, metodos de tratamiento ,procesos para la preparacion de estos derivados, y compuestos intermediarios
AR034517A1 (es) * 2001-06-21 2004-02-25 Astrazeneca Ab Formulacion farmaceutica
UA78195C2 (uk) * 2001-08-30 2007-03-15 Astrazeneca Ab Похідні мигдалевої кислоти та їх застосування як інгібіторів тромбіну, фармацевтична композиція на їх основі
MXPA04003170A (es) * 2001-10-03 2004-07-08 Pharmacia Corp Compuestos policiclicos, sustituidos, provisto de 5 miembros, utiles para la inhibicion selectiva de la cascada de coagulacion.
SE0201659D0 (sv) * 2002-05-31 2002-05-31 Astrazeneca Ab Modified release pharmaceutical formulation
SE0201658D0 (sv) * 2002-05-31 2002-05-31 Astrazeneca Ab Immediate release pharmaceutical formulation
SE0201661D0 (sv) * 2002-05-31 2002-05-31 Astrazeneca Ab New salts
US7781424B2 (en) * 2003-05-27 2010-08-24 Astrazeneca Ab Modified release pharmaceutical formulation
US7524354B2 (en) * 2005-07-07 2009-04-28 Research Foundation Of State University Of New York Controlled synthesis of highly monodispersed gold nanoparticles
TW200827336A (en) * 2006-12-06 2008-07-01 Astrazeneca Ab New crystalline forms
US20090061000A1 (en) * 2007-08-31 2009-03-05 Astrazeneca Ab Pharmaceutical formulation use 030

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU178398B (en) 1979-06-12 1982-04-28 Gyogyszerkutato Intezet Process for producing new agmatine derivatives of activity against haemagglutination
HU192646B (en) 1984-12-21 1987-06-29 Gyogyszerkutato Intezet Process for preparing new n-alkyl-peptide aldehydes
CA1341029C (en) 1985-02-04 2000-06-20 Michael Kolb Peptidase inhibitors
US5187157A (en) 1987-06-05 1993-02-16 Du Pont Merck Pharmaceutical Company Peptide boronic acid inhibitors of trypsin-like proteases
EP0362002B1 (en) 1988-09-01 1995-07-26 Merrell Dow Pharmaceuticals Inc. HIV protease inhibitors
ZA897515B (en) 1988-10-07 1990-06-27 Merrell Dow Pharma Novel peptidase inhibitors
TW201303B (is) 1990-07-05 1993-03-01 Hoffmann La Roche
CA2075154A1 (en) 1991-08-06 1993-02-07 Neelakantan Balasubramanian Peptide aldehydes as antithrombotic agents
SE9102462D0 (sv) 1991-08-28 1991-08-28 Astra Ab New isosteric peptides
ZA928581B (en) 1991-11-12 1994-05-06 Lilly Co Eli Antithrombotic agents
SE9103612D0 (sv) 1991-12-04 1991-12-04 Astra Ab New peptide derivatives
ES2110599T3 (es) 1992-03-04 1998-02-16 Gyogyszerkutato Intezet Nuevos derivados de peptidos anticoagulantes y composiciones farmaceuticas que contienen los mismos, asi como un proceso para su preparacion.
TW223629B (is) 1992-03-06 1994-05-11 Hoffmann La Roche
SE9301916D0 (sv) 1993-06-03 1993-06-03 Ab Astra New peptides derivatives
EP0648780A1 (en) 1993-08-26 1995-04-19 Bristol-Myers Squibb Company Heterocyclic thrombin inhibitors
TW394760B (en) 1993-09-07 2000-06-21 Hoffmann La Roche Novel Carboxamides, process for their preparation and pharmaceutical composition containing the same
AU1025795A (en) 1994-01-27 1995-08-03 Mitsubishi Chemical Corporation Prolineamide derivatives
US5707966A (en) 1994-03-04 1998-01-13 Eli Lilly And Company Antithrombotic agents
ZA951617B (en) 1994-03-04 1997-02-27 Lilly Co Eli Antithrombotic agents.
US5705487A (en) 1994-03-04 1998-01-06 Eli Lilly And Company Antithrombotic agents
DE4421052A1 (de) 1994-06-17 1995-12-21 Basf Ag Neue Thrombininhibitoren, ihre Herstellung und Verwendung
US5510369A (en) 1994-07-22 1996-04-23 Merck & Co., Inc. Pyrrolidine thrombin inhibitors
CN1198839C (zh) 1995-02-17 2005-04-27 艾伯特有限及两合公司 作为凝血酶抑制剂的新的二肽脒类
US5710130A (en) 1995-02-27 1998-01-20 Eli Lilly And Company Antithrombotic agents
JPH11503161A (ja) 1995-04-04 1999-03-23 メルク エンド カンパニー インコーポレーテッド トロンビン阻害剤
US5629324A (en) 1995-04-10 1997-05-13 Merck & Co., Inc. Thrombin inhibitors
SA96170106A (ar) * 1995-07-06 2005-12-03 أسترا أكتيبولاج مشتقات حامض أميني جديدة
TW541316B (en) 1995-12-21 2003-07-11 Astrazeneca Ab Prodrugs of thrombin inhibitors
AU1990197A (en) 1996-03-12 1997-10-01 Bristol-Myers Squibb Company Carbamyl guanidine and amidine prodrugs
SE9602263D0 (sv) * 1996-06-07 1996-06-07 Astra Ab New amino acid derivatives
US5863929A (en) 1996-06-25 1999-01-26 Eli Lilly And Company Anticoagulant agents
DE19632772A1 (de) 1996-08-14 1998-02-19 Basf Ag Neue Benzamidine
AR013084A1 (es) 1997-06-19 2000-12-13 Astrazeneca Ab Derivados de amidino utiles como inhibidores de la trombina, composicion farmaceutica, utilizacion de dichos compuestos para la preparacion demedicamentos y proceso para la preparacion de los compuestos mencionados

Also Published As

Publication number Publication date
JP2002535250A (ja) 2002-10-22
CA2355792A1 (en) 2000-07-20
IL143987A (en) 2005-12-18
DE60037183D1 (de) 2008-01-03
CY1107149T1 (el) 2012-10-24
TR200102037T2 (tr) 2001-10-22
KR100639274B1 (ko) 2006-10-27
NZ512714A (en) 2003-10-31
EP1150996B1 (en) 2007-11-21
DK1150996T3 (da) 2008-02-11
AU764121B2 (en) 2003-08-07
CN1170842C (zh) 2004-10-13
KR20010101493A (ko) 2001-11-14
EE200100371A (et) 2002-02-15
BR0007453A (pt) 2001-10-30
NO20013319L (no) 2001-09-12
US6599894B1 (en) 2003-07-29
WO2000042059A1 (en) 2000-07-20
CN1343217A (zh) 2002-04-03
ES2295004T3 (es) 2008-04-16
IL143987A0 (en) 2002-04-21
AU2336200A (en) 2000-08-01
CZ20012529A3 (cs) 2001-11-14
PL349769A1 (en) 2002-09-09
EP1150996A1 (en) 2001-11-07
PT1150996E (pt) 2008-01-15
NO20013319D0 (no) 2001-07-04
DE60037183T2 (de) 2008-10-09

Similar Documents

Publication Publication Date Title
IS6656A (is) Útskiptar kínasólínafleiður og notkun þeirra sem hemla
IS5302A (is) Nýjar amidínóafleiður og notkun þeirra sem þrombínhemla
IS2529B (is) Nýjar spírótrísýklískar afleiður og notkun þeirra sem fosfódíesterasa-7-hindrar
IS4930A (is) Nýjar amidínóafleiður og notkun þeirra sem þrombínhemla
IS6828A (is) Nýjar afleiður möndlusýru og notkun þeirra sem þrombínhemla
IS6264A (is) Arýlmetýl-karbónýlamínó-þíósól afleiður og notkunþeirra sem miðla gegn æxlum
NO20022656D0 (no) Caspaseinhibitorer og anvendelse derav
IS6385A (is) Ný notkun og nýjar N-asabísýkló-amíð afleiður
IS7792A (is) Hýdantóínafleiður og notkun þeirra sem TACE hemla
NO20012570D0 (no) Substituerte benzimidazoler og deres anvendelse som PARP- inhibitorer
AU2002230836A1 (en) Benzylamine derivatives and their use as thrombin inhibitors
IS4906A (is) Nýjar amínósýruafleiður og notkun þeirra sem þrombínhemla
IS5990A (is) Nýjar amidínbensýlamínafleiður og notkun þeirra sem þrombínhemlar
AU2003232848A8 (en) Phenylaminopyrimidines and their use as rho-kinase inhibitors
NO20014875D0 (no) Promedikamenter for trombin inhibitorer
IL156214A0 (en) New guanidine and amidine derivatives as factor xa inhibitors
IL152396A0 (en) New thiochromane derivatives derivatives and their use as thrombin inhibitors
ATE309211T1 (de) Amidino- und guanidino-azetidinone tryptase- inhibitoren
PT1189929E (pt) Inibidores do factor viia
DK1230227T3 (da) Benzoxa- og benzthiazolylsulfamater og anvendelse deraf som steroid-sulfataseinhibitorer
EP1189618A4 (en) thrombin
NO20025135L (no) Antihypertensive midler og anvendelse
SI1150996T1 (sl) Novi amidinobenzilaminski derivati in njihova uporaba kot trombinski inhibitorji
ZA200105277B (en) New amidinobenzylamine derivatives and their use as thrombin inhibitors.
ZA985036B (en) New amidino derivatives and their use as thrombin inhibitors