NO20013319D0 - Nye amidinobenzylaminderivater og deres anvendelse som trombininhibitorer - Google Patents

Nye amidinobenzylaminderivater og deres anvendelse som trombininhibitorer

Info

Publication number
NO20013319D0
NO20013319D0 NO20013319A NO20013319A NO20013319D0 NO 20013319 D0 NO20013319 D0 NO 20013319D0 NO 20013319 A NO20013319 A NO 20013319A NO 20013319 A NO20013319 A NO 20013319A NO 20013319 D0 NO20013319 D0 NO 20013319D0
Authority
NO
Norway
Prior art keywords
novel
thrombin inhibitors
amidinobenzylamine
derivatives
amidinobenzylamine derivatives
Prior art date
Application number
NO20013319A
Other languages
English (en)
Other versions
NO20013319L (no
Inventor
Tord Inghardt
Jan-Erik Nystroem
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE9900071A external-priority patent/SE9900071D0/xx
Priority claimed from SE9904228A external-priority patent/SE9904228D0/xx
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of NO20013319D0 publication Critical patent/NO20013319D0/no
Publication of NO20013319L publication Critical patent/NO20013319L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
NO20013319A 1999-01-13 2001-07-04 Nye amidinobenzylaminderivater og deres anvendelse som trombininhibitorer NO20013319L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE9900071A SE9900071D0 (sv) 1999-01-13 1999-01-13 New compounds
SE9904228A SE9904228D0 (sv) 1999-11-22 1999-11-22 New compounds
PCT/SE2000/000052 WO2000042059A1 (en) 1999-01-13 2000-01-13 New amidinobenzylamine derivatives and their use as thrombin inhibitors

Publications (2)

Publication Number Publication Date
NO20013319D0 true NO20013319D0 (no) 2001-07-04
NO20013319L NO20013319L (no) 2001-09-12

Family

ID=26663479

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20013319A NO20013319L (no) 1999-01-13 2001-07-04 Nye amidinobenzylaminderivater og deres anvendelse som trombininhibitorer

Country Status (22)

Country Link
US (1) US6599894B1 (no)
EP (1) EP1150996B1 (no)
JP (1) JP2002535250A (no)
KR (1) KR100639274B1 (no)
CN (1) CN1170842C (no)
AU (1) AU764121B2 (no)
BR (1) BR0007453A (no)
CA (1) CA2355792A1 (no)
CY (1) CY1107149T1 (no)
CZ (1) CZ20012529A3 (no)
DE (1) DE60037183T2 (no)
DK (1) DK1150996T3 (no)
EE (1) EE200100371A (no)
ES (1) ES2295004T3 (no)
IL (1) IL143987A (no)
IS (1) IS5990A (no)
NO (1) NO20013319L (no)
NZ (1) NZ512714A (no)
PL (1) PL349769A1 (no)
PT (1) PT1150996E (no)
TR (1) TR200102037T2 (no)
WO (1) WO2000042059A1 (no)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0001803D0 (sv) * 2000-05-16 2000-05-16 Astrazeneca Ab New compounds i
AU2001280395B2 (en) * 2000-08-16 2005-11-24 Astrazeneca Ab New amidino derivatives and their use as thrombin inhibitors
US6433186B1 (en) 2000-08-16 2002-08-13 Astrazeneca Ab Amidino derivatives and their use as thormbin inhibitors
SE0102921D0 (sv) 2001-08-30 2001-08-30 Astrazeneca Ab Pharmaceutically useful compounds
US7129233B2 (en) 2000-12-01 2006-10-31 Astrazeneca Ab Mandelic acid derivatives and their use as thrombin inhibitors
AR035216A1 (es) * 2000-12-01 2004-05-05 Astrazeneca Ab Derivados de acido mandelico ,derivados farmaceuticamente aceptables, uso de estos derivados para la fabricacion de medicamentos, metodos de tratamiento ,procesos para la preparacion de estos derivados, y compuestos intermediarios
AR034517A1 (es) * 2001-06-21 2004-02-25 Astrazeneca Ab Formulacion farmaceutica
UA78195C2 (uk) * 2001-08-30 2007-03-15 Astrazeneca Ab Похідні мигдалевої кислоти та їх застосування як інгібіторів тромбіну, фармацевтична композиція на їх основі
MXPA04003170A (es) * 2001-10-03 2004-07-08 Pharmacia Corp Compuestos policiclicos, sustituidos, provisto de 5 miembros, utiles para la inhibicion selectiva de la cascada de coagulacion.
SE0201659D0 (sv) * 2002-05-31 2002-05-31 Astrazeneca Ab Modified release pharmaceutical formulation
SE0201658D0 (sv) * 2002-05-31 2002-05-31 Astrazeneca Ab Immediate release pharmaceutical formulation
SE0201661D0 (sv) * 2002-05-31 2002-05-31 Astrazeneca Ab New salts
US7781424B2 (en) * 2003-05-27 2010-08-24 Astrazeneca Ab Modified release pharmaceutical formulation
US7524354B2 (en) * 2005-07-07 2009-04-28 Research Foundation Of State University Of New York Controlled synthesis of highly monodispersed gold nanoparticles
TW200827336A (en) * 2006-12-06 2008-07-01 Astrazeneca Ab New crystalline forms
US20090061000A1 (en) * 2007-08-31 2009-03-05 Astrazeneca Ab Pharmaceutical formulation use 030

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU178398B (en) 1979-06-12 1982-04-28 Gyogyszerkutato Intezet Process for producing new agmatine derivatives of activity against haemagglutination
HU192646B (en) 1984-12-21 1987-06-29 Gyogyszerkutato Intezet Process for preparing new n-alkyl-peptide aldehydes
CA1341029C (en) 1985-02-04 2000-06-20 Michael Kolb Peptidase inhibitors
US5187157A (en) 1987-06-05 1993-02-16 Du Pont Merck Pharmaceutical Company Peptide boronic acid inhibitors of trypsin-like proteases
EP0362002B1 (en) 1988-09-01 1995-07-26 Merrell Dow Pharmaceuticals Inc. HIV protease inhibitors
ZA897515B (en) 1988-10-07 1990-06-27 Merrell Dow Pharma Novel peptidase inhibitors
TW201303B (no) 1990-07-05 1993-03-01 Hoffmann La Roche
CA2075154A1 (en) 1991-08-06 1993-02-07 Neelakantan Balasubramanian Peptide aldehydes as antithrombotic agents
SE9102462D0 (sv) 1991-08-28 1991-08-28 Astra Ab New isosteric peptides
ZA928581B (en) 1991-11-12 1994-05-06 Lilly Co Eli Antithrombotic agents
SE9103612D0 (sv) 1991-12-04 1991-12-04 Astra Ab New peptide derivatives
ES2110599T3 (es) 1992-03-04 1998-02-16 Gyogyszerkutato Intezet Nuevos derivados de peptidos anticoagulantes y composiciones farmaceuticas que contienen los mismos, asi como un proceso para su preparacion.
TW223629B (no) 1992-03-06 1994-05-11 Hoffmann La Roche
SE9301916D0 (sv) 1993-06-03 1993-06-03 Ab Astra New peptides derivatives
EP0648780A1 (en) 1993-08-26 1995-04-19 Bristol-Myers Squibb Company Heterocyclic thrombin inhibitors
TW394760B (en) 1993-09-07 2000-06-21 Hoffmann La Roche Novel Carboxamides, process for their preparation and pharmaceutical composition containing the same
AU1025795A (en) 1994-01-27 1995-08-03 Mitsubishi Chemical Corporation Prolineamide derivatives
US5707966A (en) 1994-03-04 1998-01-13 Eli Lilly And Company Antithrombotic agents
ZA951617B (en) 1994-03-04 1997-02-27 Lilly Co Eli Antithrombotic agents.
US5705487A (en) 1994-03-04 1998-01-06 Eli Lilly And Company Antithrombotic agents
DE4421052A1 (de) 1994-06-17 1995-12-21 Basf Ag Neue Thrombininhibitoren, ihre Herstellung und Verwendung
US5510369A (en) 1994-07-22 1996-04-23 Merck & Co., Inc. Pyrrolidine thrombin inhibitors
CN1198839C (zh) 1995-02-17 2005-04-27 艾伯特有限及两合公司 作为凝血酶抑制剂的新的二肽脒类
US5710130A (en) 1995-02-27 1998-01-20 Eli Lilly And Company Antithrombotic agents
JPH11503161A (ja) 1995-04-04 1999-03-23 メルク エンド カンパニー インコーポレーテッド トロンビン阻害剤
US5629324A (en) 1995-04-10 1997-05-13 Merck & Co., Inc. Thrombin inhibitors
SA96170106A (ar) * 1995-07-06 2005-12-03 أسترا أكتيبولاج مشتقات حامض أميني جديدة
TW541316B (en) 1995-12-21 2003-07-11 Astrazeneca Ab Prodrugs of thrombin inhibitors
AU1990197A (en) 1996-03-12 1997-10-01 Bristol-Myers Squibb Company Carbamyl guanidine and amidine prodrugs
SE9602263D0 (sv) * 1996-06-07 1996-06-07 Astra Ab New amino acid derivatives
US5863929A (en) 1996-06-25 1999-01-26 Eli Lilly And Company Anticoagulant agents
DE19632772A1 (de) 1996-08-14 1998-02-19 Basf Ag Neue Benzamidine
AR013084A1 (es) 1997-06-19 2000-12-13 Astrazeneca Ab Derivados de amidino utiles como inhibidores de la trombina, composicion farmaceutica, utilizacion de dichos compuestos para la preparacion demedicamentos y proceso para la preparacion de los compuestos mencionados

Also Published As

Publication number Publication date
JP2002535250A (ja) 2002-10-22
CA2355792A1 (en) 2000-07-20
IL143987A (en) 2005-12-18
DE60037183D1 (de) 2008-01-03
CY1107149T1 (el) 2012-10-24
TR200102037T2 (tr) 2001-10-22
KR100639274B1 (ko) 2006-10-27
NZ512714A (en) 2003-10-31
EP1150996B1 (en) 2007-11-21
DK1150996T3 (da) 2008-02-11
AU764121B2 (en) 2003-08-07
CN1170842C (zh) 2004-10-13
KR20010101493A (ko) 2001-11-14
EE200100371A (et) 2002-02-15
BR0007453A (pt) 2001-10-30
IS5990A (is) 2001-07-05
NO20013319L (no) 2001-09-12
US6599894B1 (en) 2003-07-29
WO2000042059A1 (en) 2000-07-20
CN1343217A (zh) 2002-04-03
ES2295004T3 (es) 2008-04-16
IL143987A0 (en) 2002-04-21
AU2336200A (en) 2000-08-01
CZ20012529A3 (cs) 2001-11-14
PL349769A1 (en) 2002-09-09
EP1150996A1 (en) 2001-11-07
PT1150996E (pt) 2008-01-15
DE60037183T2 (de) 2008-10-09

Similar Documents

Publication Publication Date Title
DK1347955T3 (da) Nye mandelsyrederivater og deres anvendelse som throbin-hæmmere
NO20026010L (no) Substituerte quinazolinderivater og deres anvendelse som inhibitorer
NO996313L (no) Nye amidinoderivater og deres anvendelse som trombininhibitorer
NO20034187D0 (no) Nye spirotricykliske derivater og anvendelse derav som fosfodiesterase-7 inhibitorer
NO986180D0 (no) Nye amidinoderivater og deres anvendelse som trombininhibitorer
NO20030298D0 (no) Nye heteroarylderivater og deres anvendelse som farmasöytiske midler
DK1133477T3 (da) Substituerede benzimidazoler og deres anvendelse som parpinhibitorer
NO20030302D0 (no) Nye heteroarylderivater og deres anvendelse som medikamenter
DK1527050T3 (da) Quinolin-derivater og deres anvendelse som mycobakterielle inhibitorer
NO20032830L (no) Tetrahydropyridinderivater, fremstilling derav og anvendelse som celleproliferasjonsinhibitorer
NO20014135D0 (no) Nye sulfonamidforbindelser og deres anvendelse
NO20013452L (no) Benzoheterocykler og deres anvendelse som MEK-inhibitorer
DK0910573T3 (da) Nye aminosyrederivater og deres anvendelse som thrombininhibitorer
NO20034324D0 (no) Bipiperidinylderivater og deres anvendelse som kjemokin reseptorinhibitor
NO20042719L (no) Substituerte 2-amino-cykloalkankarboksamider og deres anvendelse som protease-inhibitorer
DK1150996T3 (da) Nye amidinobenzylaminderivater og deres anvendelse som thrombin-inhibitorer
NO20030382D0 (no) Nye indolderivater og deres anvendelse som medikamenter
NO20035328D0 (no) Nye forbindelser og preparater som katepsinhibitorer
NO20025504D0 (no) Nye tiokromanderivater og anvendelse derav som trombininhibitorer
DK1214302T3 (da) Substituerede 3-phenyl-5-alkoxy-1,3,4-oxadiazol-2-oner og deres anvendelse som lipasehæmmere
NO20023951D0 (no) Arylpiperaziner og arylpiperidiner og deres anvendelse som metalloproteinaseinhiberende midler
NO20030813L (no) Bifenylderivater og deres anvendelse som integrininhibitorer
NO20025884L (no) 2-aminotiazolinderivater og deres anvendelse som NO- syntaseinhibitorer
DK1200409T3 (da) Substituerede isoquinolinderivater og deres anvendelse som krampestillende midler
NO20014149D0 (no) Nye dipeptidforbindelser og deres anvendelse som medisiner