IN2015DN02873A - - Google Patents

Info

Publication number
IN2015DN02873A
IN2015DN02873A IN2873DEN2015A IN2015DN02873A IN 2015DN02873 A IN2015DN02873 A IN 2015DN02873A IN 2873DEN2015 A IN2873DEN2015 A IN 2873DEN2015A IN 2015DN02873 A IN2015DN02873 A IN 2015DN02873A
Authority
IN
India
Prior art keywords
dehydrogenase
generated
organic acids
recombinant microorganisms
produce organic
Prior art date
Application number
Other languages
English (en)
Inventor
Michael; Guettler
Robert; Hanchar
Susanne; Kleff
Sanchin; Jadhav
Original Assignee
Michigan Biotech Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Michigan Biotech Inst filed Critical Michigan Biotech Inst
Publication of IN2015DN02873A publication Critical patent/IN2015DN02873A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/44—Polycarboxylic acids
    • C12P7/46—Dicarboxylic acids having four or less carbon atoms, e.g. fumaric acid, maleic acid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C12P1/04—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/52—Propionic acid; Butyric acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01037—Malate dehydrogenase (1.1.1.37)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01049—Glucose-6-phosphate dehydrogenase (1.1.1.49)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
IN2873DEN2015 2012-10-02 2013-10-02 IN2015DN02873A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261708998P 2012-10-02 2012-10-02
PCT/US2013/063100 WO2014055670A1 (en) 2012-10-02 2013-10-02 Recombinant microorganisms for producing organic acids

Publications (1)

Publication Number Publication Date
IN2015DN02873A true IN2015DN02873A (zh) 2015-09-11

Family

ID=49486664

Family Applications (1)

Application Number Title Priority Date Filing Date
IN2873DEN2015 IN2015DN02873A (zh) 2012-10-02 2013-10-02

Country Status (10)

Country Link
US (2) US20140093925A1 (zh)
EP (1) EP2904104B1 (zh)
JP (1) JP2015530121A (zh)
KR (1) KR101521045B1 (zh)
CN (1) CN104854244A (zh)
CA (1) CA2883407A1 (zh)
IN (1) IN2015DN02873A (zh)
MX (1) MX2015004180A (zh)
PH (1) PH12015500737A1 (zh)
WO (1) WO2014055670A1 (zh)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8647642B2 (en) 2008-09-18 2014-02-11 Aviex Technologies, Llc Live bacterial vaccines resistant to carbon dioxide (CO2), acidic PH and/or osmolarity for viral infection prophylaxis or treatment
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
KR102129379B1 (ko) 2018-10-10 2020-07-02 한국과학기술원 고활성의 말산 탈수소효소가 도입된 숙신산 생성용 변이 미생물 및 이를 이용한 숙신산 제조방법
CN116656637B (zh) * 2023-07-07 2024-05-14 上海逐药科技有限公司 一种苹果酸脱氢酶的变体

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5521075A (en) 1994-12-19 1996-05-28 Michigan Biotechnology Institute Method for making succinic acid, anaerobiospirillum succiniciproducens variants for use in process and methods for obtaining variants
US5573931A (en) 1995-08-28 1996-11-12 Michigan Biotechnology Institute Method for making succinic acid, bacterial variants for use in the process, and methods for obtaining variants
EP3130676A1 (en) * 2004-08-27 2017-02-15 Rice University Mutant e. coli strain with increased succinic acid production
CN101023178A (zh) * 2004-09-17 2007-08-22 莱斯大学 高琥珀酸产出细菌
ES2541538T3 (es) * 2004-12-22 2015-07-21 The Michigan Biotechnology Institute Microorganismos recombinantes para una mayor producción de ácidos orgánicos
CN101649300B (zh) * 2009-09-07 2011-06-15 安徽丰原发酵技术工程研究有限公司 一种产l-苹果酸的基因工程菌及其构建方法和应用
WO2012103261A2 (en) * 2011-01-25 2012-08-02 Finley Kenneth R Compositions and methods for succinate production

Also Published As

Publication number Publication date
CA2883407A1 (en) 2014-04-10
JP2015530121A (ja) 2015-10-15
KR20140108486A (ko) 2014-09-11
CN104854244A (zh) 2015-08-19
EP2904104A1 (en) 2015-08-12
KR101521045B1 (ko) 2015-05-15
US20140093925A1 (en) 2014-04-03
MX2015004180A (es) 2015-07-06
WO2014055670A1 (en) 2014-04-10
PH12015500737A1 (en) 2015-06-01
EP2904104B1 (en) 2018-08-15
US20160326554A1 (en) 2016-11-10

Similar Documents

Publication Publication Date Title
PH12015502401A1 (en) Compositions and methods for enhancing microbial stability
PH12014502445B1 (en) Targeted modification of malate dehydrogenase
EP2558582A4 (en) MICROORGANISMS AND PROCESSES FOR THE PRODUCTION OF ETHYLENE GLYCOL
MX367859B (es) Metodos y materiales para la biosintesis de compuestos mogrosidos.
UA116092C2 (uk) Спосіб та композиція для боротьби з бур'янами (варіанти)
MX349630B (es) Alfa-amilasas.
EP2818543A4 (en) BACILLUS, HYALURONIC ACID ZYM AND USES THEREOF
HUE047092T2 (hu) Eljárás lignocellulóz anyag enzimatikus hidrolízisére oxigén hozzáadásával
IN2014MN00989A (zh)
MY182946A (en) Production of organic acids by fermentation at low ph
MX2015012487A (es) Control de fases de producción por inducción del crecimiento.
EP2561084A4 (en) DIGESTIBLE LIGNOCELLULOSIC BIOMASS, WOOD EXTRACTION PRODUCTS AND METHODS OF MAKING SAME
IN2015DN00636A (zh)
MY182924A (en) Enzyme compositions and uses thereof
IN2015DN00634A (zh)
PH12015500737A1 (en) Recombinant microorganisms for producing organic acids
EP2880050A4 (en) NOVEL ENZYMES, ENZYME COMPONENTS AND USES THEREOF
EA201290623A1 (ru) Лактобациллы с антиоксидантным действием
IN2014DN06104A (zh)
IN2014DN00161A (zh)
MY155330A (en) Methods for salt production
IN2015DN02292A (zh)
MX2011012623A (es) Construcciones de casb7439.
IN2014DN09585A (zh)
MX2014007760A (es) Bacterias con unidades transcripcionales reconstruidas y los usos de las mismas.