IN2015DN02636A - - Google Patents

Download PDF

Info

Publication number
IN2015DN02636A
IN2015DN02636A IN2636DEN2015A IN2015DN02636A IN 2015DN02636 A IN2015DN02636 A IN 2015DN02636A IN 2636DEN2015 A IN2636DEN2015 A IN 2636DEN2015A IN 2015DN02636 A IN2015DN02636 A IN 2015DN02636A
Authority
IN
India
Prior art keywords
improving
systems
efficiency
disclosed
methods
Prior art date
Application number
Other languages
English (en)
Inventor
Bob Miller
David Hesketh
Ernest Dion
Original Assignee
Conformis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Conformis Inc filed Critical Conformis Inc
Publication of IN2015DN02636A publication Critical patent/IN2015DN02636A/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F5/00Orthopaedic methods or devices for non-surgical treatment of bones or joints; Nursing devices ; Anti-rape devices
    • A61F5/01Orthopaedic devices, e.g. long-term immobilising or pressure directing devices for treating broken or deformed bones such as splints, casts or braces
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2/3094Designing or manufacturing processes
    • A61F2/30942Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2/3094Designing or manufacturing processes
    • A61F2/30942Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques
    • A61F2002/30962Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques using stereolithography
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B33ADDITIVE MANUFACTURING TECHNOLOGY
    • B33YADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y80/00Products made by additive manufacturing

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Transplantation (AREA)
  • Physics & Mathematics (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cardiology (AREA)
  • Manufacturing & Machinery (AREA)
  • Geometry (AREA)
  • Nursing (AREA)
  • Prostheses (AREA)
IN2636DEN2015 2012-09-21 2013-09-20 IN2015DN02636A (pm)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261703780P 2012-09-21 2012-09-21
US201261704712P 2012-09-24 2012-09-24
PCT/US2013/061042 WO2014047514A1 (en) 2012-09-21 2013-09-20 Methods and systems for optimizing design and manufacture of implant components using solid freeform fabrication

Publications (1)

Publication Number Publication Date
IN2015DN02636A true IN2015DN02636A (pm) 2015-09-18

Family

ID=50339037

Family Applications (1)

Application Number Title Priority Date Filing Date
IN2636DEN2015 IN2015DN02636A (pm) 2012-09-21 2013-09-20

Country Status (5)

Country Link
US (1) US9849019B2 (pm)
JP (1) JP2015532858A (pm)
CN (1) CN104780872B (pm)
IN (1) IN2015DN02636A (pm)
WO (1) WO2014047514A1 (pm)

Families Citing this family (147)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070233269A1 (en) * 2001-05-25 2007-10-04 Conformis, Inc. Interpositional Joint Implant
US8545569B2 (en) 2001-05-25 2013-10-01 Conformis, Inc. Patient selectable knee arthroplasty devices
US8617242B2 (en) 2001-05-25 2013-12-31 Conformis, Inc. Implant device and method for manufacture
US9603711B2 (en) 2001-05-25 2017-03-28 Conformis, Inc. Patient-adapted and improved articular implants, designs and related guide tools
US8882847B2 (en) 2001-05-25 2014-11-11 Conformis, Inc. Patient selectable knee joint arthroplasty devices
US8480754B2 (en) 2001-05-25 2013-07-09 Conformis, Inc. Patient-adapted and improved articular implants, designs and related guide tools
US8556983B2 (en) 2001-05-25 2013-10-15 Conformis, Inc. Patient-adapted and improved orthopedic implants, designs and related tools
US20030055502A1 (en) * 2001-05-25 2003-03-20 Philipp Lang Methods and compositions for articular resurfacing
US8439926B2 (en) 2001-05-25 2013-05-14 Conformis, Inc. Patient selectable joint arthroplasty devices and surgical tools
JP2006505366A (ja) 2002-11-07 2006-02-16 コンフォーミス・インコーポレイテッド 半月板サイズおよび形状の決定および工夫した処置の方法
US8831302B2 (en) 2007-08-17 2014-09-09 Mohamed Rashwan Mahfouz Implant design analysis suite
WO2009111626A2 (en) 2008-03-05 2009-09-11 Conformis, Inc. Implants for altering wear patterns of articular surfaces
WO2009140294A1 (en) 2008-05-12 2009-11-19 Conformis, Inc. Devices and methods for treatment of facet and other joints
FR2932674B1 (fr) 2008-06-20 2011-11-18 Tornier Sa Procede de modelisation d'une surface glenoidienne d'une omoplate, dispositif d'implantation d'un composant glenoidien d'une prothese d'epaule, et procede de fabrication d'un tel compose.
WO2010099231A2 (en) 2009-02-24 2010-09-02 Conformis, Inc. Automated systems for manufacturing patient-specific orthopedic implants and instrumentation
CA2753488C (en) 2009-02-25 2014-04-29 Mohamed Rashwan Mahfouz Customized orthopaedic implants and related methods
US9078755B2 (en) 2009-02-25 2015-07-14 Zimmer, Inc. Ethnic-specific orthopaedic implants and custom cutting jigs
CA2778057C (en) 2009-10-29 2019-02-19 Zimmer, Inc. Patient-specific mill guide
CA2782137A1 (en) 2009-12-11 2011-06-16 Conformis, Inc. Patient-specific and patient-engineered orthopedic implants
EP2632349B1 (en) 2010-10-29 2018-03-07 The Cleveland Clinic Foundation System for assisting with attachment of a stock implant to a patient tissue
CA3054709C (en) 2010-10-29 2022-04-12 The Cleveland Clinic Foundation System and method for association of a guiding aid with a patient tissue
US9717508B2 (en) 2010-10-29 2017-08-01 The Cleveland Clinic Foundation System of preoperative planning and provision of patient-specific surgical aids
US9254155B2 (en) 2010-10-29 2016-02-09 The Cleveland Clinic Foundation System and method for assisting with arrangement of a stock instrument with respect to a patient tissue
WO2012112694A2 (en) 2011-02-15 2012-08-23 Conformis, Inc. Medeling, analyzing and using anatomical data for patient-adapted implants. designs, tools and surgical procedures
US10130378B2 (en) 2011-05-11 2018-11-20 The Cleveland Clinic Foundation Generating patient specific instruments for use as surgical aids
CA2836535C (en) 2011-05-19 2019-09-24 The Cleveland Clinic Foundation Apparatus and method for providing a reference indication to a patient tissue
US9408686B1 (en) 2012-01-20 2016-08-09 Conformis, Inc. Devices, systems and methods for manufacturing orthopedic implants
EP2806810B1 (en) 2012-01-24 2018-03-28 Zimmer, Inc. Method and system for creating patient-specific instrumentation for chondral graft transfer
JP6166775B2 (ja) 2012-03-28 2017-07-19 オーソソフト インコーポレイティド 患者特有の器具を使用した関節窩インプラント術
US10327786B2 (en) 2012-05-24 2019-06-25 Zimmer, Inc. Patient-specific instrumentation and method for articular joint repair
CA2873074C (en) 2012-07-23 2020-09-22 Orthosoft Inc. Patient-specific instrumentation for implant revision surgery
AU2013296108B2 (en) 2012-07-24 2017-08-31 Orthosoft Ulc Patient specific instrumentation with mems in surgery
US9636229B2 (en) 2012-09-20 2017-05-02 Conformis, Inc. Solid freeform fabrication of implant components
JP2015532858A (ja) 2012-09-21 2015-11-16 コンフォーミス・インコーポレイテッドConforMIS, Inc. 固体自由造形製造を使用してインプラント構成要素の設計および製造を最適化するための方法およびシステム
CN105246433B (zh) 2013-06-11 2018-06-05 奥尔索夫特公司 髋臼杯假体定位器械和方法
US10124124B2 (en) 2013-06-11 2018-11-13 Zimmer, Inc. Computer assisted subchondral injection
US10667829B2 (en) 2013-08-21 2020-06-02 Laboratoires Bodycad Inc. Bone resection guide and method
WO2015024122A1 (en) 2013-08-21 2015-02-26 Laboratoires Bodycad Inc. Anatomically adapted orthopedic implant and method of manufacturing same
US9924950B2 (en) 2013-09-25 2018-03-27 Zimmer, Inc. Patient specific instrumentation (PSI) for orthopedic surgery and systems and methods for using X-rays to produce same
US10405993B2 (en) 2013-11-13 2019-09-10 Tornier Sas Shoulder patient specific instrument
US10220569B2 (en) * 2013-12-03 2019-03-05 Autodesk, Inc. Generating support material for three-dimensional printing
WO2015120168A1 (en) * 2014-02-06 2015-08-13 United Technologies Corporation An additive manufacturing system with a multi-energy beam gun and method of operation
US9747394B2 (en) 2014-03-18 2017-08-29 Palo Alto Research Center Incorporated Automated design and manufacturing feedback for three dimensional (3D) printability
US9946816B2 (en) * 2014-03-18 2018-04-17 Palo Alto Research Center Incorporated System for visualizing a three dimensional (3D) model as printed from a 3D printer
US10061870B2 (en) 2014-03-18 2018-08-28 Palo Alto Research Center Incorporated Automated metrology and model correction for three dimensional (3D) printability
US10350022B2 (en) 2014-04-30 2019-07-16 Zimmer, Inc. Acetabular cup impacting using patient-specific instrumentation
US10217530B2 (en) 2014-06-03 2019-02-26 Zimmer, Inc. Patient-specific cutting block and method of manufacturing same
US9486878B2 (en) 2014-06-20 2016-11-08 Velo3D, Inc. Apparatuses, systems and methods for three-dimensional printing
US10409932B2 (en) * 2014-09-19 2019-09-10 Siemens Product Lifecyle Management Software Inc. Computer-aided simulation of multi-layer selective laser sintering and melting additive manufacturing processes
EP3197403B1 (en) 2014-09-24 2022-04-06 DePuy Ireland Unlimited Company Surgical planning
CN107205783B (zh) 2015-02-02 2020-04-14 奥尔索夫特无限责任公司 髋臼边缘数字化装置和方法
CN106132654B (zh) * 2015-02-03 2019-05-17 飞利浦照明控股有限公司 用于成型和复制对象的基于熔融沉积成型的模具、用于其制造的方法以及熔融沉积成型3d打印机
WO2016149824A1 (en) 2015-03-25 2016-09-29 Orthosoft Inc. Method and system for assisting implant placement in thin bones such as scapula
US10271858B2 (en) 2015-05-28 2019-04-30 Zimmer, Inc. Patient-specific bone grafting system and method
AU2016290962B2 (en) 2015-07-08 2021-04-08 Zimmer, Inc. Patient-specific instrumentation for implant revision surgery
EP3120796A1 (de) * 2015-07-17 2017-01-25 Mimedis AG Verfahren und system zur herstellung eines implantats
US10195784B2 (en) 2015-07-31 2019-02-05 The Boeing Company Systems for additively manufacturing composite parts
US10232550B2 (en) 2015-07-31 2019-03-19 The Boeing Company Systems for additively manufacturing composite parts
US10343330B2 (en) * 2015-07-31 2019-07-09 The Boeing Company Systems for additively manufacturing composite parts
US10343355B2 (en) 2015-07-31 2019-07-09 The Boeing Company Systems for additively manufacturing composite parts
US10112380B2 (en) 2015-07-31 2018-10-30 The Boeing Company Methods for additively manufacturing composite parts
US10201941B2 (en) 2015-07-31 2019-02-12 The Boeing Company Systems for additively manufacturing composite parts
US10232570B2 (en) 2015-07-31 2019-03-19 The Boeing Company Systems for additively manufacturing composite parts
WO2017040248A1 (en) * 2015-08-28 2017-03-09 Materialise N.V. Self supporting in additive manufacturing
EP3355831A4 (en) 2015-09-30 2020-05-13 Zimmer, Inc. PATIENT-SPECIFIC INSTRUMENTS FOR PATELLAR RESURFACING SURGERY AND METHOD
US10065270B2 (en) 2015-11-06 2018-09-04 Velo3D, Inc. Three-dimensional printing in real time
US10624764B2 (en) 2015-11-26 2020-04-21 Orthosoft Ulc System and method for the registration of an anatomical feature
AU2016362943B2 (en) * 2015-12-03 2021-04-08 Rutgers, The State University Of New Jersey System and method for making personalized fibrocartilage implants
US10286603B2 (en) 2015-12-10 2019-05-14 Velo3D, Inc. Skillful three-dimensional printing
EP3389513A1 (en) 2015-12-16 2018-10-24 Tornier, Inc. Patient specific instruments and methods for joint prosthesis
US20170239719A1 (en) 2016-02-18 2017-08-24 Velo3D, Inc. Accurate three-dimensional printing
WO2017153614A1 (es) * 2016-03-07 2017-09-14 Edesdev S.L.U. Procedimiento de fabricación de piezas elaboradas por acoplamiento de semiproductos mediante el método de fabricación aditiva por sinterizado láser
US11691343B2 (en) 2016-06-29 2023-07-04 Velo3D, Inc. Three-dimensional printing and three-dimensional printers
EP3492244A1 (en) 2016-06-29 2019-06-05 VELO3D, Inc. Three-dimensional printing system and method for three-dimensional printing
HK1224885A (zh) * 2016-09-08 2017-08-25 科能三维技术(医疗)有限公司 製造人工實心骨的裝置和方法
US10070959B2 (en) * 2016-09-28 2018-09-11 DePuy Synthes Products, Inc. Method of texturing prosthetic implants
US20180093418A1 (en) 2016-09-30 2018-04-05 Velo3D, Inc. Three-dimensional objects and their formation
US10457033B2 (en) 2016-11-07 2019-10-29 The Boeing Company Systems and methods for additively manufacturing composite parts
US20180126460A1 (en) 2016-11-07 2018-05-10 Velo3D, Inc. Gas flow in three-dimensional printing
US11440261B2 (en) 2016-11-08 2022-09-13 The Boeing Company Systems and methods for thermal control of additive manufacturing
US10766241B2 (en) 2016-11-18 2020-09-08 The Boeing Company Systems and methods for additive manufacturing
USD808524S1 (en) 2016-11-29 2018-01-23 Laboratoires Bodycad Inc. Femoral implant
US10843452B2 (en) 2016-12-01 2020-11-24 The Boeing Company Systems and methods for cure control of additive manufacturing
US20180186082A1 (en) 2017-01-05 2018-07-05 Velo3D, Inc. Optics in three-dimensional printing
US10576683B2 (en) 2017-01-16 2020-03-03 The Boeing Company Multi-part filaments for additive manufacturing and related systems and methods
US10315252B2 (en) 2017-03-02 2019-06-11 Velo3D, Inc. Three-dimensional printing of three-dimensional objects
US10449696B2 (en) 2017-03-28 2019-10-22 Velo3D, Inc. Material manipulation in three-dimensional printing
EP3415108B1 (en) 2017-05-25 2024-09-04 Stryker European Operations Holdings LLC Fusion cage with integrated fixation and insertion features
US10759159B2 (en) 2017-05-31 2020-09-01 The Boeing Company Feedstock lines for additive manufacturing
US10814550B2 (en) 2017-07-06 2020-10-27 The Boeing Company Methods for additive manufacturing
US10821672B2 (en) 2017-07-06 2020-11-03 The Boeing Company Methods for additive manufacturing
US11006981B2 (en) * 2017-07-07 2021-05-18 K2M, Inc. Surgical implant and methods of additive manufacturing
EP3651664A1 (en) 2017-07-11 2020-05-20 Tornier, Inc. Guides and instruments for improving accuracy of glenoid implant placement
US10959742B2 (en) 2017-07-11 2021-03-30 Tornier, Inc. Patient specific humeral cutting guides
US11166764B2 (en) 2017-07-27 2021-11-09 Carlsmed, Inc. Systems and methods for assisting and augmenting surgical procedures
IT201700098767A1 (it) * 2017-09-04 2019-03-04 Panotec Srl Metodo e sistema per il posizionamento ottimizzato di oggetti all'interno di almento una scatola
US11112770B2 (en) * 2017-11-09 2021-09-07 Carlsmed, Inc. Systems and methods for assisting a surgeon and producing patient-specific medical devices
US11083586B2 (en) 2017-12-04 2021-08-10 Carlsmed, Inc. Systems and methods for multi-planar orthopedic alignment
EP3498197A3 (en) 2017-12-12 2019-10-16 Orthosoft, Inc. Patient-specific instrumentation for implant revision surgery
US10272525B1 (en) 2017-12-27 2019-04-30 Velo3D, Inc. Three-dimensional printing systems and methods of their use
CA3087066A1 (en) 2017-12-29 2019-07-04 Tornier, Inc. Patient specific humeral implant components
CN108258606A (zh) * 2018-01-10 2018-07-06 广西电网有限责任公司电力科学研究院 一种正向闭环制造零部件的系统
US10144176B1 (en) 2018-01-15 2018-12-04 Velo3D, Inc. Three-dimensional printing systems and methods of their use
US11432943B2 (en) 2018-03-14 2022-09-06 Carlsmed, Inc. Systems and methods for orthopedic implant fixation
US11439514B2 (en) 2018-04-16 2022-09-13 Carlsmed, Inc. Systems and methods for orthopedic implant fixation
US11376054B2 (en) 2018-04-17 2022-07-05 Stryker European Operations Limited On-demand implant customization in a surgical setting
DE102018206147A1 (de) 2018-04-20 2019-10-24 Ford Global Technologies, Llc Additives Fertigungsverfahren
US10520923B2 (en) * 2018-05-22 2019-12-31 Mantle Inc. Method and system for automated toolpath generation
WO2019245865A1 (en) 2018-06-19 2019-12-26 Tornier, Inc. Mixed reality indication of points at which 3d bone and implant models collide
USD958151S1 (en) 2018-07-30 2022-07-19 Carlsmed, Inc. Display screen with a graphical user interface for surgical planning
WO2020056186A1 (en) 2018-09-12 2020-03-19 Carlsmed, Inc. Systems and methods for orthopedic implants
EP3888095A4 (en) 2018-11-29 2022-08-31 Carlsmed, Inc. Systems and methods for orthopedic implants
US11325314B2 (en) * 2018-12-19 2022-05-10 3D Systems, Inc. Three-dimensional article manufacturing system with build plan optimization for high risk article design
US20240225790A1 (en) * 2019-02-24 2024-07-11 Abdelmadjid Djemai Dental implant and self-locking fastening element with heterogeneous porous structures, and method for its production
CN109781038B (zh) * 2019-03-12 2020-10-02 湘潭大学 一种选择性激光烧结铺粉层厚测量及均匀性表征的方法
CN109855549B (zh) * 2019-03-12 2020-10-02 湘潭大学 一种选择性激光烧结铺粉层厚测量及均匀性表征的方法
US11213403B2 (en) 2019-03-14 2022-01-04 Medos International Sarl Devices and methods for optimized spinal fixation
US12220863B2 (en) * 2019-04-11 2025-02-11 Smith & Nephew, Inc. Medical devices and methods for forming medical devices containing a build plate
CA3148849A1 (en) 2019-07-26 2021-02-04 Velo3D, Inc. Quality assurance in formation of three-dimensional objects
US11534307B2 (en) 2019-09-16 2022-12-27 K2M, Inc. 3D printed cervical standalone implant
US11878365B2 (en) 2019-11-20 2024-01-23 Concept Laser Gmbh Focus adjustment and laser beam caustic estimation via frequency analysis of time traces and 2D raster scan data
EP3831323A1 (en) 2019-12-05 2021-06-09 Universiteit Antwerpen Improved implantable plate and method of manufacturing thereof
EP4072828A4 (en) 2019-12-10 2023-08-16 Hewlett-Packard Development Company, L.P. THREE-DIMENSIONAL (3D) PRINTED OBJECTS WITH FRACTURE CHANNELS
US11376076B2 (en) 2020-01-06 2022-07-05 Carlsmed, Inc. Patient-specific medical systems, devices, and methods
US10902944B1 (en) 2020-01-06 2021-01-26 Carlsmed, Inc. Patient-specific medical procedures and devices, and associated systems and methods
USD920517S1 (en) 2020-01-08 2021-05-25 Restor3D, Inc. Osteotomy wedge
USD920515S1 (en) 2020-01-08 2021-05-25 Restor3D, Inc. Spinal implant
WO2021140000A1 (en) 2020-01-08 2021-07-15 Quant Ip Gmbh System and method for retrieving compatible data packages to originating data
USD920516S1 (en) 2020-01-08 2021-05-25 Restor3D, Inc. Osteotomy wedge
US12226315B2 (en) 2020-08-06 2025-02-18 Carlsmed, Inc. Kinematic data-based patient-specific artificial discs, implants and associated systems and methods
US11638959B2 (en) * 2020-09-03 2023-05-02 General Electric Company Systems and methods for estimating powder dosing in additive manufacturing processes
WO2022109259A1 (en) 2020-11-20 2022-05-27 Carlsmed, Inc. Patient-specific jig for personalized surgery
CN113102772B (zh) * 2021-04-09 2023-01-03 广州柔岩科技有限公司 一种增材制造骨科钽金属、制备方法及应用
US12232980B2 (en) 2021-06-08 2025-02-25 Carlsmed, Inc. Patient-specific expandable spinal implants and associated systems and methods
US11324525B1 (en) 2021-06-30 2022-05-10 Kinos Medical Inc. Surgical alignment guide assembly for total ankle replacement and method of using the same
US11304760B1 (en) * 2021-10-06 2022-04-19 Ix Innovation Llc Customized kit assembly for surgical implants
JP2024542048A (ja) 2021-11-01 2024-11-13 カールスメッド インコーポレイテッド 沈み込みが低減された脊椎インプラント及び外科処置、並びに関連するシステム及び方法
US11443838B1 (en) 2022-02-23 2022-09-13 Carlsmed, Inc. Non-fungible token systems and methods for storing and accessing healthcare data
US12409496B2 (en) 2022-04-27 2025-09-09 The Boeing Company Pre-heating methods for performing electron beam powder bed fusion
US12343933B2 (en) 2022-08-25 2025-07-01 The Boeing Company Methods of additively manufacturing a manufactured component and systems that perform the methods
US11806241B1 (en) 2022-09-22 2023-11-07 Carlsmed, Inc. System for manufacturing and pre-operative inspecting of patient-specific implants
US11806028B1 (en) 2022-10-04 2023-11-07 Restor3D, Inc. Surgical guides and processes for producing and using the same
US11793577B1 (en) 2023-01-27 2023-10-24 Carlsmed, Inc. Techniques to map three-dimensional human anatomy data to two-dimensional human anatomy data
USD1053353S1 (en) 2023-03-24 2024-12-03 Restor3D, Inc. Orthopedic screw
USD1051384S1 (en) 2023-03-24 2024-11-12 Restor3D, Inc. Bone fixation pin
USD1052732S1 (en) 2023-05-25 2024-11-26 Restor3D, Inc. Subtalar wedge
US11960266B1 (en) 2023-08-23 2024-04-16 Restor3D, Inc. Patient-specific medical devices and additive manufacturing processes for producing the same

Family Cites Families (150)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4673409A (en) 1984-04-25 1987-06-16 Minnesota Mining And Manufacturing Company Implant with attachment surface
DE3933459A1 (de) 1989-10-06 1991-04-18 Karsten Dipl Ing Reumann Vorrichtung und verfahren zum individuellen implantataufbau aus biokompatiblen bausteinen
US5067964A (en) 1989-12-13 1991-11-26 Stryker Corporation Articular surface repair
US5246530A (en) 1990-04-20 1993-09-21 Dynamet Incorporated Method of producing porous metal surface
US5365996A (en) 1992-06-10 1994-11-22 Amei Technologies Inc. Method and apparatus for making customized fixation devices
DE4219939C2 (de) 1992-06-18 1995-10-19 Klaus Dipl Ing Radermacher Vorrichtung zur Ausrichtung, Positionierung und Führung von Bearbeitungswerkzeugen, Bearbeitungs- oder Meßvorrichtungen zur Bearbeitung einer knöchernen Struktur und Verfahren zur Erstellung dieser Vorrichtung
AU691162B2 (en) 1992-12-14 1998-05-14 Biomedical Engineering Trust I Fixed bearing joint endoprosthesis
JP2980805B2 (ja) 1994-03-01 1999-11-22 株式会社三協精機製作所 人工骨材およびその加工方法
JP3398481B2 (ja) 1994-07-19 2003-04-21 帝人製機株式会社 光造形法におけるサポート形成方法
DE4434539C2 (de) 1994-09-27 1998-06-04 Luis Dr Med Schuster Verfahren zur Herstellung einer Endoprothese als Gelenkersatz bei Kniegelenken
US6540786B2 (en) 1995-08-23 2003-04-01 Jean Chibrac Joint prosthesis members and method for making same
JP3155185B2 (ja) 1995-12-20 2001-04-09 松下電工株式会社 三次元形状造形物の製造方法
GB2318058B (en) 1996-09-25 2001-03-21 Ninian Spenceley Peckitt Improvements relating to prosthetic implants
US6989115B2 (en) 1996-12-20 2006-01-24 Z Corporation Method and apparatus for prototyping a three-dimensional object
US8617242B2 (en) 2001-05-25 2013-12-31 Conformis, Inc. Implant device and method for manufacture
US8556983B2 (en) 2001-05-25 2013-10-15 Conformis, Inc. Patient-adapted and improved orthopedic implants, designs and related tools
US8480754B2 (en) * 2001-05-25 2013-07-09 Conformis, Inc. Patient-adapted and improved articular implants, designs and related guide tools
US9603711B2 (en) * 2001-05-25 2017-03-28 Conformis, Inc. Patient-adapted and improved articular implants, designs and related guide tools
US8735773B2 (en) 2007-02-14 2014-05-27 Conformis, Inc. Implant device and method for manufacture
US7468075B2 (en) 2001-05-25 2008-12-23 Conformis, Inc. Methods and compositions for articular repair
US8771365B2 (en) 2009-02-25 2014-07-08 Conformis, Inc. Patient-adapted and improved orthopedic implants, designs, and related tools
US8882847B2 (en) 2001-05-25 2014-11-11 Conformis, Inc. Patient selectable knee joint arthroplasty devices
DE69823955T2 (de) 1997-03-04 2005-06-16 Technology Finance Corp. (Pty.) Ltd., Sandton Als knochenimplantat geeignetes erzeugnis
US6261322B1 (en) 1998-05-14 2001-07-17 Hayes Medical, Inc. Implant with composite coating
US6206927B1 (en) 1999-04-02 2001-03-27 Barry M. Fell Surgically implantable knee prothesis
DE19922279A1 (de) 1999-05-11 2000-11-16 Friedrich Schiller Uni Jena Bu Verfahren zur Generierung patientenspezifischer Implantate
US6251143B1 (en) 1999-06-04 2001-06-26 Depuy Orthopaedics, Inc. Cartilage repair unit
DE19936682C1 (de) 1999-08-04 2001-05-10 Luis Schuster Verfahren zur Herstellung einer Endoprothese als Gelenkersatz bei Kniegelenken
ES2553715T3 (es) 2000-03-10 2015-12-11 Smith & Nephew, Inc. Aparato para uso en artroplastia en una articulación de rodilla
US6632246B1 (en) 2000-03-14 2003-10-14 Chondrosite, Llc Cartilage repair plug
US6712856B1 (en) 2000-03-17 2004-03-30 Kinamed, Inc. Custom replacement device for resurfacing a femur and method of making the same
AU2001249935A1 (en) 2000-04-05 2001-10-23 Therics, Inc. System and method for rapidly customizing a design and remotely manufacturing biomedical devices using a computer system
US6772026B2 (en) 2000-04-05 2004-08-03 Therics, Inc. System and method for rapidly customizing design, manufacture and/or selection of biomedical devices
US6679917B2 (en) 2000-05-01 2004-01-20 Arthrosurface, Incorporated System and method for joint resurface repair
US20020082741A1 (en) 2000-07-27 2002-06-27 Jyoti Mazumder Fabrication of biomedical implants using direct metal deposition
US6592515B2 (en) 2000-09-07 2003-07-15 Ams Research Corporation Implantable article and method
AU2001296873A1 (en) 2000-09-14 2002-03-26 Leland Stanford Junior University Technique for manipulating medical images
AU2002214869A1 (en) 2000-10-31 2002-05-15 Centre National De La Recherche Scientifique (C.N.R.S.) High precision modeling of a body part using a 3d imaging system
DE10055465A1 (de) 2000-11-09 2002-05-23 Blz Gmbh Knochenersatzwerkstoff und Verfahren zur Herstellung eines Knochenersatz-Implantats
US6510334B1 (en) 2000-11-14 2003-01-21 Luis Schuster Method of producing an endoprosthesis as a joint substitute for a knee joint
US6786930B2 (en) 2000-12-04 2004-09-07 Spineco, Inc. Molded surgical implant and method
US8439926B2 (en) 2001-05-25 2013-05-14 Conformis, Inc. Patient selectable joint arthroplasty devices and surgical tools
US20170164957A1 (en) 2001-05-25 2017-06-15 Conformis, Inc. Patient Selectable Joint Arthroplasty Devices and Surgical Tools
GB2378151A (en) 2001-07-31 2003-02-05 Dtm Corp Fabricating a three-dimensional article from powder
GB2378150A (en) 2001-07-31 2003-02-05 Dtm Corp Fabricating a three-dimensional article from powder
US7324103B2 (en) 2001-10-30 2008-01-29 Ford Motor Company System and method of direct mesh manipulation
EP1480549A4 (en) 2002-03-05 2010-05-26 Zimmer Inc MINIMAL INVASIVE KNEE TOTALARTHROPLASTY PROCEDURE AND INSTRUMENTS
DE10220591B4 (de) 2002-05-08 2004-03-18 Mathys Medizinaltechnik Ag Gelenkprothese mit Zwischenelement mit unterschiedlichen Krümmungsradien
US8801720B2 (en) 2002-05-15 2014-08-12 Otismed Corporation Total joint arthroplasty system
WO2003101175A2 (en) 2002-05-30 2003-12-11 Osteotech, Inc. Method and apparatus for machining a surgical implant
US8086336B2 (en) * 2002-09-30 2011-12-27 Medical Modeling Inc. Method for design and production of a custom-fit prosthesis
US6978188B1 (en) * 2002-09-30 2005-12-20 Medical Modeling, Llc Method for contouring bone reconstruction plates
US20060147332A1 (en) 2004-12-30 2006-07-06 Howmedica Osteonics Corp. Laser-produced porous structure
JP4148316B2 (ja) 2002-11-18 2008-09-10 株式会社神戸製鋼所 人工膝関節
WO2004047688A1 (ja) 2002-11-22 2004-06-10 Juridical Foundation Osaka Industrial Promotion Organization 人工関節、医用インプラント、人工関節作成方法及び医用インプラント作成方法
GB2403416A (en) 2003-07-02 2005-01-05 Biomet Merck Ltd Prosthesis with artificial ligament
CN1267068C (zh) 2003-07-08 2006-08-02 西安交通大学 个体化人工半关节面替代物制备方法及其人工半关节替代物和手术定位器
AU2004283727A1 (en) 2003-10-23 2005-05-06 Trans1 Inc. Tools and tool kits for performing minimally invasive procedures on the spine
US7001672B2 (en) 2003-12-03 2006-02-21 Medicine Lodge, Inc. Laser based metal deposition of implant structures
US8175683B2 (en) 2003-12-30 2012-05-08 Depuy Products, Inc. System and method of designing and manufacturing customized instrumentation for accurate implantation of prosthesis by utilizing computed tomography data
US20060069318A1 (en) 2004-09-30 2006-03-30 The Regents Of The University Of California Method for assessment of the structure-function characteristics of structures in a human or animal body
US7828853B2 (en) 2004-11-22 2010-11-09 Arthrosurface, Inc. Articular surface implant and delivery system
US20060136058A1 (en) 2004-12-17 2006-06-22 William Pietrzak Patient specific anatomically correct implants to repair or replace hard or soft tissue
WO2006088946A2 (en) * 2005-02-14 2006-08-24 Mayo Medical Ventures Tissue support structure
US8292967B2 (en) 2005-04-21 2012-10-23 Biomet Manufacturing Corp. Method and apparatus for use of porous implants
US7368065B2 (en) 2005-06-23 2008-05-06 Depuy Products, Inc. Implants with textured surface and methods for producing the same
US7983777B2 (en) 2005-08-19 2011-07-19 Mark Melton System for biomedical implant creation and procurement
WO2007045000A2 (en) 2005-10-14 2007-04-19 Vantus Technology Corporation Personal fit medical implants and orthopedic surgical instruments and methods for making
US20070118055A1 (en) 2005-11-04 2007-05-24 Smith & Nephew, Inc. Systems and methods for facilitating surgical procedures involving custom medical implants
US8728387B2 (en) 2005-12-06 2014-05-20 Howmedica Osteonics Corp. Laser-produced porous surface
CA2572095C (en) 2005-12-30 2009-12-08 Howmedica Osteonics Corp. Laser-produced implants
CN105030296A (zh) 2006-02-06 2015-11-11 康复米斯公司 患者可选择的关节成形术装置和手术器具
CA2642615A1 (en) 2006-02-15 2007-08-30 Otismed Corp Arthroplasty jigs and related methods
US9808262B2 (en) 2006-02-15 2017-11-07 Howmedica Osteonics Corporation Arthroplasty devices and related methods
US20080257363A1 (en) 2007-04-17 2008-10-23 Biomet Manufacturing Corp. Method And Apparatus For Manufacturing An Implant
US8591516B2 (en) 2006-02-27 2013-11-26 Biomet Manufacturing, Llc Patient-specific orthopedic instruments
US9907659B2 (en) 2007-04-17 2018-03-06 Biomet Manufacturing, Llc Method and apparatus for manufacturing an implant
US9173661B2 (en) 2006-02-27 2015-11-03 Biomet Manufacturing, Llc Patient specific alignment guide with cutting surface and laser indicator
US9345548B2 (en) 2006-02-27 2016-05-24 Biomet Manufacturing, Llc Patient-specific pre-operative planning
US8858561B2 (en) 2006-06-09 2014-10-14 Blomet Manufacturing, LLC Patient-specific alignment guide
US8407067B2 (en) 2007-04-17 2013-03-26 Biomet Manufacturing Corp. Method and apparatus for manufacturing an implant
US8377066B2 (en) 2006-02-27 2013-02-19 Biomet Manufacturing Corp. Patient-specific elbow guides and associated methods
US7967868B2 (en) 2007-04-17 2011-06-28 Biomet Manufacturing Corp. Patient-modified implant and associated method
US8298237B2 (en) 2006-06-09 2012-10-30 Biomet Manufacturing Corp. Patient-specific alignment guide for multiple incisions
US8282646B2 (en) 2006-02-27 2012-10-09 Biomet Manufacturing Corp. Patient specific knee alignment guide and associated method
US8070752B2 (en) 2006-02-27 2011-12-06 Biomet Manufacturing Corp. Patient specific alignment guide and inter-operative adjustment
US8092465B2 (en) 2006-06-09 2012-01-10 Biomet Manufacturing Corp. Patient specific knee alignment guide and associated method
US8337508B2 (en) 2006-03-20 2012-12-25 Perception Raisonnement Action En Medecine Distractor system
DE102006037067B4 (de) 2006-08-08 2011-06-16 Metoxit Ag Verfahren zum Herstellen eines Implantats mit einer porösen, keramischen Oberflächenschicht
EP2083758B1 (en) 2006-08-18 2017-11-01 Smith & Nephew, Inc. Systems and methods for designing, analyzing and using orthopaedic devices
US8460302B2 (en) 2006-12-18 2013-06-11 Otismed Corporation Arthroplasty devices and related methods
US7603192B2 (en) 2007-02-13 2009-10-13 Orthohelix Surgical Designs, Inc. Method of making orthopedic implants and the orthopedic implants
WO2008109751A1 (en) 2007-03-06 2008-09-12 The Cleveland Clinic Foundation Method and apparatus for preparing for a surgical procedure
DE102007014985A1 (de) 2007-03-28 2008-10-02 Aepsilon Rechteverwaltungs Gmbh Verfahren zum Herstellen von Zahnersatzteilen, Verfahren zum Erstellen eines Datensatzes und computerlesbares Medium
GB0712290D0 (en) 2007-06-25 2007-08-01 Depuy Orthopaedie Gmbh Surgical instrument
EP2481555B1 (en) 2007-09-17 2021-08-25 3D Systems, Inc. Region-based supports for parts produced by solid freeform fabrication
EP2194889B1 (en) 2007-09-30 2015-09-23 DePuy Products, Inc. Customized patient-specific orthopaedic surgical instrumentation
US8460303B2 (en) 2007-10-25 2013-06-11 Otismed Corporation Arthroplasty systems and devices, and related methods
US10582934B2 (en) 2007-11-27 2020-03-10 Howmedica Osteonics Corporation Generating MRI images usable for the creation of 3D bone models employed to make customized arthroplasty jigs
GB0723452D0 (en) 2007-11-29 2008-01-09 Ortho Pro Teknica Ltd Method for manufacturing orthodontic appliances
US8311306B2 (en) 2008-04-30 2012-11-13 Otismed Corporation System and method for image segmentation in generating computer models of a joint to undergo arthroplasty
US8221430B2 (en) 2007-12-18 2012-07-17 Otismed Corporation System and method for manufacturing arthroplasty jigs
US8160345B2 (en) 2008-04-30 2012-04-17 Otismed Corporation System and method for image segmentation in generating computer models of a joint to undergo arthroplasty
US8737700B2 (en) 2007-12-18 2014-05-27 Otismed Corporation Preoperatively planning an arthroplasty procedure and generating a corresponding patient specific arthroplasty resection guide
US8545509B2 (en) 2007-12-18 2013-10-01 Otismed Corporation Arthroplasty system and related methods
GB0803510D0 (en) 2008-02-27 2008-04-02 Depuy Orthopaedie Gmbh Cutting guide
GB0803514D0 (en) 2008-02-27 2008-04-02 Depuy Int Ltd Customised surgical apparatus
WO2009111626A2 (en) 2008-03-05 2009-09-11 Conformis, Inc. Implants for altering wear patterns of articular surfaces
WO2009158318A1 (en) 2008-06-27 2009-12-30 Zimmer, Inc. Acl accommodating tibial design
US8617175B2 (en) 2008-12-16 2013-12-31 Otismed Corporation Unicompartmental customized arthroplasty cutting jigs and methods of making the same
US8992538B2 (en) 2008-09-30 2015-03-31 DePuy Synthes Products, Inc. Customized patient-specific acetabular orthopaedic surgical instrument and method of use and fabrication
CA2753488C (en) 2009-02-25 2014-04-29 Mohamed Rashwan Mahfouz Customized orthopaedic implants and related methods
US9078755B2 (en) 2009-02-25 2015-07-14 Zimmer, Inc. Ethnic-specific orthopaedic implants and custom cutting jigs
US20100217270A1 (en) * 2009-02-25 2010-08-26 Conformis, Inc. Integrated Production of Patient-Specific Implants and Instrumentation
WO2010120990A1 (en) 2009-04-15 2010-10-21 James Schroeder Personal fit medical implants and orthopedic surgical instruments and methods for making
US8794977B2 (en) 2009-04-29 2014-08-05 Lifemodeler, Inc. Implant training system
SG178836A1 (en) 2009-08-26 2012-04-27 Conformis Inc Patient-specific orthopedic implants and models
CA2778057C (en) 2009-10-29 2019-02-19 Zimmer, Inc. Patient-specific mill guide
AU2010315099B2 (en) 2009-11-04 2014-08-21 Conformis, Inc. Patient-adapted and improved orthopedic implants, designs and related tools
US8900316B2 (en) 2010-01-29 2014-12-02 Smith & Nephew, Inc. Cruciate-retaining knee prosthesis
GB201002855D0 (en) 2010-02-19 2010-04-07 Materialise Dental Nv Method and system for achiving subject-specific, three-dimensional information about the geometry of part of the body
US9066727B2 (en) 2010-03-04 2015-06-30 Materialise Nv Patient-specific computed tomography guides
GB201003921D0 (en) 2010-03-10 2010-04-21 Depuy Orthopaedie Gmbh Orthopaedic instrument
ES2632995T3 (es) 2010-07-24 2017-09-18 Zimmer, Inc. Componentes asimétricos de tibia para una prótesis de rodilla
US9232955B2 (en) 2010-08-12 2016-01-12 Smith & Nephew, Inc. Methods and devices for installing standard and reverse shoulder implants
WO2012021846A2 (en) 2010-08-13 2012-02-16 Smith & Nephew, Inc. Patient-matched acetabular guide
AU2011289154B2 (en) 2010-08-13 2016-06-09 Smith & Nephew, Inc. Systems and methods for optimizing parameters of orthopaedic procedures
US9474582B2 (en) 2010-08-25 2016-10-25 Siemens Aktiengesellschaft Personalized orthopedic implant CAD model generation
CN101953726B (zh) * 2010-09-20 2013-06-05 李长安 一种个性化颅骨修复体的制备方法
US20120078598A1 (en) 2010-09-27 2012-03-29 Siemens Corporation Custom Physics Simulation Joints
BR112013009069A2 (pt) 2010-10-14 2016-07-19 Smith & Nephew Inc instrumentação unida ao paciente e métodos
US20120276509A1 (en) 2010-10-29 2012-11-01 The Cleveland Clinic Foundation System of preoperative planning and provision of patient-specific surgical aids
US9717508B2 (en) 2010-10-29 2017-08-01 The Cleveland Clinic Foundation System of preoperative planning and provision of patient-specific surgical aids
BE1019572A5 (nl) 2010-11-10 2012-08-07 Materialise Nv Geoptimaliseerde methoden voor de productie van patientspecifieke medische hulpmiddelen.
WO2012112694A2 (en) 2011-02-15 2012-08-23 Conformis, Inc. Medeling, analyzing and using anatomical data for patient-adapted implants. designs, tools and surgical procedures
US9186154B2 (en) 2011-03-17 2015-11-17 Zimmer, Inc. Patient-specific instruments for total ankle arthroplasty
US8956364B2 (en) 2011-04-29 2015-02-17 Biomet Manufacturing, Llc Patient-specific partial knee guides and other instruments
WO2012154534A1 (en) 2011-05-06 2012-11-15 Zimmer, Inc. Patient-specific manufacturing of porous metal prostheses
US9084618B2 (en) 2011-06-13 2015-07-21 Biomet Manufacturing, Llc Drill guides for confirming alignment of patient-specific alignment guides
US8764760B2 (en) 2011-07-01 2014-07-01 Biomet Manufacturing, Llc Patient-specific bone-cutting guidance instruments and methods
US8597365B2 (en) 2011-08-04 2013-12-03 Biomet Manufacturing, Llc Patient-specific pelvic implants for acetabular reconstruction
US20130119579A1 (en) 2011-09-20 2013-05-16 The Cleveland Clinic Foundation Method and system for producing at least one patient-specific surgical aid
US9408686B1 (en) 2012-01-20 2016-08-09 Conformis, Inc. Devices, systems and methods for manufacturing orthopedic implants
US20130220570A1 (en) * 2012-02-29 2013-08-29 Ford Motor Company Additive fabrication technologies for creating molds for die components
CA2873224A1 (en) 2012-04-06 2013-10-10 Conformis, Inc. Advanced methods, techniques, devices, and systems for cruciate retaining knee implants
EP2836168B1 (en) 2012-04-13 2016-09-28 ConforMIS, Inc. Methods for additive manufacturing of implant components
US8888480B2 (en) * 2012-09-05 2014-11-18 Aprecia Pharmaceuticals Company Three-dimensional printing system and equipment assembly
US9636229B2 (en) 2012-09-20 2017-05-02 Conformis, Inc. Solid freeform fabrication of implant components
JP2015532858A (ja) 2012-09-21 2015-11-16 コンフォーミス・インコーポレイテッドConforMIS, Inc. 固体自由造形製造を使用してインプラント構成要素の設計および製造を最適化するための方法およびシステム
US20140259629A1 (en) 2013-03-15 2014-09-18 Conformis, Inc. Devices, methods and systems for forming implant components

Also Published As

Publication number Publication date
US20140086780A1 (en) 2014-03-27
JP2015532858A (ja) 2015-11-16
WO2014047514A1 (en) 2014-03-27
CN104780872B (zh) 2017-04-05
US9849019B2 (en) 2017-12-26
CN104780872A (zh) 2015-07-15

Similar Documents

Publication Publication Date Title
IN2015DN02636A (pm)
MX2019008211A (es) Estructuras fibrosas que comprenden particulas y metodos para fabricarlas.
MY169357A (en) Methods for additive manufacturing of implant components
PH12014501427A1 (en) Anti-php-tau antibodies and their uses
MA39819A (fr) Méthodes et compositions d'immunomodulation
MX2015006324A (es) Metodos para la fabricacion de polipeptidos proteoliticamente procesados.
MX2014002053A (es) Anticuerpos anti -mcsp y metodos de uso.
IN2015DN00127A (pm)
IN2014DN08481A (pm)
TN2013000378A1 (en) Anti - sclerostin antibody crystals and formulations thereof
MX359769B (es) Metodos para descelularizar huesos.
UA111186C2 (uk) Способи та композиції для одержання норибогаїну з воакангіну
UA117565C2 (uk) Модифікований олігонуклеотид
AU2013225816A8 (en) Compositions and methods for treating Type III Gaucher Disease
MX2015002487A (es) Proceso para la preparacion de teneligliptina.
IN2013MU00646A (pm)
GEP201706626B (en) Synthesis of (s)-nifuratel
WO2013163297A8 (en) Modified glycoproteins
IN2014DN08412A (pm)
MX2014000878A (es) Composiciones y metodos para reducir la incidencia de transtornos digestivos equinos.
IN2014CN00312A (pm)
MX2013014488A (es) Metodos y composiciones para tratar el cancer cerebral.
MX350452B (es) Enfriamiento y procesamiento de materiales.
IN2014DN07103A (pm)
IN2014DE01009A (pm)