IN2015DN01688A - - Google Patents
Info
- Publication number
- IN2015DN01688A IN2015DN01688A IN1688DEN2015A IN2015DN01688A IN 2015DN01688 A IN2015DN01688 A IN 2015DN01688A IN 1688DEN2015 A IN1688DEN2015 A IN 1688DEN2015A IN 2015DN01688 A IN2015DN01688 A IN 2015DN01688A
- Authority
- IN
- India
- Prior art keywords
- prepare
- inhibiting properties
- synthetic
- integrase inhibiting
- provides
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
- C07C43/225—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/257—Ethers having an ether-oxygen atom bound to carbon atoms both belonging to six-membered aromatic rings
- C07C43/29—Ethers having an ether-oxygen atom bound to carbon atoms both belonging to six-membered aromatic rings containing halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
- C07C45/30—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
- C07C45/46—Friedel-Crafts reactions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/12—Preparation of carboxylic acid esters from asymmetrical anhydrides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
- C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Quinoline Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261679475P | 2012-08-03 | 2012-08-03 | |
| PCT/US2013/053295 WO2014022707A1 (fr) | 2012-08-03 | 2013-08-01 | Procédé et intermédiaires pour préparer des inhibiteurs d'intégrase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2015DN01688A true IN2015DN01688A (fr) | 2015-07-03 |
Family
ID=48980354
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN1688DEN2015 IN2015DN01688A (fr) | 2012-08-03 | 2013-08-01 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US8877931B2 (fr) |
| EP (1) | EP2880017B1 (fr) |
| JP (1) | JP6147856B2 (fr) |
| KR (1) | KR20150040340A (fr) |
| CN (1) | CN104520275B (fr) |
| AU (1) | AU2013296289B2 (fr) |
| BR (1) | BR112015002275A2 (fr) |
| CA (1) | CA2878699C (fr) |
| EA (1) | EA026089B1 (fr) |
| ES (1) | ES2608860T3 (fr) |
| HK (2) | HK1209415A1 (fr) |
| IL (1) | IL236618A (fr) |
| IN (1) | IN2015DN01688A (fr) |
| MX (1) | MX337094B (fr) |
| NZ (1) | NZ630199A (fr) |
| PT (1) | PT2880017T (fr) |
| SG (1) | SG11201500812QA (fr) |
| WO (1) | WO2014022707A1 (fr) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RS54873B1 (sr) | 2012-12-21 | 2016-10-31 | Gilead Sciences | Policiklična-karbamoilpiridonska jedinjenja i njihova farmaceutska upotreba |
| NO2865735T3 (fr) | 2013-07-12 | 2018-07-21 | ||
| SI3019503T1 (sl) | 2013-07-12 | 2017-11-30 | Gilead Sciences, Inc. | Policiklične karbamoilpiridonske spojine in njihova uporaba za zdravljenje HIV infekcij |
| TWI744723B (zh) | 2014-06-20 | 2021-11-01 | 美商基利科學股份有限公司 | 多環型胺甲醯基吡啶酮化合物之合成 |
| TW201613936A (en) | 2014-06-20 | 2016-04-16 | Gilead Sciences Inc | Crystalline forms of(2R,5S,13aR)-8-hydroxy-7,9-dioxo-n-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide |
| NO2717902T3 (fr) | 2014-06-20 | 2018-06-23 | ||
| TWI695003B (zh) | 2014-12-23 | 2020-06-01 | 美商基利科學股份有限公司 | 多環胺甲醯基吡啶酮化合物及其醫藥用途 |
| NZ735575A (en) | 2015-04-02 | 2018-11-30 | Gilead Sciences Inc | Polycyclic-carbamoylpyridone compounds and their pharmaceutical use |
| EP4036096A4 (fr) * | 2019-09-24 | 2023-08-09 | Asymchem Laboratories (Tianjin) Co., Ltd. | Procédé de préparation en continu d'halogénure de zinc benzyle et de ses dérivés |
| CN112661698A (zh) * | 2021-01-14 | 2021-04-16 | 浙江海森药业股份有限公司 | 一种艾维雷韦的制备方法 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9904108D0 (sv) * | 1999-11-15 | 1999-11-15 | New Pharma Research Ab | Nya föreningar |
| ATE300522T1 (de) | 2000-12-14 | 2005-08-15 | Procter & Gamble | Cyclisierungsverfahrensschritt bei der herstellung von chinolonen und naphthyridinen |
| TW200300349A (en) | 2001-11-19 | 2003-06-01 | Sankyo Co | A 4-oxoqinoline derivative |
| AU2003235447A1 (en) | 2002-05-31 | 2003-12-19 | Banyu Pharmaceutical Co., Ltd. | Method of substituent introduction through halogen-metal exchange reaction |
| US6803469B2 (en) | 2002-08-05 | 2004-10-12 | The Procter & Gamble Company | Process for preparing quinolone antibiotic intermediates |
| TW200409759A (en) | 2002-09-25 | 2004-06-16 | Wyeth Corp | Substituted 4-(indazol-3-yl)phenols |
| BRPI0306214B1 (pt) | 2002-11-20 | 2017-08-08 | Japan Tobacco Inc. | 4-oxoquinoline compound and use of this as a hiv integrase inhibitor |
| EP1582524B1 (fr) | 2004-04-02 | 2008-08-13 | Ludwig Maximilians Universität | Procédé de préparation de composés organomagnésiens |
| EP1582523A1 (fr) | 2004-04-02 | 2005-10-05 | Ludwig-Maximilians-Universität München | Procédé de préparation de composés organomagnésiens |
| MY134672A (en) | 2004-05-20 | 2007-12-31 | Japan Tobacco Inc | Stable crystal of 4-oxoquinoline compound |
| US7531554B2 (en) | 2004-05-20 | 2009-05-12 | Japan Tobacco Inc. | 4-oxoquinoline compound and use thereof as HIV integrase inhibitor |
| JP4629104B2 (ja) | 2004-05-21 | 2011-02-09 | 日本たばこ産業株式会社 | ４−オキソキノリン誘導体および抗ｈｉｖ剤を含む併用剤 |
| WO2007063869A1 (fr) | 2005-11-30 | 2007-06-07 | Japan Tobacco Inc. | Procede de fabrication d’un compose de quinolone de grande purete |
| US20090233964A1 (en) | 2005-12-30 | 2009-09-17 | Gilead Sciences, Inc. | Methods for improving the pharmacokinetics of hiv integrase inhibitors |
| PL1992607T3 (pl) | 2006-03-06 | 2015-05-29 | Japan Tobacco Inc | Sposób wytwarzania związku 4-oksochinolinowego |
| US8420821B2 (en) | 2006-03-06 | 2013-04-16 | Japan Tobacco Inc. | Process for production of 4-oxoquinoline compound |
| TW200811153A (en) | 2006-06-23 | 2008-03-01 | Japan Tobacco Inc | 6-(heterocyclyl-substituted benzyl)-4-oxoquinoline compound and use thereof as HIV integrase inhibitor |
| NZ575542A (en) | 2006-09-12 | 2012-03-30 | Gilead Sciences Inc | Process and intermediates for preparing 4-oxoquinolone integrase inhibitors |
| TW200916103A (en) | 2007-06-29 | 2009-04-16 | Gilead Sciences Inc | Therapeutic compositions and methods |
| SG182229A1 (en) | 2007-06-29 | 2012-07-30 | Gilead Sciences Inc | Therapeutic compositions and the use thereof |
| AR068403A1 (es) * | 2007-09-11 | 2009-11-18 | Gilead Sciences Inc | Proceso e intermediarios para la preparacion de inhibidores de integrasa |
-
2013
- 2013-08-01 MX MX2015001506A patent/MX337094B/es active IP Right Grant
- 2013-08-01 EP EP13748229.5A patent/EP2880017B1/fr active Active
- 2013-08-01 AU AU2013296289A patent/AU2013296289B2/en not_active Ceased
- 2013-08-01 WO PCT/US2013/053295 patent/WO2014022707A1/fr active Application Filing
- 2013-08-01 EA EA201590018A patent/EA026089B1/ru not_active IP Right Cessation
- 2013-08-01 BR BR112015002275A patent/BR112015002275A2/pt not_active IP Right Cessation
- 2013-08-01 CA CA2878699A patent/CA2878699C/fr not_active Expired - Fee Related
- 2013-08-01 IN IN1688DEN2015 patent/IN2015DN01688A/en unknown
- 2013-08-01 SG SG11201500812QA patent/SG11201500812QA/en unknown
- 2013-08-01 CN CN201380041287.6A patent/CN104520275B/zh not_active Expired - Fee Related
- 2013-08-01 US US13/956,905 patent/US8877931B2/en active Active
- 2013-08-01 ES ES13748229.5T patent/ES2608860T3/es active Active
- 2013-08-01 NZ NZ630199A patent/NZ630199A/en not_active IP Right Cessation
- 2013-08-01 KR KR20157005620A patent/KR20150040340A/ko active IP Right Grant
- 2013-08-01 PT PT137482295T patent/PT2880017T/pt unknown
- 2013-08-01 JP JP2015525605A patent/JP6147856B2/ja not_active Expired - Fee Related
-
2015
- 2015-01-11 IL IL236618A patent/IL236618A/en not_active IP Right Cessation
- 2015-10-13 HK HK15109962.8A patent/HK1209415A1/xx not_active IP Right Cessation
- 2015-10-28 HK HK15110645.1A patent/HK1209748A1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2013296289B2 (en) | 2017-10-05 |
| MX337094B (es) | 2016-02-10 |
| CN104520275A (zh) | 2015-04-15 |
| MX2015001506A (es) | 2015-04-08 |
| IL236618A (en) | 2017-04-30 |
| KR20150040340A (ko) | 2015-04-14 |
| NZ630199A (en) | 2016-12-23 |
| EP2880017A1 (fr) | 2015-06-10 |
| AU2013296289A1 (en) | 2015-02-19 |
| CA2878699A1 (fr) | 2014-02-06 |
| ES2608860T3 (es) | 2017-04-17 |
| PT2880017T (pt) | 2016-12-14 |
| SG11201500812QA (en) | 2015-04-29 |
| IL236618A0 (en) | 2015-02-26 |
| JP6147856B2 (ja) | 2017-06-14 |
| EA201590018A1 (ru) | 2015-05-29 |
| US20140039194A1 (en) | 2014-02-06 |
| HK1209748A1 (en) | 2016-04-08 |
| CA2878699C (fr) | 2018-09-11 |
| BR112015002275A2 (pt) | 2017-07-04 |
| HK1209415A1 (en) | 2016-04-01 |
| WO2014022707A1 (fr) | 2014-02-06 |
| US8877931B2 (en) | 2014-11-04 |
| EA026089B1 (ru) | 2017-02-28 |
| JP2015524822A (ja) | 2015-08-27 |
| EP2880017B1 (fr) | 2016-10-05 |
| CN104520275B (zh) | 2016-11-02 |
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