IN2015DN01331A - - Google Patents
Info
- Publication number
- IN2015DN01331A IN2015DN01331A IN1331DEN2015A IN2015DN01331A IN 2015DN01331 A IN2015DN01331 A IN 2015DN01331A IN 1331DEN2015 A IN1331DEN2015 A IN 1331DEN2015A IN 2015DN01331 A IN2015DN01331 A IN 2015DN01331A
- Authority
- IN
- India
- Prior art keywords
- trifluoromethylpyridin
- morpholinyl
- pyrimidinyl
- intermediates
- amine
- Prior art date
Links
- CWHUFRVAEUJCEF-UHFFFAOYSA-N BKM120 Chemical compound C1=NC(N)=CC(C(F)(F)F)=C1C1=CC(N2CCOCC2)=NC(N2CCOCC2)=N1 CWHUFRVAEUJCEF-UHFFFAOYSA-N 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical class Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261717237P | 2012-10-23 | 2012-10-23 | |
| US201361842101P | 2013-07-02 | 2013-07-02 | |
| PCT/EP2013/071996 WO2014064058A1 (en) | 2012-10-23 | 2013-10-21 | Improved process for manufacturing 5-(2,6-di-4-morpholinyl-4-pyrimidinyl)-4-trifluoromethylpyridin-2-amine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2015DN01331A true IN2015DN01331A (enExample) | 2015-07-03 |
Family
ID=49448162
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN1331DEN2015 IN2015DN01331A (enExample) | 2012-10-23 | 2013-10-21 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US9637468B2 (enExample) |
| EP (1) | EP2912030B1 (enExample) |
| JP (1) | JP6267213B2 (enExample) |
| KR (1) | KR102128127B1 (enExample) |
| CN (1) | CN104736532B (enExample) |
| AU (2) | AU2013336807B2 (enExample) |
| BR (1) | BR112015007243B1 (enExample) |
| CA (1) | CA2885471C (enExample) |
| ES (1) | ES2605638T3 (enExample) |
| IN (1) | IN2015DN01331A (enExample) |
| MX (1) | MX360703B (enExample) |
| PL (1) | PL2912030T3 (enExample) |
| PT (1) | PT2912030T (enExample) |
| RU (1) | RU2646760C2 (enExample) |
| WO (1) | WO2014064058A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112014007310A2 (pt) | 2011-09-27 | 2017-04-04 | Novartis Ag | 3-pirimidin-4-il-oxazolidin-2-onas como inibidores de idh mutante |
| UY34632A (es) | 2012-02-24 | 2013-05-31 | Novartis Ag | Compuestos de oxazolidin- 2- ona y usos de los mismos |
| US9296733B2 (en) | 2012-11-12 | 2016-03-29 | Novartis Ag | Oxazolidin-2-one-pyrimidine derivative and use thereof for the treatment of conditions, diseases and disorders dependent upon PI3 kinases |
| WO2014110466A1 (en) * | 2013-01-12 | 2014-07-17 | Dawei Zhang | Pyridine compounds used as pi3 kinase inhibitors |
| JP6387360B2 (ja) | 2013-03-14 | 2018-09-05 | ノバルティス アーゲー | 変異ｉｄｈの阻害薬としての３−ピリミジン−４−イル−オキサゾリジン−２−オン |
| ES2713452T3 (es) | 2014-04-22 | 2019-05-21 | Univ Basel | Proceso de fabricación para derivados de triazina, pirimidina y piridina |
| CN107001317B (zh) * | 2014-09-29 | 2019-05-24 | 山东轩竹医药科技有限公司 | 高选择性取代嘧啶类pi3k抑制剂 |
| CN105085476B (zh) * | 2014-11-24 | 2018-03-09 | 苏州晶云药物科技有限公司 | 5‑[2,6‑二(4‑吗啉基)‑4‑嘧啶基]‑4‑(三氟甲基)‑2‑吡啶胺二盐酸盐的晶型及其制备方法 |
| CN105001151B (zh) * | 2015-08-28 | 2017-07-14 | 苏州明锐医药科技有限公司 | 布帕尼西中间体及其制备方法 |
| CN106543140A (zh) * | 2015-09-21 | 2017-03-29 | 苏州晶云药物科技有限公司 | 5-[2,6-二(4-吗啉基)-4-嘧啶基]-4-(三氟甲基)-2-吡啶胺盐酸盐的晶型及其制备方法 |
| CN107793394A (zh) * | 2017-08-03 | 2018-03-13 | 上海厚璞生物科技有限公司 | 一种生产选择性pi3k抑制剂的系列关键中间体 |
| IL283901B2 (en) | 2018-12-18 | 2025-03-01 | Astrazeneca Ab | Process and intermediates for the preparation of 4-{4-[(3R)-3-methylmorpholin-4-yl]-6-[1-((R)-S-methylsulfonimidoyl)cyclopropyl]pyrimidin-2-yl}-1H-pyrrolo[2,3-b]pyridine |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4061194B2 (ja) * | 2001-02-08 | 2008-03-12 | 富山化学工業株式会社 | ６−置換アルキルアミノ−３−ピリジルホウ酸誘導体またはその塩およびそれらの製造法 |
| EA013811B1 (ru) * | 2002-11-21 | 2010-08-30 | Новартис Вэксинес Энд Дайэгностикс, Инк. | 2,4,6-тризамещённые пиримидины, являющиеся ингибиторами фосфотидилинозитол(pi)-3-киназы, и их применение при лечении рака |
| JO2660B1 (en) * | 2006-01-20 | 2012-06-17 | نوفارتيس ايه جي | Pi-3 inhibitors and methods of use |
| SG188439A1 (en) * | 2010-10-01 | 2013-05-31 | Novartis Ag | Manufacturing process for pyrimidine derivatives |
-
2013
- 2013-10-21 AU AU2013336807A patent/AU2013336807B2/en active Active
- 2013-10-21 CN CN201380055482.4A patent/CN104736532B/zh active Active
- 2013-10-21 JP JP2015538398A patent/JP6267213B2/ja active Active
- 2013-10-21 BR BR112015007243-7A patent/BR112015007243B1/pt active IP Right Grant
- 2013-10-21 IN IN1331DEN2015 patent/IN2015DN01331A/en unknown
- 2013-10-21 PL PL13779841T patent/PL2912030T3/pl unknown
- 2013-10-21 EP EP13779841.9A patent/EP2912030B1/en active Active
- 2013-10-21 ES ES13779841.9T patent/ES2605638T3/es active Active
- 2013-10-21 US US14/437,177 patent/US9637468B2/en active Active
- 2013-10-21 RU RU2015119259A patent/RU2646760C2/ru active
- 2013-10-21 WO PCT/EP2013/071996 patent/WO2014064058A1/en not_active Ceased
- 2013-10-21 MX MX2015005188A patent/MX360703B/es active IP Right Grant
- 2013-10-21 CA CA2885471A patent/CA2885471C/en active Active
- 2013-10-21 KR KR1020157010087A patent/KR102128127B1/ko not_active Expired - Fee Related
- 2013-10-21 PT PT137798419T patent/PT2912030T/pt unknown
-
2016
- 2016-10-07 AU AU2016238941A patent/AU2016238941A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CN104736532A (zh) | 2015-06-24 |
| BR112015007243A2 (pt) | 2017-07-04 |
| MX360703B (es) | 2018-11-14 |
| ES2605638T3 (es) | 2017-03-15 |
| MX2015005188A (es) | 2015-09-07 |
| RU2015119259A (ru) | 2016-12-20 |
| WO2014064058A1 (en) | 2014-05-01 |
| CN104736532B (zh) | 2017-04-05 |
| JP2016502510A (ja) | 2016-01-28 |
| EP2912030A1 (en) | 2015-09-02 |
| BR112015007243B1 (pt) | 2022-02-08 |
| EP2912030B1 (en) | 2016-08-31 |
| KR102128127B1 (ko) | 2020-06-30 |
| PL2912030T3 (pl) | 2017-02-28 |
| KR20150072408A (ko) | 2015-06-29 |
| US9637468B2 (en) | 2017-05-02 |
| PT2912030T (pt) | 2016-11-30 |
| CA2885471C (en) | 2021-02-23 |
| JP6267213B2 (ja) | 2018-01-24 |
| RU2646760C2 (ru) | 2018-03-07 |
| US20150246897A1 (en) | 2015-09-03 |
| AU2013336807B2 (en) | 2016-10-27 |
| AU2013336807A1 (en) | 2015-03-05 |
| AU2016238941A1 (en) | 2016-11-03 |
| CA2885471A1 (en) | 2014-05-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IN2015DN01331A (enExample) | ||
| MY171055A (en) | 3,5-disubstituted alkynylbenzene compound and salt thereof | |
| LT3577110T (lt) | 8-oksetan-3-il-3,8-diazabiciklo[3.2.1]oktan-3-ilo pakeistieji junginiai, kaip živ inhibitoriai | |
| SG11201912770SA (en) | a, ß-UNSATURATED AMIDE COMPOUND | |
| MY163187A (en) | Novel imidazo-oxazine compound or salt thereof | |
| MX361499B (es) | Baricitinib deuterado. | |
| IN2014DN06812A (enExample) | ||
| IN2015DN00598A (enExample) | ||
| BR112015001201A2 (pt) | compostos anti-infecciosos 5,5-heteroaromáticos. | |
| PT3418275T (pt) | Composto inovador de tiofeno substituído em 2,3,5 como inibidor de proteína quinase | |
| MX366983B (es) | Derivados de 1,5-naftiridina e inhibidores de cinasa de cremallallera de leucina embrionica materna que los contienen. | |
| IL231468A0 (en) | 3,1-diaryl-converted heterocyclic pesticides | |
| EP3083555A4 (en) | Processes for the diazotization of 2,5-dichloroanilines | |
| MY166058A (en) | Method for preparation of medetomidine | |
| IL251500A (en) | A new compound containing nitrogen or its salt or metallic complex | |
| IT1403920B1 (it) | Composti fotosensibilizzanti "metal free". | |
| HK1224305A1 (zh) | 用於治療重度低血糖症的新型化合物 | |
| HK1215571A1 (zh) | 二盐酸科比思特 | |
| WO2014064714A3 (en) | Process for preparation of lurasidone hydrochloride | |
| EP4403223A3 (en) | Crystal forms | |
| MX2020006006A (es) | Polimorfos cristalinos de {(2s,3r)-1-[(2s)-2-{5-[(2r,5r)-1-{3,5-di fluoro-4-[4-(4-fluorofenil)piperidin-1-il]fenil}-5-(6-fluoro-2-{( 2s)-1-[n-(metoxicarbonil)-o-metil-l-treonil]pirrolidin-2-il}-1h-b enzimidazol-5-il)pirrolidin-2-il]-6-fluoro-1h-benzimidazol-2-il}p irrolidin-1-il]-3-metoxi-1-oxobutan-2-il}carbamato de metilo. | |
| IT1402456B1 (it) | Macchina per realizzare gabbie metalliche. | |
| MY174415A (en) | Salt form, crystal form and intermediate of 1,2,5-thiadiazolidine-1,1-dioxide and preparation method thereof | |
| UA87695U (uk) | Сполука 4,5,6,7-тетрагідро-3н-2-n-(пара-метоксифенациламіно)-азепіну гідрохлорид, що має інотропну активність | |
| UA88965U (uk) | Сполука 1,3-біс-(2-гидроксіетил)-урацил, що має інотропну активність |