IN2014MN02106A - - Google Patents
Download PDFInfo
- Publication number
- IN2014MN02106A IN2014MN02106A IN2106MUN2014A IN2014MN02106A IN 2014MN02106 A IN2014MN02106 A IN 2014MN02106A IN 2106MUN2014 A IN2106MUN2014 A IN 2106MUN2014A IN 2014MN02106 A IN2014MN02106 A IN 2014MN02106A
- Authority
- IN
- India
- Prior art keywords
- compound
- formula
- disclosed
- preparation
- pharmaceutically acceptable
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
- C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C309/04—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing only one sulfo group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/20—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Furan Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261618004P | 2012-03-30 | 2012-03-30 | |
| US201261647127P | 2012-05-15 | 2012-05-15 | |
| PCT/CA2013/050254 WO2013142999A1 (fr) | 2012-03-30 | 2013-03-28 | Procédé de synthèse pour la préparation d'analogues c1-céto macrocycliques de l'halichondrine b et intermédiaires utiles dans celui-ci |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2014MN02106A true IN2014MN02106A (fr) | 2015-09-11 |
Family
ID=49258019
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN2106MUN2014 IN2014MN02106A (fr) | 2012-03-30 | 2013-03-28 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US9278979B2 (fr) |
| EP (1) | EP2831082B1 (fr) |
| JP (1) | JP6531911B2 (fr) |
| CN (1) | CN104334562A (fr) |
| AU (1) | AU2013239290B2 (fr) |
| CA (1) | CA2868627C (fr) |
| IN (1) | IN2014MN02106A (fr) |
| WO (1) | WO2013142999A1 (fr) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2567984C (fr) | 2004-06-03 | 2014-05-20 | Eisai Co., Ltd. | Intermediaires pour la preparation d'analogues d'halichondrine b |
| CN104311571B (zh) | 2007-10-03 | 2019-07-02 | 卫材R&D管理有限公司 | 用于合成软海绵素b类似物的中间体和方法 |
| CN102803254B (zh) | 2010-01-26 | 2016-09-14 | 卫材R&D管理有限公司 | 用于软海绵素b类似物合成的呋喃并[3,2-b]吡喃衍生物 |
| AU2012344697A1 (en) | 2011-11-30 | 2014-07-10 | Alphora Research Inc. | Process for preparation of (3R)-2,4-di-leaving group-3-methylbut-1-ene |
| AU2012350420A1 (en) | 2011-12-16 | 2014-07-10 | Alphora Research Inc. | Process for preparation of 3-((2S,5S)-4-methylene-5-(3-oxopropyl)tetrahydrofuran-2-yl) propanol derivatives and intermediates useful thereof |
| WO2013097042A1 (fr) | 2011-12-29 | 2013-07-04 | Alphora Research Inc. | Dérivés de 2-((2s,3s,4r,5r)-5-((s)-3-amino-2-hydroxyprop-1-yl)-4-méthoxy-3-(phénylsulfonylméthyl)tétrahydrofurane-2-yl)acétaldéhyde et procédé pour leur préparation |
| CN105431438A (zh) * | 2013-07-03 | 2016-03-23 | 阿方拉研究股份有限公司 | 用于制备软海绵素b 的大环c1-酮基类似物的合成方法和可用于其中的中间体、包括含有-so2-(对甲苯基)基团的中间体 |
| CN103483352A (zh) * | 2013-10-18 | 2014-01-01 | 李友香 | 抗肿瘤的药用原料药 |
| RU2710545C2 (ru) * | 2013-11-04 | 2019-12-27 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Реакции макроциклизации и промежуточные соединения и другие фрагменты, пригодные в получении аналогов халихондрина b |
| MX370611B (es) | 2013-12-06 | 2019-12-18 | Eisai R&D Man Co Ltd | Metodos utiles en la sintesis de analogos de halicondrina b. |
| TW201617326A (zh) * | 2014-03-06 | 2016-05-16 | Ａｌｐｈｏｒａ研發股份有限公司 | （ｓ）－１－（（２ｒ，３ｒ，４ｓ，５ｓ）－５－烯丙－３－甲氧－４－（對甲苯磺醯甲基）四氫呋喃－２－基）－３－氨基丙－２－醇之結晶衍生物 |
| US10556910B2 (en) | 2014-06-30 | 2020-02-11 | President And Fellows Of Harvard College | Synthesis of halichondrin analogs and uses thereof |
| CN105713031B (zh) * | 2014-12-05 | 2021-05-07 | 正大天晴药业集团股份有限公司 | 一种用于制备艾日布林的中间体及其制备方法 |
| US10344038B2 (en) | 2015-04-30 | 2019-07-09 | President And Fellows Of Harvard College | Chromium-mediated coupling and application to the synthesis of halichondrins |
| US10308661B2 (en) * | 2015-05-07 | 2019-06-04 | Eisai R&D Management Co., Ltd. | Macrocyclization reactions and intermediates and other fragments useful in the synthesis of halichondrin macrolides |
| MX2018009794A (es) | 2016-02-12 | 2018-12-17 | Eisai R&D Man Co Ltd | Intermediarios en la sintesis de eribulina y metodos de sintesis relacionados. |
| CN114191428A (zh) | 2016-03-02 | 2022-03-18 | 卫材研究发展管理有限公司 | 基于艾日布林的抗体-药物偶联物和使用方法 |
| JP2019521969A (ja) * | 2016-05-26 | 2019-08-08 | ドクター レディズ ラボラトリーズ リミテッド | エリブリン及びその中間体の製造方法 |
| MX2018016329A (es) | 2016-06-30 | 2019-09-18 | Eisai R&D Man Co Ltd | Reaccion de prins e intermediarios utiles en la sintesis de macrolidos de halicondrina y analogos de los mismos. |
| JP6978758B2 (ja) | 2016-11-11 | 2021-12-08 | プレジデント アンド フェローズ オブ ハーバード カレッジ | パラジウム媒介ケトール化 |
| WO2018096478A2 (fr) | 2016-11-23 | 2018-05-31 | Dr. Reddy’S Laboratories Limited | Procédé de préparation d'éribuline et de ses intermédiaires |
| CN108658956B (zh) * | 2017-03-28 | 2021-02-02 | 上海时莱生物技术有限公司 | 艾日布林中间体及其制备方法 |
| TWI781163B (zh) | 2017-04-05 | 2022-10-21 | 哈佛大學校長及研究員協會 | 巨環化合物及其用途 |
| US9938288B1 (en) | 2017-04-05 | 2018-04-10 | President And Fellows Of Harvard College | Macrocyclic compound and uses thereof |
| CN108948064B (zh) | 2017-05-17 | 2021-02-02 | 上海时莱生物技术有限公司 | 一种艾日布林中间体及其制备方法 |
| WO2018217894A1 (fr) * | 2017-05-24 | 2018-11-29 | Eisai R&D Management Co., Ltd. | Dérivés d'halichondrine marqués au fluor et procédés de synthèse associés |
| US11498892B2 (en) | 2017-07-06 | 2022-11-15 | President And Fellows Of Harvard College | Fe/Cu-mediated ketone synthesis |
| EP3649135B1 (fr) * | 2017-07-06 | 2022-12-28 | President and Fellows of Harvard College | Synthèse d'halichondrines |
| WO2019099646A1 (fr) | 2017-11-15 | 2019-05-23 | President And Fellows Of Harvard College | Composés macrocycliques et utilisations de ces composés |
| MX2020006945A (es) | 2018-01-03 | 2020-11-09 | Eisai R&D Man Co Ltd | Reaccion de prins y compuestos utiles en la sintesis de macrolidos de halicondrina y analogos de los mismos. |
| CN114213429B (zh) * | 2021-12-22 | 2023-06-20 | 苏州正济药业有限公司 | 一种甲磺酸艾立布林杂质的制备方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5338865A (en) | 1992-03-12 | 1994-08-16 | President And Fellows Of Harvard College | Synthesis of halichondrin B and norhalichondrin B |
| US5436238A (en) | 1992-03-12 | 1995-07-25 | President And Fellows Of Harvard College | Halichondrins and related compounds |
| WO1995001960A1 (fr) | 1993-07-09 | 1995-01-19 | Laboratoire Theramex S.A. | Nouveaux analogues structuraux de la vitamine d |
| KR100798600B1 (ko) | 1998-06-17 | 2008-01-28 | 에자이 가부시키가이샤 | 마크로시클릭 유사체 및 그들의 이용 및 제조방법 |
| US7001982B2 (en) | 2003-03-31 | 2006-02-21 | Council Of Scientific And Industrial Research | Non-natural C-linked carbo-β-peptides with robust secondary structures |
| CA2567984C (fr) | 2004-06-03 | 2014-05-20 | Eisai Co., Ltd. | Intermediaires pour la preparation d'analogues d'halichondrine b |
| US20060045846A1 (en) * | 2004-08-30 | 2006-03-02 | Horstmann Thomas E | Reagents and methods for labeling terminal olefins |
| MX2010010902A (es) * | 2008-04-04 | 2010-12-21 | Eisai R&D Man Co Ltd | Analogos de halicondrina b. |
| AU2012344697A1 (en) | 2011-11-30 | 2014-07-10 | Alphora Research Inc. | Process for preparation of (3R)-2,4-di-leaving group-3-methylbut-1-ene |
| AU2012350420A1 (en) | 2011-12-16 | 2014-07-10 | Alphora Research Inc. | Process for preparation of 3-((2S,5S)-4-methylene-5-(3-oxopropyl)tetrahydrofuran-2-yl) propanol derivatives and intermediates useful thereof |
| WO2013097042A1 (fr) | 2011-12-29 | 2013-07-04 | Alphora Research Inc. | Dérivés de 2-((2s,3s,4r,5r)-5-((s)-3-amino-2-hydroxyprop-1-yl)-4-méthoxy-3-(phénylsulfonylméthyl)tétrahydrofurane-2-yl)acétaldéhyde et procédé pour leur préparation |
| AR096238A1 (es) | 2013-05-15 | 2015-12-16 | Alphora Res Inc | Proceso para preparar derivados de 3-((2s,5s)-4-metilen-5-(3-oxopropil)tetrahidrofuran-2-il)propanol e intermediarios útiles para el mismo |
-
2013
- 2013-03-28 WO PCT/CA2013/050254 patent/WO2013142999A1/fr active Application Filing
- 2013-03-28 JP JP2015502027A patent/JP6531911B2/ja not_active Expired - Fee Related
- 2013-03-28 CA CA2868627A patent/CA2868627C/fr active Active
- 2013-03-28 US US14/389,439 patent/US9278979B2/en not_active Expired - Fee Related
- 2013-03-28 IN IN2106MUN2014 patent/IN2014MN02106A/en unknown
- 2013-03-28 CN CN201380028907.2A patent/CN104334562A/zh active Pending
- 2013-03-28 AU AU2013239290A patent/AU2013239290B2/en not_active Ceased
- 2013-03-28 EP EP13769493.1A patent/EP2831082B1/fr not_active Not-in-force
-
2016
- 2016-02-04 US US15/015,161 patent/US9695187B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP6531911B2 (ja) | 2019-06-19 |
| WO2013142999A1 (fr) | 2013-10-03 |
| CA2868627C (fr) | 2021-02-16 |
| EP2831082A1 (fr) | 2015-02-04 |
| CA2868627A1 (fr) | 2013-10-03 |
| US20150065733A1 (en) | 2015-03-05 |
| US9278979B2 (en) | 2016-03-08 |
| CN104334562A (zh) | 2015-02-04 |
| AU2013239290A1 (en) | 2014-10-30 |
| US20160152631A1 (en) | 2016-06-02 |
| AU2013239290B2 (en) | 2017-08-03 |
| EP2831082B1 (fr) | 2019-02-20 |
| US9695187B2 (en) | 2017-07-04 |
| JP2015512897A (ja) | 2015-04-30 |
| EP2831082A4 (fr) | 2016-01-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IN2014MN02106A (fr) | ||
| GEP20146146B (en) | Pyrrolopyrimidine compounds as inhibitors of cdk4/6 | |
| MX2016006336A (es) | Compuestos pirazolopirimidina. | |
| GEP20207105B (en) | 1,1,1-trifluoro-3-hydroxypropan-2-yl carbamate derivatives and 1,1,1-trifluoro-4-hydroxybutan-2yl carbamate derivatives as magl inhibitors | |
| IN2014MN01521A (fr) | ||
| IN2014MN02598A (fr) | ||
| AU2012214029A8 (en) | Rorgammat inhibitors | |
| UA110354C2 (uk) | Противірусні сполуки | |
| PH12014502040A1 (en) | Heterocyclyl compounds | |
| TN2011000400A1 (en) | Inhibitors of beta-secretase | |
| NZ729037A (en) | Carboxylic acid compound, method for preparation thereof, and use thereof | |
| MY175854A (en) | Novel quinolone derivatives | |
| EA201491362A1 (ru) | Анестезирующие соединения и способы их применения | |
| IN2014MN02459A (fr) | ||
| IN2014CN04530A (fr) | ||
| PH12014501514A1 (en) | New azetidine derivatives, pharmaceutical compositions and uses thereof | |
| CR20200286A (es) | DERIVADOS DE DIHIDRO-BENZO-OXAZINA Y DIHIDRO-PIRIDO-OXAZINA (Divisional 2014-0294) | |
| IN2015DN01119A (fr) | ||
| PH12016500885A1 (en) | Novel heterocyclic compounds | |
| PH12016500394A1 (en) | Polymorphic form of pyrrole derivative and intermediate thereof | |
| MD20160105A2 (ro) | 2-Amino-6-metil-4,4a,5,6-tetrahidropirano[3,4-d][1,3]tiazin-8a(8H)-il-1,3-tiazol-4-il amide | |
| MX364400B (es) | Compuestos de tetraciclina. | |
| IN2012DN02502A (fr) | ||
| MX2013008340A (es) | Novedosas 4-amino-n-hidroxi-benzamidas para el tratamiento de cancer. | |
| IN2014CN04449A (fr) |