IN2014MN02105A - - Google Patents

Download PDF

Info

Publication number
IN2014MN02105A
IN2014MN02105A IN2105MUN2014A IN2014MN02105A IN 2014MN02105 A IN2014MN02105 A IN 2014MN02105A IN 2105MUN2014 A IN2105MUN2014 A IN 2105MUN2014A IN 2014MN02105 A IN2014MN02105 A IN 2014MN02105A
Authority
IN
India
Prior art keywords
compound
infection
treating
medicament
treating herpes
Prior art date
Application number
Other languages
English (en)
Inventor
Ji Wang Chern
Shin Yu Lai
Pei Teh Chang
Original Assignee
Annji Pharm Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Annji Pharm Co Ltd filed Critical Annji Pharm Co Ltd
Publication of IN2014MN02105A publication Critical patent/IN2014MN02105A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/30Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32Oxygen atoms
    • C07D209/34Oxygen atoms in position 2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52Purines, e.g. adenine
    • A61K31/522Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/45Transferases (2)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • A61P31/22Antivirals for DNA viruses for herpes viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
    • C07D473/26Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32Nitrogen atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404Indoles, e.g. pindolol
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
    • C07D473/02Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
IN2105MUN2014 2012-04-20 2013-04-02 IN2014MN02105A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261635931P 2012-04-20 2012-04-20
PCT/US2013/035042 WO2013158367A1 (en) 2012-04-20 2013-04-02 Cyclopropanecarboxylate esters of purine analogues

Publications (1)

Publication Number Publication Date
IN2014MN02105A true IN2014MN02105A (ko) 2015-09-11

Family

ID=49380678

Family Applications (2)

Application Number Title Priority Date Filing Date
IN2105MUN2014 IN2014MN02105A (ko) 2012-04-20 2013-04-02
IN2107MUN2014 IN2014MN02107A (ko) 2012-04-20 2013-04-03

Family Applications After (1)

Application Number Title Priority Date Filing Date
IN2107MUN2014 IN2014MN02107A (ko) 2012-04-20 2013-04-03

Country Status (13)

Country Link
US (2) US8969361B2 (ko)
EP (2) EP2838538B1 (ko)
JP (2) JP6177879B2 (ko)
KR (2) KR101774861B1 (ko)
CN (2) CN104394868A (ko)
AU (2) AU2013249708B2 (ko)
BR (1) BR112014026182A2 (ko)
ES (2) ES2621257T3 (ko)
IL (2) IL235098A0 (ko)
IN (2) IN2014MN02105A (ko)
RU (2) RU2642463C2 (ko)
TW (2) TWI496784B (ko)
WO (2) WO2013158367A1 (ko)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014155301A1 (en) * 2013-03-26 2014-10-02 Piramal Enterprises Limited Substituted bicyclic compounds as inhibitors of ezh2
MY197370A (en) 2015-11-06 2023-06-14 Hoffmann La Roche Indolin-2-one derivatives
CN106831707B (zh) * 2016-12-28 2019-09-20 杭州市西溪医院 作为c-Met激酶抑制剂的苯并杂环类衍生物及其医疗用途
GB201709456D0 (en) * 2017-06-14 2017-07-26 Ucb Biopharma Sprl Therapeutic agents
EP4267642A1 (de) 2020-12-23 2023-11-01 Basf Se Neuer katalysator zur herstellung von polyurethanen
CN113307799B (zh) * 2021-05-21 2022-07-19 大连医科大学 一种检测葡萄糖醛酸转移酶1a1荧光探针及其应用
CN113999221B (zh) * 2021-11-04 2024-04-05 南京中医药大学 6-位取代的吲哚酮衍生物及其医药用途
CN114380802B (zh) * 2022-01-07 2023-11-17 贵州大学 一类含咔唑基咪唑盐类化合物及其制备方法和应用
WO2024110395A1 (de) 2022-11-24 2024-05-30 Basf Se Verbesserung der lagerstabilität von hydrofluorolefinen in aminhaltigen polyolkomponenten für die herstellung von polyurethanen

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT351865B (de) 1977-04-01 1979-08-27 Hoffmann La Roche Akarizide mittel
US5543414A (en) * 1994-07-28 1996-08-06 Syntex (Usa) Inc. Achiral amino acid acyl esters of ganciclovir and its derivatives
AU759226B2 (en) * 1998-05-29 2003-04-10 Sugen, Inc. Pyrrole substituted 2-indolinone protein kinase inhibitors
ME00415B (me) 2000-02-15 2011-10-10 Pharmacia & Upjohn Co Llc Pirol supstituisani 2-indol protein kinazni inhibitori
US20090264494A1 (en) 2002-10-18 2009-10-22 Board Of Regents, The University Of Texas System Use of neuroprotective 3-substituted indolone compositions
EP1680401A2 (en) 2003-10-24 2006-07-19 Schering Aktiengesellschaft Indolinone derivatives and their use in treating disease-states such as cancer
GT200500321A (es) 2004-11-09 2006-09-04 Compuestos y composiciones como inhibidores de proteina kinase.
ATE546451T1 (de) * 2005-05-25 2012-03-15 Lilly Co Eli Cyclopropancarbonsäureester von acyclovir
CN101282965A (zh) 2005-09-22 2008-10-08 斯克利普斯研究院 基于烷氧基吲哚酮的蛋白激酶抑制剂
CN1850794A (zh) * 2006-05-30 2006-10-25 中国医学科学院医药生物技术研究所 3-酰胺基取代苯甲酰脲类化合物及其抗肿瘤作用
WO2008073480A1 (en) 2006-12-11 2008-06-19 Irm Llc Compounds and compositions as kinase inhibitors
CA2671470C (en) * 2006-12-13 2012-05-01 F. Hoffmann-La Roche Ag Powder formulation for valganciclovir
EP2167465A1 (en) 2007-06-12 2010-03-31 Boehringer Ingelheim International GmbH Indolinone derivatives and their use in treating disease-states such as cancer
US7846793B2 (en) 2007-10-03 2010-12-07 Applied Materials, Inc. Plasma surface treatment for SI and metal nanocrystal nucleation
AU2009221761A1 (en) * 2008-03-07 2009-09-11 Ray W. Exley Treatment of herpes virus related diseases
US8946243B2 (en) * 2008-03-28 2015-02-03 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Compounds and methods for the treatment of viral infection
UY31929A (es) * 2008-06-25 2010-01-05 Irm Llc Compuestos y composiciones como inhibidores de cinasa
RU2011103189A (ru) * 2008-06-30 2012-08-10 Силин Фармасьютикалз, Инк. (Us) Производные оксиндола
US20100298376A1 (en) 2009-05-13 2010-11-25 Board Of Regents, The University Of Texas System Use of novel neuroprotective 3-substituted indolone compositions
GB201014374D0 (en) 2010-08-27 2010-10-13 Univ Greenwich Novel hybrid compounds
EA201390532A1 (ru) * 2010-10-08 2013-09-30 Новартис Аг Композиции сульфамидых ингибиторов ns3, содержащие витамин е

Also Published As

Publication number Publication date
AU2013249714B2 (en) 2016-12-15
RU2014145481A (ru) 2016-06-10
AU2013249708B2 (en) 2017-03-16
TWI458709B (zh) 2014-11-01
TW201350485A (zh) 2013-12-16
IL235098A0 (en) 2014-12-31
ES2621257T3 (es) 2017-07-03
EP2838538A1 (en) 2015-02-25
AU2013249714A1 (en) 2014-11-13
US20130281451A1 (en) 2013-10-24
CN104302287A (zh) 2015-01-21
KR20150005630A (ko) 2015-01-14
TWI496784B (zh) 2015-08-21
RU2014145480A (ru) 2016-06-10
JP6174119B2 (ja) 2017-08-02
KR20150005600A (ko) 2015-01-14
WO2013158373A8 (en) 2014-10-30
CN104302287B (zh) 2017-12-26
EP2838538B1 (en) 2017-03-15
CN104394868A (zh) 2015-03-04
KR101778095B1 (ko) 2017-09-13
ES2600467T3 (es) 2017-02-09
US20130281517A1 (en) 2013-10-24
EP2838531A1 (en) 2015-02-25
JP2015514762A (ja) 2015-05-21
EP2838538A4 (en) 2015-09-02
US8946282B2 (en) 2015-02-03
WO2013158373A1 (en) 2013-10-24
IN2014MN02107A (ko) 2015-09-11
IL235097A (en) 2017-07-31
JP2015514761A (ja) 2015-05-21
EP2838531B1 (en) 2016-09-21
US8969361B2 (en) 2015-03-03
JP6177879B2 (ja) 2017-08-09
EP2838531A4 (en) 2015-12-16
RU2642463C2 (ru) 2018-01-25
KR101774861B1 (ko) 2017-09-05
TW201343627A (zh) 2013-11-01
WO2013158367A1 (en) 2013-10-24
RU2627706C2 (ru) 2017-08-10
AU2013249708A1 (en) 2014-11-13
BR112014026182A2 (pt) 2017-06-27

Similar Documents

Publication Publication Date Title
IN2014MN02105A (ko)
UA117103C2 (uk) Сполука, яка має активність агоніста глюкагону
PH12018502251A1 (en) Formulations of an lsd1 inhibitor
PH12017501500A1 (en) Methods for treating non- small cell lung cancer using tor kinase inhibitor combination therapy
PH12016500538A1 (en) Inhibitors of kras g12c
MX2018000777A (es) Compuestos de quinazolina sustituido y su uso como inhibidores de proteinas kras, hras y/o nras mutantes g12c.
PH12015501965A1 (en) Quinazoline inhibitors of activating mutant forms of epidermal growth factor receptor
MX2020002150A (es) Terapia de combinación para el tratamiento del cáncer.
TW201613593A (en) Molecules for administration to ROS1 mutant cancer cells
NZ627277A (en) Imidazopyrrolidinone compounds
AU2013270326B2 (en) Pyrrolo[2,1-f][1,2,4]triazine compound, and preparation method and application thereof
JO3754B1 (ar) أشكال كريستالين لمثبط أنزيم كيناز تيروسين بروتون
CA2922684A1 (en) Combination of an alk inhibitor and a cdk inhibitor for the treatment of cell proliferative diseases
CY1124316T1 (el) Κρυσταλλικο τοσυλικο αλας ενος ρι3κ δελτα εκλεκτικου αναστολεα για χρηση σε φαρμακευτικα σκευασματα
CR20160131A (es) Formulaciones de (s)-3-(4- ((4- (morfolinometil)benzil) oxi) -1-oxoisoindolin)-2-il) piperidin -2,6-diona
MD4643B1 (ro) Noi compuşi de indolizină, procedeu de obţinere a lor şi compoziţii farmaceutice care le conţin
BR112015023705A2 (pt) composto da fórmula (ia) ou um sal, hidrato, solvato ou forma cristalina farmaceuticamente aceitável do mesmo, composição farmacêutica, uso de um composto, composto e método para síntese do composto da fórmula (ia)
EP3763815A4 (en) THERAPEUTIC AGENT FOR GLYCOGEN STORAGE DISEASE TYPE IA
MX371119B (es) Productos de combinacion con los inhibidores de cinasa de tirosina y su uso.
WO2012061683A3 (en) Methods for treating cancer
MX2016003522A (es) Derivados de quinazolinas y su uso como inhibidores de la adn metiltransferasa.
MX2016016388A (es) Uso de compuestos de tienotriazolodiazepina para el tratamiento de cancer de pulmon de celula no pequeña y/o cancer de pulmon de celula pequeña.
BR112018011196A2 (pt) uso de pirimido-pirimidazinonas para tratar o câncer
WO2014165829A3 (en) Nanoparticle formulations
WO2014015137A3 (en) Compositions and methods for treating dysproliferative diseases