IN2014MN01981A - - Google Patents

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Publication number
IN2014MN01981A
IN2014MN01981A IN1981MUN2014A IN2014MN01981A IN 2014MN01981 A IN2014MN01981 A IN 2014MN01981A IN 1981MUN2014 A IN1981MUN2014 A IN 1981MUN2014A IN 2014MN01981 A IN2014MN01981 A IN 2014MN01981A
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IN
India
Prior art keywords
vein
allogeneic
methods
recellurization
recellularized
Prior art date
Application number
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English (en)
Inventor
Holgersson Suchitra Sumitran
Michael Olausson
Original Assignee
Novahep Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novahep Ab filed Critical Novahep Ab
Publication of IN2014MN01981A publication Critical patent/IN2014MN01981A/en

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/507Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials for artificial blood vessels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14Blood; Artificial blood
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/34Muscles; Smooth muscle cells; Heart; Cardiac stem cells; Myoblasts; Myocytes; Cardiomyocytes
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    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/44Vessels; Vascular smooth muscle cells; Endothelial cells; Endothelial progenitor cells
    • AHUMAN NECESSITIES
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    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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    • A61K35/545Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
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    • A61L27/14Macromolecular materials
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    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
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    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
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    • A61L27/38Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3886Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells comprising two or more cell types
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    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0641Erythrocytes
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    • C12N5/069Vascular Endothelial cells
    • C12N5/0691Vascular smooth muscle cells; 3D culture thereof, e.g. models of blood vessels
    • CCHEMISTRY; METALLURGY
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    • A61F2240/00Manufacturing or designing of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2240/001Designing or manufacturing processes
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    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
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    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
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    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
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    • A61L2430/00Materials or treatment for tissue regeneration
    • A61L2430/34Materials or treatment for tissue regeneration for soft tissue reconstruction
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    • C12N2533/90Substrates of biological origin, e.g. extracellular matrix, decellularised tissue

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Biotechnology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Vascular Medicine (AREA)
  • Botany (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Reproductive Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Gynecology & Obstetrics (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
IN1981MUN2014 2012-03-16 2013-03-01 IN2014MN01981A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261611810P 2012-03-16 2012-03-16
PCT/IB2013/000873 WO2013136184A2 (fr) 2012-03-16 2013-03-01 Vaisseau sanguin allogénéique formé par génie biologique

Publications (1)

Publication Number Publication Date
IN2014MN01981A true IN2014MN01981A (fr) 2015-07-10

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Family Applications (1)

Application Number Title Priority Date Filing Date
IN1981MUN2014 IN2014MN01981A (fr) 2012-03-16 2013-03-01

Country Status (13)

Country Link
US (5) US9090879B2 (fr)
EP (1) EP2782995B1 (fr)
JP (2) JP6165787B2 (fr)
CN (1) CN104411816B (fr)
AU (3) AU2013234037A1 (fr)
CA (1) CA2867441C (fr)
DK (1) DK2782995T3 (fr)
ES (1) ES2615102T3 (fr)
HK (1) HK1202582A1 (fr)
IN (1) IN2014MN01981A (fr)
PL (1) PL2782995T3 (fr)
PT (1) PT2782995T (fr)
WO (1) WO2013136184A2 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2782995B1 (fr) 2012-03-16 2016-11-09 Novahep AB Vaisseau sanguin allogénéique formé par génie biologique
JP2016524954A (ja) * 2014-05-27 2016-08-22 ノーバヘップ アーベー 生物工学で作製された同種異系弁
US10293082B2 (en) * 2014-07-23 2019-05-21 Clemson University Research Foundation Decellularization method and system and decellularized tissue formed thereby
US20160338834A1 (en) * 2015-05-21 2016-11-24 Cook Medical Technologies Llc Medical siphon
NZ776411A (en) 2015-10-09 2023-09-29 Deka Products Lp Fluid pumping and bioreactor system
US11299705B2 (en) 2016-11-07 2022-04-12 Deka Products Limited Partnership System and method for creating tissue
WO2018127554A1 (fr) 2017-01-06 2018-07-12 Novahep Ab Procédés de préparation d'un organe ou d'un tissu modifié par bio-ingénierie ou bio-imprimé, et leurs utilisations
FR3063736B1 (fr) * 2017-03-09 2021-06-25 Univ Bordeaux Microfibre cellulaire creuse et procede de fabrication d'une telle microfibre cellulaire creuse
JPWO2018221402A1 (ja) * 2017-05-30 2020-04-30 株式会社Adeka 移植用脱細胞化材料の製造方法及び当該材料を含む生体適合性材料からなる移植片組成物
CA3066959A1 (fr) * 2017-06-16 2018-12-20 Imba - Institut Fur Molekulare Biotechnologie Gmbh Organoide de vaisseau sanguin, procedes de production et d'utilisation desdits organoides
CN108144121B (zh) * 2018-01-23 2021-05-14 首都医科大学宣武医院 一种生物源性小口径组织工程血管的制备方法
ES2953744T3 (es) 2018-08-03 2023-11-15 VeriGraft AB Métodos de preparación de vasos sanguíneos personalizados
JP7352906B2 (ja) 2019-09-20 2023-10-02 三菱ケミカル株式会社 リン酸エステル系難燃剤、(メタ)アクリル系樹脂組成物及び樹脂成形体
CN115154669B (zh) * 2022-08-12 2023-07-25 中国医科大学附属口腔医院 仿生型脱落乳牙干细胞细胞外基质复合神经支架的制备和应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6376244B1 (en) 1999-12-29 2002-04-23 Children's Medical Center Corporation Methods and compositions for organ decellularization
AU2002356180A1 (en) * 2001-08-06 2003-03-10 The Regents Of The University Of California Methods for inhibiting angiogenesis
WO2006099372A2 (fr) 2005-03-11 2006-09-21 Wake Forest University Health Sciences Vaisseaux sanguins realises par genie tissulaire
PL1928519T3 (pl) * 2005-08-26 2012-08-31 Univ Minnesota Decelularyzacja i recelularyzacja narządów i tkanek
US20070208420A1 (en) 2006-02-08 2007-09-06 Northwestern University Functionalizing implantable devices with a poly (diol co-citrate) polymer
US20080306610A1 (en) * 2007-06-07 2008-12-11 Zimmer Orthobiologics, Inc. Tissue processing for nonimmunogenic implants
CN101474426B (zh) * 2009-01-14 2012-09-05 首都医科大学宣武医院 一种脱除血管组织内细胞的血管基质及其制备方法
EP3545980A1 (fr) * 2010-02-26 2019-10-02 DeCell Technologies Inc. Procédés de décellularisation de tissu
EP2782995B1 (fr) 2012-03-16 2016-11-09 Novahep AB Vaisseau sanguin allogénéique formé par génie biologique
JP2016524954A (ja) 2014-05-27 2016-08-22 ノーバヘップ アーベー 生物工学で作製された同種異系弁

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US20140377864A1 (en) 2014-12-25
AU2018204796B2 (en) 2020-06-04
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US10517996B2 (en) 2019-12-31
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JP2016144470A (ja) 2016-08-12
US9090879B2 (en) 2015-07-28
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PT2782995T (pt) 2017-02-14
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AU2013234037A1 (en) 2014-10-02
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US9662421B2 (en) 2017-05-30
CA2867441C (fr) 2019-01-15
HK1202582A1 (zh) 2015-10-02
WO2013136184A2 (fr) 2013-09-19
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EP2782995A2 (fr) 2014-10-01
CN104411816A (zh) 2015-03-11
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US20170049935A1 (en) 2017-02-23

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