IN2014MN01521A - - Google Patents
Info
- Publication number
- IN2014MN01521A IN2014MN01521A IN1521MUN2014A IN2014MN01521A IN 2014MN01521 A IN2014MN01521 A IN 2014MN01521A IN 1521MUN2014 A IN1521MUN2014 A IN 1521MUN2014A IN 2014MN01521 A IN2014MN01521 A IN 2014MN01521A
- Authority
- IN
- India
- Prior art keywords
- formula
- compound
- preparation
- disclosed
- eribulin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/20—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
- C07H7/02—Acyclic radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
- C07H9/02—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing only oxygen as ring hetero atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161581164P | 2011-12-29 | 2011-12-29 | |
| PCT/CA2012/050939 WO2013097042A1 (en) | 2011-12-29 | 2012-12-24 | 2-((2s,3s,4r,5r)-5-((s)-3-amino-2-hydroxyprop-1-yl)-4-methoxy-3-(phenylsulfonylmethyl)tetrahydrofuran-2-yl)acetaldehyde derivatives and process for their preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2014MN01521A true IN2014MN01521A (da) | 2015-05-01 |
Family
ID=48696142
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN1521MUN2014 IN2014MN01521A (da) | 2011-12-29 | 2012-12-24 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US9062020B2 (da) |
| EP (1) | EP2797945B1 (da) |
| JP (1) | JP6300030B2 (da) |
| CN (1) | CN104080793B (da) |
| AU (1) | AU2012363334B2 (da) |
| CA (1) | CA2860446C (da) |
| IN (1) | IN2014MN01521A (da) |
| SI (1) | SI2797945T1 (da) |
| WO (1) | WO2013097042A1 (da) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2857385A1 (en) | 2011-11-30 | 2013-06-06 | Alphora Research Inc. | Process for preparation of (3r)-2,4-di-leaving group-3-methylbut-1-ene |
| US9174956B2 (en) | 2011-12-16 | 2015-11-03 | Alphora Research Inc. | Process for preparation of 3-((2S,5S)-4-methylene-5-(3-oxopropyl)tetrahydrofuran-2-yl)propanol derivatives and intermediates useful thereof |
| CN104334562A (zh) | 2012-03-30 | 2015-02-04 | 阿方拉研究股份有限公司 | 用于制备软海绵素b的大环c1-酮类似物的合成方法及其中有用的中间体 |
| TW201617326A (zh) | 2014-03-06 | 2016-05-16 | Ａｌｐｈｏｒａ研發股份有限公司 | （ｓ）－１－（（２ｒ，３ｒ，４ｓ，５ｓ）－５－烯丙－３－甲氧－４－（對甲苯磺醯甲基）四氫呋喃－２－基）－３－氨基丙－２－醇之結晶衍生物 |
| JP2017520586A (ja) | 2014-06-30 | 2017-07-27 | プレジデント アンド フェローズ オブ ハーバード カレッジ | ハリコンドリン類似体の合成およびその使用 |
| US10147463B2 (en) | 2014-12-10 | 2018-12-04 | Nxp Usa, Inc. | Video processing unit and method of buffering a source video stream |
| WO2016176560A1 (en) | 2015-04-30 | 2016-11-03 | President And Fellows Of Harvard College | Chromium-mediated coupling and application to the synthesis of halichondrins |
| AR107787A1 (es) | 2016-03-02 | 2018-06-06 | Eisai Co Ltd | Conjugados de anticuerpos basados en eribulina y métodos de uso |
| JP6978758B2 (ja) | 2016-11-11 | 2021-12-08 | プレジデント アンド フェローズ オブ ハーバード カレッジ | パラジウム媒介ケトール化 |
| US9938288B1 (en) | 2017-04-05 | 2018-04-10 | President And Fellows Of Harvard College | Macrocyclic compound and uses thereof |
| EP3606928B1 (en) | 2017-04-05 | 2022-09-07 | President and Fellows of Harvard College | Macrocyclic compound and uses thereof |
| US11498892B2 (en) | 2017-07-06 | 2022-11-15 | President And Fellows Of Harvard College | Fe/Cu-mediated ketone synthesis |
| AU2018297305B2 (en) | 2017-07-06 | 2023-02-16 | Eisai R & D Management Co., Ltd. | Synthesis of halichondrins |
| CN117924310A (zh) | 2017-11-15 | 2024-04-26 | 哈佛大学的校长及成员们 | 大环化合物及其用途 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5338865A (en) | 1992-03-12 | 1994-08-16 | President And Fellows Of Harvard College | Synthesis of halichondrin B and norhalichondrin B |
| US5436238A (en) | 1992-03-12 | 1995-07-25 | President And Fellows Of Harvard College | Halichondrins and related compounds |
| DK0972762T3 (da) | 1993-07-09 | 2004-02-09 | Theramex | Hidtil ukendte strukturelle analoger af vitamin D |
| HU227912B1 (en) * | 1998-06-17 | 2012-05-29 | Eisai R & D Man Co | Halichondrin analogs and methods of their use and preparation |
| US7001982B2 (en) | 2003-03-31 | 2006-02-21 | Council Of Scientific And Industrial Research | Non-natural C-linked carbo-β-peptides with robust secondary structures |
| CN104876896A (zh) | 2004-06-03 | 2015-09-02 | 卫材R&D管理有限公司 | 用于制备软海绵素b的类似物的中间体 |
| CN1993342A (zh) * | 2004-06-03 | 2007-07-04 | 卫材株式会社 | 用于制备软海绵素b的中间体 |
| US8598373B2 (en) | 2008-04-04 | 2013-12-03 | Eisai R&D Management Co., Ltd. | Halichondrin B analogs |
| CA2857385A1 (en) | 2011-11-30 | 2013-06-06 | Alphora Research Inc. | Process for preparation of (3r)-2,4-di-leaving group-3-methylbut-1-ene |
| US9174956B2 (en) | 2011-12-16 | 2015-11-03 | Alphora Research Inc. | Process for preparation of 3-((2S,5S)-4-methylene-5-(3-oxopropyl)tetrahydrofuran-2-yl)propanol derivatives and intermediates useful thereof |
| CN104334562A (zh) | 2012-03-30 | 2015-02-04 | 阿方拉研究股份有限公司 | 用于制备软海绵素b的大环c1-酮类似物的合成方法及其中有用的中间体 |
| US9650397B2 (en) | 2013-05-15 | 2017-05-16 | Alphora Research Inc. | 3-((2S,5S)-4-methylene-5-(3-oxopropyl)tetrahydrofuran-2-yl)propanol derivatives, their preparation and intermediates useful thereof |
-
2012
- 2012-12-24 JP JP2014549284A patent/JP6300030B2/ja not_active Expired - Fee Related
- 2012-12-24 EP EP12863099.3A patent/EP2797945B1/en not_active Not-in-force
- 2012-12-24 US US14/369,442 patent/US9062020B2/en not_active Expired - Fee Related
- 2012-12-24 SI SI201230582A patent/SI2797945T1/sl unknown
- 2012-12-24 CN CN201280064611.1A patent/CN104080793B/zh not_active Expired - Fee Related
- 2012-12-24 AU AU2012363334A patent/AU2012363334B2/en not_active Ceased
- 2012-12-24 WO PCT/CA2012/050939 patent/WO2013097042A1/en active Application Filing
- 2012-12-24 CA CA2860446A patent/CA2860446C/en active Active
- 2012-12-24 IN IN1521MUN2014 patent/IN2014MN01521A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US9062020B2 (en) | 2015-06-23 |
| WO2013097042A1 (en) | 2013-07-04 |
| EP2797945A4 (en) | 2015-06-03 |
| SI2797945T1 (sl) | 2016-07-29 |
| US20150011776A1 (en) | 2015-01-08 |
| EP2797945B1 (en) | 2016-03-16 |
| AU2012363334B2 (en) | 2017-02-02 |
| CA2860446C (en) | 2017-01-10 |
| JP6300030B2 (ja) | 2018-03-28 |
| JP2015503525A (ja) | 2015-02-02 |
| CN104080793B (zh) | 2017-09-19 |
| CA2860446A1 (en) | 2013-07-04 |
| CN104080793A (zh) | 2014-10-01 |
| AU2012363334A1 (en) | 2014-08-21 |
| EP2797945A1 (en) | 2014-11-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IN2014MN01521A (da) | ||
| IN2014MN02106A (da) | ||
| IN2014MN02496A (da) | ||
| UA110354C2 (uk) | Противірусні сполуки | |
| TN2011000400A1 (en) | Inhibitors of beta-secretase | |
| MD20180040A2 (ro) | Inhibitori ai virusului hepatic C | |
| MX2013011257A (es) | Proceso para la preparacion de dronedarona por n-butilacion. | |
| AU2012313888A8 (en) | 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant IDH | |
| IN2014MN02459A (da) | ||
| MX2016006336A (es) | Compuestos pirazolopirimidina. | |
| PH12015500008B1 (en) | Dimethyl-benzoic acid compounds | |
| IN2013MN02014A (da) | ||
| EP2681204A4 (en) | SYNTHESIS OF INTERMEDIATE PRODUCTS FOR TREPROSTINE PRODUCTION | |
| EP2590649A4 (en) | PROCESS FOR SYNTHESIS OF SUBSTITUTED MORPHINANES | |
| CR20130501A (es) | Derivados novedosos de cefalosporinas y composiciones farmacéuticas de estos | |
| IN2014CN04449A (da) | ||
| MX364400B (es) | Compuestos de tetraciclina. | |
| IN2014KN01062A (da) | ||
| IN2014DN00144A (da) | ||
| IN2014MN00850A (da) | ||
| MX2013000294A (es) | Intermedios y procedimiento de preparación de un inhibidor específico de la trombina. | |
| MY164880A (en) | Process for the preparation of isoxazolyl-methoxy-nicotinic acids | |
| SG10201901578UA (en) | Processes for the preparation of pyrimidinylcyclopentane compounds | |
| MX2013004193A (es) | Procedimiento para la preparacion de derivados de acido 3-(6-amino-piridin-3-il)-2-acrilico. | |
| MX2013006670A (es) | Derivado de 2-carboxamida-4-piperazinil-benzofurano. |