IN2014DN09922A - - Google Patents
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- Publication number
- IN2014DN09922A IN2014DN09922A IN9922DEN2014A IN2014DN09922A IN 2014DN09922 A IN2014DN09922 A IN 2014DN09922A IN 9922DEN2014 A IN9922DEN2014 A IN 9922DEN2014A IN 2014DN09922 A IN2014DN09922 A IN 2014DN09922A
- Authority
- IN
- India
- Prior art keywords
- bcn
- amino acid
- relates
- group
- ylmethanol
- Prior art date
Links
- 0 CC(c1ccc(CNC(*2C=CC(C(OC3(c(ccc(OC(C)=O)c4)c4Oc4c5)c4ccc5OC(C)=O)=O)=C3C=C2)=O)cc1)=NN=CN=C* Chemical compound CC(c1ccc(CNC(*2C=CC(C(OC3(c(ccc(OC(C)=O)c4)c4Oc4c5)c4ccc5OC(C)=O)=O)=C3C=C2)=O)cc1)=NN=CN=C* 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/006—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length of peptides containing derivatised side chain amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/13—Labelling of peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2/00—Peptides of undefined number of amino acids; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/93—Ligases (6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y601/00—Ligases forming carbon-oxygen bonds (6.1)
- C12Y601/01—Ligases forming aminoacyl-tRNA and related compounds (6.1.1)
- C12Y601/01026—Pyrrolysine-tRNAPyl ligase (6.1.1.26)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/24—All rings being cycloaliphatic the ring system containing nine carbon atoms, e.g. perhydroindane
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1208875.3A GB201208875D0 (en) | 2012-05-18 | 2012-05-18 | Methods |
| GBGB1210303.2A GB201210303D0 (en) | 2012-06-08 | 2012-06-08 | Polypeptides and methods |
| PCT/GB2013/051249 WO2013171485A1 (fr) | 2012-05-18 | 2013-05-15 | Procédés d'incorporation d'un acide aminé comprenant un groupe bcn dans un polypeptide à l'aide d'un codon orthogonal codant pour ledit acide et d'une pylrs synthase orthogonale |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2014DN09922A true IN2014DN09922A (fr) | 2015-08-14 |
Family
ID=48748281
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN9922DEN2014 IN2014DN09922A (fr) | 2012-05-18 | 2013-05-15 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US20150148525A1 (fr) |
| EP (1) | EP2852664B1 (fr) |
| JP (1) | JP6343604B2 (fr) |
| CN (2) | CN108410827B (fr) |
| BR (1) | BR112014028588B1 (fr) |
| CA (1) | CA2873793C (fr) |
| HK (1) | HK1208704A1 (fr) |
| IN (1) | IN2014DN09922A (fr) |
| WO (1) | WO2013171485A1 (fr) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20150148525A1 (en) | 2012-05-18 | 2015-05-28 | Medical Research Council | Methods of incorporating an amino acid comprising a bcn group into a polypeptide using an orthogonal codon encoding it and an orthorgonal pylrs synthase |
| CN104744293B (zh) * | 2013-12-31 | 2016-08-17 | 深圳先进技术研究院 | 胆碱类似物及其制备方法和应用、由染料分子标记的四嗪探针及其制备方法和应用 |
| GB2528227A (en) | 2014-03-14 | 2016-01-20 | Medical Res Council | Cyclopropene amino acids and methods |
| US20190077776A1 (en) * | 2015-04-30 | 2019-03-14 | Oregon State University | Reagents and methods for bioorthogonal labeling of biomolecules in living cells |
| JP6967221B2 (ja) * | 2015-08-19 | 2021-11-17 | 国立研究開発法人理化学研究所 | 非天然アミノ酸導入抗体 |
| CN105254655B (zh) * | 2015-11-20 | 2017-03-22 | 江汉大学 | 一种基于bodipy的荧光氨基酸及其合成方法与应用 |
| CN106565762B (zh) * | 2016-11-17 | 2018-10-23 | 陕西师范大学 | 一种原位产生近红外荧光的bodipy类染料及其制备和应用 |
| KR20200007776A (ko) | 2017-03-22 | 2020-01-22 | 제넨테크, 인크. | 히드로겔 가교된 히알루론산 전구약물 조성물 및 방법 |
| JOP20190245A1 (ar) | 2017-04-20 | 2019-10-15 | Novartis Ag | أنظمة توصيل إطلاق مستدام تتضمن روابط بلا أثر لنقطة الربط |
| US11560384B2 (en) | 2017-05-04 | 2023-01-24 | University Of Utah Research Foundation | Benzonorbornadiene derivatives and reactions thereof |
| AR111963A1 (es) * | 2017-05-26 | 2019-09-04 | Univ California | Método y moléculas |
| TW202027794A (zh) | 2018-10-03 | 2020-08-01 | 瑞士商諾華公司 | 血管生成素樣３多肽之持續遞送 |
| CN111849929B (zh) * | 2019-04-30 | 2021-05-11 | 苏州鲲鹏生物技术有限公司 | 高效引入赖氨酸衍生物的氨酰基—tRNA合成酶 |
| IL267744A (en) * | 2019-06-30 | 2019-08-29 | Nat Inst Biotechnology Negev Ltd | Labelling molecules and methods of use thereof |
| CN115701451B (zh) * | 2021-08-02 | 2023-08-01 | 宁波鲲鹏生物科技有限公司 | 高效引入赖氨酸衍生物的氨酰基-tRNA合成酶及其应用 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040029129A1 (en) * | 2001-10-25 | 2004-02-12 | Liangsu Wang | Identification of essential genes in microorganisms |
| CN102618605B (zh) | 2003-06-18 | 2015-09-02 | 斯克利普斯研究院 | 非天然活性氨基酸遗传密码增加 |
| DE602004011789T2 (de) * | 2003-07-07 | 2009-02-12 | The Scripps Research Institute, La Jolla | Zusammensetzungen der orthogonalen Lysyl-tRNA und Aminoacyl-tRNA Synthetase Paaren und ihre Verwendungen |
| US7741071B2 (en) | 2003-12-18 | 2010-06-22 | The Scripps Research Institute | Selective incorporation of 5-hydroxytryptophan into proteins in mammalian cells |
| WO2006034332A2 (fr) | 2004-09-21 | 2006-03-30 | The Scripps Research Institute | Incorporation in vivo d'acides amines d'alkynyle dans des proteines d'eubacteries |
| MX2007004892A (es) | 2004-10-27 | 2007-08-16 | Scripps Research Inst | Componentes de traduccion ortogonales para la incorporacion in vivo de aminoacidos no naturales. |
| JP2007037445A (ja) | 2005-08-02 | 2007-02-15 | Institute Of Physical & Chemical Research | ｔＲＮＡ合成方法、核酸、アミノアシルｔＲＮＡ合成方法及び非天然型アミノ酸組み込み蛋白質の製造方法 |
| WO2007090198A2 (fr) | 2006-02-01 | 2007-08-09 | Encode Bio, Inc. | Essais fluorescents faisant intervenir des paires orthogonales aminoacyle-arnt synthétases |
| US20080096819A1 (en) | 2006-05-02 | 2008-04-24 | Allozyne, Inc. | Amino acid substituted molecules |
| US20090110662A1 (en) | 2007-04-30 | 2009-04-30 | Intezyne Technologies, Inc. | Modification of biological targeting groups for the treatment of cancer |
| AU2008301614A1 (en) * | 2007-09-20 | 2009-03-26 | Riken | Mutant pyrrolysyl-TRNA synthetase, and method for production of protein having non-natural amino acid integrated therein by using the same |
| GB0721291D0 (en) * | 2007-10-30 | 2007-12-12 | Medical Res Council | Methods and compositions |
| PE20120616A1 (es) * | 2009-02-25 | 2012-05-26 | Bigtec Private Ltd | Sondas y cebadores para la deteccion de chikungunya |
| GB2470770A (en) | 2009-06-04 | 2010-12-08 | Medical Res Council | Incorporation of unnatural amino acids having an orthogonal functional group into polypeptides using orthogonal tRNA/tRNA synthetase pairs |
| GB0917242D0 (en) * | 2009-10-01 | 2009-11-18 | Medical Res Council | Acetyl lysine incorporation with tRNA synthetase |
| GB0917240D0 (en) * | 2009-10-01 | 2009-11-18 | Medical Res Council | Incorporation of methyl lysine into poiypeptide |
| JP5875083B2 (ja) | 2010-04-15 | 2016-03-02 | メディミューン リミテッド | 増殖性疾患治療用ピロロベンゾジアゼピン |
| EP3604264A1 (fr) * | 2010-04-27 | 2020-02-05 | SynAffix B.V. | Composés de cyclooctyne condensés |
| US20120077186A1 (en) | 2010-05-07 | 2012-03-29 | Oregon Health & Science University | Use of cysteine-derived suppressor trnas for non-native amino acid incorporation |
| WO2011156686A2 (fr) | 2010-06-11 | 2011-12-15 | The Regents Of The University Of Colorado, A Body Corporate | Méthode de synthèse d'un peptide multivalent cyclique au moyen d'une réaction médiée par thiol |
| DK2670767T3 (en) | 2011-02-03 | 2018-03-26 | European Molecular Biology Laboratory | Non-naturally occurring amino acids comprising a cyclooctynyl or transcyclooctynyl analog group and uses thereof |
| GB201110815D0 (en) * | 2011-06-24 | 2011-08-10 | Medical Res Council | Incorporation of subtituted lysines into polypeptides |
| EP2753607B1 (fr) * | 2011-09-09 | 2016-04-13 | Berry And Associates, Inc. | REACTIFS BICYCLO[6.1.0]NON-4-YNE DESTINES A DES & xA; MODIFICATIONS CHIMIQUES D'OLIGONUCLÉOTIDES |
| GB201201100D0 (en) | 2012-01-20 | 2012-03-07 | Medical Res Council | Polypeptides and methods |
| US20150148525A1 (en) | 2012-05-18 | 2015-05-28 | Medical Research Council | Methods of incorporating an amino acid comprising a bcn group into a polypeptide using an orthogonal codon encoding it and an orthorgonal pylrs synthase |
| WO2014036492A1 (fr) | 2012-08-31 | 2014-03-06 | Sutro Biopharma, Inc. | Acides aminés modifiés comprenant un groupe azido |
| CA2885796C (fr) | 2012-09-24 | 2022-05-03 | Allozyne, Inc. | Lignee cellulaire |
| GB2528227A (en) | 2014-03-14 | 2016-01-20 | Medical Res Council | Cyclopropene amino acids and methods |
| GB201419109D0 (en) | 2014-10-27 | 2014-12-10 | Medical Res Council | Incorporation of unnatural amino acids into proteins |
| US20180171321A1 (en) * | 2015-03-27 | 2018-06-21 | The University Of Queensland | Platform for a non-natural amino acid incorporation into proteins |
| GB201817444D0 (en) | 2018-10-26 | 2018-12-12 | Res & Innovation Uk | Methods and compositions |
| EP3868882A1 (fr) * | 2020-02-21 | 2021-08-25 | European Molecular Biology Laboratory | Synthétases trna pyrrolysine archéale pour utilisation orthogonale |
-
2013
- 2013-05-15 US US14/401,803 patent/US20150148525A1/en not_active Abandoned
- 2013-05-15 CA CA2873793A patent/CA2873793C/fr active Active
- 2013-05-15 EP EP13734818.1A patent/EP2852664B1/fr active Active
- 2013-05-15 BR BR112014028588-8A patent/BR112014028588B1/pt active IP Right Grant
- 2013-05-15 JP JP2015512124A patent/JP6343604B2/ja active Active
- 2013-05-15 CN CN201810228028.9A patent/CN108410827B/zh active Active
- 2013-05-15 WO PCT/GB2013/051249 patent/WO2013171485A1/fr active Application Filing
- 2013-05-15 CN CN201380037290.0A patent/CN104718285A/zh active Pending
- 2013-05-15 IN IN9922DEN2014 patent/IN2014DN09922A/en unknown
-
2015
- 2015-09-23 HK HK15109341.0A patent/HK1208704A1/xx unknown
-
2020
- 2020-05-12 US US16/872,826 patent/US11732001B2/en active Active
-
2023
- 2023-05-16 US US18/198,205 patent/US20230340013A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2013171485A1 (fr) | 2013-11-21 |
| BR112014028588B1 (pt) | 2023-03-21 |
| CN108410827A (zh) | 2018-08-17 |
| EP2852664A1 (fr) | 2015-04-01 |
| US20200271658A1 (en) | 2020-08-27 |
| US20150148525A1 (en) | 2015-05-28 |
| CN104718285A (zh) | 2015-06-17 |
| CA2873793C (fr) | 2022-02-22 |
| US11732001B2 (en) | 2023-08-22 |
| US20230340013A1 (en) | 2023-10-26 |
| CA2873793A1 (fr) | 2013-11-21 |
| BR112014028588A2 (pt) | 2017-06-27 |
| CN108410827B (zh) | 2023-05-09 |
| JP2015523965A (ja) | 2015-08-20 |
| HK1208704A1 (en) | 2016-03-11 |
| JP6343604B2 (ja) | 2018-06-13 |
| EP2852664B1 (fr) | 2017-09-06 |
| BR112014028588A8 (pt) | 2021-06-29 |
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