IN2014DN08215A - - Google Patents
Download PDFInfo
- Publication number
- IN2014DN08215A IN2014DN08215A IN8215DEN2014A IN2014DN08215A IN 2014DN08215 A IN2014DN08215 A IN 2014DN08215A IN 8215DEN2014 A IN8215DEN2014 A IN 8215DEN2014A IN 2014DN08215 A IN2014DN08215 A IN 2014DN08215A
- Authority
- IN
- India
- Prior art keywords
- osteoclasts
- pharmaceutical composition
- antibody
- inhibiting
- gene
- Prior art date
Links
- 210000002997 osteoclast Anatomy 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 101000709472 Homo sapiens Sialic acid-binding Ig-like lectin 15 Proteins 0.000 abstract 1
- 230000002159 abnormal effect Effects 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 230000004097 bone metabolism Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 102000057657 human SIGLEC15 Human genes 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000000069 prophylactic effect Effects 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 230000008685 targeting Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Rheumatology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Mycology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2012078842 | 2012-03-30 | ||
| PCT/JP2013/059654 WO2013147213A1 (ja) | 2012-03-30 | 2013-03-29 | ＣＤＲ改変抗Ｓｉｇｌｅｃ－１５抗体 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2014DN08215A true IN2014DN08215A (enrdf_load_stackoverflow) | 2015-05-15 |
Family
ID=49260454
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN8215DEN2014 IN2014DN08215A (enrdf_load_stackoverflow) | 2012-03-30 | 2013-03-29 |
Country Status (20)
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8168181B2 (en) | 2006-02-13 | 2012-05-01 | Alethia Biotherapeutics, Inc. | Methods of impairing osteoclast differentiation using antibodies that bind siglec-15 |
| PT2206727E (pt) * | 2007-10-11 | 2015-08-05 | Daiichi Sankyo Co Ltd | Anticorpo direccionado para proteína siglec-15 relacionada com osteoclastos |
| EA201590247A1 (ru) | 2012-07-19 | 2015-10-30 | Алетиа Байотерапьютикс Инк. | Антитела к siglec-15 |
| JP2017523148A (ja) * | 2014-06-18 | 2017-08-17 | 第一三共株式会社 | 骨形成不全症の治療に使用するための抗Ｓｉｇｌｅｃ−１５抗体 |
| CA3052553A1 (en) * | 2017-02-03 | 2018-08-09 | Sumitomo Chemical Company, Limited | Pancreatic cancer detection method |
| CN110913905A (zh) | 2017-06-30 | 2020-03-24 | 国立大学法人北海道大学 | 不产生生长障碍的小儿骨质疏松症治疗药 |
| CN113817057B (zh) * | 2020-06-19 | 2024-02-20 | 盛禾(中国)生物制药有限公司 | 一种抗siglec15抗体及其应用 |
| BR112023016904A2 (pt) * | 2021-02-23 | 2023-11-07 | Jiangxi Jemincare Group Co Ltd | Preparação da proteína de ligação à siglec-15 e uso da mesma |
| CN114957468A (zh) * | 2021-02-25 | 2022-08-30 | 石药集团巨石生物制药有限公司 | 一种抗Siglec15抗体及其用途 |
| CN113577283A (zh) * | 2021-07-19 | 2021-11-02 | 河北医科大学第三医院 | Siglec-15抑制剂在制备防治骨巨细胞瘤药物中的应用 |
| WO2023030311A1 (zh) * | 2021-08-31 | 2023-03-09 | 上海医药集团股份有限公司 | 靶向Siglec15的抗原结合蛋白及其用途 |
| WO2023241538A1 (en) * | 2022-06-13 | 2023-12-21 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Anti-siglec15 antibodies and uses thereof |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5260203A (en) | 1986-09-02 | 1993-11-09 | Enzon, Inc. | Single polypeptide chain binding molecules |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US5091513A (en) | 1987-05-21 | 1992-02-25 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
| IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
| IL117175A (en) | 1995-02-20 | 2005-11-20 | Sankyo Co | Osteoclastogenesis inhibitory factor protein |
| DE19653646A1 (de) | 1996-12-20 | 1998-06-25 | Hoechst Ag | Substituierte Purinderivate, Verfahren zu deren Herstellung, sie enthaltende Mittel und deren Verwendung |
| EP0911342B2 (en) | 1997-04-15 | 2013-05-22 | Daiichi Sankyo Company, Limited | Novel protein and process for producing the same |
| WO1999054342A1 (en) | 1998-04-20 | 1999-10-28 | Pablo Umana | Glycosylation engineering of antibodies for improving antibody-dependent cellular cytotoxicity |
| EP3031917A1 (en) | 1999-04-09 | 2016-06-15 | Kyowa Hakko Kirin Co., Ltd. | Method for controlling the activity of immunologically functional molecule |
| EA013563B1 (ru) | 2000-10-06 | 2010-06-30 | Киова Хакко Кирин Ко., Лтд. | Трансгенное животное, продуцирующее антитела с измененными углеводными цепями, способ получения антител и содержащее антитела лекарственное средство |
| US7608704B2 (en) | 2000-11-08 | 2009-10-27 | Incyte Corporation | Secreted proteins |
| CA2428140A1 (en) | 2000-11-08 | 2002-05-16 | Incyte Genomics, Inc. | Secreted proteins |
| CA2439129A1 (en) | 2001-02-15 | 2002-08-22 | Mochida Pharmaceutical Co., Ltd. | Novel cellular adhesion molecule of activated leukocyte |
| DE60235989D1 (de) | 2001-06-26 | 2010-05-27 | Amgen Fremont Inc | Antikörper gegen opgl |
| WO2003048305A2 (en) | 2001-11-13 | 2003-06-12 | Incyte Genomics, Inc. | Receptors and membrane-associated proteins |
| US7193069B2 (en) | 2002-03-22 | 2007-03-20 | Research Association For Biotechnology | Full-length cDNA |
| JP4761710B2 (ja) | 2002-04-05 | 2011-08-31 | アムジェン インコーポレイテッド | 選択的ｏｐｇｌ経路インヒビターとしてのヒト抗ｏｐｇｌ中和抗体 |
| EP1583830B1 (en) | 2003-01-07 | 2006-09-06 | Symphogen A/S | Method for manufacturing recombinant polyclonal proteins |
| TWI359026B (en) | 2004-02-12 | 2012-03-01 | Sankyo Co | Pharmaceutical composition for the osteoclast rela |
| US7405037B2 (en) | 2004-05-07 | 2008-07-29 | Lonza Walkersville, Inc. | Methods and tools for detecting collagen degradation |
| JP4604184B2 (ja) | 2005-07-12 | 2010-12-22 | 独立行政法人産業技術総合研究所 | 新規糖鎖認識蛋白質及びその遺伝子 |
| ES2397441T5 (es) | 2006-02-13 | 2022-09-14 | Daiichi Sankyo Co Ltd | Secuencias polinucleotídicas y polipeptídicas implicadas en el proceso de remodelación ósea |
| US8168181B2 (en) * | 2006-02-13 | 2012-05-01 | Alethia Biotherapeutics, Inc. | Methods of impairing osteoclast differentiation using antibodies that bind siglec-15 |
| PT2206727E (pt) * | 2007-10-11 | 2015-08-05 | Daiichi Sankyo Co Ltd | Anticorpo direccionado para proteína siglec-15 relacionada com osteoclastos |
| MY152033A (en) | 2009-04-09 | 2014-08-15 | Daiichi Sankyo Co Ltd | Anti-siglec-15 antibody |
| EP2625205A2 (en) | 2010-10-05 | 2013-08-14 | Daiichi Sankyo Company, Limited | Antibody targeting osteoclast-related protein siglec-15 |
-
2013
- 2013-03-29 US US14/388,347 patent/US9464133B2/en not_active Expired - Fee Related
- 2013-03-29 BR BR112014024269A patent/BR112014024269A8/pt not_active IP Right Cessation
- 2013-03-29 EP EP13768508.7A patent/EP2832857B1/en not_active Not-in-force
- 2013-03-29 JP JP2014508117A patent/JP6059205B2/ja not_active Expired - Fee Related
- 2013-03-29 CA CA2868959A patent/CA2868959A1/en not_active Abandoned
- 2013-03-29 TW TW102111480A patent/TW201343672A/zh unknown
- 2013-03-29 RU RU2014143798A patent/RU2014143798A/ru not_active Application Discontinuation
- 2013-03-29 MX MX2014011828A patent/MX2014011828A/es unknown
- 2013-03-29 ES ES13768508.7T patent/ES2660472T3/es active Active
- 2013-03-29 HK HK15105295.4A patent/HK1204657A1/en unknown
- 2013-03-29 AU AU2013241003A patent/AU2013241003A1/en not_active Abandoned
- 2013-03-29 SG SG11201405966PA patent/SG11201405966PA/en unknown
- 2013-03-29 IN IN8215DEN2014 patent/IN2014DN08215A/en unknown
- 2013-03-29 CN CN201380028931.6A patent/CN104334722A/zh active Pending
- 2013-03-29 NZ NZ631509A patent/NZ631509A/en not_active IP Right Cessation
- 2013-03-29 WO PCT/JP2013/059654 patent/WO2013147213A1/ja active Application Filing
- 2013-03-29 KR KR20147026899A patent/KR20150003170A/ko not_active Withdrawn
-
2014
- 2014-09-29 ZA ZA2014/07079A patent/ZA201407079B/en unknown
- 2014-09-29 IL IL234883A patent/IL234883A0/en unknown
- 2014-09-29 PH PH12014502187A patent/PH12014502187A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MX2014011828A (es) | 2014-12-10 |
| EP2832857A1 (en) | 2015-02-04 |
| EP2832857B1 (en) | 2018-01-03 |
| SG11201405966PA (en) | 2014-11-27 |
| CA2868959A1 (en) | 2013-10-03 |
| PH12014502187A1 (en) | 2014-12-10 |
| JPWO2013147213A1 (ja) | 2015-12-14 |
| EP2832857A4 (en) | 2016-02-17 |
| AU2013241003A1 (en) | 2014-10-16 |
| CN104334722A (zh) | 2015-02-04 |
| US20150056189A1 (en) | 2015-02-26 |
| IL234883A0 (en) | 2014-12-31 |
| WO2013147213A1 (ja) | 2013-10-03 |
| RU2014143798A (ru) | 2016-05-27 |
| ZA201407079B (en) | 2016-02-24 |
| KR20150003170A (ko) | 2015-01-08 |
| HK1204657A1 (en) | 2015-11-27 |
| US9464133B2 (en) | 2016-10-11 |
| BR112014024269A8 (pt) | 2017-07-25 |
| JP6059205B2 (ja) | 2017-01-11 |
| TW201343672A (zh) | 2013-11-01 |
| ES2660472T3 (es) | 2018-03-22 |
| NZ631509A (en) | 2016-09-30 |
| BR112014024269A2 (enrdf_load_stackoverflow) | 2017-06-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IN2014DN08215A (enrdf_load_stackoverflow) | ||
| TN2013000310A1 (en) | Effervescent composition in solid form for use in vaginal applications for the treatment of vaginal infections | |
| TN2012000465A1 (en) | Derivatives of 1-amino-2-cyclopropylethylboronic acid | |
| AP3847A (en) | Substituted benzylindazoles for use as bub1 kinase inhibitors in the treatment of hyperproliferative diseases | |
| MX356525B (es) | Vectores de virus asociados con adeno (aav) para uso en terapia de genes de coroideremia. | |
| MX2013008192A (es) | Inhibidores de bace-2 para tratamiento de transtornos metabolicos. | |
| MX2015007921A (es) | Compuestos heterociclicos novedosos como inhibidores de bromodominio. | |
| MY164356A (en) | Substituted 5-fluoro-1h-pyrazolopyridines and their use | |
| PH12017501688A1 (en) | Intranasal benzodiazepine pharmaceutical compositions | |
| MX366130B (es) | Inhibidores bivalentes de las proteinas iap y métodos terapéuticos que usan los mismos. | |
| MY181828A (en) | Bicyclically substituted uracils and the use therapy | |
| MX337549B (es) | Derivados de insulina que contienen enlaces disulfuro adicionales. | |
| MY163257A (en) | Humanised anti-cd52 antibodies | |
| IN2014DN08385A (enrdf_load_stackoverflow) | ||
| UA107204C2 (uk) | Протигрибкова композиція, що містить грибковий організм pythium oligandrum | |
| MX2015008877A (es) | Conjugados de disulfuro mixto de compuestos de tienopiridina y sus usos. | |
| IN2014DN03010A (enrdf_load_stackoverflow) | ||
| IN2014DN00123A (enrdf_load_stackoverflow) | ||
| MX369774B (es) | Uso de pregn-4-en-20-in-3-ona para el tratamiento de trastornos depresivos. | |
| UA115307C2 (uk) | Застосування лікарського засобу, що містить рекомбінантний лектин омели для лікування раку шкіри | |
| NZ606186A (en) | Use of lactoferrin to treat proteinuria | |
| CA2860159C (en) | Peptides targeting receptor activator of nuclear factor-kappa b (rank) and their applications | |
| TR201200212A2 (tr) | Risedronat içeren geliştirilmiş formülasyonlar. | |
| UA66925U (en) | orthopedic spinal support | |
| LV14461A (lv) | Līdzeklis efektīvai augsta glutamāta līmeņa pazemināšanai asinīs |