IN2014DN07984A - - Google Patents

Info

Publication number
IN2014DN07984A
IN2014DN07984A IN7984DEN2014A IN2014DN07984A IN 2014DN07984 A IN2014DN07984 A IN 2014DN07984A IN 7984DEN2014 A IN7984DEN2014 A IN 7984DEN2014A IN 2014DN07984 A IN2014DN07984 A IN 2014DN07984A
Authority
IN
India
Prior art keywords
chloroacetone
dimethylbenzene
bromo
preparation
discloses
Prior art date
Application number
Other languages
English (en)
Inventor
Doerwald Florencio Zaragoza
Anna Kulesza
Stephan Elzner
Robert Bujok
Zbigniew Wrobel
Krzysztof Wojciechowski
Original Assignee
Lonza Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47557694&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IN2014DN07984(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from PCT/EP2012/070875 external-priority patent/WO2012172121A1/en
Application filed by Lonza Ag filed Critical Lonza Ag
Publication of IN2014DN07984A publication Critical patent/IN2014DN07984A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/58—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
IN7984DEN2014 2012-06-28 2012-11-15 IN2014DN07984A (es)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201261665510P 2012-06-28 2012-06-28
EP12174102 2012-06-28
EP12188104 2012-10-11
PCT/EP2012/070875 WO2012172121A1 (en) 2012-06-28 2012-10-22 Method for the preparation of medetomidine with chloroacetone
EP12192625 2012-11-14
PCT/EP2012/072798 WO2013011157A1 (en) 2012-06-28 2012-11-15 Method for preparation of medetomidine with chloroacetone

Publications (1)

Publication Number Publication Date
IN2014DN07984A true IN2014DN07984A (es) 2015-05-01

Family

ID=47557694

Family Applications (1)

Application Number Title Priority Date Filing Date
IN7984DEN2014 IN2014DN07984A (es) 2012-06-28 2012-11-15

Country Status (21)

Country Link
US (2) US9156793B2 (es)
EP (1) EP2867211B1 (es)
JP (1) JP5777841B2 (es)
KR (1) KR101560116B1 (es)
CN (2) CN105218453B (es)
AU (1) AU2012285677B2 (es)
CA (1) CA2866437C (es)
CL (2) CL2014002907A1 (es)
CY (1) CY1117492T1 (es)
DK (1) DK2867211T3 (es)
EA (1) EA027921B1 (es)
ES (1) ES2565066T3 (es)
HK (2) HK1201530A1 (es)
HR (1) HRP20160216T1 (es)
HU (1) HUE027382T2 (es)
IN (1) IN2014DN07984A (es)
MY (1) MY165218A (es)
PL (1) PL2867211T3 (es)
SG (1) SG11201405609WA (es)
TW (2) TWI560182B (es)
WO (1) WO2013011157A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN2014DN07982A (es) 2012-05-08 2015-05-01 Lonza Ag
ES2563816T3 (es) * 2012-05-08 2016-03-16 Lonza Ltd Método de preparación de medetomidina
JP5777841B2 (ja) * 2012-06-28 2015-09-09 ロンザ・リミテッド クロロアセトンを用いてメデトミジンを調製するための方法
DK2867195T3 (en) 2012-06-28 2016-04-04 Lonza Ag PROCESS FOR THE PREPARATION OF 2- (2,3-dimethylphenyl) -1-propanal WITH chloroacetone
CN108541366B (zh) * 2016-02-12 2022-03-01 索尼公司 用于执行发送和接收处理的装置和方法
CN106518812A (zh) * 2016-10-25 2017-03-22 湖南大学 一种美托咪定及其中间体的制备方法
CN113044857B (zh) * 2020-12-30 2023-05-23 重庆柒兴克米科技有限公司 高收率制取高纯氰化钠或氰化钾的生产工艺
CN114671811A (zh) * 2022-04-14 2022-06-28 南京正科医药股份有限公司 一种右美托咪定拆分副产物的外消旋化回收方法

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE23400E (en) 1951-08-14 Electkic low and high-voltage fuses
BE790604A (fr) 1971-10-28 1973-04-26 Sandoz Sa Nouveaux aminoalcanols, leur preparation et leur application comme medicaments
JPS51100042A (en) 1975-02-26 1976-09-03 Kanebo Ltd 22 * 44 isobuchirufueniru * puropionsanno seizoho
JPS51100041A (en) 1975-02-26 1976-09-03 Kanebo Ltd 22 * 44 isobuchirufueniru * puropionsanno seizoho
GB2092569B (en) 1981-02-05 1984-09-19 Farmos Oy Substituted imidazole derivatives and their preparation and use
GB2101114B (en) 1981-07-10 1985-05-22 Farmos Group Ltd Substituted imidazole derivatives and their preparation and use
EP0153692B1 (en) 1984-02-24 1992-07-29 Sagami Chemical Research Center Method for isomerization a glycidate derivative
JPS62103037A (ja) * 1985-10-29 1987-05-13 Hamari Yakuhin Kogyo Kk ２−（４−イソブチルフエニル）−プロピオンアルデヒドの製造法
DE19714042A1 (de) 1997-04-05 1998-10-08 Henkel Kgaa Verfahren zur Herstellung aromatischer Aldehyde
SE513474C2 (sv) 1999-01-25 2000-09-18 Hans Elwing Instutionen Foer C Metod för att förhindra kräftdjurs, särskilt havstulpaners, etablering på fasta ytor med hjälp av en substans som stör nervsignaler, varvid substansen är medetomidin, dvs (+)-4-/1- (2,3-dimetylfenyl)-etyl/-IH-imidazol
EP1918282A1 (en) 2006-11-06 2008-05-07 "Joint Stock Company Grindeks" Method for preparing medetomidine and its salts
GB2453982B (en) * 2007-10-24 2009-09-16 Norbrook Lab Ltd Chemical process for the preparation of Medetomidine
US7902247B2 (en) 2008-01-09 2011-03-08 Allergan, Inc. Substituted-aryl-2-phenylethyl-1H-imidazole compounds as subtype selective modulators of alpha 2B and/or alpha 2C adrenergic receptors
CN101921234B (zh) * 2009-06-12 2012-05-30 中国中化股份有限公司 一种制备美托咪啶的方法
WO2011070069A1 (en) 2009-12-09 2011-06-16 I-Tech Ab Process for preparation of medetomidine
WO2012172120A2 (en) * 2012-05-08 2012-12-20 Lonza Ltd 2-(2,3-dimethylphenyl)-1-propanal and its use as perfume
IN2014DN07982A (es) * 2012-05-08 2015-05-01 Lonza Ag
ES2563816T3 (es) * 2012-05-08 2016-03-16 Lonza Ltd Método de preparación de medetomidina
WO2012172119A2 (en) * 2012-05-08 2012-12-20 Lonza Ltd Method for the preparation of medetomidine
DK2867195T3 (en) * 2012-06-28 2016-04-04 Lonza Ag PROCESS FOR THE PREPARATION OF 2- (2,3-dimethylphenyl) -1-propanal WITH chloroacetone
WO2012172121A1 (en) * 2012-06-28 2012-12-20 Lonza Ltd Method for the preparation of medetomidine with chloroacetone
JP5777841B2 (ja) * 2012-06-28 2015-09-09 ロンザ・リミテッド クロロアセトンを用いてメデトミジンを調製するための方法
WO2012172122A2 (en) * 2012-06-28 2012-12-20 Lonza Ltd Method for the preparation of 2-(2,3-dimethylphenyl)-1-propanal

Also Published As

Publication number Publication date
SG11201405609WA (en) 2015-02-27
CA2866437A1 (en) 2013-01-24
CN104245678B (zh) 2016-02-24
DK2867211T3 (en) 2016-02-29
MY165218A (en) 2018-03-09
TW201630888A (zh) 2016-09-01
KR101560116B1 (ko) 2015-10-13
HK1201530A1 (zh) 2015-09-04
EP2867211A1 (en) 2015-05-06
CN105218453A (zh) 2016-01-06
PL2867211T3 (pl) 2016-06-30
AU2012285677B2 (en) 2016-03-31
CN105218453B (zh) 2017-04-12
CL2014002907A1 (es) 2015-01-16
JP5777841B2 (ja) 2015-09-09
EP2867211B1 (en) 2015-12-30
TWI543970B (zh) 2016-08-01
TWI560182B (en) 2016-12-01
EA201400939A1 (ru) 2015-01-30
US20150099889A1 (en) 2015-04-09
US9156793B2 (en) 2015-10-13
US9434694B2 (en) 2016-09-06
HK1213893A1 (zh) 2016-07-15
JP2015517474A (ja) 2015-06-22
HUE027382T2 (en) 2016-10-28
HRP20160216T1 (hr) 2016-03-25
US20150336909A1 (en) 2015-11-26
KR20140129399A (ko) 2014-11-06
CL2016001664A1 (es) 2017-01-27
EA027921B1 (ru) 2017-09-29
CY1117492T1 (el) 2017-04-26
CN104245678A (zh) 2014-12-24
TW201402553A (zh) 2014-01-16
AU2012285677A1 (en) 2014-09-25
WO2013011157A1 (en) 2013-01-24
NZ700642A (en) 2016-04-29
ES2565066T3 (es) 2016-03-31
CA2866437C (en) 2018-01-02

Similar Documents

Publication Publication Date Title
IN2014DN08121A (es)
ZA201700019B (en) Substituted [1,2,4]triazole compounds
IN2014DN07984A (es)
EP2936375A4 (en) DETERMINATION OF URL REPUTATION INCORPORATED IN EMAIL AT TIMING
MX2014002053A (es) Anticuerpos anti -mcsp y metodos de uso.
IN2014DN07983A (es)
MX340259B (es) Formulaciones de testosterona.
MX370649B (es) Proceso para la preparacion de teneligliptina.
WO2012172122A3 (en) Method for the preparation of 2-(2,3-dimethylphenyl)-1-propanal
WO2012172119A3 (en) Method for the preparation of medetomidine
IN2014DN09798A (es)
WO2014091167A3 (fr) Composes cyclopropylboroniques, leur procede de preparation et leur utilisation
IN2014CN00312A (es)
EP3184172A4 (en) Hydrosilylation iron catalyst
EA201400937A1 (ru) Способ получения 2-(2,3-диметилфенил)-1-пропаналя
MY165088A (en) Pharmaceutical compositions comprising alisporivir
IN2012DN01971A (es)
GB201012359D0 (en) Invention 6.5.10
EP3281180A4 (en) Generating optimized geometries
IL239340A0 (en) Sage fragrance
WO2014093305A3 (en) Micrornas and uses thereof
GB201015621D0 (en) Invention 30.08.10
UA111528C2 (uk) Спосіб одержання 2-(2,3-диметилфеніл)-1-пропаналю з використанням хлорацетону
MX2016016577A (es) Aleacion de fundicion de aluminio.
GB201510046D0 (en) Chordal - automatic harmonizer for melody