HK1213893A1 - 用氯丙酮製備美托咪定的方法 - Google Patents

用氯丙酮製備美托咪定的方法

Info

Publication number
HK1213893A1
HK1213893A1 HK16101923.2A HK16101923A HK1213893A1 HK 1213893 A1 HK1213893 A1 HK 1213893A1 HK 16101923 A HK16101923 A HK 16101923A HK 1213893 A1 HK1213893 A1 HK 1213893A1
Authority
HK
Hong Kong
Prior art keywords
medetomidine
chloroacetone
preparation
Prior art date
Application number
HK16101923.2A
Other languages
English (en)
Inventor
Doerwald Florencio Zaragoza
Anna Kulesza
Stephan Elzner
Robert Bujok
Zbigniew Wrobel
Krzysztof Wojciechowski
Original Assignee
Lonza Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47557694&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1213893(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from PCT/EP2012/070875 external-priority patent/WO2012172121A1/en
Application filed by Lonza Ag filed Critical Lonza Ag
Publication of HK1213893A1 publication Critical patent/HK1213893A1/zh

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/58Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D263/00Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
HK16101923.2A 2012-06-28 2016-02-22 用氯丙酮製備美托咪定的方法 HK1213893A1 (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261665510P 2012-06-28 2012-06-28
EP12174102 2012-06-28
EP12188104 2012-10-11
PCT/EP2012/070875 WO2012172121A1 (en) 2012-06-28 2012-10-22 Method for the preparation of medetomidine with chloroacetone
EP12192625 2012-11-14

Publications (1)

Publication Number Publication Date
HK1213893A1 true HK1213893A1 (zh) 2016-07-15

Family

ID=47557694

Family Applications (2)

Application Number Title Priority Date Filing Date
HK15102120.2A HK1201530A1 (zh) 2012-06-28 2015-03-03 用氯丙酮製備美托咪定的方法
HK16101923.2A HK1213893A1 (zh) 2012-06-28 2016-02-22 用氯丙酮製備美托咪定的方法

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HK15102120.2A HK1201530A1 (zh) 2012-06-28 2015-03-03 用氯丙酮製備美托咪定的方法

Country Status (21)

Country Link
US (2) US9156793B2 (zh)
EP (1) EP2867211B1 (zh)
JP (1) JP5777841B2 (zh)
KR (1) KR101560116B1 (zh)
CN (2) CN104245678B (zh)
AU (1) AU2012285677B2 (zh)
CA (1) CA2866437C (zh)
CL (2) CL2014002907A1 (zh)
CY (1) CY1117492T1 (zh)
DK (1) DK2867211T3 (zh)
EA (1) EA027921B1 (zh)
ES (1) ES2565066T3 (zh)
HK (2) HK1201530A1 (zh)
HR (1) HRP20160216T1 (zh)
HU (1) HUE027382T2 (zh)
IN (1) IN2014DN07984A (zh)
MY (1) MY165218A (zh)
PL (1) PL2867211T3 (zh)
SG (1) SG11201405609WA (zh)
TW (2) TWI543970B (zh)
WO (1) WO2013011157A1 (zh)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA025591B1 (ru) 2012-05-08 2017-01-30 Лонца Лтд. Способ получения 2-(2,3-диметилфенил)-1-пропанала
AU2012285675B2 (en) * 2012-05-08 2016-03-03 Lonza Ltd Method for preparation of medetomidine
EA027921B1 (ru) * 2012-06-28 2017-09-29 Лонца Лтд. Способ получения медетомидина с использованием хлорацетона
WO2013011158A2 (en) 2012-06-28 2013-01-24 Lonza Ltd Method for preparation of 2-(2,3-dimethylphenyl)-1-propanal with chloroacetone
WO2017138224A1 (ja) * 2016-02-12 2017-08-17 ソニー株式会社 装置及び方法
CN106518812A (zh) * 2016-10-25 2017-03-22 湖南大学 一种美托咪定及其中间体的制备方法
CN113044857B (zh) * 2020-12-30 2023-05-23 重庆柒兴克米科技有限公司 高收率制取高纯氰化钠或氰化钾的生产工艺
CN114671811A (zh) * 2022-04-14 2022-06-28 南京正科医药股份有限公司 一种右美托咪定拆分副产物的外消旋化回收方法

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE23400E (en) 1951-08-14 Electkic low and high-voltage fuses
BE790604A (fr) 1971-10-28 1973-04-26 Sandoz Sa Nouveaux aminoalcanols, leur preparation et leur application comme medicaments
JPS51100041A (en) 1975-02-26 1976-09-03 Kanebo Ltd 22 * 44 isobuchirufueniru * puropionsanno seizoho
JPS51100042A (en) 1975-02-26 1976-09-03 Kanebo Ltd 22 * 44 isobuchirufueniru * puropionsanno seizoho
GB2092569B (en) 1981-02-05 1984-09-19 Farmos Oy Substituted imidazole derivatives and their preparation and use
GB2101114B (en) 1981-07-10 1985-05-22 Farmos Group Ltd Substituted imidazole derivatives and their preparation and use
ATE78722T1 (de) 1984-02-24 1992-08-15 Sagami Chem Res Methode zum isomerisieren eines glycidats.
JPS62103037A (ja) * 1985-10-29 1987-05-13 Hamari Yakuhin Kogyo Kk 2−(4−イソブチルフエニル)−プロピオンアルデヒドの製造法
DE19714042A1 (de) 1997-04-05 1998-10-08 Henkel Kgaa Verfahren zur Herstellung aromatischer Aldehyde
SE513474C2 (sv) 1999-01-25 2000-09-18 Hans Elwing Instutionen Foer C Metod för att förhindra kräftdjurs, särskilt havstulpaners, etablering på fasta ytor med hjälp av en substans som stör nervsignaler, varvid substansen är medetomidin, dvs (+)-4-/1- (2,3-dimetylfenyl)-etyl/-IH-imidazol
EP1918282A1 (en) 2006-11-06 2008-05-07 "Joint Stock Company Grindeks" Method for preparing medetomidine and its salts
GB2453982B (en) * 2007-10-24 2009-09-16 Norbrook Lab Ltd Chemical process for the preparation of Medetomidine
US7902247B2 (en) 2008-01-09 2011-03-08 Allergan, Inc. Substituted-aryl-2-phenylethyl-1H-imidazole compounds as subtype selective modulators of alpha 2B and/or alpha 2C adrenergic receptors
CN101921234B (zh) * 2009-06-12 2012-05-30 中国中化股份有限公司 一种制备美托咪啶的方法
CN102753532B (zh) * 2009-12-09 2015-05-13 I-技术有限公司 美托咪定的制备方法
WO2012172119A2 (en) * 2012-05-08 2012-12-20 Lonza Ltd Method for the preparation of medetomidine
AU2012285675B2 (en) 2012-05-08 2016-03-03 Lonza Ltd Method for preparation of medetomidine
EA025591B1 (ru) 2012-05-08 2017-01-30 Лонца Лтд. Способ получения 2-(2,3-диметилфенил)-1-пропанала
WO2012172120A2 (en) * 2012-05-08 2012-12-20 Lonza Ltd 2-(2,3-dimethylphenyl)-1-propanal and its use as perfume
WO2012172121A1 (en) * 2012-06-28 2012-12-20 Lonza Ltd Method for the preparation of medetomidine with chloroacetone
WO2013011158A2 (en) 2012-06-28 2013-01-24 Lonza Ltd Method for preparation of 2-(2,3-dimethylphenyl)-1-propanal with chloroacetone
EA027921B1 (ru) * 2012-06-28 2017-09-29 Лонца Лтд. Способ получения медетомидина с использованием хлорацетона
WO2012172122A2 (en) * 2012-06-28 2012-12-20 Lonza Ltd Method for the preparation of 2-(2,3-dimethylphenyl)-1-propanal

Also Published As

Publication number Publication date
HK1201530A1 (zh) 2015-09-04
KR20140129399A (ko) 2014-11-06
CN105218453B (zh) 2017-04-12
CA2866437C (en) 2018-01-02
EP2867211B1 (en) 2015-12-30
KR101560116B1 (ko) 2015-10-13
DK2867211T3 (en) 2016-02-29
AU2012285677A1 (en) 2014-09-25
ES2565066T3 (es) 2016-03-31
CN105218453A (zh) 2016-01-06
TW201402553A (zh) 2014-01-16
EP2867211A1 (en) 2015-05-06
SG11201405609WA (en) 2015-02-27
AU2012285677B2 (en) 2016-03-31
JP2015517474A (ja) 2015-06-22
PL2867211T3 (pl) 2016-06-30
CL2016001664A1 (es) 2017-01-27
WO2013011157A1 (en) 2013-01-24
NZ700642A (en) 2016-04-29
US20150336909A1 (en) 2015-11-26
CN104245678B (zh) 2016-02-24
US20150099889A1 (en) 2015-04-09
TWI560182B (en) 2016-12-01
HRP20160216T1 (hr) 2016-03-25
HUE027382T2 (en) 2016-10-28
CN104245678A (zh) 2014-12-24
JP5777841B2 (ja) 2015-09-09
CL2014002907A1 (es) 2015-01-16
EA027921B1 (ru) 2017-09-29
US9156793B2 (en) 2015-10-13
US9434694B2 (en) 2016-09-06
CY1117492T1 (el) 2017-04-26
CA2866437A1 (en) 2013-01-24
EA201400939A1 (ru) 2015-01-30
TWI543970B (zh) 2016-08-01
MY165218A (en) 2018-03-09
TW201630888A (zh) 2016-09-01
IN2014DN07984A (zh) 2015-05-01

Similar Documents

Publication Publication Date Title
EP2855745A4 (en) METHODS RELATING TO ADALIMUM AB
EP2852687A4 (en) METHODS FOR PREPARING A SAMPLE
PL2825719T3 (pl) Sposób obsługi odwiertów
EP2813512A4 (en) METHOD FOR CYCLING PEPTIDE COMPOUND
ZA201305972B (en) Method for the preparation of biphephos
HK1213893A1 (zh) 用氯丙酮製備美托咪定的方法
EP2861655A4 (en) METHODS OF DEOLVANTIZATION OF BAGASSE
PL2800476T3 (pl) Sposób karmienia
PL2797436T3 (pl) Sposoby wytwarzania napojów na bazie roślin
HK1201532A1 (zh) 美托咪定的製備方法
EP2917314A4 (en) OLIGOMERATZUSAMMENSETZUNG
EP2875348A4 (en) METHOD OF ISOLATING MICROVESICLES
EP2856159A4 (en) METHODS RELATING TO DENOSUMAB
ZA201503034B (en) Method of weight management
IL236312A0 (en) Preparation of 18f-flucyclobin
HUE041814T2 (hu) Eljárás izoidid elõállítására
AP3754A (en) Method of culturing algae
GB201220155D0 (en) Method of manufacture
IL237862A0 (en) Methods to reduce the formation of scale
EP2850057A4 (en) PROCESS FOR THE PREPARATION OF THIADIAZOLENE
GB201215942D0 (en) Method of treatent
GB2501101B (en) Method of culturing algae
EP2873659A4 (en) PROCESS FOR THE PRODUCTION OF HIGH GRADE ZEAXANTHINE
EP2887938A4 (en) PROCESS FOR PREPARING TECOVIRIMAT
ZA201503833B (en) Method of hemoglobin-f determination

Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20211115