IN2014DN03049A - - Google Patents
Info
- Publication number
- IN2014DN03049A IN2014DN03049A IN3049DEN2014A IN2014DN03049A IN 2014DN03049 A IN2014DN03049 A IN 2014DN03049A IN 3049DEN2014 A IN3049DEN2014 A IN 3049DEN2014A IN 2014DN03049 A IN2014DN03049 A IN 2014DN03049A
- Authority
- IN
- India
- Prior art keywords
- extracellular matrix
- tissue
- interstitial
- expression
- ecm
- Prior art date
Links
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 abstract 3
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 abstract 3
- 210000002744 extracellular matrix Anatomy 0.000 abstract 3
- 210000001519 tissue Anatomy 0.000 abstract 2
- 102000012422 Collagen Type I Human genes 0.000 abstract 1
- 108010022452 Collagen Type I Proteins 0.000 abstract 1
- 102000004127 Cytokines Human genes 0.000 abstract 1
- 108090000695 Cytokines Proteins 0.000 abstract 1
- UFULAYFCSOUIOV-UHFFFAOYSA-N cysteamine Chemical compound NCCS UFULAYFCSOUIOV-UHFFFAOYSA-N 0.000 abstract 1
- 230000008021 deposition Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 210000002950 fibroblast Anatomy 0.000 abstract 1
- 230000003176 fibrotic effect Effects 0.000 abstract 1
- 230000008595 infiltration Effects 0.000 abstract 1
- 238000001764 infiltration Methods 0.000 abstract 1
- 210000002540 macrophage Anatomy 0.000 abstract 1
- 229960003151 mercaptamine Drugs 0.000 abstract 1
- 108020004999 messenger RNA Proteins 0.000 abstract 1
- 230000002206 pro-fibrotic effect Effects 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 231100000241 scar Toxicity 0.000 abstract 1
- 230000000451 tissue damage Effects 0.000 abstract 1
- 231100000827 tissue damage Toxicity 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/145—Amines having sulfur, e.g. thiurams (>N—C(S)—S—C(S)—N< and >N—C(S)—S—S—C(S)—N<), Sulfinylamines (—N=SO), Sulfonylamines (—N=SO2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2011/057935 WO2013062544A1 (en) | 2011-10-26 | 2011-10-26 | Cysteamine in the treatment of fibrotic disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2014DN03049A true IN2014DN03049A (de) | 2015-05-15 |
Family
ID=48168215
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN3049DEN2014 IN2014DN03049A (de) | 2011-10-26 | 2011-10-26 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US9468612B2 (de) |
| AU (1) | AU2011379972B2 (de) |
| BR (1) | BR112014009789A2 (de) |
| CA (1) | CA2853484C (de) |
| IN (1) | IN2014DN03049A (de) |
| MX (1) | MX2014004994A (de) |
| WO (1) | WO2013062544A1 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112017028448A2 (pt) * | 2015-07-02 | 2018-08-28 | Horizon Orphan Llc | análogos de cisteamina resistentes a ado e usos dos mesmos |
| AU2017235631B2 (en) | 2016-03-17 | 2023-03-02 | Thiogenesis Therapeutics, Inc. | Compositions for controlled release of cysteamine and systemic treatment of cysteamine sensitive disorders |
| US10155948B2 (en) * | 2016-05-12 | 2018-12-18 | Kangwon National University University-Industry Cooperation Foundation and | Pharmaceutical composition for preventing or treating diabetic complications and screening method for preventive or therapeutic agent for diabetic complications |
| GB201609940D0 (en) * | 2016-06-07 | 2016-07-20 | Novabiotics Ltd | Microparticles |
| US10905660B2 (en) | 2016-06-07 | 2021-02-02 | Novabiotics Limited | Microparticles |
| EP3579923A4 (de) * | 2017-02-07 | 2020-11-18 | Children's Hospital Medical Center | Behandlung von asthma mit cysteamin |
| CA3076392A1 (en) | 2017-09-20 | 2019-03-28 | Thiogenesis Therapeutics, Inc. | Methods for the treatment of cysteamine sensitive disorders |
| WO2019094862A1 (en) * | 2017-11-10 | 2019-05-16 | Wisconsin Alumni Research Foundation | Compositions and methods for the inhibition of fibrosis |
| US20220177918A1 (en) * | 2019-04-12 | 2022-06-09 | The Regents Of The University Of California | Methods for treating inherited eye defects |
| US12263144B2 (en) | 2020-10-13 | 2025-04-01 | Accubit LLC—Biotechnology | Methods of treating IgA nephropathy with thiol-containing molecules |
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| US5869462A (en) | 1992-09-10 | 1999-02-09 | The Board Of Trustees Of The Leland Stanford Junior University | Inhibition of proliferation of vascular smooth muscle cell |
| AU5587094A (en) | 1992-10-26 | 1994-05-24 | Kirin Brewery Company, Limited | Method for producing large latent transforming growth factor-beta complexes and large latency associated peptide |
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| WO1994025588A2 (en) | 1993-04-30 | 1994-11-10 | Biognostik Gesellschaft für Biomolekulare Diagnostik mbH | ANTISENSE-OLIGONUCLEOTIDES FOR THE TREATMENT OF IMMUNOSUPPRESSIVE EFFECTS OF TRANSFORMING GROWTH FACTOR-β (TGF-β) |
| EP0737071A1 (de) | 1993-06-15 | 1996-10-16 | Il- Yang Pharm. Co., Ltd. | Anti-sense-oligodeoxynukleotide zu fibrogenen cytokinen und ihre verwendung |
| WO1995010610A1 (en) | 1993-10-15 | 1995-04-20 | La Jolla Cancer Research Foundation | BETAGLYCAN POLYPEPTIDES HAVING TGF-β BINDING ACTIVITY |
| US5981483A (en) | 1994-05-04 | 1999-11-09 | Mount Sinai Hospital Corporation | Compositions comprising modulators of cytokines of the TGF-β superfamily |
| US5772995A (en) | 1994-07-18 | 1998-06-30 | Sidney Kimmel Cancer Center | Compositions and methods for enhanced tumor cell immunity in vivo |
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| US5824655A (en) | 1995-02-15 | 1998-10-20 | The University Of Utah | Anti-transforming growth factor-β gene therapy |
| US5714519A (en) | 1995-06-07 | 1998-02-03 | Ergo Science Incorporated | Method for regulating glucose metabolism |
| GB9601081D0 (en) | 1995-10-06 | 1996-03-20 | Cambridge Antibody Tech | Specific binding members for human transforming growth factor beta;materials and methods |
| AU2749697A (en) | 1996-04-30 | 1997-11-19 | Genzyme Corporation | Use of prolactin as a tgf-beta antagonist |
| JPH1067674A (ja) | 1996-06-19 | 1998-03-10 | Advanced Sukin Res Kenkyusho:Kk | 細胞外マトリツクスの異常蓄積抑制剤 |
| AU740052B2 (en) | 1996-10-25 | 2001-10-25 | Ethicon Inc. | Anti-fibrotic agent assay |
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| US6468522B1 (en) | 1999-07-22 | 2002-10-22 | University Of Medicine And Dentistry Of New Jersey | Controlled release of thioamide moiety-containing therapeutic agents |
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| GB0102665D0 (en) | 2001-02-02 | 2001-03-21 | Glaxo Group Ltd | Compounds |
| GB0102668D0 (en) | 2001-02-02 | 2001-03-21 | Glaxo Group Ltd | Compounds |
| GB0102672D0 (en) | 2001-02-02 | 2001-03-21 | Glaxo Group Ltd | Compounds |
| WO2002066462A1 (en) | 2001-02-02 | 2002-08-29 | Glaxo Group Limited | Pyrazole derivatives against tgf overexpression |
| EP1363904A1 (de) | 2001-02-02 | 2003-11-26 | Glaxo Group Limited | Pyrazole als tgf-inhibitoren |
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| EP1786803A1 (de) | 2004-08-31 | 2007-05-23 | Biogen Idec MA, Inc. | Pyrimidinylpyrazole als tgf-beta-inhibitoren |
| EP1786802A1 (de) | 2004-08-31 | 2007-05-23 | Biogen Idec MA, Inc. | Pyrimidinylimidazole als tgf-beta-hemmer |
| US7511056B2 (en) | 2004-11-10 | 2009-03-31 | Eli Lilly And Company | TGF-β inhibitors |
| ES2711213T3 (es) | 2005-02-08 | 2019-04-30 | Genzyme Corp | Anticuerpos de TGFbeta |
| ES2388310T7 (es) | 2006-01-27 | 2017-05-03 | The Regents Of The University Of California | Cisteamina con recubrimiento entérico, cistamina y derivados de las mismas |
| WO2008070117A1 (en) | 2006-12-04 | 2008-06-12 | Promedior, Inc. | Conjoint therapy for treating fibrotic diseases |
| KR20100091219A (ko) * | 2007-11-30 | 2010-08-18 | 더 리전트 오브 더 유니버시티 오브 캘리포니아 | 시스테아민 산물을 이용한 비-알코올성 지방성간염(nash) 치료 방법 |
-
2011
- 2011-10-26 IN IN3049DEN2014 patent/IN2014DN03049A/en unknown
- 2011-10-26 AU AU2011379972A patent/AU2011379972B2/en not_active Expired - Fee Related
- 2011-10-26 BR BR112014009789A patent/BR112014009789A2/pt not_active IP Right Cessation
- 2011-10-26 CA CA2853484A patent/CA2853484C/en active Active
- 2011-10-26 US US14/353,273 patent/US9468612B2/en active Active
- 2011-10-26 WO PCT/US2011/057935 patent/WO2013062544A1/en not_active Ceased
- 2011-10-26 MX MX2014004994A patent/MX2014004994A/es unknown
-
2016
- 2016-10-03 US US15/284,416 patent/US9925154B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| MX2014004994A (es) | 2014-08-27 |
| AU2011379972A1 (en) | 2014-05-15 |
| BR112014009789A2 (pt) | 2017-04-25 |
| US9925154B2 (en) | 2018-03-27 |
| WO2013062544A1 (en) | 2013-05-02 |
| US9468612B2 (en) | 2016-10-18 |
| CA2853484A1 (en) | 2013-05-02 |
| AU2011379972B2 (en) | 2016-05-12 |
| CA2853484C (en) | 2018-08-21 |
| US20170165207A1 (en) | 2017-06-15 |
| US20140275279A1 (en) | 2014-09-18 |
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