IN2014CN00302A - - Google Patents

Info

Publication number
IN2014CN00302A
IN2014CN00302A IN302CHN2014A IN2014CN00302A IN 2014CN00302 A IN2014CN00302 A IN 2014CN00302A IN 302CHN2014 A IN302CHN2014 A IN 302CHN2014A IN 2014CN00302 A IN2014CN00302 A IN 2014CN00302A
Authority
IN
India
Prior art keywords
formula
methods
compounds
compositions
directed
Prior art date
Application number
Other languages
English (en)
Inventor
Charles Q Meng
Clare Louise Murray
CHERTUDI Itta BLUHN
Mustapha Soukri
Mary George Johnson
Original Assignee
Merial Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merial Ltd filed Critical Merial Ltd
Publication of IN2014CN00302A publication Critical patent/IN2014CN00302A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81Amides; Imides
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/40Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/10Anthelmintics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/14Ectoparasiticides, e.g. scabicides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/06Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
    • C07D213/16Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
    • C07D213/18Salts thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Environmental Sciences (AREA)
  • Pest Control & Pesticides (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Agronomy & Crop Science (AREA)
  • Wood Science & Technology (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IN302CHN2014 2011-06-27 2012-06-27 IN2014CN00302A (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161501492P 2011-06-27 2011-06-27
PCT/US2012/044476 WO2013003505A1 (en) 2011-06-27 2012-06-27 Amido-pyridyl ether compounds and compositions and their use against parasites

Publications (1)

Publication Number Publication Date
IN2014CN00302A true IN2014CN00302A (fi) 2015-04-03

Family

ID=46545894

Family Applications (1)

Application Number Title Priority Date Filing Date
IN302CHN2014 IN2014CN00302A (fi) 2011-06-27 2012-06-27

Country Status (12)

Country Link
US (1) US8946270B2 (fi)
EP (1) EP2723716B1 (fi)
JP (1) JP6041359B2 (fi)
CN (1) CN103717573B (fi)
AU (1) AU2012275435B2 (fi)
BR (1) BR112013033568B1 (fi)
CA (1) CA2840396C (fi)
EA (1) EA201400058A1 (fi)
ES (1) ES2618813T3 (fi)
IN (1) IN2014CN00302A (fi)
MX (1) MX344911B (fi)
WO (1) WO2013003505A1 (fi)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014054425A1 (ja) * 2012-10-01 2014-04-10 住友化学株式会社 アミド化合物
WO2014168052A1 (ja) * 2013-04-10 2014-10-16 住友化学株式会社 アミド化合物
EP3037408A4 (en) * 2013-08-23 2017-03-08 Ishihara Sangyo Kaisha, Ltd. Harmful organism control agent
CN106132955B (zh) * 2014-04-01 2018-10-16 住友化学株式会社 酰胺化合物
ES2902661T3 (es) 2014-07-28 2022-03-29 Sumitomo Chemical Co Compuesto amida y uso del mismo para el control de artrópodos nocivos
TWI664905B (zh) 2014-07-29 2019-07-11 日商住友化學股份有限公司 含有醯胺化合物之有害節肢動物控制劑
EP3291808A1 (en) * 2015-05-06 2018-03-14 I-Tech AB Medetomidine for use in controlling parasitic crustaceans on fish
WO2017195173A1 (en) 2016-05-12 2017-11-16 Verdesian Life Sciences, U.S., Llc Compositions for controlling enzyme-induced urea decomposition
MY201375A (en) 2017-03-28 2024-02-20 Verdesian Life Sciences Us Llc Triarylmethane compounds for controlling enzyme-induced urea decomposition

Family Cites Families (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL160809C (nl) 1970-05-15 1979-12-17 Duphar Int Res Werkwijze ter bereiding van benzoylureumverbindingen, alsmede werkwijze ter bereiding van insekticide prepara- ten op basis van benzoylureumverbindingen.
US3950360A (en) 1972-06-08 1976-04-13 Sankyo Company Limited Antibiotic substances
JPS4914624A (fi) 1972-06-08 1974-02-08
US3818047A (en) 1972-08-07 1974-06-18 C Henrick Substituted pyrones
SE434277B (sv) 1976-04-19 1984-07-16 Merck & Co Inc Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis
US4166452A (en) 1976-05-03 1979-09-04 Generales Constantine D J Jr Apparatus for testing human responses to stimuli
CH604517A5 (fi) 1976-08-19 1978-09-15 Ciba Geigy Ag
US4256108A (en) 1977-04-07 1981-03-17 Alza Corporation Microporous-semipermeable laminated osmotic system
US4134973A (en) 1977-04-11 1979-01-16 Merck & Co., Inc. Carbohydrate derivatives of milbemycin and processes therefor
US4199569A (en) 1977-10-03 1980-04-22 Merck & Co., Inc. Selective hydrogenation products of C-076 compounds and derivatives thereof
US4144352A (en) 1977-12-19 1979-03-13 Merck & Co., Inc. Milbemycin compounds as anthelmintic agents
US4203976A (en) 1978-08-02 1980-05-20 Merck & Co., Inc. Sugar derivatives of C-076 compounds
US4265874A (en) 1980-04-25 1981-05-05 Alza Corporation Method of delivering drug with aid of effervescent activity generated in environment of use
JPS57139012A (en) 1981-02-23 1982-08-27 Sankyo Co Ltd Anthelmintic composition
US4427663A (en) 1982-03-16 1984-01-24 Merck & Co., Inc. 4"-Keto-and 4"-amino-4"-deoxy avermectin compounds and substituted amino derivatives thereof
DE3235931A1 (de) 1982-09-29 1984-03-29 Bayer Ag, 5090 Leverkusen Koeder zur bekaempfung von ungeziefer
JPS59199673A (ja) 1983-04-25 1984-11-12 Sumitomo Chem Co Ltd 含窒素複素環化合物、その製造法およびそれを有効成分とする有害生物防除剤
DE3580444D1 (en) 1984-10-18 1990-12-13 Ciba Geigy Ag Benzoylphenylharnstoffe.
ATE67493T1 (de) 1985-02-04 1991-10-15 Bayer Agrochem Kk Heterocyclische verbindungen.
EP0237482A1 (de) 1986-03-06 1987-09-16 Ciba-Geigy Ag C(29)-Carbonyloxi-milbemycin-Derivate zur Bekämpfung von tier- und pflanzenparasitären Schädlingen
EP0246739B1 (en) 1986-03-25 1991-01-23 Sankyo Company Limited Macrolide compounds, their preparation and their use
DE3778768D1 (de) 1986-07-02 1992-06-11 Ciba Geigy Ag Pestizide.
US4855317A (en) 1987-03-06 1989-08-08 Ciba-Geigy Corporation Insecticides and parasiticides
US4871719A (en) 1987-03-24 1989-10-03 Ciba-Geigy Corporation Composition for controlling parasites in productive livestock
US4874749A (en) 1987-07-31 1989-10-17 Merck & Co., Inc. 4"-Deoxy-4-N-methylamino avermectin Bla/Blb
EP0319142B1 (en) 1987-11-03 1994-04-06 Beecham Group Plc Intermediates for the preparation of anthelmintic macrolide antibiotics
NZ232422A (en) 1989-02-16 1992-11-25 Merck & Co Inc 13-ketal milbemycin derivatives and parasiticides
IE904606A1 (en) 1989-12-21 1991-07-03 Beecham Group Plc Novel products
NZ247278A (en) 1991-02-12 1995-03-28 Ancare Distributors Veterinary anthelmintic drench comprising a suspension of praziquantel in a liquid carrier
WO1992022555A1 (en) 1991-06-17 1992-12-23 Beecham Group Plc Paraherquamide derivatives, precursor thereof, processes for their preparation, microorganism used and their use as antiparasitic agents
US5345377A (en) 1992-10-30 1994-09-06 Electric Power Research Institute, Inc. Harmonic controller for an active power line conditioner
GB9300883D0 (en) 1993-01-18 1993-03-10 Pfizer Ltd Antiparasitic agents
US5399582A (en) 1993-11-01 1995-03-21 Merck & Co., Inc. Antiparasitic agents
AUPM969994A0 (en) 1994-11-28 1994-12-22 Virbac S.A. Equine anthelmintic formulations
US5962499A (en) 1995-03-20 1999-10-05 Merck & Co., Inc. Nodulisporic acid derivatives
US6221894B1 (en) 1995-03-20 2001-04-24 Merck & Co., Inc. Nodulisporic acid derivatives
DE19520613A1 (de) 1995-06-06 1996-12-12 Bayer Ag Phenylpyridazinone
MY113806A (en) 1995-07-21 2002-05-31 Upjohn Co Antiparasitic marcfortines and paraherquamides
FR2739255B1 (fr) 1995-09-29 1998-09-04 Rhone Merieux Composition antiparasitaire pour le traitement et la protection des animaux de compagnie
IE80657B1 (en) 1996-03-29 1998-11-04 Merial Sas Insecticidal combination to control mammal fleas in particular fleas on cats and dogs
US5885607A (en) 1996-03-29 1999-03-23 Rhone Merieux N-phenylpyrazole-based anti-flea and anti-tick external device for cats and dogs
FR2752525B1 (fr) 1996-08-20 2000-05-05 Rhone Merieux Procede de lutte contre les myiases des cheptels bovins et ovins et compositions pour la mise en oeuvre de ce procede
US6010710A (en) 1996-03-29 2000-01-04 Merial Direct pour-on skin solution for antiparasitic use in cattle and sheep
US6998131B2 (en) 1996-09-19 2006-02-14 Merial Limited Spot-on formulations for combating parasites
US6426333B1 (en) 1996-09-19 2002-07-30 Merial Spot-on formulations for combating parasites
FR2753377B1 (fr) 1996-09-19 1999-09-24 Rhone Merieux Nouvelle association parasiticide a base de 1-n-phenylpyra- zoles et de lactones macrocycliques endectocides
JP2976277B2 (ja) * 1996-09-30 1999-11-10 大塚化学株式会社 ベンジルオキシピリジン誘導体及び該誘導体を含有する殺虫、殺ダニ剤
US6207647B1 (en) 1997-07-18 2001-03-27 Smithkline Beecham Corporation RatA
DE19823396A1 (de) 1998-05-26 1999-12-02 Bayer Ag Synergistische insektizide Mischungen
US6174540B1 (en) 1998-09-14 2001-01-16 Merck & Co., Inc. Long acting injectable formulations containing hydrogenated caster oil
US6787342B2 (en) 2000-02-16 2004-09-07 Merial Limited Paste formulations
PE20011289A1 (es) 2000-04-07 2001-12-21 Upjohn Co Composiciones antihelminticas que comprenden lactonas macrociclicas y espirodioxepinoindoles
US6399786B1 (en) 2000-07-14 2002-06-04 Merck & Co., Inc. Nonacyclic nodulisporic acid derivatives
US7001889B2 (en) 2002-06-21 2006-02-21 Merial Limited Anthelmintic oral homogeneous veterinary pastes
AR042420A1 (es) 2002-09-11 2005-06-22 Novartis Ag Benzotriazolil- aminoacetonitril compuestos, proceso para su preparacion, metodo y uso de los mismos en el control de endo- y ecto-parasitos dentro y sobre ganado productor de sangre caliente y animales domesticos y plantas, y en la preparacion de una composicion farmaceutica
WO2004060865A2 (en) 2002-12-18 2004-07-22 Fmc Corporation N-(substituted arylmethyl)-4-(disubstituted methyl)piperidines and piperazines
DE10331675A1 (de) 2003-07-14 2005-02-10 Bayer Cropscience Ag Hetarylsubstituierte Pyrazolidindion-Derivate
WO2005041654A2 (de) 2003-11-03 2005-05-12 Bayer Cropscience Gmbh Herbizid wirksames mittel
AU2005219788B2 (en) 2004-03-05 2010-06-03 Nissan Chemical Corporation Isoxazoline-substituted benzamide compound and noxious organism control agent
ATE516291T1 (de) * 2004-10-21 2011-07-15 Dow Agrosciences Llc Thenopyrimidin-verbindungen mit fungizider aktivität
WO2006138475A2 (en) * 2005-06-16 2006-12-28 Jenrin Discovery Mao-b inhibitors useful for treating obesity
WO2007008963A1 (en) * 2005-07-13 2007-01-18 Jenrin Discovery Mao-b inhibitors useful for treating obesity
JP2007031395A (ja) * 2005-07-29 2007-02-08 Bayer Cropscience Ag 殺虫性3−アシルアミノベンズアニリド類
DE102005053680A1 (de) 2005-11-10 2007-05-16 Bayer Cropscience Ag Synergistische insektizide Mischungen zur Behandlung von Saatgut
KR20080080168A (ko) 2005-12-14 2008-09-02 이 아이 듀폰 디 네모아 앤드 캄파니 무척추 해충 방제용 이속사졸린
TW200803740A (en) 2005-12-16 2008-01-16 Du Pont 5-aryl isoxazolines for controlling invertebrate pests
TWI412322B (zh) 2005-12-30 2013-10-21 Du Pont 控制無脊椎害蟲之異唑啉
US8119671B2 (en) 2007-03-07 2012-02-21 Nissan Chemical Industries, Ltd. Isoxazoline-substituted benzamide compound and pest control agent
EP2181100A2 (en) 2007-04-10 2010-05-05 Bayer CropScience AG Insecticidal aryl isoxazoline derivatives
JP2008266230A (ja) * 2007-04-23 2008-11-06 Bayer Cropscience Ag 殺虫性アリールピロリジン類
TWI430995B (zh) 2007-06-26 2014-03-21 Du Pont 萘異唑啉無脊椎有害動物控制劑
CN105640952A (zh) 2007-06-27 2016-06-08 杜邦公司 动物虫害控制方法
PL2170321T3 (pl) 2007-06-29 2013-12-31 Zoetis Services Llc Połączenie przeciwrobacze
TWI556741B (zh) 2007-08-17 2016-11-11 英特威特國際股份有限公司 異唑啉組成物及其作為抗寄生蟲藥上的應用
US8415379B2 (en) * 2009-05-05 2013-04-09 Hoffmann-La Roche Inc. Pyridines
WO2010151797A2 (en) 2009-06-26 2010-12-29 University Of Massachusetts Compounds for modulating rna binding proteins and uses therefor
KR20130034011A (ko) 2010-02-22 2013-04-04 신젠타 파티서페이션즈 아게 살곤충 화합물로서의 디하이드로푸란 유도체

Also Published As

Publication number Publication date
EA201400058A1 (ru) 2014-07-30
MX2013015436A (es) 2014-04-10
US8946270B2 (en) 2015-02-03
EP2723716A1 (en) 2014-04-30
CA2840396C (en) 2020-07-14
US20140179746A1 (en) 2014-06-26
AU2012275435B2 (en) 2016-07-21
NZ619552A (en) 2015-12-24
AU2012275435A1 (en) 2014-01-23
BR112013033568A2 (pt) 2016-09-06
CA2840396A1 (en) 2013-01-03
EP2723716B1 (en) 2017-01-11
JP6041359B2 (ja) 2016-12-07
ES2618813T3 (es) 2017-06-22
CN103717573A (zh) 2014-04-09
MX344911B (es) 2017-01-11
JP2014522834A (ja) 2014-09-08
WO2013003505A1 (en) 2013-01-03
BR112013033568B1 (pt) 2020-11-24
CN103717573B (zh) 2016-02-24

Similar Documents

Publication Publication Date Title
IN2014CN00302A (fi)
PH12016501375A1 (en) Pyridin-2-amides useful as cb2 agonists
CR20140237A (es) Procedimiento de preparación de 5-fluoro-1h-pirazolopiridinas sustituidas
MD20180040A2 (ro) Inhibitori ai virusului hepatic C
UA110354C2 (uk) Противірусні сполуки
MX2012012530A (es) Derivados de n1-sulfonil-5-fluorpirimidinona.
MY193277A (en) Certain amino-pyrimidines, compositions thereof, and methods for their use
MX2016006336A (es) Compuestos pirazolopirimidina.
PH12015501083A1 (en) Novel pyridine derivatives
CR20130001A (es) Derivados de indolizina, su procedimiento de preparación y su aplicación en terapéutica
PH12015501073A1 (en) Novel pyridine derivatives
MX2014002446A (es) Compuestos de ciclohexano sustituidos novedosos.
IN2014CN04449A (fi)
MX2014004920A (es) Nuevos derivados de pirazina.
MX2013007567A (es) Procedimiento para preparar poliestereteroles.
IN2014DN01629A (fi)
CO6852083A2 (es) Indol- y bencimidazolcarboxamidas como insecticidas y acaricidas
MX2014010433A (es) Nueva forma cristalina de sulfato de sitagliptina.
JO3196B1 (ar) عملية تحضير ملح ل – ارجينين البيريندوبريل
IN2014DN06192A (fi)
IN2014MN00850A (fi)
IN2015DN00085A (fi)
MY164880A (en) Process for the preparation of isoxazolyl-methoxy-nicotinic acids
UA109804C2 (xx) 2-метоксипіридин-4-ільні похідні
MX359399B (es) Inhibidores de 17alfa-hidroxilasa/c17-20-liasa.