IN2012DN05171A - - Google Patents
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- Publication number
- IN2012DN05171A IN2012DN05171A IN5171DEN2012A IN2012DN05171A IN 2012DN05171 A IN2012DN05171 A IN 2012DN05171A IN 5171DEN2012 A IN5171DEN2012 A IN 5171DEN2012A IN 2012DN05171 A IN2012DN05171 A IN 2012DN05171A
- Authority
- IN
- India
- Prior art keywords
- sphingosine
- modulators
- pharmaceuticals
- preparing
- processes
- Prior art date
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- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- -1 cyclic amine Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000010452 phosphate Substances 0.000 abstract 1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
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- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/40—Radicals substituted by oxygen atoms
- C07D307/42—Singly bound oxygen atoms
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- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
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US26403809P | 2009-11-24 | 2009-11-24 | |
PCT/US2010/057336 WO2011066179A1 (en) | 2009-11-24 | 2010-11-19 | Novel compounds as receptor modulators with therapeutic utility |
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EP (2) | EP2504323B1 (es) |
JP (2) | JP2013512243A (es) |
KR (2) | KR20120098796A (es) |
CN (2) | CN102712618B (es) |
AU (2) | AU2010324983A1 (es) |
BR (2) | BR112012012259A2 (es) |
CA (2) | CA2780908A1 (es) |
CL (1) | CL2012001352A1 (es) |
IL (2) | IL219759A0 (es) |
IN (2) | IN2012DN05171A (es) |
MX (2) | MX2012006028A (es) |
NZ (1) | NZ599966A (es) |
RU (2) | RU2012125184A (es) |
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MX2013011979A (es) * | 2011-04-14 | 2014-02-06 | Allergan Inc | Derivados de metilamina biciclica de fenilo como moduladores de los receptores de la esfingosina-1 fosfato. |
EP2817290A1 (en) * | 2012-02-21 | 2014-12-31 | Allergan, Inc. | Phenoxy-azetidine derivatives as sphingosine 1-phosphate (s1p) receptor modulators |
WO2014093253A1 (en) * | 2012-12-13 | 2014-06-19 | Allergan, Inc. | Novel aromatic thio compounds as receptor modulators |
PL2958913T3 (pl) * | 2013-02-20 | 2019-03-29 | Lg Chem, Ltd. | Agoniści receptora sfingozyno-1-fosforanowego, sposoby ich przygotowania i zawierające je jako środek aktywny farmaceutyczne kompozycje |
WO2014138075A1 (en) * | 2013-03-07 | 2014-09-12 | Allergan, Inc. | Phosphonic acid compounds as sphingosine-1-phosphate receptor modulators |
US20150045328A1 (en) * | 2013-08-08 | 2015-02-12 | Allergan, Inc. | Disubstituted aryl oxy derivatives as sphingosine-1 phosphate receptors modulators |
US20150045341A1 (en) * | 2013-08-08 | 2015-02-12 | Allergan, Inc. | Disubstituted aryl azetidine derivatives as sphingosine-1 phosphate receptors modulators |
WO2015073547A1 (en) * | 2013-11-13 | 2015-05-21 | Allergan, Inc. | Disubstituted phenoxy azetidine derivatives as sphingosine-1-phosphate (s1p) receptor modulators |
JOP20200186A1 (ar) | 2018-02-02 | 2020-07-29 | Univ Kyoto | دواء للوقاية من أو علاج مرض بصري مرتبط بزيادة تكوين أوعية دموية جديدة داخل العين و/ أو نفاذية الأوعية الدموية داخل العين |
CN117177964A (zh) * | 2021-04-14 | 2023-12-05 | 株式会社Lg化学 | 制备鞘氨醇-1-磷酸酯受体激动剂的新方法 |
EP4306516A1 (en) * | 2021-04-14 | 2024-01-17 | Lg Chem, Ltd. | Novel method for preparing sphingosine-1-phosphate receptor agonist |
WO2022220610A1 (ko) * | 2021-04-14 | 2022-10-20 | 주식회사 엘지화학 | 스핑고신-1-인산 수용체 효능제 합성을 위한 중간체의 제조방법 |
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EP0146810A3 (de) | 1983-12-05 | 1987-05-13 | Solco Basel AG | Verfahren zur Herstellung von Sphingosinderivaten |
US5110987A (en) | 1988-06-17 | 1992-05-05 | Emory University | Method of preparing sphingosine derivatives |
NZ233285A (en) | 1989-04-18 | 1992-06-25 | Duphar Int Res | Imidazole-substituted carbamoyl-indoles and condensed analogues thereof and pharmaceutical compositions |
US5294722A (en) | 1992-04-16 | 1994-03-15 | E. R. Squibb & Sons, Inc. | Process for the preparation of imidazoles useful in angiotensin II antagonism |
US5403851A (en) | 1994-04-05 | 1995-04-04 | Interneuron Pharmaceuticals, Inc. | Substituted tryptamines, phenalkylamines and related compounds |
KR100559817B1 (ko) | 1997-03-12 | 2006-03-10 | 다카라 바이오 가부시키가이샤 | 스핑고신 유사화합물 |
JP4091250B2 (ja) | 1997-09-11 | 2008-05-28 | タカラバイオ株式会社 | スフィンゴシン類誘導体及び医薬組成物 |
DE10010067A1 (de) * | 2000-03-02 | 2001-09-06 | Bayer Ag | Neue Imidazotriazinone und ihre Verwendung |
DK1397130T3 (da) | 2001-06-20 | 2007-11-12 | Wyeth Corp | Substituerede indolsyrederivater som inhibitorer af plasminogenaktivatorinhibitor-1 (PAI-1) |
US7351725B2 (en) * | 2002-01-18 | 2008-04-01 | Merck & Co., Inc. | N-(benzyl)aminoalkylcarboxylates, phosphinates, phosphonates and tetrazoles as Edg receptor agonists |
AU2003216054B2 (en) * | 2002-01-18 | 2007-01-04 | Merck & Co., Inc. | Selective S1P1/Edg1 receptor agonists |
JP4430941B2 (ja) * | 2002-01-18 | 2010-03-10 | メルク エンド カムパニー インコーポレーテッド | Edg受容体作動薬 |
CA2524054C (en) * | 2003-05-19 | 2012-04-24 | Irm Llc | Immunosuppressant compounds and compositions |
CN101407471A (zh) * | 2003-08-29 | 2009-04-15 | 小野药品工业株式会社 | 能够结合s1p受体的化合物及其药物用途 |
ES2754221T3 (es) * | 2003-08-29 | 2020-04-16 | Ono Pharmaceutical Co | Compuesto capaz de unirse al receptor de S1P y uso farmacéutico del mismo |
AU2005274277A1 (en) * | 2004-08-17 | 2006-02-23 | Galderma Research & Development, S.N.C. | Novel biaromatic compounds which activate receptors of PPAR type and their use in cosmetic or pharmaceutical compositions |
GB0612721D0 (en) * | 2006-06-27 | 2006-08-09 | Novartis Ag | Organic compounds |
AU2007292347A1 (en) * | 2006-09-07 | 2008-03-13 | Allergan, Inc. | Heteroaromatic compounds having sphingosine-1-phosphate (S1P) receptor agonist and/or antagonist biological activity |
BRPI0716601A2 (pt) * | 2006-09-07 | 2013-09-17 | Allergan Inc | compostos de heteroaromÁticos tendo atividade biolàgica agonista de receptor de esfingosina-1-fosfato(s1p) |
JP5732182B2 (ja) * | 2006-10-27 | 2015-06-10 | エルパス・インコーポレイテッドLpath, Inc. | 眼疾患と症状を処置するための組成物および方法 |
TW200827346A (en) * | 2006-11-03 | 2008-07-01 | Astrazeneca Ab | Chemical compounds |
US8633245B2 (en) | 2008-04-11 | 2014-01-21 | Institute Of Medicinal Molecular Design, Inc. | PAI-1 inhibitor |
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- 2010-11-19 RU RU2012125184/04A patent/RU2012125184A/ru not_active Application Discontinuation
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- 2010-11-19 MX MX2012006028A patent/MX2012006028A/es not_active Application Discontinuation
- 2010-11-19 CN CN201080062128.0A patent/CN102712618B/zh not_active Expired - Fee Related
- 2010-11-19 EP EP10782507.7A patent/EP2504323B1/en active Active
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