IN2012DN05171A - - Google Patents

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Publication number
IN2012DN05171A
IN2012DN05171A IN5171DEN2012A IN2012DN05171A IN 2012DN05171 A IN2012DN05171 A IN 2012DN05171A IN 5171DEN2012 A IN5171DEN2012 A IN 5171DEN2012A IN 2012DN05171 A IN2012DN05171 A IN 2012DN05171A
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India
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sphingosine
modulators
pharmaceuticals
preparing
processes
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English (en)
Inventor
M Heidelbaugh Todd
X Nguyen Phong
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Allergan Inc
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Publication of IN2012DN05171A publication Critical patent/IN2012DN05171A/en

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    • C07F9/65586Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
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Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2013011979A (es) * 2011-04-14 2014-02-06 Allergan Inc Derivados de metilamina biciclica de fenilo como moduladores de los receptores de la esfingosina-1 fosfato.
EP2817290A1 (en) * 2012-02-21 2014-12-31 Allergan, Inc. Phenoxy-azetidine derivatives as sphingosine 1-phosphate (s1p) receptor modulators
WO2014093253A1 (en) * 2012-12-13 2014-06-19 Allergan, Inc. Novel aromatic thio compounds as receptor modulators
PL2958913T3 (pl) * 2013-02-20 2019-03-29 Lg Chem, Ltd. Agoniści receptora sfingozyno-1-fosforanowego, sposoby ich przygotowania i zawierające je jako środek aktywny farmaceutyczne kompozycje
WO2014138075A1 (en) * 2013-03-07 2014-09-12 Allergan, Inc. Phosphonic acid compounds as sphingosine-1-phosphate receptor modulators
US20150045328A1 (en) * 2013-08-08 2015-02-12 Allergan, Inc. Disubstituted aryl oxy derivatives as sphingosine-1 phosphate receptors modulators
US20150045341A1 (en) * 2013-08-08 2015-02-12 Allergan, Inc. Disubstituted aryl azetidine derivatives as sphingosine-1 phosphate receptors modulators
WO2015073547A1 (en) * 2013-11-13 2015-05-21 Allergan, Inc. Disubstituted phenoxy azetidine derivatives as sphingosine-1-phosphate (s1p) receptor modulators
JOP20200186A1 (ar) 2018-02-02 2020-07-29 Univ Kyoto دواء للوقاية من أو علاج مرض بصري مرتبط بزيادة تكوين أوعية دموية جديدة داخل العين و/ أو نفاذية الأوعية الدموية داخل العين
CN117177964A (zh) * 2021-04-14 2023-12-05 株式会社Lg化学 制备鞘氨醇-1-磷酸酯受体激动剂的新方法
EP4306516A1 (en) * 2021-04-14 2024-01-17 Lg Chem, Ltd. Novel method for preparing sphingosine-1-phosphate receptor agonist
WO2022220610A1 (ko) * 2021-04-14 2022-10-20 주식회사 엘지화학 스핑고신-1-인산 수용체 효능제 합성을 위한 중간체의 제조방법

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0146810A3 (de) 1983-12-05 1987-05-13 Solco Basel AG Verfahren zur Herstellung von Sphingosinderivaten
US5110987A (en) 1988-06-17 1992-05-05 Emory University Method of preparing sphingosine derivatives
NZ233285A (en) 1989-04-18 1992-06-25 Duphar Int Res Imidazole-substituted carbamoyl-indoles and condensed analogues thereof and pharmaceutical compositions
US5294722A (en) 1992-04-16 1994-03-15 E. R. Squibb & Sons, Inc. Process for the preparation of imidazoles useful in angiotensin II antagonism
US5403851A (en) 1994-04-05 1995-04-04 Interneuron Pharmaceuticals, Inc. Substituted tryptamines, phenalkylamines and related compounds
KR100559817B1 (ko) 1997-03-12 2006-03-10 다카라 바이오 가부시키가이샤 스핑고신 유사화합물
JP4091250B2 (ja) 1997-09-11 2008-05-28 タカラバイオ株式会社 スフィンゴシン類誘導体及び医薬組成物
DE10010067A1 (de) * 2000-03-02 2001-09-06 Bayer Ag Neue Imidazotriazinone und ihre Verwendung
DK1397130T3 (da) 2001-06-20 2007-11-12 Wyeth Corp Substituerede indolsyrederivater som inhibitorer af plasminogenaktivatorinhibitor-1 (PAI-1)
US7351725B2 (en) * 2002-01-18 2008-04-01 Merck & Co., Inc. N-(benzyl)aminoalkylcarboxylates, phosphinates, phosphonates and tetrazoles as Edg receptor agonists
AU2003216054B2 (en) * 2002-01-18 2007-01-04 Merck & Co., Inc. Selective S1P1/Edg1 receptor agonists
JP4430941B2 (ja) * 2002-01-18 2010-03-10 メルク エンド カムパニー インコーポレーテッド Edg受容体作動薬
CA2524054C (en) * 2003-05-19 2012-04-24 Irm Llc Immunosuppressant compounds and compositions
CN101407471A (zh) * 2003-08-29 2009-04-15 小野药品工业株式会社 能够结合s1p受体的化合物及其药物用途
ES2754221T3 (es) * 2003-08-29 2020-04-16 Ono Pharmaceutical Co Compuesto capaz de unirse al receptor de S1P y uso farmacéutico del mismo
AU2005274277A1 (en) * 2004-08-17 2006-02-23 Galderma Research & Development, S.N.C. Novel biaromatic compounds which activate receptors of PPAR type and their use in cosmetic or pharmaceutical compositions
GB0612721D0 (en) * 2006-06-27 2006-08-09 Novartis Ag Organic compounds
AU2007292347A1 (en) * 2006-09-07 2008-03-13 Allergan, Inc. Heteroaromatic compounds having sphingosine-1-phosphate (S1P) receptor agonist and/or antagonist biological activity
BRPI0716601A2 (pt) * 2006-09-07 2013-09-17 Allergan Inc compostos de heteroaromÁticos tendo atividade biolàgica agonista de receptor de esfingosina-1-fosfato(s1p)
JP5732182B2 (ja) * 2006-10-27 2015-06-10 エルパス・インコーポレイテッドLpath, Inc. 眼疾患と症状を処置するための組成物および方法
TW200827346A (en) * 2006-11-03 2008-07-01 Astrazeneca Ab Chemical compounds
US8633245B2 (en) 2008-04-11 2014-01-21 Institute Of Medicinal Molecular Design, Inc. PAI-1 inhibitor

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